Metals in the pathogenesis of type 2 diabetes

Journal of Diabetes and Metabolic Disorders

Volumn 13, Issue 1, 2014, Pages

  Khan, Abdul R ^a,b   Awan, Fazli R ^a  

^a NATIONAL INSTITUTE FOR BIOTECHNOLOGY AND GENETIC ENGINEERING NIBGE   (Pakistan)

^b UNIVERSITY OF AZAD JAMMU AND KASHMIR   (Pakistan)

Author keywords

Diabetes; Essential metals; Insulin; Toxic metals; Zinc

Indexed keywords

CHROMIUM; GLUCOSE; INSULIN RECEPTOR; IRON; MAGNESIUM; MANGANESE; PROTEIN; TRACE ELEMENT; TRANSCRIPTION FACTOR; ZINC;

DIABETOGENESIS; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; INSULIN DEFICIENCY; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SYNTHESIS; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHYSIOLOGICAL PROCESS; REVIEW; SYMPTOM; TARGET ORGAN; URINARY EXCRETION;

EID: 84910056616     PISSN: None     EISSN: 22516581     Source Type: Journal    
DOI: 10.1186/2251-6581-13-16     Document Type: Review

References (78)

1. Kazi TG, Afridi HI, Kazi N, Jamali MK, Arain MB, Jalbani N, Kandhro GA. Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 2008, 122(1):1-18. 10.1007/s12011-007-8062-y, 18193174.
2. Simsek A, Aykut O. Evaluation of the microelement profile of turkish hazelnut (corylus avellana L.) varieties for human nutrition and health. Int J Food Sci Nutr 2007, 58(8):677-688. 10.1080/09637480701403202, 17852487.
3. Soetan KO, Olaiya CO, Oyewole OE. The importance of mineral elements for humans, domestic animals and plants: a review. Afr J Food Sci 2010, 4(5):220-222.
4. Grivetti L. Value of traditional foods in meeting of macro- and micronutrients needs: the wild plants connection. Nutr Res Rev 2000, 13:31-46. 10.1079/095442200108728990, 19087432.
5. Fraga CG. Relevance, essentiality and toxicity of trace elements in human health. Mol Aspects Med 2005, 26(4-5):235-244.
6. McCall KA, Huang C, Fierke CA. Function and mechanism of zinc metalloenzymes. J Nutr 2000, 130(5S Suppl):1437S-1446S.
7. Lu Y, Yeung N, Sieracki N, Marshall NM. Design of functional metalloproteins. Nature 2009, 460(7257):855-862. 10.1038/nature08304, 2770889, 19675646.
8. Lutsenko S, Barnes NL, Bartee MY, Dmitriev OY. Function and regulation of human copper-transporting ATPases. Physiol Rev 2007, 87(3):1011-1046. 10.1152/physrev.00004.2006, 17615395.
9. Guidotti T, McNamara J, Moses M. The interpretation of trace element analysis in body fluids. Indian J Med Res 2010, 128(4):524.
10. Chen YW. Heavy metals, islet function and diabetes development. Islets 2009, 1(3):169-176. 10.4161/isl.1.3.9262, 21099269.
11. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005, 12(10):1161-1208. 10.2174/0929867053764635, 15892631.
12. Galhardi CM, Diniz YS, Faine LA, Rodrigues HG, Burneiko RC, Ribas BO, Novelli EL. Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. Food Chem Toxicol 2004, 42(12):2053-2060. 10.1016/j.fct.2004.07.020, 15500942.
13. Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 2004, 291(6):711-717. 10.1001/jama.291.6.711, 14871914.
14. Kazi TG, Jalbani N, Kazi N, Arain MB, Jamali MK, Afridi HI, Kandhro GA, Sarfraz RA, Shah AQ, Ansari R. Estimation of toxic metals in scalp hair samples of chronic kidney patients. Biol Trace Elem Res 2009, 127(1):16-27. 10.1007/s12011-008-8222-8, 18810333.
15. Serdar MA, Bakir F, Hasimi A, Celik T, Akin O, Kenar L, Aykut O, Yildirimkaya M. Trace and toxic element patterns in nonsmoker patients with noninsulin-dependent diabetes mellitus, impaired glucose tolerance, and fasting glucose. Int J Diabetes Dev Ctries 2009, 29(1):35-40. 10.4103/0973-3930.50713, 2802363, 20062562.
16. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 2006, 290(2):G199-203. 10.1152/ajpgi.00412.2005, 16407589.
17. Stechmiller JK. Understanding the role of nutrition and wound healing. Nutr Clin Pract 2010, 25(1):61-68. 10.1177/0884533609358997, 20130158.
