Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells

Ophthalmic Research

Volumn 52, Issue 3, 2014, Pages 151-159

  Mergler, Stefan ^a   Valtink, Monika ^b   Takayoshi, Sumioka ^c   Okada, Yuka ^c   Miyajima, Masayasu ^c   Saika, Shizuya ^c   Reinach, Peter S ^d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Calcium; Cornea; Electrophysiology; Fibrosis; Inflammation; Thermo transient receptor potential channels; Wound healing

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; 4ALPHA PHORBOL DIDECANOATE; CAMPHOR; CAPSAICIN; CAPSAZEPINE; CINEOLE; GSK 1016790A; ICILIN; MENTHOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR AGONIST; CALCIUM CHANNEL; NERVE PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPA1 PROTEIN, HUMAN; TRPM8 PROTEIN, HUMAN; VANILLOID RECEPTOR;

CORNEA; CORNEA CELL; CORNEA DISEASE; CORNEA ENDOTHELIUM; CORNEA EPITHELIUM; CORNEA INJURY; CORNEA STROMA; DRUG TARGETING; FIBROBLAST; HOMEOSTASIS; HUMAN; MOLECULAR SENSOR; NERVE FIBER; NONHUMAN; REVIEW; STROMA; TEMPERATURE; THERMOGRAPHY; WOUND HEALING; BODY TEMPERATURE; METABOLISM; PHYSIOLOGY;

BODY TEMPERATURE; CALCIUM CHANNELS; CORNEA; HUMANS; NERVE TISSUE PROTEINS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPM CATION CHANNELS; TRPV CATION CHANNELS;

EID: 84910619672     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000365334     Document Type: Review

References (43)

