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Volumn 15, Issue 18, 2014, Pages 2721-2731

Efficacy of α-lipoic acid in diabetic neuropathy

Author keywords

Diabetes mellitus; Diabetic neuropathy; Efficacy; Oxidative stress; Thioctic acid; Treatment

Indexed keywords

THIOCTIC ACID; ANTIOXIDANT; REACTIVE OXYGEN METABOLITE;

EID: 84910627065     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2014.972935     Document Type: Review
Times cited : (142)

References (90)
  • 1
    • 44449144074 scopus 로고    scopus 로고
    • Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: The monica/kora augsburg surveys s2 and s3
    • KORA Study Group
    • Ziegler D, Rathmann W, Dickhaus T, KORA Study Group. Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3. Diabetes Care 2008;31: 464-9
    • (2008) Diabetes Care , vol.31 , pp. 464-469
    • Ziegler, D.1    Rathmann, W.2    Dickhaus, T.3
  • 2
    • 78651101592 scopus 로고    scopus 로고
    • Diabetic neuropathies: Update on definitions, diagnostic criteria, estimation of severity, and treatments
    • Tesfaye S, Boulton AJ, Dyck PJ, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 2010;33: 2285-93
    • (2010) Diabetes Care , vol.33 , pp. 2285-2293
    • Tesfaye, S.1    Boulton, A.J.2    Dyck, P.J.3
  • 3
    • 34547771648 scopus 로고    scopus 로고
    • The diabetic foot: Established and emerging treatments
    • Papanas N, Maltezos E. The diabetic foot: established and emerging treatments. Acta Clin Belg 2007;62: 230-8
    • (2007) Acta Clin Belg , vol.62 , pp. 230-238
    • Papanas, N.1    Maltezos, E.2
  • 4
    • 0033760009 scopus 로고    scopus 로고
    • Independent effects of peripheral nerve dysfunction on lower-extremity physical function in old age the women's health and aging study
    • Resnick HE, Vinik AI, Schwartz AV, et al. Independent effects of peripheral nerve dysfunction on lower-extremity physical function in old age. The Women's Health and Aging Study. Diabetes Care 2000;23: 1642-7
    • (2000) Diabetes Care , vol.23 , pp. 1642-1647
    • Resnick, H.E.1    Vinik, A.I.2    Schwartz, A.V.3
  • 5
    • 84881329001 scopus 로고    scopus 로고
    • Current options and perspectives in the treatment of diabetic neuropathy
    • Vaaaaarkonyi T, Putz Z, Keresztes K, et al. Current options and perspectives in the treatment of diabetic neuropathy. Curr Pharm Des 2013;19: 4981-5007
    • (2013) Curr Pharm des , vol.19 , pp. 4981-5007
    • Vaaaaarkonyi, T.1    Putz, Z.2    Keresztes, K.3
  • 6
    • 0033988613 scopus 로고    scopus 로고
    • Painful diabetic neuropathy: Epidemiology, pain description, and quality of life
    • Galer BS, Gianas A, Jensen MP. Painful diabetic neuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract 2000;47: 123-8
    • (2000) Diabetes Res Clin Pract , vol.47 , pp. 123-128
    • Galer, B.S.1    Gianas, A.2    Jensen, M.P.3
  • 7
    • 15444360456 scopus 로고    scopus 로고
    • Risk factors for mortality in type ii (non-insulin-dependent) diabetes: Evidence of a role for neuropathy and a protective effect of hla-dr4
    • Forsblom CM, Sane T, Groop PH, et al. Risk factors for mortality in Type II (non-insulin-dependent) diabetes: evidence of a role for neuropathy and a protective effect of HLA-DR4. Diabetologia 1998;4: 1253-62
    • (1998) Diabetologia , vol.4 , pp. 1253-1262
    • Forsblom, C.M.1    Sane, T.2    Groop, P.H.3
  • 8
    • 0034101471 scopus 로고    scopus 로고
    • Showing neuropathy is related to increased mortality in diabetic patients-A survival analysis using an accelerated failure time model
    • Coppini DV, Bowtell PA, Weng C, et al. Showing neuropathy is related to increased mortality in diabetic patients-A survival analysis using an accelerated failure time model. J Clin Epidemiol 2000;53: 519-23
    • (2000) J Clin Epidemiol , vol.53 , pp. 519-523
    • Coppini, D.V.1    Bowtell, P.A.2    Weng, C.3
  • 9
    • 80053593410 scopus 로고    scopus 로고
    • Cardiovascular autonomic neuropathy in diabetes: Clinical impact, assessment, diagnosis, and management
    • Spallone V, Ziegler D, Freeman R, et al. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev 2011;27: 639-53
    • (2011) Diabetes Metab Res Rev , vol.27 , pp. 639-653