18. Wish JB. Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol 2006, 1(Supplement 1):S4-S8. 10.2215/CJN.01490506, 17699374.
19. McClain DA, Abraham D, Rogers J, Brady R, Gault P, Ajioka R, Kushner JP. High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis. Diabetologia 2006, 49(7):1661-1669. 10.1007/s00125-006-0200-0, 16538487.
20. Kundu D, Roy A, Mandal T, Bandyopadhyay U, Ghosh E, Ray D. Relation of iron stores to oxidative stress in type 2 diabetes. Niger J Clin Pract 2013, 16(1):100-103. 10.4103/1119-3077.106776, 23377481.
21. Raj S, Rajan G. Correlation between elevated serum ferritin and HbA1c in type 2 diabetes mellitus. Int J 2013, 1(1):12.
22. Rajpathak S, Ma J, Manson J, Willett WC, Hu FB. Iron intake and the risk of type 2 diabetes in women: a prospective cohort study. Diabetes Care 2006, 29(6):1370-1376. 10.2337/dc06-0119, 16732023.
23. Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR. Hemochromatosis and iron-overload screening in a racially diverse population. New Engl J Med 2005, 352(17):1769-1778. 10.1056/NEJMoa041534, 15858186.
24. Acton RT, Barton JC, Passmore LV, Adams PC, Speechley MR, Dawkins FW, Sholinsky P, Reboussin DM, McLaren GD, Harris EL. Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the hemochromatosis and iron overload screening (HEIRS) study. Diabetes Care 2006, 29(9):2084-2089. 10.2337/dc05-1592, 16936157.
25. Worwood M. Serum transferrin receptor assays and their application. Ann Clin Biochem 2002, 39(3):221-230. 10.1258/0004563021902152, 12038596.
26. Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in US adults. Diabetes Care 2004, 27(10):2422-2428. 10.2337/diacare.27.10.2422, 15451911.
27. Fernández-Real JM, Peñarroja G, Castro A, García-Bragado F, Hernández-Aguado I, Ricart W. Blood letting in high-ferritin type 2 diabetes effects on insulin sensitivity and β-cell function. Diabetes 2002, 51(4):1000-1004. 10.2337/diabetes.51.4.1000, 11916918.
28. Papanikolaou G, Pantopoulos K. Iron metabolism and toxicity. Toxicol Appl Pharmacol 2005, 202(2):199-211. 10.1016/j.taap.2004.06.021, 15629195.
29. Lee D-H, Liu DY, Jacobs DR, Shin H-R, Song K, Lee I-K, Kim B, Hider RC. Common presence of Non-transferrin-bound iron among patients with type 2 diabetes. Diabetes Care 2006, 29(5):1090-1095. 10.2337/dc05-2471, 16644642.
30. Sharifi F, Nasab NM, Zadeh HJ. Elevated serum ferritin concentrations in prediabetic subjects. Diab Vasc Dis Res 2008, 5(1):15-18. 10.3132/dvdr.2008.003, 18398807.
31. Kim C-H, Kim H-K, Bae SJ, Park J-Y, Lee K-U. Association of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and women. Metabolism 2011, 60(3):414-420. 10.1016/j.metabol.2010.03.007, 20423745.
32. Forouhi N, Harding A, Allison M, Sandhu M, Welch A, Luben R, Bingham S, Khaw K, Wareham N. Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia 2007, 50(5):949-956. 10.1007/s00125-007-0604-5, 17333112.
33. Rajpathak S, Wylie-Rosett J, Gunter M, Negassa A, Kabat G, Rohan T, Crandall J. Biomarkers of body iron stores and risk of developing type 2 diabetes. Diabetes Obes Metab 2009, 11(5):472-479. 10.1111/j.1463-1326.2008.00985.x, 19207293.
34. Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 2004, 27(1):134-140. 10.2337/diacare.27.1.134, 14693979.
35. Swaminathan R. Magnesium metabolism and its disorders. Clin Biochemist Rev 2003, 24(2):47-66.
36. Afridi HI, Kazi TG, Kazi N, Jamali MK, Arain MB, Jalbani N, Sarfaraz RA, Shah A, Kandhro GA, Shah AQ, et al. Potassium, calcium, magnesium, and sodium levels in biological samples of hypertensive and nonhypertensive diabetes mellitus patients. Biol Trace Elem Res 2008, 124(3):206-224. 10.1007/s12011-008-8142-7, 18488152.
37. Mooren FC, Kruger K, Volker K, Golf SW, Wadepuhl M, Kraus A. Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial. Diabetes Obes Metab 2011, 13(3):281-284. 10.1111/j.1463-1326.2010.01332.x, 21205110.
