메뉴 건너뛰기




Volumn 119, Issue 1, 2014, Pages 65-77

Enhanced biosynthesis of bioactive abietane diterpenes by overexpressing AtDXS or AtDXR genes in Salvia sclarea hairy roots

Author keywords

Bioactive diterpenes; Hairy roots; Metabolic engineering; Salvia sclarea

Indexed keywords

BIOCHEMISTRY; CELL CULTURE; GENES; LIPIDS; METABOLIC ENGINEERING; METABOLISM; QUINONE;

EID: 84910125236     PISSN: 01676857     EISSN: 15735044     Source Type: Journal    
DOI: 10.1007/s11240-014-0514-4     Document Type: Article
Times cited : (49)

References (64)
  • 1
    • 77952066972 scopus 로고    scopus 로고
    • Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology—Part 2
    • PID: 20186655, COI: 1:CAS:528:DC%2BC3cXotlahs7Y%3D
    • Alasbahi RH, Melzig MF (2010) Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology—Part 2. Planta Med 76:753–765
    • (2010) Planta Med , vol.76 , pp. 753-765
    • Alasbahi, R.H.1    Melzig, M.F.2
  • 2
    • 33644841888 scopus 로고    scopus 로고
    • Caterpillar herbivory and salivary enzymes decrease transcript levels of Medicago truncatula genes encoding early enzymes in terpenoid biosynthesis
    • PID: 16525889, COI: 1:CAS:528:DC%2BD28XitFOhs7c%3D
    • Bede JC, Musser RO, Felton GW, Korth KL (2006) Caterpillar herbivory and salivary enzymes decrease transcript levels of Medicago truncatula genes encoding early enzymes in terpenoid biosynthesis. Plant Mol Biol 60:519–531
    • (2006) Plant Mol Biol , vol.60 , pp. 519-531
    • Bede, J.C.1    Musser, R.O.2    Felton, G.W.3    Korth, K.L.4
  • 3
    • 84864148741 scopus 로고    scopus 로고
    • Discovery and functional characterization of two diterpene synthase for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture
    • PID: 22834731, COI: 1:CAS:528:DC%2BC3sXot1Wlsbg%3D
    • Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, Magnard JL, Bohlmann J, Legendre L (2012) Discovery and functional characterization of two diterpene synthase for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. BMC Plant Biol 12:119–132
    • (2012) BMC Plant Biol , vol.12 , pp. 119-132
    • Caniard, A.1    Zerbe, P.2    Legrand, S.3    Cohade, A.4    Valot, N.5    Magnard, J.L.6    Bohlmann, J.7    Legendre, L.8
  • 4
    • 0037008188 scopus 로고    scopus 로고
    • Expression and molecular analysis of the Arabidopsis DXR gene enconding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway
    • PID: 12177470, COI: 1:CAS:528:DC%2BD38Xmtl2gsbY%3D
    • Carretero-Paulet L, Ahumada I, Cunillera N, Rodríguez-Concepción M, Ferrer A, Boronat A, Campos N (2002) Expression and molecular analysis of the Arabidopsis DXR gene enconding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. Plant Physiol 129:1581–1591
    • (2002) Plant Physiol , vol.129 , pp. 1581-1591
    • Carretero-Paulet, L.1    Ahumada, I.2    Cunillera, N.3    Rodríguez-Concepción, M.4    Ferrer, A.5    Boronat, A.6    Campos, N.7
  • 5
    • 33750487491 scopus 로고    scopus 로고
    • Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants overexpressing deoxylulose 5-phosphate reductoisomerase
    • PID: 16941216, COI: 1:CAS:528:DC%2BD28XhtFaks7fN
    • Carretero-Paulet L, Cairó A, Botella-Pavía P, Besumbes O, Campos N, Boronat A, Rodríguez-Concepción M (2006) Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants overexpressing deoxylulose 5-phosphate reductoisomerase. Plant Mol Biol 62:683–695
    • (2006) Plant Mol Biol , vol.62 , pp. 683-695
    • Carretero-Paulet, L.1    Cairó, A.2    Botella-Pavía, P.3    Besumbes, O.4    Campos, N.5    Boronat, A.6    Rodríguez-Concepción, M.7
  • 6
    • 0028837082 scopus 로고
