메뉴 건너뛰기




Volumn 11, Issue 1, 2014, Pages

Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis

Author keywords

Apoptosis; Astroglial proliferation; lipopolysaccharide; Microglia; Nitric oxide; P2Y6 receptors; Uracil nucleotides

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 3 (2 OXO 2 PHENYLETHYL)URIDINE 5' DIPHOSPHATE SODIUM; 3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MRS 2578; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIMIDINE NUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE; ENZYME INHIBITOR; GLIAL FIBRILLARY ACIDIC PROTEIN; PURINERGIC P2 RECEPTOR; THYMIDINE; TRITIUM;

EID: 84910037446     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-014-0141-3     Document Type: Article
Times cited : (48)

References (45)
  • 1
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: biology and pathology
    • 20012068
    • Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 2010, 119:7-35. 10.1007/s00401-009-0619-8, 20012068.
    • (2010) Acta Neuropathol , vol.119 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 2
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • 17965659
    • Hanisch UK, Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 2007, 10:1387-1394. 10.1038/nn1997, 17965659.
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 3
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • 15846805
    • Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434. 10.1002/glia.20207, 15846805.
    • (2005) Glia , vol.50 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 4
    • 0014783392 scopus 로고
    • The proliferation of astrocytes around a needle wound in the rat brain
    • 4912665
    • Cavanagh JB. The proliferation of astrocytes around a needle wound in the rat brain. J Anat 1970, 106:471-487. 4912665.
    • (1970) J Anat , vol.106 , pp. 471-487
    • Cavanagh, J.B.1
  • 5
    • 71749103005 scopus 로고    scopus 로고
    • Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential
    • 19765548
    • Buffo A, Rolando C, Ceruti S. Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential. Biochem Pharmacol 2010, 79:77-89. 10.1016/j.bcp.2009.09.014, 19765548.
    • (2010) Biochem Pharmacol , vol.79 , pp. 77-89
    • Buffo, A.1    Rolando, C.2    Ceruti, S.3
  • 6
    • 77955091036 scopus 로고    scopus 로고
    • Astrogliosis in CNS pathologies: is there a role for microglia?
    • 20148316
    • Zhang D, Hu X, Qian L, O'Callaghan JP, Hong JS. Astrogliosis in CNS pathologies: is there a role for microglia?. Mol Neurobiol 2010, 41:232-241. 10.1007/s12035-010-8098-4, 20148316.
    • (2010) Mol Neurobiol , vol.41 , pp. 232-241
    • Zhang, D.1    Hu, X.2    Qian, L.3    O'Callaghan, J.P.4    Hong, J.S.5
  • 7
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • 12379902
    • Hanisch UK. Microglia as a source and target of cytokines. Glia 2002, 40:140-155. 10.1002/glia.10161, 12379902.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 8
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • 22025055
    • Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 2011, 11:775-787. 10.1038/nri3086, 22025055.
    • (2011) Nat Rev Immunol , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 9
    • 38949139570 scopus 로고    scopus 로고
    • In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia
    • 18186084
    • Cacci E, Ajmone-Cat MA, Anelli T, Biagioni S, Minghetti L. In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia. Glia 2008, 56:412-425. 10.1002/glia.20616, 18186084.
    • (2008) Glia , vol.56 , pp. 412-425
    • Cacci, E.1    Ajmone-Cat, M.A.2    Anelli, T.3    Biagioni, S.4    Minghetti, L.5
  • 10
    • 84882920844 scopus 로고    scopus 로고
    • Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures
    • 23918452
    • Ajmone-Cat MA, Mancini M, De Simone R, Cilli P, Minghetti L. Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures. Glia 2013, 61:1698-1711. 10.1002/glia.22550, 23918452.
    • (2013) Glia , vol.61 , pp. 1698-1711
    • Ajmone-Cat, M.A.1    Mancini, M.2    De Simone, R.3    Cilli, P.4    Minghetti, L.5
  • 11
    • 0031471718 scopus 로고    scopus 로고
    • Regeneration of adult axons in white matter tracts of the central nervous system
    • 9414159
    • Davies SJ, Fitch MT, Memberg SP, Hall AK, Raisman G, Silver J. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 1997, 390:680-683. 9414159.
    • (1997) Nature , vol.390 , pp. 680-683
    • Davies, S.J.1    Fitch, M.T.2    Memberg, S.P.3    Hall, A.K.4    Raisman, G.5    Silver, J.6
  • 12
    • 84861526094 scopus 로고    scopus 로고
    • Pathophysiology of astroglial purinergic signalling
    • 22544529
    • Franke H, Verkhratsky A, Burnstock G, Illes P. Pathophysiology of astroglial purinergic signalling. Purinergic Signal 2012, 8:629-657. 10.1007/s11302-012-9300-0, 22544529.
    • (2012) Purinergic Signal , vol.8 , pp. 629-657