38. Orbea A, Ortiz-Zarragoitia M, Sole M, Porte C, Cajaraville MP. Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs, crabs and fish from the Urdaibai and Plentzia estuaries (Bay of Biscay). Aquat Toxicol 2002, 58(1-2):75-98.
39. Rico H, Gomez-Raso N, Revilla M, Hernandez ER, Seco C, Paez E, Crespo E. Effects on bone loss of manganese alone or with copper supplement in ovariectomized rats. A morphometric and densitomeric study. Eur J Obstet Gynecol Reprod Biol 2000, 90(1):97-101. 10.1016/S0301-2115(99)00223-7, 10767519.
40. Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, Oggiano R, Madeddu R. Blood metals concentration in type 1 and type 2 diabetics. Biol Trace Elem Res 2013, 156(1-3):79-90.
41. Olivares M, Araya M, Uauy R. Copper homeostasis in infant nutrition: deficit and excess. J Pediatr Gastroenterol Nutr 2000, 31(2):102-111. 10.1097/00005176-200008000-00004, 10941959.
42. Jackson RF, Roche GC, Wisler K. Reduction in Cholesterol and Triglyceride Serum Levels Following Low-Level Laser Irradiation: A Noncontrolled, Nonrandomized Pilot Study. The American Journal of Cosmetic Surgery 2010, 27(4):177-184.
43. Kako K, Takehara A, Arai H, Onodera T, Takahashi Y, Hanagata H, Ogra Y, Takagi H, Kodama H, Suzuki KT, et al. A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p. Biochem Biophys Res Commun 2004, 324(4):1379-1385. 10.1016/j.bbrc.2004.09.211, 15504366.
44. Lin C-C, Huang J-F, Tsai L-Y, Huang Y-L. Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. Biol Trace Elem Res 2006, 109(1):15-23. 10.1385/BTER:109:1:015, 16388099.
45. Quilliot D. Evidence that diabetes mellitus favors impaired metabolism of zinc, copper, and selenium in chronic pancreatitis. Pancreas 2001, 22(3):299-306. 10.1097/00006676-200104000-00012, 11291933.
46. Klevay L. Cardiovascular disease from copper deficiency. J Nutr 2000, 130:489S-492S.
47. Chwiej J, Winiarski W, Ciarach M, Janeczko K, Lankosz M, Rickers K, Setkowicz Z. The role of trace elements in the pathogenesis and progress of pilocarpine-induced epileptic seizures. J Biol Inorg Chem 2008, 13(8):1267-1274. 10.1007/s00775-008-0411-6, 18688660.
48. Eaton JW, Qian M. Interactions of copper with glycated proteins: possible involvement in the etiology of diabetic neuropathy. Mol Cell Biochem 2002, 234-235(1-2):135-142.
49. John E, Laskow TC, Buchser WJ, Pitt BR, Basse PH, Butterfield LH, Kalinski P, Lotze MT. Zinc in innate and adaptive tumor immunity. J Transl Med 2010, 8:118. 10.1186/1479-5876-8-118, 3002329, 21087493.
50. Zheng H, Blat D, Fridkin M. Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: potential candidates for the control of neurodegenerative diseases. J Neural Transm Suppl 2006, 71:163-172.
51. Karamouzis MV, Gorgoulis VG, Papavassiliou AG. Transcription factors and neoplasia: vistas in novel drug design. Clin Cancer Res 2002, 8(5):949-961.
52. Jansen J, Karges W, Rink L. Zinc and diabetes-clinical links and molecular mechanisms. J Nutr Biochem 2009, 20(6):399-417. 10.1016/j.jnutbio.2009.01.009, 19442898.
53. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002, 82(1):47-95.
54. Wapnir RA. Zinc deficiency, malnutrition and the gastrointestinal tract. J Nutr 2000, 130(5S Suppl):1388S-1392S.
55. Rungby J. Zinc, zinc transporters and diabetes. Diabetologia 2010, 53(8):1549-1551. 10.1007/s00125-010-1793-x, 20490449.
56. Brender JR, Hartman K, Nanga RP, Popovych N, de la Salud BR, Vivekanandan S, Marsh EN, Ramamoorthy A. Role of zinc in human islet amyloid polypeptide aggregation. J Am Chem Soc 2010, 132(26):8973-8983. 10.1021/ja1007867, 2904811, 20536124.
57. Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA, Wheeler MB. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia 2010, 53(8):1656-1668. 10.1007/s00125-010-1733-9, 20424817.