    • Biochemistry and molecular biology of the isoprenoid pathway in plants
    • COI: 1:CAS:528:DyaK2MXmsVCquro%3D
    • Chappell J (1995) Biochemistry and molecular biology of the isoprenoid pathway in plants. Annu Rev Plant Mol Biol 46:521–547
    • (1995) Annu Rev Plant Mol Biol , vol.46 , pp. 521-547
    • Chappell, J.1
  • 7
    • 67650915528 scopus 로고    scopus 로고
    • Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants
    • PID: 19584121, COI: 1:CAS:528:DC%2BD1MXosFWjtb0%3D
    • Cordoba E, Salmi M, León P (2009) Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants. J Exp Bot 60:2933–2943
    • (2009) J Exp Bot , vol.60 , pp. 2933-2943
    • Cordoba, E.1    Salmi, M.2    León, P.3
  • 8
    • 34548098412 scopus 로고    scopus 로고
    • Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1
    • PID: 17583950, COI: 1:CAS:528:DC%2BD2sXms1Cit7w%3D
    • Dat NT, Jin X, Lee JH, Lee D, Hong YS, Lee K, Kim YH, Lee JJ (2007) Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1. J Nat Prod 70:1093–1097
    • (2007) J Nat Prod , vol.70 , pp. 1093-1097
    • Dat, N.T.1    Jin, X.2    Lee, J.H.3    Lee, D.4    Hong, Y.S.5    Lee, K.6    Kim, Y.H.7    Lee, J.J.8
  • 9
    • 0000479431 scopus 로고
    • A rapid total DNA preparation procedure for fresh plant tissue
    • Doyle JJ, Doyle JL (1990) A rapid total DNA preparation procedure for fresh plant tissue. Focus 12:13–15
    • (1990) Focus , vol.12 , pp. 13-15
    • Doyle, J.J.1    Doyle, J.L.2
  • 10
  • 11
    • 84874206168 scopus 로고    scopus 로고
    • Biosynthesis, function and metabolic engineering of plant volatile organic compounds
    • PID: 23383981, COI: 1:CAS:528:DC%2BC3sXjtlWntb0%3D
    • Dudareva N, Klempien A, Muhlemann JK, Kaplan I (2013) Biosynthesis, function and metabolic engineering of plant volatile organic compounds. New Phytol 198:16–32
    • (2013) New Phytol , vol.198 , pp. 16-32
    • Dudareva, N.1    Klempien, A.2    Muhlemann, J.K.3    Kaplan, I.4
  • 12
    • 27644474656 scopus 로고    scopus 로고
    • Metabolic engineering of the mevalonate and non mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato
    • COI: 1:CAS:528:DC%2BD2MXhvFyqs7k%3D
    • Enfissi EM, Fraser PD, Lois LM, Boronat A, Schuch W, Bramley PM (2005) Metabolic engineering of the mevalonate and non mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. Plant Biotech J 3:17–27
    • (2005) Plant Biotech J , vol.3 , pp. 17-27
    • Enfissi, E.M.1    Fraser, P.D.2    Lois, L.M.3    Boronat, A.4    Schuch, W.5    Bramley, P.M.6
  • 13
    • 0035933854 scopus 로고    scopus 로고
    • 1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants
    • PID: 11264287
    • Estévez JM, Cantero A, Reindl A, Reichler S, León P (2001) 1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants. J Biol Chem 276:22901–22909
    • (2001) J Biol Chem , vol.276 , pp. 22901-22909
    • Estévez, J.M.1    Cantero, A.2    Reindl, A.3    Reichler, S.4    León, P.5
  • 14
    • 84860660662 scopus 로고    scopus 로고
    • Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action
    • PID: 22436445, COI: 1:CAS:528:DC%2BC38Xms12ntrY%3D
    • Fronza M, Lamy E, Günther S, Heinzmann B, Laufer S, Merfort I (2012) Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action. Phytochemistry 78:107–119
    • (2012) Phytochemistry , vol.78 , pp. 107-119
    • Fronza, M.1    Lamy, E.2    Günther, S.3    Heinzmann, B.4    Laufer, S.5    Merfort, I.6
  • 15
    • 84866355700 scopus 로고    scopus 로고
    • Genetically transformed roots: from plant disease to biotechnological resource
    • COI: 1:CAS:528:DC%2BC38Xht1emtLnN