    • Spallone, V.1    Ziegler, D.2    Freeman, R.3
  • 10
    • 33846435723 scopus 로고    scopus 로고
    • Diabetic cardiovascular autonomic neuropathy
    • Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation 2007;115: 387-97
    • (2007) Circulation , vol.115 , pp. 387-397
    • Vinik, A.I.1    Ziegler, D.2
  • 11
    • 77958180456 scopus 로고    scopus 로고
    • Neuropathy: The crystal ball for cardiovascular disease
    • Vinik AI, Maser RE, Ziegler D. Neuropathy: the crystal ball for cardiovascular disease? Diabetes Care 2010;33: 1688-90
    • (2010) Diabetes Care , vol.33 , pp. 1688-1690
    • Vinik, A.I.1    Maser, R.E.2    Ziegler, D.3
  • 12
    • 84911962778 scopus 로고    scopus 로고
    • New vistas in the diagnosis of diabetic polyneuropathy
    • Epub ahead of print]
    • Papanas N, Ziegler D. New vistas in the diagnosis of diabetic polyneuropathy. Endocrine 2014. [Epub ahead of print]
    • (2014) Endocrine
    • Papanas, N.1    Ziegler, D.2
  • 13
    • 84876361101 scopus 로고    scopus 로고
    • A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy
    • Papanas N, Boulton AJ, Malik RA, et al. A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy. Diabet Med 2013;30: 525-34
    • (2013) Diabet Med , vol.30 , pp. 525-534
    • Papanas, N.1    Boulton, A.J.2    Malik, R.A.3
  • 14
    • 0021984563 scopus 로고
    • The value of cardiovascular autonomic function tests: 10 years experience in diabetes
    • Ewing DJ, Martyn CN, Young RJ, Clarke BF. The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 1985;8: 491-8
    • (1985) Diabetes Care , vol.8 , pp. 491-498
    • Ewing, D.J.1    Martyn, C.N.2    Young, R.J.3    Clarke, B.F.4
  • 16
    • 84856065932 scopus 로고    scopus 로고
    • Alpha-lipoic acid, diabetic neuropathy, and Nathan's prophecy
    • Papanas N, Maltezos E. Alpha-lipoic acid, diabetic neuropathy, and Nathan's prophecy. Angiology 2012;63: 81-3
    • (2012) Angiology , vol.63 , pp. 81-83
    • Papanas, N.1    Maltezos, E.2
  • 18
    • 2642548826 scopus 로고    scopus 로고
    • Thioctic acid for patients with symptomatic diabetic polyneuropathy: A critical review
    • Ziegler D. Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review. Treat Endocrinol 2004;3: 173-89
    • (2004) Treat Endocrinol , vol.3 , pp. 173-189
    • Ziegler, D.1
  • 19
    • 84886099805 scopus 로고    scopus 로고
    • The role of nerve growth factor in the prophylaxis and treatment of diabetic foot ulcers
    • Tiaka EK, Papanas N, Manolakis AC, Maltezos E. The role of nerve growth factor in the prophylaxis and treatment of diabetic foot ulcers. Int J Burns Trauma 2011;1: 68-76
    • (2011) Int J Burns Trauma , vol.1 , pp. 68-76
    • Tiaka, E.K.1    Papanas, N.2    Manolakis, A.C.3    Maltezos, E.4
  • 20
    • 67650076664 scopus 로고    scopus 로고
    • Ranirestat for the management of diabetic sensorimotor polyneuropathy
    • Ranirestat Study Group
    • Bril V, Hirose T, Tomioka S, Buchanan R; Ranirestat Study Group. Ranirestat for the management of diabetic sensorimotor polyneuropathy. Diabetes Care 2009;32: 1256-60
    • (2009) Diabetes Care , vol.32 , pp. 1256-1260
    • Bril, V.1    Hirose, T.2    Tomioka, S.3    Buchanan, R.4
  • 21
    • 77956227831 scopus 로고    scopus 로고
    • Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: A review
    • Schemmel KE, Padiyara RS, D'Souza JJ. Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review. J Diabetes Complications 2010;24: 354-60
    • (2010) J Diabetes Complications , vol.24 , pp. 354-360
    • Schemmel, K.E.1    Padiyara, R.S.2    D'souza, J.J.3
  • 22
    • 84887163693 scopus 로고    scopus 로고
    • Ruboxistaurin for the treatment of diabetic peripheral neuropathy: A systematic review of randomized clinical trials
    • Bansal D, Badhan Y, Gudala K, Schifano F. Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials. Diabetes Metab J 2013;37: 375-84
    • (2013) Diabetes Metab J , vol.37 , pp. 375-384
    • Bansal, D.1    Badhan, Y.2    Gudala, K.3    Schifano, F.4
  • 23
    • 41149125988 scopus 로고    scopus 로고
    • Lipid-lowering therapy and peripheral sensory neuropathy in type 2 diabetes: The fremantle diabetes study
