The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action

European Journal of Pharmacology

Volumn 666, Issue 1-3, 2011, Pages 173-182

  Mahaira, Louisa G ^a   Tsimplouli, Chrisiida ^a   Sakellaridis, Nikos ^b   Alevizopoulos, Konstantinos ^c   Demetzos, Costas ^d   Han, Zhiyong ^e   Pantazis, Panayotis ^a   Dimas, Konstantinos ^a,b  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

^c Medexis Biotech SA   (Greece)

^d UNIVERSITY OF ATHENS   (Greece)

^e NEW YORK COLLEGE OF PODIATRIC MEDICINE   (United States)

Author keywords

Apoptosis; COMPARE; p53; Sclareol; Tumor growth suppression

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; PROTEIN P53; SCLAREOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; COLON CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL; TUMOR CELL LINE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIC AMP; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DITERPENES; DNA DAMAGE; ENZYME ACTIVATION; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; INTRACELLULAR SPACE; LIPOSOMES; MALE; MICE; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79959931427     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.04.065     Document Type: Article

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