    • Georgiev M, Agostini E, Ludwig-Muller J, Xu J (2012) Genetically transformed roots: from plant disease to biotechnological resource. Trends Biotech 30:528–537
    • (2012) Trends Biotech , vol.30 , pp. 528-537
    • Georgiev, M.1    Agostini, E.2    Ludwig-Muller, J.3    Xu, J.4
  • 16
    • 0029143069 scopus 로고
    • Universal PCR primers for detection of phytopathogenic Agrobacterium strains
    • PID: 7487020, COI: 1:CAS:528:DyaK2MXnt1aitLs%3D
    • Haas JH, Moore LW, Ream W, Manulis S (1995) Universal PCR primers for detection of phytopathogenic Agrobacterium strains. Appl Environ Microbiol 61:2879–2884
    • (1995) Appl Environ Microbiol , vol.61 , pp. 2879-2884
    • Haas, J.H.1    Moore, L.W.2    Ream, W.3    Manulis, S.4
  • 17
    • 1342308540 scopus 로고    scopus 로고
    • Cloning, characterization, and immunolocalization of a mycorrhiza-inducible 1-deoxy-D-xylulose 5-phosphate reductoisomerase in arbuscule-containing cells of maize
    • PID: 14764905, COI: 1:CAS:528:DC%2BD2cXhs1Cnsbs%3D
    • Hans J, Hause B, Strack D, Walter MH (2004) Cloning, characterization, and immunolocalization of a mycorrhiza-inducible 1-deoxy-D-xylulose 5-phosphate reductoisomerase in arbuscule-containing cells of maize. Plant Physiol 134:614–624
    • (2004) Plant Physiol , vol.134 , pp. 614-624
    • Hans, J.1    Hause, B.2    Strack, D.3    Walter, M.H.4
  • 18
    • 44949130764 scopus 로고    scopus 로고
    • Overexpression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene in chloroplast contributes to increment of isoprenoid production
    • PID: 18558344, COI: 1:CAS:528:DC%2BD1cXpt1Wjsbw%3D
    • Hasunuma T, Takeno S, Hayashi S, Sendai M, Bamba T, Yoshimura S, Tomizawa K, Fukusaki E, Miyake C (2008) Overexpression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene in chloroplast contributes to increment of isoprenoid production. J Biosci Bioeng 105:518–526
    • (2008) J Biosci Bioeng , vol.105 , pp. 518-526
    • Hasunuma, T.1    Takeno, S.2    Hayashi, S.3    Sendai, M.4    Bamba, T.5    Yoshimura, S.6    Tomizawa, K.7    Fukusaki, E.8    Miyake, C.9
  • 19
    • 77956899460 scopus 로고    scopus 로고
    • Metabolic engineering by plastid transformation as a strategy to modulate isoprenoid yield in plants
    • PID: 20552454, COI: 1:CAS:528:DC%2BC3cXos1Cqsb0%3D
    • Hasunuma T, Kondo A, Miyake C (2010) Metabolic engineering by plastid transformation as a strategy to modulate isoprenoid yield in plants. Methods Mol Biol 643:213–227
    • (2010) Methods Mol Biol , vol.643 , pp. 213-227
    • Hasunuma, T.1    Kondo, A.2    Miyake, C.3
  • 20
    • 26944476691 scopus 로고    scopus 로고
    • The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis
    • PID: 15863698, COI: 1:CAS:528:DC%2BD2MXmtVaqu74%3D
    • Hsieh MH, Goodman HM (2005) The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. Plant Physiol 138:641–653
    • (2005) Plant Physiol , vol.138 , pp. 641-653
    • Hsieh, M.H.1    Goodman, H.M.2
  • 21
    • 0034789998 scopus 로고    scopus 로고
    • Taxol: biosynthesis, molecular genetics, and biotechnological applications
    • PID: 11693909, COI: 1:CAS:528:DC%2BD3MXotVSnuro%3D
    • Jennewein S, Croteau R (2001) Taxol: biosynthesis, molecular genetics, and biotechnological applications. Appl Microbiol Biotechnol 57:13–19
    • (2001) Appl Microbiol Biotechnol , vol.57 , pp. 13-19
    • Jennewein, S.1    Croteau, R.2
  • 22
    • 79955161144 scopus 로고    scopus 로고
    • Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures
    • COI: 1:CAS:528:DC%2BC3MXltFems7s%3D
    • Kai G, Xu H, Zhou C, Liao P, Xiao J, Luo X, You L, Zhang L (2011) Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures. Metab Engin 13:319–327
