The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers

Oncotarget

Volumn 5, Issue 19, 2014, Pages 9396-9409

  Strauss, Carmit ^a   Kornowski, Maya ^a   Benvenisty, Avraham ^a   Shahar, Amit ^b   Masury, Hadas ^b   Ben Porath, Ittai ^b   Ravid, Tommer ^a   Arbel Eden, Ayelet ^c   Goldberg, Michal ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY   (Israel)

^c Hadassah Academic College   (Israel)

Author keywords

DNA damage response; DNA helicases; DNA nucleases; DNA2; Estrogen; Estrogen dependent cancers

Indexed keywords

ESTROGEN; DNA HELICASE; DNA2 PROTEIN, HUMAN; ESTROGEN RECEPTOR; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; DNA2 GENE; ENZYME ACTIVITY; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENOMIC INSTABILITY; MITOSIS INHIBITION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; OVARY CANCER; SOMATIC MUTATION; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; BREAST TUMOR; CANCER TRANSPLANTATION; CELL TRANSFORMATION; DNA DAMAGE; DNA REPAIR; DRUG EFFECTS; GENETICS; HUMAN; MCF 7 CELL LINE; METABOLISM; MORTALITY; MUTATION; NONOBESE DIABETIC MOUSE; OVARY TUMOR; RNA INTERFERENCE; SCID MOUSE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; DNA HELICASES; DNA REPAIR; ESTROGENS; FEMALE; GENOMIC INSTABILITY; HUMANS; MCF-7 CELLS; MICE; MICE, INBRED NOD; MICE, SCID; MUTATION; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; RECEPTORS, ESTROGEN; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 84910071339     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2414     Document Type: Article

References (42)

