Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 15, 2011, Pages 6241-6245

  Zhang, Kang ^a,b   Hopkins, Jill J ^c   Heier, Jeffrey S ^d   Birch, David G ^e   Halperin, Lawrence S ^f   Albini, Thomas A ^g   Brown, David M ^h   Jaffe, Glenn J ⁱ   Taoj, Weng ^j   Williams, George A ^k  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SICHUAN UNIVERSITY   (China)

^c RETINA VITREOUS ASSOCIATES MEDICAL GROUP   (United States)

^d OPHTHALMIC CONSULTANTS OF BOSTON   (United States)

^e RETINA FOUNDATION OF THE SOUTHWEST   (United States)

^f Retina Group of Florida   (United States)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^h EAST TEXAS MEDICAL CENTER   (United States)

ⁱ DUKE UNIVERSITY EYE CENTER   (United States)

^j Neurotech USA   (United States)

^k WILLIAM BEAUMONT HOSPITAL   (United States)

more..

Author keywords

Apoptosis; Photoreceptor degeneration; Retina

Indexed keywords

CILIARY NEUROTROPHIC FACTOR;

ADULT; AGED; CATARACT; CELL ENCAPSULATION; CONFERENCE PAPER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG IMPLANT; DRUG MEGADOSE; ENCAPSULATED CELL INTRAOCULAR IMPLANT; ENDOPHTHALMITIS; ENDOPTHALMITIS; EROSION; EYE DISEASE; FEMALE; GEOGRAPHIC ATROPHY; HUMAN; INTRAOCULAR HEMORRHAGE; INTRAOCULAR PRESSURE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MIOSIS; MULTICENTER STUDY; OUTCOME ASSESSMENT; PHOTOPSIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA DETACHMENT; RETINA MACULA DEGENERATION; SAFETY; SHAM PROCEDURE; SIDE EFFECT; TREATMENT OUTCOME; VISUAL ACUITY; VISUAL FIELD;

EID: 79955032437     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018987108     Document Type: Article

References (27)

1. Bressler NM (2004) Age-related macular degeneration is the leading cause of blindness⋯. JAMA 291:1900-1901. (Pubitemid 38509505)
2. Friedman DS, et al.; Eye Diseases Prevalence Research Group (2004) Prevalence of agerelated macular degeneration in the United States. Arch Ophthalmol 122:564-572. (Pubitemid 38456293)
3. Resnikoff S, et al. (2004) Global data on visual impairment in the year 2002. Bull World Health Organ 82:844-851. (Pubitemid 39573742)
4. Anonymous; Age-Related Eye Disease Study Research Group (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119:1417-1436.
5. Sunness JS, et al. (1999) Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology 106: 1768-1779. (Pubitemid 30194280)
6. Ferris FL, 3rd, Fine SL, Hyman L (1984) Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol 102:1640-1642. (Pubitemid 15204559)
7. Sarks JP, Sarks SH, Killingsworth MC (1988) Evolution of geographic atrophy of the retinal pigment epithelium. Eye (Lond) 2:552-577. (Pubitemid 19142671)
8. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM (1990) Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347:83-86.
9. McDonald NQ, Panayotatos N, Hendrickson WA (1995) Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J 14: 2689-2699.
10. Panayotatos N, et al. (1995) Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines. J Biol Chem 270:14007-14014.
11. Stahl N, Yancopoulos GD (1994) The tripartite CNTF receptor complex: Activation and signaling involves components shared with other cytokines. J Neurobiol 25:1454-1466. (Pubitemid 24325068)
12. Fuhrmann S, Grabosch K, Kirsch M, Hofmann HD (2003) Distribution of CNTF receptor alpha protein in the central nervous system of the chick embryo. J Comp Neurol 461: 111-122. (Pubitemid 36578600)
13. Fuhrmann S, Kirsch M, Hofmann HD (1995) Ciliary neurotrophic factor promotes chick photoreceptor development in vitro. Development 121:2695-2706.
14. LaVail MM, et al. (1998) Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39:592-602. (Pubitemid 28110693)
15. Cayouette M, Behn D, Sendtner M, Lachapelle P, Gravel C (1998) Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci 18: 9282-9293. (Pubitemid 28512459)
16. CayouetteM, Gravel C (1997) Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 8:423-430. (Pubitemid 27140545)
17. Tao W, et al. (2002) Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 43: 3292-3298.
18. LaVail MM, et al. (1992) Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci USA 89:11249-11253.
19. Sieving PA, et al. (2006) Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci USA 103:3896-3901. (Pubitemid 43376652)
20. Tao W (2006) Application of encapsulated cell technology for retinal degenerative diseases. Expert Opin Biol Ther 6:717-726.
21. Lujan B, Roorda A, Knighton RW, Carroll J (2010) Revealing Henle's fiber layer using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci,10.1167/ iovs.10-5946.
22. Sunness JS, et al. (2007) The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trials. Ophthalmology 114:271-277. (Pubitemid 46161807)
23. Bush RA, et al. (2004) Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology. Invest Ophthalmol Vis Sci 45:2420-2430. (Pubitemid 38902618)
24. Li Y, et al. (2010) CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS ONE 5:e9495.
25. Talcott KE, et al. (2010) Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment. Invest Ophthalmol Vis Sci, 10.1167/iovs.10-6479.
26. Beck RW, et al. (2003) A computerized method of visual acuity testing: adaptation of the early treatment of diabetic retinopathy study testing protocol. Am J Ophthalmol 135:194-205. (Pubitemid 36151797)
27. Marmor MF, Holder GE, Seeliger MW, Yamamoto S; International Society for Clinical Electrophysiology of Vision (2004) Standard for clinical electroretinography (2004 update). Doc Ophthalmol 108:107-114. (Pubitemid 39140118)