-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994 372 425-432. (doi:10.1038/372425a0)
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
2
-
-
0028845877
-
Leptin levels in human and rodent:Measurement of plasma leptin and ob RNA in obese and weightreduced subjects
-
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S et al . Leptin levels in human and rodent:measurement of plasma leptin and ob RNA in obese and weightreduced subjects. Nature Medicine 1995 1 1155-1161. (doi:10.1038/ nm1195-1155)
-
(1995)
Nature Medicine
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
Pratley, R.E.4
Lee, G.H.5
Zhang, Y.6
Fei, H.7
Kim, S.8
Lallone, R.9
Ranganathan, S.10
-
3
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E & Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996 382 250-252. (doi:10.1038/382250a0)
-
(1996)
Nature
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
Prabakaran, D.2
Mantzoros, C.3
Qu, D.4
Lowell, B.5
Maratos-Flier, E.6
Flier, J.S.7
-
4
-
-
0032527071
-
Distributions of leptin receptor mRNA isoforms in the rat brain
-
Elmquist JK, Bjorbaek C, Ahima RS, Flier JS & Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. Journal of Comparative Neurology 1998 395 535-547. (doi:10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>O3.0.CO;2-2)
-
(1998)
Journal of Comparative Neurology
, vol.395
, pp. 535-547
-
-
Elmquist, J.K.1
Bjorbaek, C.2
Ahima, R.S.3
Flier, J.S.4
Saper, C.B.5
-
5
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ & Baskin DG. Central nervous system control of food intake. Nature 2000 404 661-671. (doi:10.1038/oby.2006.275)
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte, D.3
Seeley, R.J.4
Baskin, D.G.5
-
6
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H,Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997 387 903-908. (doi:10.1038/43185)
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
Sewter, C.P.7
Digby, J.E.8
Mohammed, S.N.9
Hurst, J.A.10
-
7
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA & O'Rahilly S. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 1999 341 879-884. (doi:10.1056/NEJM199909163411204)
-
(1999)
New England Journal of Medicine
, vol.341
, pp. 879-884
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
Lawrence, E.4
Cheetham, C.H.5
Prentice, A.M.6
Hughes, I.A.7
McCamish, M.A.8
O'Rahilly, S.9
-
8
-
-
34548675339
-
Leptin regulates striatal regions and human eating behavior
-
Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S & Fletcher PC. Leptin regulates striatal regions and human eating behavior. Science 2007 317 1355. (doi:10.1126/science.1144599)
-
(2007)
Science
, vol.317
, pp. 1355
-
-
Farooqi, I.S.1
Bullmore, E.2
Keogh, J.3
Gillard, J.4
O'Rahilly, S.5
Fletcher, P.C.6
-
9
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [see comments]
-
Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J & Lacorte JM. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [see comments]. Nature 1998 392 398-401. (doi:10.1038/32911)
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clément, K.1
Vaisse, C.2
Lahlou, N.3
Cabrol, S.4
Pelloux, V.5
Cassuto, D.6
Gourmelen, M.7
Dina, C.8
Chambaz, J.9
Lacorte, J.M.10
-
10
-
-
33846409122
-
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
-
Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I et al. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. New England Journal of Medicine 2007 356 237-247. (doi:10.1056/NEJMoa063988)
-
(2007)
New England Journal of Medicine
, vol.356
, pp. 237-247
-
-
Farooqi, I.S.1
Wangensteen, T.2
Collins, S.3
Kimber, W.4
Matarese, G.5
Keogh, J.M.6
Lank, E.7
Bottomley, B.8
Lopez-Fernandez, J.9
Ferraz-Amaro, I.10
-
11
-
-
0033304576
-
Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
-
Ozata M, Ozdemir IC & Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. Journal of Clinical Endocrinology and Metabolism 1999 84 3686-3695. (doi:10.1210/ jcem.84.10.5999)
-
(1999)
Journal of Clinical Endocrinology and Metabolism
, vol.84
, pp. 3686-3695
-
-
Ozata, M.1
Ozdemir, I.C.2
Licinio, J.3
-
12
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Journal of Clinical Investigation 2002 110 1093-1103. (doi:10.1172/JCI0215693)
-
(2002)
Journal of Clinical Investigation
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
Keogh, J.M.4