    • Davis TM, Yeap BB, Davis WA, Bruce DG. Lipid-lowering therapy and peripheral sensory neuropathy in type 2 diabetes: the Fremantle Diabetes Study. Diabetologia 2008;51: 562-6
    • (2008) Diabetologia , vol.51 , pp. 562-566
    • Davis, T.M.1    Yeap, B.B.2    Davis, W.A.3    Bruce, D.G.4
  • 24
    • 84879398726 scopus 로고    scopus 로고
    • Lipid-lowering therapy in the diabetic foot: Seeing the whole iceberg and not just the tip
    • Epub ahead of print]
    • Antonoglou C, Papanas N, Maltezos E. Lipid-lowering therapy in the diabetic foot: seeing the whole iceberg and not just the tip. Curr Vasc Pharmacol 2012. [Epub ahead of print]
    • (2012) Curr Vasc Pharmacol
    • Antonoglou, C.1    Papanas, N.2    Maltezos, E.3
  • 25
    • 65649142619 scopus 로고    scopus 로고
    • Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (field study): A prespecified analysis of a randomised controlled trial
    • Rajamani K, Colman PG, Li LP, et al. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. Lancet 2009;373: 1780-8
    • (2009) Lancet , vol.373 , pp. 1780-1788
    • Rajamani, K.1    Colman, P.G.2    Li, L.P.3
  • 26
    • 70349642885 scopus 로고    scopus 로고
    • Dyslipidemia-induced neuropathy in mice: The role of oxldl/lox-1
    • Vincent AM, Hayes JM, McLean LL, et al. Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1. Diabetes 2009;58: 2376-85
    • (2009) Diabetes , vol.58 , pp. 2376-2385
    • Vincent, A.M.1    Hayes, J.M.2    McLean, L.L.3
  • 27
    • 19944433694 scopus 로고    scopus 로고
    • Vascular risk factors and diabetic neuropathy
    • Tesfaye S, Chaturvedi N, Eaton SE, et al. Vascular risk factors and diabetic neuropathy. N Engl J Med 2005;352: 341-50
    • (2005) N Engl J Med , vol.352 , pp. 341-350
    • Tesfaye, S.1    Chaturvedi, N.2    Eaton, S.E.3
  • 28
    • 80054925161 scopus 로고    scopus 로고
    • Neuropathy in prediabetes: Does the clock start ticking early
    • Papanas N, Vinik AI, Ziegler D. Neuropathy in prediabetes: does the clock start ticking early? Nat Rev Endocrinol 2011;7: 682-90
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 682-690
    • Papanas, N.1    Vinik, A.I.2    Ziegler, D.3
  • 29
    • 84910659971 scopus 로고    scopus 로고
    • Available from Last accessed 5 July 2014]
    • Available from: http://pubchem.ncbi.nlm. nih.gov/summary/summary.cgi?cid=6112 [Last accessed 5 July 2014]
  • 30
    • 84910613671 scopus 로고    scopus 로고
    • Available from [Last accessed 5 July 2014]
    • Available from: http://toxnet.nlm.nih. gov/cgi-bin/sis/search2/r?dbs+hsdb: @term +@rn+@rel+1077-28-7 [Last accessed 5 July 2014]
  • 31
    • 37549020089 scopus 로고    scopus 로고
    • The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects
    • Carlson DA, Smith AR, Fischer SJ, et al. The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects. Altern Med Rev 2007;12: 343-51
    • (2007) Altern Med Rev , vol.12 , pp. 343-351
    • Carlson, D.A.1    Smith, A.R.2    Fischer, S.J.3
  • 32
    • 0032770213 scopus 로고    scopus 로고
    • The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy
    • Haak ES, Usadel KH, Kohleisen M, et al. The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. Microvasc Res 1999;58: 28-34
    • (1999) Microvasc Res , vol.58 , pp. 28-34
    • Haak, E.S.1    Usadel, K.H.2    Kohleisen, M.3
  • 33
    • 0034107946 scopus 로고    scopus 로고
    • Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy
    • Haak E, Usadel KH, Kusterer K, et al. Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. Exp Clin Endocrinol Diabetes 2000;108: 168-74
    • (2000) Exp Clin Endocrinol Diabetes , vol.108 , pp. 168-174
    • Haak, E.1    Usadel, K.H.2    Kusterer, K.3
  • 34
    • 0035399871 scopus 로고    scopus 로고
    • Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: Relation to parameters of oxidative stress
    • Heitzer T, Finckh B, Albers S, et al. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic Biol Med 2001;31: 53-61
    • (2001) Free Radic Biol Med , vol.31 , pp. 53-61
    • Heitzer, T.1    Finckh, B.2    Albers, S.3
  • 35
    • 84910657463 scopus 로고    scopus 로고
    • Lipoate prevention of diabetic microangiopathy
    • Fuchs J, Packer L, Zimmer G, editors. Marcel Decker New York
