Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 11, 2000, Pages 3492-3502

  Sohn, J H ^a   Kaplan, H J ^a   Suk, H J ^a   Bora, P S ^a   Bora, N S ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; COBROTOXIN; COMPLEMENT COMPONENT C3; COMPLEMENT MEMBRANE ATTACK COMPLEX; DECAY ACCELERATING FACTOR; IMMUNOGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE COFACTOR PROTEIN; MONOCLONAL ANTIBODY; ZYMOSAN;

ANIMAL TISSUE; ANTIGEN DETECTION; AQUEOUS HUMOR; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT SYSTEM; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; IRIDOCYCLITIS; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMAL; ANTIGENS, CD; ANTIGENS, CD55; ANTIGENS, CD59; BASE SEQUENCE; BLOTTING, WESTERN; COMPLEMENT ACTIVATION; COMPLEMENT HEMOLYTIC ACTIVITY ASSAY; COMPLEMENT PATHWAY, ALTERNATIVE; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EYE; IMMUNOENZYME TECHNIQUES; MALE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; RATS; RATS, INBRED LEW; RECEPTORS, COMPLEMENT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS; SUPPORT, U.S. GOV'T, P.H.S.; UVEITIS, ANTERIOR; ZYMOSAN;

EID: 0033775686     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Molecular organization and function of the complement system
2. Control of the complement system
3. Decay accelerating factor (CD55)
4. Membrane cofactor protein (MCP or CD46): Newest member of the regulators of complement activation gene cluster
5. Membrane inhibitor of reactive lysis
6. Differential expression of the complement regulatory proteins in the human eye
7. Localization of the complement membrane attack complex inhibitor (CD59) in human conjunctiva and lacrimal gland
8. Expression of the complement regulatory proteins in the normal and diseased (EAI) rat eye
9. Tissue distribution of complement regulatory membrane proteins in rats
10. Cell surface regulators of complement, 512 antigen, and CD59, in the rat eye and adnexal tissues
11. Complement inhibitors in normal cornea and aqueous humor
12. Soluble forms of membrane cofactor protein (CD46, MCP) are present in plasma, tears, and seminal fluid in normal subjects
13. Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluid
14. Complement and complement regulatory proteins in human tears
15. A small molecular weight factor in aqueous humor acts on C1q to prevent antibody-dependent complement activation
16. Immunologic privilege of the eye
17. Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis, I. induction by a detergent-insoluble, intrinsic protein fraction of the retina pigment epithelium
18. Experimental autoimmune anterior uveitis (EAAU):Induction with melanin associated antigen from the iris and ciliary body
19. Intraocular cytokine quantification of experimental autoimmune uveoretinitis in rats
20. A refined and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
21. Quantitative determinations of complement components and immunoglobulins in tears and aqueous humor
22. Complement levels in normal and inflamed aqueous humor
23. Alternate and classical pathway components of complement in the normal cornea
24. Isolation and characterization of the third component of rat complement
25. Physiologic inactivation of fluid phase C3b: Isolation and structural analysis of C3c, C3d, g (alpha 2D), and C3g
26. Generation of complement membrane attack complex in normal human corneas
27. Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity
28. Terminal complement complex in synovial tissue from patients affected by rheumatoid arthritis, osteoarthritis and acute joint trauma
29. Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synovium
30. Activated complement in inflamed aqueous humor
31. Expression and localization of proteins of the complement system in human skin
32. Immunohistochemical study of the C5b-9 complex of complement in human kidneys
33. Sensitive ELISA for quantitating the terminal membrane C5b-9 and fluid-phase SC5b-9 complex of human complement
34. Up-regulated production and activation of the complement system in Alzheimer's disease brain
35. Immunostaining for membrane attack complex of complement is related to cell necrosis in fulminant and acute hepatitis
36. Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium
37. The effects of functional suppression of a membrane-bound complement regulatory protein, CD59, in the synovial tissue in rats
38. A Localization of the membrane attack complex (MAC) in experimental immune complex glomerulonephritis
39. Activation of the alternative complement pathway due to resistance of the zymosan-bound amplification convertase to endogenous regulatory mechanism
40. Pulmonary responses to particulate materials capable of activating the alternative pathway of complement
41. Key role of complement activation and platelet-activating factor in exudate formation in zymosan-induced rat pleurisy
42. Zymosan-induced arthritis: A model of chronic proliferative arthritis following activation of the alternative pathway of complement
43. Molecular cloning and derived primary structure of cobra venom factor
44. In vivo characterization of Zymosan-induced mouse peritoneal inflammation
45. Binding of human and rat CD59 to the terminal complement complexes
46. Molecular cloning of a murine homologue of membrane cofactor protein (CD46): Preferential expression in testicular germ cells
47. Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes: Duplicated genes encode glycosylphophatidylinositol-anchored and transmembrane forms
48. Molecular cloning of the rat analogue of human CD59 and identification of a putative active site
49. Molecular cloning of the rat complement regulatory protein, 512 antigen
50. Complement inhibitor of rat cell membrane resembling mouse Crry/p65
51. Isolation and characterization of a membrane protein from rat erythrocytes which inhibits lysis by the membrane attack complex of rat complement
52. Local inflammation caused by a monoclonal antibody that blocks the function of the rat membrane inhibitor of C3 convertase
53. In vivo effects of monoclonal antibodies that functionally inhibit complement regulatory proteins in rats