58. Guidotti TL, McNamara J, Moses MS. The interpretation of trace element analysis in body fluids. Indian J Med Res 2008, 128(4):524-532.
59. Tudan C, Weber FX, Levine KE. The status of trace elements analysis in biological systems. Bioanalysis 2011, 3(15):1695-1697. 10.4155/bio.11.171, 21827268.
60. Belinda S, O'Connell B. Select vitamins and minerals in the management of diabetes. Diabetes Spectr 2001, 14(3):133-148.
61. Qiao W, Peng Z, Wang Z, Wei J, Zhou A. Chromium improves glucose uptake and metabolism through upregulating the mRNA levels of IR, GLUT4, GS, and UCP3 in skeletal muscle cells. Biol Trace Elem Res 2009, 131(2):133-142. 10.1007/s12011-009-8357-2, 19283340.
62. Wiernsperger N, Rapin J. Trace elements in glucometabolic disorders: an update. Diabetology & Metabolic Syndrome 2010, 2(70):1-9. 2836983, 20180954.
63. Lai MH, Chen YY, Cheng HH. Chromium yeast supplementation improves fasting plasma glucose and LDL-cholesterol in streptozotocin-induced diabetic rats. Int J Vitam Nutr Res 2006, 76(6):391-397. 10.1024/0300-9831.76.6.391, 17607959.
64. Chiu A, Katz AJ, Beaubier J, Chiu N, Shi X. Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings. Mol Cell Biochem 2004, 255(1):181-194.
65. Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T. Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia. Environ Toxicol Chem 2011, 30(8):1892-1897. 10.1002/etc.580, 21590713.
66. Kowdley KV. Iron, hemochromatosis, and hepatocellular carcinoma. Gastroenterology 2004, 127(5):S79-S86. 10.1016/j.gastro.2004.09.019, 15508107.
67. Schwarzenbach RP, Egli T, Hofstetter TB, Von Gunten U, Wehrli B. Global water pollution and human health. Annu Rev Environ Resour 2010, 35:109-136.
68. Flora SJ. Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxidative Med Cell Longev 2009, 2(4):191-206.
69. Duruibe J. Heavy metal pollution and human biotoxic effects. Int J Phys Sci 2007, 2(5):112-118.
70. Afridi HI, Kazi TG, Kazi NG, Jamali MK, Arain MB, Sirajuddin, Baig JA, Kandhro GA, Wadhwa SK, Shah AQ. Evaluation of cadmium, lead, nickel and zinc status in biological samples of smokers and nonsmokers hypertensive patients. J Hum Hypertens 2010, 24(1):34-43. 10.1038/jhh.2009.39, 3011091, 20010608.
71. Afridi HI, Kazi TG, Kazi N, Jamali MK, Arain MB, Jalbani N, Baig JA, Sarfraz RA. Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Res Clin Pract 2008, 80(2):280-288. 10.1016/j.diabres.2007.12.021, 18276029.
72. Martinez-Finley EJ, Chakraborty S, Fretham SJ, Aschner M. Cellular transport and homeostasis of essential and nonessential metals. Metallomics 2012, 4:593-605. 10.1039/c2mt00185c, 22337135.
73. Yu CC, Lin JL, Lin-Tan DT. Environmental exposure to lead and progression of chronic renal diseases: a four-year prospective longitudinal study. J Am Soc Nephrol 2004, 15(4):1016-1022. 10.1097/01.ASN.0000118529.01681.4F, 15034104.
74. Beyersmann D, Hartwig A. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Arch Toxicol 2008, 82(8):493-512. 10.1007/s00204-008-0313-y, 18496671.
75. Chen YW, Yang CY, Huang CF, Hung DZ, Leung YM, Liu SH. Heavy metals, islet function and diabetes development. Islets 2009, 1(3):169-176. 10.4161/isl.1.3.9262, 21099269.
76. Das KK, Das SN, Dhundasi SA. Nickel, its adverse health effects & oxidative stress. Indian J Med Res 2008, 128(4):412-425.
77. Kubrak OI, Husak VV, Rovenko BM, Poigner H, Mazepa MA, Kriews M, Abele D, Lushchak VI. Tissue specificity in nickel uptake and induction of oxidative stress in kidney and spleen of goldfish carassius auratus, exposed to waterborne nickel. Aquat Toxicol 2012, 118-119:88-96.
78. Barany E, Bergdahl IA, Bratteby LE, Lundh T, Samuelson G, Skerfving S, Oskarsson A. Iron status influences trace element levels in human blood and serum. Environ Res 2005, 98(2):215-223. 10.1016/j.envres.2004.09.010, 15820728.