    • Hoffman M, Zimmer G. Lipoate prevention of diabetic microangiopathy. In: Fuchs J, Packer L, Zimmer G, editors. Lipoic acid in health and disease. Marcel Decker; New York: 1997. p. 168-74
    • (1997) Lipoic Acid in Health and Disease , pp. 168-174
    • Hoffman, M.1    Zimmer, G.2
  • 36
    • 12844260091 scopus 로고    scopus 로고
    • Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: Results of the irbesartan and lipoic acid in endothelial dysfunction (island) study
    • Sola S, Mir MQ, Cheema FA, et al. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the irbesartan and lipoic acid in endothelial dysfunction (ISLAND) study. Circulation 2005;111: 343-8
    • (2005) Circulation , vol.111 , pp. 343-348
    • Sola, S.1    Mir, M.Q.2    Cheema, F.A.3
  • 37
    • 0033010474 scopus 로고    scopus 로고
    • Alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria
    • Borcea V, Nourooz-Zadeh J, Wolff SP, et al. Alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic Biol Med 1999;26: 1495-500
    • (1999) Free Radic Biol Med , vol.26 , pp. 1495-1500
    • Borcea, V.1    Nourooz-Zadeh, J.2    Wolff, S.P.3
  • 38
    • 0034067261 scopus 로고    scopus 로고
    • In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy
    • Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo 2000;14: 327-30
    • (2000) Vivo , vol.14 , pp. 327-330
    • Androne, L.1    Gavan, N.A.2    Veresiu, I.A.3    Orasan, R.4
  • 39
    • 0031880437 scopus 로고    scopus 로고
    • Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes
    • Hofmann MA, Schiekofer S, Kanitz M, et al. Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes. Diabetes Care 1998;21: 1310-16
    • (1998) Diabetes Care , vol.21 , pp. 1310-1316
    • Hofmann, M.A.1    Schiekofer, S.2    Kanitz, M.3
  • 40
    • 0032897751 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB
    • Hofmann MA, Schiekofer S, Isermann B, et al. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. Diabetologia 1999;42: 222-32
    • (1999) Diabetologia , vol.42 , pp. 222-232
    • Hofmann, M.A.1    Schiekofer, S.2    Isermann, B.3
  • 41
    • 0029978685 scopus 로고    scopus 로고
    • Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid
    • Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes 1996;104: 284-8
    • (1996) Exp Clin Endocrinol Diabetes , vol.104 , pp. 284-288
    • Jacob, S.1    Henriksen, E.J.2    Tritschler, H.J.3
  • 42
    • 0032718972 scopus 로고    scopus 로고
    • Thioctic acid-effects on insulin sensitivity and glucose-metabolism
    • Jacob S, Rett K, Henriksen EJ, Haddddring HU. Thioctic acid-effects on insulin sensitivity and glucose-metabolism. Biofactors 1999;10: 169-74
    • (1999) Biofactors , vol.10 , pp. 169-174
    • Jacob, S.1    Rett, K.2    Henriksen, E.J.3    Haddddring, H.U.4
  • 43
    • 0033764060 scopus 로고    scopus 로고
    • Alpha-lipoic acid: A multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes
    • Evans JL, Goldfine ID. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther 2000;2: 401-13
    • (2000) Diabetes Technol Ther , vol.2 , pp. 401-413
    • Evans, J.L.1    Goldfine, I.D.2
  • 44
    • 0030506789 scopus 로고    scopus 로고
    • Thioctic acid stimulates muscle ATP production in patients with type-2-diabetes and diabetic polyneuropathy
    • Suppl
    • Barbiroli B, Medori R, Tritschler HJ, Iotti S. Thioctic acid stimulates muscle ATP production in patients with type-2-diabetes and diabetic polyneuropathy. Diabetes Stoffwechsel 1996;5(3 Suppl): 71-6
    • (1996) Diabetes Stoffwechsel , vol.5 , Issue.3 , pp. 71-76
    • Barbiroli, B.1    Medori, R.2    Tritschler, H.J.3    Iotti, S.4
  • 45
    • 0029090976 scopus 로고
    • Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy
    • Nagamatsu M, Nickander KK, Schmelzer JD, et al. Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 1995;18: 1160-7
    • (1995) Diabetes Care , vol.18 , pp. 1160-1167
    • Nagamatsu, M.1    Nickander, K.K.2    Schmelzer, J.D.3
  • 46
    • 0029764551 scopus 로고    scopus 로고
    • Alpha-lipoic acid: Antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy
    • Nickander KK, McPhee BR, Low PA, Tritschler H. Alpha-lipoic acid: antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy. Free Radic Biol Med 1996;21: 631-9
    • (1996) Free Radic Biol Med , vol.21 , pp. 631-639