    • (2011) Metab Engin , vol.13 , pp. 319-327
    • Kai, G.1    Xu, H.2    Zhou, C.3    Liao, P.4    Xiao, J.5    Luo, X.6    You, L.7    Zhang, L.8
  • 23
  • 24
    • 33845899407 scopus 로고    scopus 로고
    • Antimicrobial activity of diterpenoids from hairy roots of Salvia sclarea L: salvipisone as a potential antibiofilm agent active against antibiotic resistant staphylococci
    • PID: 17190643
    • Kuźma L, Rozalsk M, Walencka E, Rozalska B, Wysokinska H (2007) Antimicrobial activity of diterpenoids from hairy roots of Salvia sclarea L: salvipisone as a potential antibiofilm agent active against antibiotic resistant staphylococci. Phytomedicine 14:31–35
    • (2007) Phytomedicine , vol.14 , pp. 31-35
    • Kuźma, L.1    Rozalsk, M.2    Walencka, E.3    Rozalska, B.4    Wysokinska, H.5
  • 25
    • 0343614184 scopus 로고    scopus 로고
    • A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway
    • PID: 9482845, COI: 1:CAS:528:DyaK1cXhslejtbo%3D
    • Lange BM, Wildung MR, McCaskill D, Croteau R (1998) A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. Proc Nat Acad Sci USA 95:2100–2104
    • (1998) Proc Nat Acad Sci USA , vol.95 , pp. 2100-2104
    • Lange, B.M.1    Wildung, M.R.2    McCaskill, D.3    Croteau, R.4
  • 26
    • 0034700150 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
    • PID: 11078528, COI: 1:CAS:528:DC%2BD3cXosVKqur0%3D
    • Lange BM, Rujan T, Martin W, Croteau R (2000) Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc Natl Acad Sci USA 97:13172–13177
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13172-13177
    • Lange, B.M.1    Rujan, T.2    Martin, W.3    Croteau, R.4
  • 27
    • 77953155672 scopus 로고    scopus 로고
    • The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1)and targets tumor vasculature
    • PID: 20460505, COI: 1:CAS:528:DC%2BC3cXmslWgt7g%3D
    • Li L, Shukla S, Lee A, Garfield SH, Maloney DJ, Ambudkar SV, Yuspa SH (2010) The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1)and targets tumor vasculature. Cancer Res 70:4509–4519
    • (2010) Cancer Res , vol.70 , pp. 4509-4519
    • Li, L.1    Shukla, S.2    Lee, A.3    Garfield, S.H.4    Maloney, D.J.5    Ambudkar, S.V.6    Yuspa, S.H.7
  • 28
    • 0032478189 scopus 로고    scopus 로고
    • Cloning and characterization of a gene from Escherichia coli encoding a tranketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5 –phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis
    • PID: 9482846, COI: 1:CAS:528:DyaK1cXhslejtbg%3D
    • Lois LM, Campos N, Putra SR, Danielsen K, Rohmer M, Boronat A (1998) Cloning and characterization of a gene from Escherichia coli encoding a tranketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5 –phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. Proc Natl Acad Sci USA 95:2105–2110
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2105-2110
    • Lois, L.M.1    Campos, N.2    Putra, S.R.3    Danielsen, K.4    Rohmer, M.5    Boronat, A.6
  • 29
    • 70350765325 scopus 로고    scopus 로고
    • Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer
    • COI: 1:CAS:528:DC%2BD1MXhsFWltbvI
    • Lu Q, Zhang P, Zhang X, Chen J (2009) Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer. J Int Mol Med 24:773–780
    • (2009) J Int Mol Med , vol.24 , pp. 773-780
    • Lu, Q.1    Zhang, P.2    Zhang, X.3    Chen, J.4
  • 30
    • 79959931427 scopus 로고    scopus 로고
    • The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action
    • PID: 21620827, COI: 1:CAS:528:DC%2BC3MXosVGltLo%3D
