Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase i and Rrn3

Molecular Cancer Research

Volumn 12, Issue 11, 2014, Pages 1586-1596

  Rothblum, Katrina ^a   Hu, Qiyue ^b   Penrod, Yvonne ^a   Rothblum, Lawrence I ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b South Cove Community Health Care Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

22MER PEPTIDE; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE III; NUCLEOTIDYLTRANSFERASE INHIBITOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; MOLECULAR LIBRARY; PEPTIDE; PROTEIN BINDING; RIBOSOME DNA; RRN3 PROTEIN, HUMAN; RRN3 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL DEATH; CELL DIVISION; CELL GROWTH; CONTROLLED STUDY; DNA TRANSCRIPTION; HUMAN; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION TERMINATION; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR LIBRARY; PHARMACOLOGY; PHENOTYPE; RAT; TUMOR CELL LINE; TWO HYBRID SYSTEM;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA, RIBOSOMAL; DNA-BINDING PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES; PHENOTYPE; POL1 TRANSCRIPTION INITIATION COMPLEX PROTEINS; PROTEIN BINDING; RATS; RNA POLYMERASE I; SMALL MOLECULE LIBRARIES; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84910624734     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-14-0229     Document Type: Article

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