Lawrence, E.5
Agwu, C.6
Sanna, V.7
Jebb, S.A.8
Perna, F.9
Fontana, S.10
-
13
-
-
76149128662
-
Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients
-
Galgani JE, Greenway FL, Caglayan S, Wong ML, Licinio J & Ravussin E. Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. Journal of Clinical Endocrinology and Metabolism 2010 95 851-855. (doi:10.1210/jc.2009-1739)
-
(2010)
Journal of Clinical Endocrinology and Metabolism
, vol.95
, pp. 851-855
-
-
Galgani, J.E.1
Greenway, F.L.2
Caglayan, S.3
Wong, M.L.4
Licinio, J.5
Ravussin, E.6
-
14
-
-
2942631413
-
Proopiomelanocortin and energy balance: Insights from human and murine genetics
-
Coll AP, Farooqi IS, Challis BG, Yeo GS & O'Rahilly S. Proopiomelanocortin and energy balance: insights from human and murine genetics. Journal of Clinical Endocrinology and Metabolism 2004 89 2557-2562. (doi:10.1210/jc.2004-0428)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, pp. 2557-2562
-
-
Coll, A.P.1
Farooqi, I.S.2
Challis, B.G.3
Yeo, G.S.4
O'Rahilly, S.5
-
15
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997 88 131-141. (doi:10.1016/S0092-8674(00)81865-6)
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
-
16
-
-
0033927916
-
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B & Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. Journal of Clinical Investigation 2000 106 253-262. (doi:10.1172/JCI9238)
-
(2000)
Journal of Clinical Investigation
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
Hercberg, S.4
Guy-Grand, B.5
Froguel, P.6
-
17
-
-
0343953074
-
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
-
Farooqi IS, Yeo GSH, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T & O'Rahilly S. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. Journal of Clinical Investigation 2000 106 271-279. (doi:10.1172/JCI9397)
-
(2000)
Journal of Clinical Investigation
, vol.106
, pp. 271-279
-
-
Farooqi, I.S.1
Yeo, G.S.H.2
Keogh, J.M.3
Aminian, S.4
Jebb, S.A.5
Butler, G.6
Cheetham, T.7
O'Rahilly, S.8
-
18
-
-
33645280903
-
The severely obese patient - A genetic work-up
-
quiz following 177
-
Farooqi IS. The severely obese patient - a genetic work-up. Nature Clinical Practice. Endocrinology & Metabolism 2006 2 172-177 quiz following 177. (doi:10.1038/ncpendmet0137)
-
(2006)
Nature Clinical Practice. Endocrinology & Metabolism
, vol.2
, pp. 172-177
-
-
Farooqi, I.S.1
-
19
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T & O'Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. New England Journal of Medicine 2003 348 1085-1095. (doi:10.1056/NEJMoa022050)
-
(2003)
New England Journal of Medicine
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.3
Lank, E.J.4
Cheetham, T.5
O'Rahilly, S.6
-
20
-
-
78649594776
-
Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity
-
René P, Le Gouill C, Pogozheva ID, Lee G, Mosberg HI, Farooqi IS, Valenzano KJ & Bouvier M. Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity. Journal of Pharmacology and Experimental Therapeutics 2010 335 520-532. (doi:10.1124/jpet.110.172098)
-
(2010)
Journal of Pharmacology and Experimental Therapeutics
, vol.335
, pp. 520-532
-
-
René, P.1
Le Gouill, C.2
Pogozheva, I.D.3
Lee, G.4
Mosberg, H.I.5
Farooqi, I.S.6
Valenzano, K.J.7
Bouvier, M.8
-
21
-
-
58249087146
-
Modulation of blood pressure by central melanocortinergic pathways
-
Greenfield JR, Miller JM, Keogh JW, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC et al . Modulation of blood pressure by central melanocortinergic pathways. New England Journal of Medicine 2009 360 44-52. (doi:10.1056/NEJMoa0803085)
-
(2009)
New England Journal of Medicine
, vol.360
, pp. 44-52
-
-
Greenfield, J.R.1
Miller, J.M.2
Keogh, J.W.3
Henning, E.4
Satterwhite, J.H.5
Cameron, G.S.6
Astruc, B.7
Mayer, J.P.8
Brage, S.9
See, T.C.10
-
22
-
-
84888014054
-
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation
-
Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D et al. KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell 2013 155 765-777. (doi:10.1016/j.cell.2013.09.058)
-
(2013)
Cell
, vol.155
, pp. 765-777
-
-
Pearce, L.R.1
Atanassova, N.2
Banton, M.C.3
Bottomley, B.4
Van Der Klaauw, A.A.5
Revelli, J.P.6
Hendricks, A.7
Keogh, J.M.8
Henning, E.9
Doree, D.10
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