    • Mahaira LG, Tsimplouli C, Sakellaridis N, Alevizopoulos K, Demetzos C, Han Z, Pantazis P, Dimas K (2011) The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action. Eur J Pharmacol 666:173–182
    • (2011) Eur J Pharmacol , vol.666 , pp. 173-182
    • Mahaira, L.G.1    Tsimplouli, C.2    Sakellaridis, N.3    Alevizopoulos, K.4    Demetzos, C.5    Han, Z.6    Pantazis, P.7    Dimas, K.8
  • 31
    • 0035902593 scopus 로고    scopus 로고
    • Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxy-xylulose phosphate reductoisomerase and menthofuran synthase
    • PID: 11427737, COI: 1:CAS:528:DC%2BD3MXls1Wiu7Y%3D
    • Mahmoud SS, Croteau RB (2001) Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxy-xylulose phosphate reductoisomerase and menthofuran synthase. Proc Nat Acad Sci USA 98:8915–8920
    • (2001) Proc Nat Acad Sci USA , vol.98 , pp. 8915-8920
    • Mahmoud, S.S.1    Croteau, R.B.2
  • 32
    • 33644814316 scopus 로고    scopus 로고
    • Diurnal and seasonal variation of isoprene biosynthesis-related genes in grey poplar leaves
    • PID: 16126852, COI: 1:CAS:528:DC%2BD2MXhtVCgurrJ
    • Mayrhofer S, Teuber M, Zimmer I, Louis S, Fischbach RJ, Schnitzler JP (2005) Diurnal and seasonal variation of isoprene biosynthesis-related genes in grey poplar leaves. Plant Physiol 139:474–484
    • (2005) Plant Physiol , vol.139 , pp. 474-484
    • Mayrhofer, S.1    Teuber, M.2    Zimmer, I.3    Louis, S.4    Fischbach, R.J.5    Schnitzler, J.P.6
  • 33
    • 33751082664 scopus 로고    scopus 로고
    • Up-regulation of 1-deoxy-D-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender
    • Miñoz-Bertomeu J, Arrillaga I, Ros R, Segura J (2006) Up-regulation of 1-deoxy-D-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender. Plant Physiol 142:890–900
    • (2006) Plant Physiol , vol.142 , pp. 890-900
    • Miñoz-Bertomeu, J.1    Arrillaga, I.2    Ros, R.3    Segura, J.4
  • 34
    • 84859217032 scopus 로고    scopus 로고
    • Marrubiin, a constituent of Leonotis leonurus, alleviates diabetic symptoms
    • PID: 22326550, COI: 1:CAS:528:DC%2BC38XkvFSqtrg%3D
    • Mnonopi N, Levendal RA, Mzilikazi N, Frost CL (2012) Marrubiin, a constituent of Leonotis leonurus, alleviates diabetic symptoms. Phytomedicine 19:488–493
    • (2012) Phytomedicine , vol.19 , pp. 488-493
    • Mnonopi, N.1    Levendal, R.A.2    Mzilikazi, N.3    Frost, C.L.4
  • 35
    • 33748990309 scopus 로고    scopus 로고
    • Overexpression of a bacterial 1-deoxy-D-xylulose 5-phosphate synthase gene in potato tubers perturbs the isoprenoid metabolic network: implications for the control of the tuber life cycle
    • PID: 16873449, COI: 1:CAS:528:DC%2BD28Xps1ygsb4%3D
    • Morris WL, Ducreux LJ, Hedden P, Millam S, Taylor MA (2006) Overexpression of a bacterial 1-deoxy-D-xylulose 5-phosphate synthase gene in potato tubers perturbs the isoprenoid metabolic network: implications for the control of the tuber life cycle. J Exp Bot 57:3007–3018
    • (2006) J Exp Bot , vol.57 , pp. 3007-3018
    • Morris, W.L.1    Ducreux, L.J.2    Hedden, P.3    Millam, S.4    Taylor, M.A.5
  • 36
    • 84883054025 scopus 로고    scopus 로고
    • Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro
    • PID: 23668256, COI: 1:CAS:528:DC%2BC3sXhtlGnu7%2FI
    • Moses T, Pollier J, Thevelein JM, Goossens A (2013) Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro. New Phytol 200:27–43
    • (2013) New Phytol , vol.200 , pp. 27-43
    • Moses, T.1    Pollier, J.2    Thevelein, J.M.3    Goossens, A.4
  • 37
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • PID: 6606682, COI: 1:STN:280:DyaL2c%2FovFSmtw%3D%3D
    • Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 38
    • 84982358134 scopus 로고