    • Nickander, K.K.1    McPhee, B.R.2    Low, P.A.3    Tritschler, H.4
  • 47
    • 0034038502 scopus 로고    scopus 로고
    • Effects of DL-Alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
    • Stevens MJ, Obrosova I, Cao X, et al. Effects of DL-Alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes 2000;49: 1006-15
    • (2000) Diabetes , vol.49 , pp. 1006-1015
    • Stevens, M.J.1    Obrosova, I.2    Cao, X.3
  • 48
    • 0031042744 scopus 로고    scopus 로고
    • Alpha-Lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support
    • Garrett NE, Malcangio M, Dewhurst M, Tomlinson DR. Alpha-Lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support. Neurosci Lett 1997;222: 191-4
    • (1997) Neurosci Lett , vol.222 , pp. 191-194
    • Garrett, N.E.1    Malcangio, M.2    Dewhurst, M.3    Tomlinson, D.R.4
  • 49
    • 2442631329 scopus 로고    scopus 로고
    • Advanced glycation end productinduced activation of NF-kB is suppressed by alpha-lipoic acid in cultured endothelial cells
    • Bierhaus A, Chevion S, Chevion M, et al. Advanced glycation end productinduced activation of NF-kB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997;46: 1481-90
    • (1997) Diabetes , vol.46 , pp. 1481-1490
    • Bierhaus, A.1    Chevion, S.2    Chevion, M.3
  • 50
    • 0033080764 scopus 로고    scopus 로고
    • Alpha-lipoic acid provides neuroprotection from ischemiareperfusion injury of peripheral nerve
    • Mitsui Y, Schmelzer JD, Zollman PJ, et al. Alpha-lipoic acid provides neuroprotection from ischemiareperfusion injury of peripheral nerve. J Neurol Sci 1999;163: 11-16
    • (1999) J Neurol Sci , vol.163 , pp. 11-16
    • Mitsui, Y.1    Schmelzer, J.D.2    Zollman, P.J.3
  • 51
    • 0035430412 scopus 로고    scopus 로고
    • Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve
    • Coppey LJ, Gellett JS, Davidson EP, et al. Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve. Diabetes 2001;50: 1927-37
    • (2001) Diabetes , vol.50 , pp. 1927-1937
    • Coppey, L.J.1    Gellett, J.S.2    Davidson, E.P.3
  • 52
    • 0035399658 scopus 로고    scopus 로고
    • Effect of alpha-lipoic acid on vascular responses and nociception in diabetic rats
    • Cameron NE, Jack AM, Cotter MA. Effect of alpha-lipoic acid on vascular responses and nociception in diabetic rats. Free Radic Biol Med 2001;31: 125-35
    • (2001) Free Radic Biol Med , vol.31 , pp. 125-135
    • Cameron, N.E.1    Jack, A.M.2    Cotter, M.A.3
  • 53
    • 84904774071 scopus 로고    scopus 로고
    • Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
    • Gomes MB, Negrato CA. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr 2014;6: 80
    • (2014) Diabetol Metab Syndr , vol.6 , pp. 80
    • Gomes, M.B.1    Negrato, C.A.2
  • 54
    • 84055204963 scopus 로고    scopus 로고
    • Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid
    • Santos JM, Kowluru RA. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Invest Ophthalmol Vis Sci 2011;52: 8791-8
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 8791-8798
    • Santos, J.M.1    Kowluru, R.A.2
  • 55
    • 33749154495 scopus 로고    scopus 로고
    • Alpha-lipoic acid corrects late-phase supernormal retinal oxygenation response in experimental diabetic retinopathy
    • Roberts R, Luan H, Berkowitz BA. Alpha-lipoic acid corrects late-phase supernormal retinal oxygenation response in experimental diabetic retinopathy. Invest Ophthalmol Vis Sci 2006;47: 4077-82
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 4077-4082
    • Roberts, R.1    Luan, H.2    Berkowitz, B.A.3
  • 56
    • 35748951314 scopus 로고    scopus 로고
    • Impaired apparent ion demand in experimental diabeticretinopathy: Correction by lipoic Acid
    • Berkowitz BA, Roberts R, Stemmler A, et al. Impaired apparent ion demand in experimental diabeticretinopathy: correction by lipoic Acid. Invest Ophthalmol Vis Sci 2007;48: 4753-8
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 4753-4758
    • Berkowitz, B.A.1    Roberts, R.2    Stemmler, A.3
  • 57
    • 80053107074 scopus 로고    scopus 로고
    • Alpha-lipoic acid for the prevention of diabetic macular edema
    • RETIPON Study Group