1. Pan Z, Yang H, Reinach PS: Transient receptor potential (TRP) gene superfamily encoding cation channels. Hum Genomics 2011;5:108-116.
2. Sumioka T, Okada Y, Reinach PS, Shirai K, Miyajima M, Yamanaka O, Saika S: Impairment of cornea epithelial wound healing in a TRPV1-deficient mouse. Invest Ophthalmol Vis Sci 2014;55:3295-3302.
3. Okada Y, Reinach PS, Shirai K, Kitano A, Kao WW, Flanders KC, Miyajima M, Liu H, Zhang J, Saika S: TRPV1 involvement in inflammatory tissue fibrosis in mice. Am J Pathol 2011;178:2654-2664.
4. Murata Y, Masuko S: Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons. Brain Res 2006;1085:87-94.
5. Yang H, Mergler S, Sun X, Wang Z, Lu L, Bonanno JA, Pleyer U, Reinach PS: TRPC4 knockdown suppresses EGF-induced store operated channel activation and growth in human corneal epithelial cells. J Biol Chem 2005;280:32230-32237.
6. Yang H, Sun X, Wang Z, Ning G, Zhang F, Kong J, Lu L, Reinach PS: EGF stimulates growth by enhancing capacitative calcium entry in corneal epithelial cells. J Membr Biol 2003;194:47-58.
7. Xie Q, Zhang Y, Cai S, X, Zhai C, Bonanno JA: Expression and functional evaluation of transient receptor potential channel 4 in bovine corneal endothelial cells. Exp Eye Res 2005;81:5-14.
8. Zhang F, Yang H, Wang Z, Mergler S, Liu H, Kawakita T, Tachado SD, Pan Z, Capo-Aponte JE, Pleyer U, Koziel H, Kao WW, Reinach PS: Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling. J Cell Physiol 2007;213:730-739.
9. Mergler S, Valtink M, Coulson-Thomas VJ, Lindemann D, Reinach PS, Engelmann K, Pleyer U: TRPV channels mediate temperaturesensing in human corneal endothelial cells. Exp Eye Res 2010;90:758-770.
10. Fernandes ES, Fernandes MA, Keeble JE: The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol 2012;166:510-521.
11. Pingle SC, Matta JA, Ahern GP: Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol 2007;155-171.
12. Gees M, Colsoul B, Nilius B: The role of transient receptor potential cation channels in Ca 2+ signaling. Cold Spring Harb Perspect Biol 2010;2:a003962.
13. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B: The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 2004;430:748-754.
14. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A: A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006;441:179-185.
15. Yang H, Wang Z, Capo-Aponte JE, Zhang F, Pan Z, Reinach PS: Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells. Exp Eye Res 2010;91:462-471.
16. Yang Y, Yang H, Wang Z, Varadaraj K, Kumari SS, Mergler S, Okada Y, Saika S, Kingsley PJ, Marnett LJ, Reinach PS: Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. Cell Signal 2013;25:501-511.
17. Mergler S, Cheng Y, Skosyrsky S, Garreis F, Pietrzak P, Kociok N, Dwarakanath A, Reinach PS, Kakkassery V: Altered calcium regulation by thermo-sensitive transient receptor potential channels in etoposide-resistant WERI-Rb1 retinoblastoma cells. Exp Eye Res 2012;94:157-173.
18. Mergler S, Derckx R, Reinach PS, Garreis F, Bohm A, Schmelzer L, Skosyrski S, Ramesh N, Abdelmessih S, Polat OK, Khajavi N, Riechardt AI: Calcium regulation by temperaturesensitive transient receptor potential channels in human uveal melanoma cells. Cell Signal 2013;26:56-69.
19. Pan Z, Yang H, Mergler S, Liu H, Tachado SD, Zhang F, Kao WW, Koziel H, Pleyer U, Reinach PS: Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells. Cell Calcium 2008;44:374-385.
20. Yamada T, Ueda T, Ugawa S, Ishida Y, Imayasu M, Koyama S, Shimada S: Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing. Exp Eye Res 2010;90:121-129.
21. Mergler S, Pleyer U: The human corneal endothelium: new insights into electrophysiology and ion channels. Prog Retin Eye Res 2007;26:359-378.
22. Mergler S, Pleyer U: Physiology of the human corneal endothelium: new insights from electrophysiological investigations (in German). Klin Monatsbl Augenheilkd 2011.
23. Mergler S, Dannowski H, Bednarz J, Engelmann K, Hartmann C, Pleyer U: Calcium influx induced by activation of receptor tyrosine kinases in SV40-transfected human corneal endothelial cells. Exp Eye Res 2003;77:485-495.
24. Mergler S, Pleyer U, Reinach P, Bednarz J, Dannowski H, Engelmann K, Hartmann C, Yousif T: EGF suppresses hydrogen peroxide induced Ca 2+ influx by inhibiting L-type channel activity in cultured human corneal endothelial cells. Exp Eye Res 2005;80:285-293.
25. Bari MR, Akbar S, Eweida M, Kuhn FJ, Gustafsson AJ, Luckhoff A, Islam MS: H 2 O 2-induced Ca 2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the β-cells: involvement of TRPM2 channels. J Cell Mol Med 2009;13:3260-3267.
26. Mergler S, Mertens C, Valtink M, Reinach PS, Szekely VC, Slavi N, Garreis F, Abdelmessih S, Turker E, Fels G, Pleyer U: Functional significance of thermosensitive transient receptor potential melastatin channel 8 (TRPM8) expression in immortalized human corneal endothelial cells. Exp Eye Res 2013;116:337-349.
27. Valtink M, Gruschwitz R, Funk RH, Engelmann K: Two clonal cell lines of immortalized human corneal endothelial cells show either differentiated or precursor cell characteristics. Cells Tissues Organs 2008;187:286-294.
28. Mergler S, Valtink M, Taetz K, Sahlmüller M, Fels G, Reinach PS, Engelmann K, Pleyer U: Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells. Exp Eye Res 2011;93:710-719.
29. Yang Y, Yang H, Wang Z, Mergler S, Wolosin JM, Reinach PS: Functional TRPV1 expression in human corneal fibroblasts. Exp Eye Res 2013;107:121-129.
30. Yang Y, Wang Z, Yang H, Wang L, Gillespie SR, Wolosin JM, Bernstein AM, Reinach PS: TRPV1 potentiates TGF-β induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop. PLoS One 2013;8:e77300.
31. Zorn-Kruppa M, Tykhonova S, Belge G, Bednarz J, Diehl HA, Engelke M: A human corneal equivalent constructed from SV40-immortalised corneal cell lines. Altern Lab Anim 2005;33:37-45.
32. Marfurt CF, Cox J, Deek S, Dvorscak L: Anatomy of the human corneal innervation. Exp Eye Res 2010;90:478-492.
33. Tominaga M, Caterina MJ: Thermosensation and pain. J Neurobiol 2004;61:3-12.
34. Hirata H, Oshinsky ML: Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channels. J Neurophysiol 2012;107:1199-1209.
35. Madrid R, Donovan-Rodriguez T, Meseguer V, Acosta MC, Belmonte C, Viana F: Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals. J Neurosci 2006;26:12512-12525.
36. Parra A, Madrid R, Echevarria D, Del Olmo S, Morenilla-Palao C, Acosta MC, Gallar J, Dhaka A, Viana F, Belmonte C: Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med 2010;16:1396-1399.
37. Robbins A, Kurose M, Winterson BJ, Meng ID: Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. Invest Ophthalmol Vis Sci 2012;53:7034-7042.
38. Morgan PB, Soh MP, Efron N, Tullo AB: Potential applications of ocular thermography. Optom Vis Sci 1993;70:568-576.
39. Klamann MK, Maier AK, Gonnermann J, Klein JP, Pleyer U: Measurement of dynamic ocular surface temperature in healthy subjects using a new thermography device. Curr Eye Res 2012;37:678-683.
40. Kawali AA: Thermography in ocular inflammation. Indian J Radiol Imaging 2013;23:281-283.
41. Purslow C, Wolffsohn J: The relation between physical properties of the anterior eye and ocular surface temperature. Optom Vis Sci 2007;84:197-201.
42. Toczolowski J: The effect of immunosuppressors and low temperature on the activity of collagenase in the cornea. Ann Ophthalmol 1988;20:64-67.
43. Mergler S, Garreis F, Sahlmüller M, Reinach PS, Paulsen F, Pleyer U: Thermosensitive transient receptor potential channels in human corneal epithelial cells. J Cell Physiol 2011;226:1828-1842.