    • A revised medium for rapid growth and bio assays with tobacco tissue cultures
    • COI: 1:CAS:528:DyaF3sXksFKm
    • Murashige T, Skoog F (1962) A revised medium for rapid growth and bio assays with tobacco tissue cultures. Plant Physiol 15:473–497
    • (1962) Plant Physiol , vol.15 , pp. 473-497
    • Murashige, T.1    Skoog, F.2
  • 39
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocite apoptosis by propidium iodide staining and flow cytometry
    • PID: 1710634, COI: 1:CAS:528:DyaK3MXltlenu7Y%3D
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocite apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271–279
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 40
    • 77953363768 scopus 로고    scopus 로고
    • Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo
    • PID: 20409537, COI: 1:CAS:528:DC%2BC3cXmslSgtr8%3D
    • Noori S, Hassan ZM, Mohammad M, Habibi Z, Sohrabi N, Bavanolhagh S (2010) Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo. Cell Immunol 263:148–153
    • (2010) Cell Immunol , vol.263 , pp. 148-153
    • Noori, S.1    Hassan, Z.M.2    Mohammad, M.3    Habibi, Z.4    Sohrabi, N.5    Bavanolhagh, S.6
  • 41
    • 0026691240 scopus 로고
    • The A20 zinc-finger protein protects cells from turmor necrosis factor cytotoxicity
    • Opipari AWJr, Hu HM, Yabkowitz R, Dixit VM (1992) The A20 zinc-finger protein protects cells from turmor necrosis factor cytotoxicity. J Biol Chem 297:12424–12427
    • (1992) J Biol Chem , vol.297 , pp. 12424-12427
    • Opipari, A.W.1    Hu, H.M.2    Yabkowitz, R.3    Dixit, V.M.4
  • 42
    • 77649169304 scopus 로고    scopus 로고
    • Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells
    • PID: 20049856, COI: 1:CAS:528:DC%2BC3cXis1ynsbo%3D
    • Pan TL, Hung YC, Wang PW, Chen ST, Hsu TK, Sintupisut N, Cheng CS, Lyu PC (2010) Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells. Proteomics 10:914–929
    • (2010) Proteomics , vol.10 , pp. 914-929
    • Pan, T.L.1    Hung, Y.C.2    Wang, P.W.3    Chen, S.T.4    Hsu, T.K.5    Sintupisut, N.6    Cheng, C.S.7    Lyu, P.C.8
  • 43
    • 79952103915 scopus 로고    scopus 로고
    • The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots
    • PID: 21144909, COI: 1:CAS:528:DC%2BC3MXjsFaks7g%3D
    • Peebles AM, Sander G, Hughes E, Peacok R, Shanks J, San K (2011) The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. Metab Eng 13:234–240
    • (2011) Metab Eng , vol.13 , pp. 234-240
    • Peebles, A.M.1    Sander, G.2    Hughes, E.3    Peacok, R.4    Shanks, J.5    San, K.6
  • 44
    • 56549102815 scopus 로고    scopus 로고
    • The plastidial MEP pathway unified nomenclature and resources
    • COI: 1:CAS:528:DC%2BD1cXhsVCmsLjO
    • Phillips M, León P, Boronat A, Rodríguez-Concepción M (2008) The plastidial MEP pathway unified nomenclature and resources. Trend Plant Sci 13:619–623
    • (2008) Trend Plant Sci , vol.13 , pp. 619-623
    • Phillips, M.1    León, P.2    Boronat, A.3    Rodríguez-Concepción, M.4
  • 45
    • 84888422431 scopus 로고    scopus 로고
    • Arabidopsis j-protein j20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control
    • PID: 24104567, COI: 1:CAS:528:DC%2BC3sXhvFOrtrnE
    • Pulido P, Toledo-Ortiz G, Phillips MA, Wright LP, Rodríguez-Concepción M (2013) Arabidopsis j-protein j20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control. Plant Cell 25:4183–4194
    • (2013) Plant Cell , vol.25 , pp. 4183-4194
    • Pulido, P.1    Toledo-Ortiz, G.2    Phillips, M.A.3    Wright, L.P.4    Rodríguez-Concepción, M.5
  • 46
    • 0033837128 scopus 로고    scopus 로고