1. Aguilera A and Garcia-Muse T. Causes of genome instability. Annual review of genetics. 2013; 47:1-32.
2. Cha HJ and Yim H. The accumulation of DNA repair defects is the molecular origin of carcinogenesis. Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine. 2013; 34(6):3293-3302.
3. Brosh RM, Jr. DNA helicases involved in DNA repair and their roles in cancer. Nature reviews Cancer. 2013; 13(8):542-558.
4. Suhasini AN and Brosh RM, Jr. Mechanistic and biological aspects of helicase action on damaged DNA. Cell cycle. 2010; 9(12):2317-2329.
5. Mladenov E, Magin S, Soni A and Iliakis G. DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Frontiers in oncology. 2013; 3:113.
6. Bartosova Z and Krejci L. Nucleases in homologous recombination as targets for cancer therapy. FEBS letters. 2014; doi: 10.1016/j.febslet.2014.06.010.
7. Blackwood JK, Rzechorzek NJ, Bray SM, Maman JD, Pellegrini L and Robinson NP. End-resection at DNA double-strand breaks in the three domains of life. Biochemical Society transactions. 2013; 41(1):314-320.
8. Symington LS and Gautier J. Double-strand break end resection and repair pathway choice. Annual review of genetics. 2011; 45:247-271.
9. Kramer MM and Wells CL. Does physical activity reduce risk of estrogen-dependent cancer in women? Medicine and science in sports and exercise. 1996; 28(3):322-334.
10. Moghadam SJ, Hanks AM and Keyomarsi K. Breaking the cycle: An insight into the role of eralpha in eukaryotic cell cycles. Journal of carcinogenesis. 2011; 10:25.
11. Cavalieri E, Chakravarti D, Guttenplan J, Hart E, IngleJ, Jankowiak R, Muti P, Rogan E, Russo J, Santen R and Sutter T. Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention. Biochimica et biophysica acta. 2006; 1766(1):63-78.
12. Williamson LM and Lees-Miller SP. Estrogen receptor alpha-mediated transcription induces cell cycle-dependent DNA double-strand breaks. Carcinogenesis. 2011; 32(3): 279-285.
13. Hah N and Kraus WL. Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells. Molecular and cellular endocrinology. 2014; 382(1):652-664.
14. Motoyama N and Naka K. DNA damage tumor suppressor genes and genomic instability. Current opinion in genetics & development. 2004; 14(1):11-16.
15. Bourdeau V, Deschenes J, Laperriere D, Aid M, WhiteJH and Mader S. Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells. Nucleic acids research. 2008; 36(1):76-93.
16. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, HallGF, Wang Q and et al. Genome-wide analysis of estrogen receptor binding sites. Nature genetics. 2006; 38(11):1289-1297.
17. Yu J, Yu J, Cordero KE, Johnson MD, Ghosh D, Rae JM, Chinnaiyan AM and Lippman ME. A transcriptional fingerprint of estrogen in human breast cancer predicts patient survival. Neoplasia. 2008; 10(1):79-88.
18. Easton DF. How many more breast cancer predisposition genes are there?. Breast Cancer Res. 1999; 1(1):14-17.
19. Claus EB, Schildkraut JM, Thompson WD and Risch NJ. The genetic attributable risk of breast and ovarian cancer. Cancer. 1996; 77(11):2318-2324.
20. Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, LearyRJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N and et al. The genomic landscapes of human breast and colorectal cancers. Science. 2007; 318(5853):1108-1113.
21. Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Jr. and Kinzler KW. Cancer genome landscapes. Science. 2013; 339(6127):1546-1558.
22. Stephens P, Edkins S, Davies H, Greenman C, Cox C, Hunter C, Bignell G, Teague J, Smith R, Stevens C and O'Meara S. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature genetics. 2005; 37(6):590-592.
23. Iso T, Futami K, Iwamoto T and Furuichi Y. Modulation of the expression of bloom helicase by estrogenic agents. Biological & pharmaceutical bulletin. 2007; 30(2):266-271.
24. Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, HagerJA, Beliakoff J, Whitesell LJ, Bowden GT and RomagnoloDF. An estrogen receptor-alpha/p300 complex activates the brca-1 promoter at an ap-1 site that binds jun/fos transcription factors: Repressive effects of p53 on brca-1 transcription. Neoplasia. 2005; 7(9):873-882.
25. Karanja KK, Cox SW, Duxin JP, Stewart SA and CampbellJL. Dna2 and exo1 in replication-coupled, homology-directed repair and in the interplay between hdr and the fa/brca network. Cell cycle. 2012; 11(21):3983-3996.
26. Hu J, Sun L, Shen F, Chen Y, Hua Y, Liu Y, Zhang M, HuY, Wang Q, Xu W, Sun F and et al. The intra-s phase checkpoint targets dna2 to prevent stalled replication forks from reversing. Cell. 2012; 149(6):1221-1232.
27. Budd ME and Campbell JL. The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in dsb and postreplication repair pathways. Mutation research. 2000; 459(3):173-186.
28. Aparicio T and Gautier J. More tasks for dna2 in s-phase. Cell cycle. 2012; 11(23):4299-4300.
29. Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ, Jr. and Stewart SA. Okazaki fragment processing-independent role for human dna2 enzyme during DNA replication. The Journal of biological chemistry. 2012; 287(26): 21980-21991.
30. Kang YH, Lee CH and Seo YS. Dna2 on the road to okazaki fragment processing and genome stability in eukaryotes. Critical reviews in biochemistry and molecular biology. 2010; 45(2):71-96.
31. Duxin JP, Dao B, Martinsson P, Rajala N, Guittat L, Campbell JL, Spelbrink JN and Stewart SA. Human dna2 is a nuclear and mitochondrial DNA maintenance protein. Molecular and cellular biology. 2009; 29(15):4274-4282.
32. Imamura O and Campbell JL. The human bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(14):8193-8198.
33. Hughes TR, Marton MJ, Jones AR, Roberts CJ, StoughtonR, Armour CD, Bennett HA, Coffey E, Dai H, HeYD, KiddMJ and et al. Functional discovery via a compendium of expression profiles. Cell. 2000; 102(1):109-126.
34. Peng G, Dai H, Zhang W, Hsieh HJ, Pan MR, Park YY, Tsai RY, Bedrosian I, Lee JS, Ira G and Lin SY. Human nuclease/helicase dna2 alleviates replication stress by promoting DNA end resection. Cancer research. 2012; 72(11):2802-2813.
35. Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, AksoyBA, Jacobsen A, Byrne CJ, Heuer ML, LarssonE, Antipin Y and et al. The cbio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer discovery. 2012; 2(5):401-404.
36. Moraes MC, Neto JB and Menck CF. DNA repair mechanisms protect our genome from carcinogenesis. Frontiers in bioscience. 2012; 17:1362-1388.
37. Prokofyeva D, Bogdanova N, Dubrowinskaja N, Bermisheva M, Takhirova Z, Antonenkova N, Turmanov N, Datsyuk I, Gantsev S, Christiansen H, Park-Simon TW and et al. Nonsense mutation p.Q548x in blm, the gene mutated in bloom's syndrome, is associated with breast cancer in slavic populations. Breast cancer research and treatment. 2013; 137(2):533-539.
38. Suspitsin EN, Yanus GA, Sokolenko AP, Yatsuk OS, Zaitseva OA, Bessonov AA, Ivantsov AO, HeinsteinVA, Klimashevskiy VF, Togo AV and Imyanitov EN. Development of breast tumors in chek2, nbn/nbs1 and blm mutation carriers does not commonly involve somatic inactivation of the wild-type allele. Medical oncology. 2014; 31(2):828.
39. Nimonkar AV, Genschel J, Kinoshita E, PolaczekP, CampbellJL, Wyman C, Modrich P and KowalczykowskiSC. Blm-dna2-rpa-mrn and exo1-blm-rpa-mrn constitute two DNA end resection machineries for human DNA break repair. Genes & development. 2011; 25(4):350-362.
40. Burhans WC and Weinberger M. DNA replication stress, genome instability and aging. Nucleic acids research. 2007; 35(22):7545-7556.
41. Mason PA and Cox LS. The role of DNA exonucleases in protecting genome stability and their impact on ageing. Age. 2012; 34(6):1317-1340.
42. Yarden Y and Caldas C. Basic cancer research is essential for the success of personalised medicine. European journal of cancer. 2013; 49(12):2619-2620.