    • Haritoglou C, Gerss J, Hammes HP, RETIPON Study Group. Alpha-lipoic acid for the prevention of diabetic macular edema. Ophthalmologica 2011;226: 127-37
    • (2011) Ophthalmologica , vol.226 , pp. 127-137
    • Haritoglou, C.1    Gerss, J.2    Hammes, H.P.3
  • 58
    • 84857836518 scopus 로고    scopus 로고
    • Oxidative stress in preretinopathic diabetes subjects and antioxidants
    • Nebbioso M, Federici M, Rusciano D, et al. Oxidative stress in preretinopathic diabetes subjects and antioxidants. Diabetes Technol Ther 2012;14: 257-63
    • (2012) Diabetes Technol Ther , vol.14 , pp. 257-263
    • Nebbioso, M.1    Federici, M.2    Rusciano, D.3
  • 59
    • 84862937339 scopus 로고    scopus 로고
    • Reduced expression of lipoic acid synthase accelerates diabetic nephropathy
    • Yi X, Xu L, Hiller S, et al. Reduced expression of lipoic acid synthase accelerates diabetic nephropathy. J Am Soc Nephrol 2012;23: 103-11
    • (2012) J Am Soc Nephrol , vol.23 , pp. 103-111
    • Yi, X.1    Xu, L.2    Hiller, S.3
  • 60
    • 16244413938 scopus 로고    scopus 로고
    • Mechanisms of antioxidant and prooxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney
    • Bhatti F, Mankhey RW, Asico L, et al. Mechanisms of antioxidant and prooxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney. Kidney Int 2005;67: 1371-80
    • (2005) Kidney Int , vol.67 , pp. 1371-1380
    • Bhatti, F.1    Mankhey, R.W.2    Asico, L.3
  • 61
    • 84873177708 scopus 로고    scopus 로고
    • The protective effect of alpha-Lipoic acid on mitochondria in the kidney of diabetic rats
    • Wang L, Wu CG, Fang CQ, et al. The protective effect of alpha-Lipoic acid on mitochondria in the kidney of diabetic rats. Int J Clin Exp Med 2013;6: 90-7
    • (2013) Int J Clin Exp Med , vol.6 , pp. 90-97
    • Wang, L.1    Wu, C.G.2    Fang, C.Q.3
  • 62
    • 33847634800 scopus 로고    scopus 로고
    • Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: A pilot study
    • Chang JW, Lee EK, Kim TH, et al. Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study. Am J Nephrol 2007;27: 70-4
    • (2007) Am J Nephrol , vol.27 , pp. 70-74
    • Chang, J.W.1    Lee, E.K.2    Kim, T.H.3
  • 63
    • 0035037526 scopus 로고    scopus 로고
    • Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: An exploratory study
    • Morcos M, Borcea V, Isermann B, et al. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract 2001;52: 175-83
    • (2001) Diabetes Res Clin Pract , vol.52 , pp. 175-183
    • Morcos, M.1    Borcea, V.2    Isermann, B.3
  • 64
    • 84894380843 scopus 로고    scopus 로고
    • Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy
    • Noori N, Tabibi H, Hosseinpanah F, et al. Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy. Int J Vitam Nutr Res 2013;83: 77-85
    • (2013) Int J Vitam Nutr Res , vol.83 , pp. 77-85
    • Noori, N.1    Tabibi, H.2    Hosseinpanah, F.3
  • 65
    • 0034761442 scopus 로고    scopus 로고
    • Corpus cavernosum dysfunction in diabetic rats: Effects of combined alphalipoic acid and gamma-linolenic acid treatment
    • Keegan A, Cotter MA, Cameron NE. Corpus cavernosum dysfunction in diabetic rats: effects of combined alphalipoic acid and gamma-linolenic acid treatment. Diabetes Metab Res Rev 2001;17: 380-6
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 380-386
    • Keegan, A.1    Cotter, M.A.2    Cameron, N.E.3
  • 66
    • 28444478824 scopus 로고    scopus 로고
    • The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats
    • Hurdag C, Ozkara H, Citci S, et al. The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats. Int J Tissue React 2005;27: 145-50
    • (2005) Int J Tissue React , vol.27 , pp. 145-150
    • Hurdag, C.1    Ozkara, H.2    Citci, S.3
  • 67
    • 84883469257 scopus 로고    scopus 로고
    • Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus
    • Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv) 2013;55: 55-63
    • (2013) Folia Med (Plovdiv , vol.55 , pp. 55-63
    • Mitkov, M.D.1    Aleksandrova, I.Y.2    Orbetzova, M.M.3
  • 68
    • 0142135387 scopus 로고    scopus 로고
    • Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers
    • Teichert J, Hermann R, Ruus P, Preiss R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. J Clin Pharmacol 2003;43: 1257-67