    • Malignant melanoma: prevention, early detection, and treatment in the 21st century
    • COI: 1:STN:280:DC%2BD3cvlsFOjtg%3D%3D
    • Rigel DS, Carucci JA (2000) Malignant melanoma: prevention, early detection, and treatment in the 21st century. J CA Cancer Clin 50:215–236
    • (2000) J CA Cancer Clin , vol.50 , pp. 215-236
    • Rigel, D.S.1    Carucci, J.A.2
  • 47
    • 0036851226 scopus 로고    scopus 로고
    • Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics
    • PID: 12427975
    • Rodríguez-Concepción M, Boronat A (2002) Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiol 130:1079–1089
    • (2002) Plant Physiol , vol.130 , pp. 1079-1089
    • Rodríguez-Concepción, M.1    Boronat, A.2
  • 49
    • 0029922877 scopus 로고    scopus 로고
    • Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis
    • COI: 1:CAS:528:DyaK28Xhtleitb8%3D
    • Rohmer M, Seeman M, Horbach S, Bringer-Meyer S, Sahm H (1996) Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis. J Am Chem Soc 118:2564–2566
    • (1996) J Am Chem Soc , vol.118 , pp. 2564-2566
    • Rohmer, M.1    Seeman, M.2    Horbach, S.3    Bringer-Meyer, S.4    Sahm, H.5
  • 50
    • 33748561145 scopus 로고    scopus 로고
    • Cytotoxic and proapoptotic activity of diterpenoids from in vitro cultivated Salvia sclarea roots. Studies on the leukemia cell lines
    • Rózalski M, Kuźma L, Krajewska U, Wysokinska H (2006) Cytotoxic and proapoptotic activity of diterpenoids from in vitro cultivated Salvia sclarea roots. Studies on the leukemia cell lines. Z Naturforsch 61:483–488
    • (2006) Z Naturforsch , vol.61 , pp. 483-488
    • Rózalski, M.1    Kuźma, L.2    Krajewska, U.3    Wysokinska, H.4
  • 51
    • 0023575311 scopus 로고
    • Design and construction of a versatile system for the expression of foreign genes in plants
    • PID: 3443303, COI: 1:CAS:528:DyaL1cXhtVOitbk%3D
    • Schardl CL, Byrd AD, Bezion G, Altschuler MA, Hildebrand DF, Hunt AG (1987) Design and construction of a versatile system for the expression of foreign genes in plants. Gene 61:1–11
    • (1987) Gene , vol.61 , pp. 1-11
    • Schardl, C.L.1    Byrd, A.D.2    Bezion, G.3    Altschuler, M.A.4    Hildebrand, D.F.5    Hunt, A.G.6
  • 52
    • 84863894346 scopus 로고    scopus 로고
    • Hairy roots their multiple applications and recents patents
    • COI: 1:CAS:528:DC%2BC38XhtFOntrfI
    • Talano M, Oller A, González P, Agostini E (2012) Hairy roots their multiple applications and recents patents. Recent Plant Biotech 6:115–133
    • (2012) Recent Plant Biotech , vol.6 , pp. 115-133
    • Talano, M.1    Oller, A.2    González, P.3    Agostini, E.4
  • 53
    • 70349840107 scopus 로고    scopus 로고
    • Biological activity of diterpenoids isolated from Anatolian laminaceae plants
    • COI: 1:CAS:528:DC%2BD2sXpslegtb4%3D
    • Topcu G, Goren AC (2007) Biological activity of diterpenoids isolated from Anatolian laminaceae plants. Rec Nat Prod 1:1–16
    • (2007) Rec Nat Prod , vol.1 , pp. 1-16
    • Topcu, G.1    Goren, A.C.2
  • 55
    • 0031127137 scopus 로고    scopus 로고
    • Diterpenoids from the roots of Salvia sclarea
    • Ulubelen A, Sonmez U, Topcu G (1997) Diterpenoids from the roots of Salvia sclarea. Phytochemistry 344:1297–1299
    • (1997) Phytochemistry , vol.344 , pp. 1297-1299
    • Ulubelen, A.1    Sonmez, U.2    Topcu, G.3
  • 56
    • 0034672597 scopus 로고    scopus 로고
    • Cloning and expression of cDNAs enconding two enzymes of the MEP pathway in Catharanthus roseus
    • COI: 1:CAS:528:DC%2BD3cXoslGmsLs%3D
    • Veau B, Courtois A, Oudin J, Chenieux C, Rideau M, Clastre M (2000) Cloning and expression of cDNAs enconding two enzymes of the MEP pathway in Catharanthus roseus. Biochem Biophys Acta Gene Struct Exp 1517:159–163