    • (2003) J Clin Pharmacol , vol.43 , pp. 1257-1267
    • Teichert, J.1    Hermann, R.2    Ruus, P.3    Preiss, R.4
  • 69
    • 16844375015 scopus 로고    scopus 로고
    • Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease
    • Teichert J, Tuemmers T, Achenbach H, et al. Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease. J Clin Pharmacol 2005;45: 313-28
    • (2005) J Clin Pharmacol , vol.45 , pp. 313-328
    • Teichert, J.1    Tuemmers, T.2    Achenbach, H.3
  • 70
    • 0032881613 scopus 로고    scopus 로고
    • Treatment of diabetic peripheral neuropathy with the antioxidant thioctic acid (alpha-lipoic acid a two-year multicenter randomized double blind placebo controlled trial (aladin ii)
    • Reljanovic M, Reichel C, Rett K, et al. Treatment of diabetic peripheral neuropathy with the antioxidant thioctic acid (alpha-lipoic acid). A two-year multicenter randomized double blind placebo controlled trial (ALADIN II). Free Rad Res 1999;31: 171-9
    • (1999) Free Rad Res , vol.31 , pp. 171-179
    • Reljanovic, M.1    Reichel, C.2    Rett, K.3
  • 71
    • 0004570568 scopus 로고    scopus 로고
    • Effects of 3-week oral treatment with the antioxidant thioctic acid (alphalipoic acid) in symptomatic diabetic polyneuropathy
    • Ruhnau K-J, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alphalipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 1999;16: 1040-3
    • (1999) Diabet Med , vol.16 , pp. 1040-1043
    • Ruhnau, K.-J.1    Meissner, H.P.2    Finn, J.R.3
  • 72
    • 0031028636 scopus 로고    scopus 로고
    • Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in niddm patients a 4-month randomized controlled multicenter trial (dekan study)
    • Ziegler D, Schatz H, Conrad F, et al. Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Diabetes Care 1997;20: 369-73
    • (1997) Diabetes Care , vol.20 , pp. 369-373
    • Ziegler, D.1    Schatz, H.2    Conrad, F.3
  • 73
    • 33845499323 scopus 로고    scopus 로고
    • Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The sydney 2 trial
    • Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care 2006;29: 2365-70
    • (2006) Diabetes Care , vol.29 , pp. 2365-2370
    • Ziegler, D.1    Ametov, A.2    Barinov, A.3
  • 74
    • 84858303975 scopus 로고    scopus 로고
    • Efficacy and safety of antioxidant treatment with alpha-lipoic acid over 4 years in diabetic polyneuropathy: The NATHAN 1 trial
    • Ziegler D, Low PA, Litchy WJ, et al. Efficacy and safety of antioxidant treatment with alpha-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care 2011;34: 2054-60
    • (2011) Diabetes Care , vol.34 , pp. 2054-2060
    • Ziegler, D.1    Low, P.A.2    Litchy, W.J.3
  • 75
    • 0028845524 scopus 로고
    • Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid a 3-week multicentre randomized controlled trial (aladin study)
    • Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38: 1425-33
    • (1995) Diabetologia , vol.38 , pp. 1425-1433
    • Ziegler, D.1    Hanefeld, M.2    Ruhnau, K.J.3
  • 76
    • 0032788081 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid a 7-month multicenter randomized controlled trial (aladin iii study)
    • Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid. A 7-month multicenter randomized controlled trial (ALADIN III Study). Diabetes Care 1999;22: 1296-301
    • (1999) Diabetes Care , vol.22 , pp. 1296-1301
    • Ziegler, D.1    Hanefeld, M.2    Ruhnau, K.J.3
  • 77
    • 0042668303 scopus 로고    scopus 로고
    • The sensory symptoms of diabetic polyneuropathy are improved with alphalipoic acid the sydney trial
    • Ametov A, Barinov A, O'Brien P, et al. The sensory symptoms of diabetic polyneuropathy are improved with alphalipoic acid. The SYDNEY Trial. Diabetes Care 2003;26: 770-6
    • (2003) Diabetes Care , vol.26 , pp. 770-776
    • Ametov, A.1    Barinov, A.2    O'brien, P.3
  • 78
    • 0031886141 scopus 로고    scopus 로고
    • Postmarketing surveillance of adverse drug reactions: A correlational study approach usingmultiple data sources
    • Rathmann W, Haastert B, Delling B, et al. Postmarketing surveillance of adverse drug reactions: a correlational study approach usingmultiple data sources. Pharmacoepidemiol Drug Saf 1998;7: 51-7