    • (2000) Biochem Biophys Acta Gene Struct Exp , vol.1517 , pp. 159-163
    • Veau, B.1    Courtois, A.2    Oudin, J.3    Chenieux, C.4    Rideau, M.5    Clastre, M.6
  • 57
    • 0033996644 scopus 로고    scopus 로고
    • Arbuscular mycorrhizal fungi induce the non-mevalonate methylerythritol phosphate pathway of isoprenoid biosynthesis correlated with the accumulation of the yellow pigment and other apocarotenoids
    • PID: 10758508, COI: 1:CAS:528:DC%2BD3cXjsVeru7c%3D
    • Walter M, Fester T, Strack D (2000) Arbuscular mycorrhizal fungi induce the non-mevalonate methylerythritol phosphate pathway of isoprenoid biosynthesis correlated with the accumulation of the yellow pigment and other apocarotenoids. Plant J 21:571–578
    • (2000) Plant J , vol.21 , pp. 571-578
    • Walter, M.1    Fester, T.2    Strack, D.3
  • 58
    • 57749116848 scopus 로고    scopus 로고
    • Transformation of Agrobacterium using the freeze-thaw method
    • Weigel D, Glazebrook J (2006) Transformation of Agrobacterium using the freeze-thaw method. CSH Protoc 7:110–115
    • (2006) CSH Protoc , vol.7 , pp. 110-115
    • Weigel, D.1    Glazebrook, J.2
  • 59
    • 33750890672 scopus 로고    scopus 로고
    • Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants
    • Wu S, Shalk M, Clark A, Miles RB, Coates R, Chappell J (2006) Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants. Nat Biotech 24:1141–1147
    • (2006) Nat Biotech , vol.24 , pp. 1141-1147
    • Wu, S.1    Shalk, M.2    Clark, A.3    Miles, R.B.4    Coates, R.5    Chappell, J.6
  • 60
    • 84871846483 scopus 로고    scopus 로고
    • Enanchement of artemisinin biosynthesis by overexpressing dxr, cyp71av1 and cpr in the plants of Artemisia annua L
    • COI: 1:CAS:528:DC%2BC38XhvFSksLnK
    • Xiang L, Zeng L, Yuan Y, Chen M, Wang F, Liu X, Zeng L, Lan X, Liao Z (2012) Enanchement of artemisinin biosynthesis by overexpressing dxr, cyp71av1 and cpr in the plants of Artemisia annua L. Plant Omics J 5:503–507
    • (2012) Plant Omics J , vol.5 , pp. 503-507
    • Xiang, L.1    Zeng, L.2    Yuan, Y.3    Chen, M.4    Wang, F.5    Liu, X.6    Zeng, L.7    Lan, X.8    Liao, Z.9
  • 61
    • 84894207903 scopus 로고    scopus 로고
    • Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis
    • PID: 24260395
    • Yang L, Ding G, Lin H, Cheng H, Kong Y, Wei Y, Fang X, Liu R, Wang L, Chen X, Yang C (2013) Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis. PLoS ONE 8:e80464
    • (2013) PLoS ONE , vol.8 , pp. e80464
    • Yang, L.1    Ding, G.2    Lin, H.3    Cheng, H.4    Kong, Y.5    Wei, Y.6    Fang, X.7    Liu, R.8    Wang, L.9    Chen, X.10    Yang, C.11
  • 62
    • 84895073357 scopus 로고    scopus 로고
    • Activating secondary metabolism with stress and chemicals
    • PID: 24326978, COI: 1:CAS:528:DC%2BC3sXhvFajsrvE
    • Yoon V, Nodwell JR (2014) Activating secondary metabolism with stress and chemicals. J Ind Microbiol Biotechnol 41:415–424
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 415-424
    • Yoon, V.1    Nodwell, J.R.2
  • 64
    • 50849129920 scopus 로고    scopus 로고
    • Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest
    • PID: 18721815, COI: 1:CAS:528:DC%2BD1cXhtVyjtL%2FJ
    • Zhou L, Chan WK, Xu N, Xiao K, Luo H, Luo KQ, Chang DC (2008) Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest. Life Sci 83:394–403
    • (2008) Life Sci , vol.83 , pp. 394-403
    • Zhou, L.1    Chan, W.K.2    Xu, N.3    Xiao, K.4    Luo, H.5    Luo, K.Q.6    Chang, D.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.