    • (1998) Pharmacoepidemiol Drug Saf , vol.7 , pp. 51-57
    • Rathmann, W.1    Haastert, B.2    Delling, B.3
  • 79
    • 1242337352 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-Analysis
    • Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-Analysis. Diabet Med 2004;21: 114-21
    • (2004) Diabet Med , vol.21 , pp. 114-121
    • Ziegler, D.1    Nowak, H.2    Kempler, P.3
  • 80
    • 84860323365 scopus 로고    scopus 로고
    • Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy
    • McIlduff CE, Rutkove SB. Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. Ther Clin Risk Manag 2011;7: 377-85
    • (2011) Ther Clin Risk Manag , vol.7 , pp. 377-385
    • McIlduff, C.E.1    Rutkove, S.B.2
  • 81
    • 84858324850 scopus 로고    scopus 로고
    • Alpha lipoic Acid for symptomatic peripheral neuropathy in patients with diabetes: A meta-Analysis of randomized controlled trials
    • Mijnhout GS, Kollen BJ, Alkhalaf A, et al. Alpha lipoic Acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-Analysis of randomized controlled trials. Int J Endocrinol 2012;2012: 456279
    • (2012) Int J Endocrinol , vol.2012 , pp. 456279
    • Mijnhout, G.S.1    Kollen, B.J.2    Alkhalaf, A.3
  • 82
    • 84866703792 scopus 로고    scopus 로고
    • A systematic review and meta-Analysis of alpha-lipoic acid in the treatment of diabetic peripheral neuropathy
    • Han T, Bai J, Liu W, Hu Y. A systematic review and meta-Analysis of alpha-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol 2012;167: 465-71
    • (2012) Eur J Endocrinol , vol.167 , pp. 465-471
    • Han, T.1    Bai, J.2    Liu, W.3    Hu, Y.4
  • 83
    • 84892744748 scopus 로고    scopus 로고
    • Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia
    • Lunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. Cochrane Database Syst Rev 2014;1: CD007115
    • (2014) Cochrane Database Syst Rev , vol.1 , pp. CD007115
    • Lunn, M.P.1    Hughes, R.A.2    Wiffen, P.J.3
  • 84
    • 44949256456 scopus 로고    scopus 로고
    • Painful diabetic neuropathy: Treatment and future aspects
    • Ziegler D. Painful diabetic neuropathy: treatment and future aspects. Diabetes Metab Res Rev 2008;24(Suppl 1): S52-7
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. S52-S57
    • Ziegler, D.1
  • 85
    • 65249103372 scopus 로고    scopus 로고
    • German society of out patient diabetes centres and (arbeitsgemeinschaft niedergelassener diabetologisch taddddtiger arzte ev) switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: A real-world study in outpatients
    • Ruessmann HJ; German Society of out patient diabetes centres AND (Arbeitsgemeinschaft niedergelassener diabetologisch taddddtiger Arzte e.V.). Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatients. J Diabetes Complications 2009;23: 174-7
    • (2009) J Diabetes Complications , vol.23 , pp. 174-177
    • Ruessmann, H.J.1
  • 86
    • 84893708965 scopus 로고    scopus 로고
    • Systematic review and meta-Analysis of pharmacological therapies for painful diabetic peripheral neuropathy
    • Snedecor SJ, Sudharshan L, Cappelleri JC, et al. Systematic review and meta-Analysis of pharmacological therapies for painful diabetic peripheral neuropathy. Pain Pract 2014;14: 167-84
    • (2014) Pain Pract , vol.14 , pp. 167-184
    • Snedecor, S.J.1    Sudharshan, L.2    Cappelleri, J.C.3
  • 87
    • 79957500607 scopus 로고    scopus 로고
    • Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the american academy of neurology, the american association of neuromuscular and electrodiagnostic medicine, and the american academy of physical medicine and rehabilitation
    • Bril V, England J, Franklin GM, et al. Evidence-based guideline: treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 2011;76: 1758-65
    • (2011) Neurology , vol.76 , pp. 1758-1765
    • Bril, V.1    England, J.2    Franklin, G.M.3
  • 90
    • 84872593274 scopus 로고    scopus 로고
    • Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial
    • Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. Am J Med 2013;126: 141-9
    • (2013) Am J Med , vol.126 , pp. 141-149
    • Fonseca, V.A.1    Lavery, L.A.2    Thethi, T.K.3


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