    • Franke, H.1    Verkhratsky, A.2    Burnstock, G.3    Illes, P.4
  • 13
    • 33947647866 scopus 로고    scopus 로고
    • Purinergic modulation of microglial cell activation
    • 18404425
    • Sperlagh B, Illes P. Purinergic modulation of microglial cell activation. Purinergic Signal 2007, 3:117-127. 10.1007/s11302-006-9043-x, 18404425.
    • (2007) Purinergic Signal , vol.3 , pp. 117-127
    • Sperlagh, B.1    Illes, P.2
  • 15
    • 42649145405 scopus 로고    scopus 로고
    • Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation
    • 18261711
    • Lecca D, Ceruti S. Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation. Biochem Pharmacol 2008, 75:1869-1881. 10.1016/j.bcp.2007.12.009, 18261711.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1869-1881
    • Lecca, D.1    Ceruti, S.2
  • 17
    • 27644513711 scopus 로고    scopus 로고
    • P2Y nucleotide receptor interaction with alpha integrin mediates astrocyte migration
    • 16135088
    • Wang M, Kong Q, Gonzalez FA, Sun G, Erb L, Seye C, Weisman GA. P2Y nucleotide receptor interaction with alpha integrin mediates astrocyte migration. J Neurochem 2005, 95:630-640. 10.1111/j.1471-4159.2005.03408.x, 16135088.
    • (2005) J Neurochem , vol.95 , pp. 630-640
    • Wang, M.1    Kong, Q.2    Gonzalez, F.A.3    Sun, G.4    Erb, L.5    Seye, C.6    Weisman, G.A.7
  • 18
    • 0030950658 scopus 로고    scopus 로고
    • Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation
    • 9174086
    • Queiroz G, Gebicke-Haerter PJ, Schobert A, Starke K, von Kugelgen I. Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation. Neuroscience 1997, 78:1203-1208. 10.1016/S0306-4522(96)00637-9, 9174086.
    • (1997) Neuroscience , vol.78 , pp. 1203-1208
    • Queiroz, G.1    Gebicke-Haerter, P.J.2    Schobert, A.3    Starke, K.4    von Kugelgen, I.5
  • 19
    • 0032962110 scopus 로고    scopus 로고
    • A study of the mechanism of the release of ATP from rat cortical astroglial cells evoked by activation of glutamate receptors
    • 10391492
    • Queiroz G, Meyer DK, Meyer A, Starke K, von Kugelgen I. A study of the mechanism of the release of ATP from rat cortical astroglial cells evoked by activation of glutamate receptors. Neuroscience 1999, 91:1171-1181. 10.1016/S0306-4522(98)00644-7, 10391492.
    • (1999) Neuroscience , vol.91 , pp. 1171-1181
    • Queiroz, G.1    Meyer, D.K.2    Meyer, A.3    Starke, K.4    von Kugelgen, I.5
  • 20
    • 79955484486 scopus 로고    scopus 로고
    • Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved
    • 21419195
    • Quintas C, Fraga S, Goncalves J, Queiroz G. Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved. Neuroscience 2011, 182:32-42. 10.1016/j.neuroscience.2011.03.009, 21419195.
    • (2011) Neuroscience , vol.182 , pp. 32-42
    • Quintas, C.1    Fraga, S.2    Goncalves, J.3    Queiroz, G.4
  • 21
    • 0032521330 scopus 로고    scopus 로고
    • Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors
    • 9482785
    • Cunha RA, Sebastiao AM, Ribeiro JA. Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors. J Neurosci 1998, 18:1987-1995. 9482785.
    • (1998) J Neurosci , vol.18 , pp. 1987-1995
    • Cunha, R.A.1    Sebastiao, A.M.2    Ribeiro, J.A.3
  • 22
    • 79960978463 scopus 로고    scopus 로고
    • P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation
    • 21559785
    • Quintas C, Fraga S, Goncalves J, Queiroz G. P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation. Purinergic Signal 2011, 7:251-263. 10.1007/s11302-011-9235-x, 21559785.
    • (2011) Purinergic Signal , vol.7 , pp. 251-263
    • Quintas, C.1    Fraga, S.2    Goncalves, J.3    Queiroz, G.4
  • 24
    • 23244449641 scopus 로고    scopus 로고
    • The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
    • 16045485
    • Iravani MM, Leung CC, Sadeghian M, Haddon CO, Rose S, Jenner P. The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation. Eur J Neurosci 2005, 22:317-330. 10.1111/j.1460-9568.2005.04220.x, 16045485.
    • (2005) Eur J Neurosci , vol.22 , pp. 317-330
    • Iravani, M.M.1    Leung, C.C.2    Sadeghian, M.3    Haddon, C.O.4    Rose, S.5    Jenner, P.6
  • 25
    • 0033771987 scopus 로고    scopus 로고
    • Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies
    • 10975910
    • Possel H, Noack H, Putzke J, Wolf G, Sies H. Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies. Glia 2000, 32:51-59. 10.1002/1098-1136(200010)32:1<51::AID-GLIA50>3.0.CO;2-4, 10975910.
    • (2000) Glia , vol.32 , pp. 51-59
    • Possel, H.1    Noack, H.2    Putzke, J.3    Wolf, G.4    Sies, H.5
  • 26
    • 79959339327 scopus 로고    scopus 로고
    • Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes
    • 21605665
    • Bruno CJ, Greco TM, Ischiropoulos H. Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes. Free Radic Biol Med 2011, 51:474-479. 10.1016/j.freeradbiomed.2011.04.041, 21605665.
    • (2011) Free Radic Biol Med , vol.51 , pp. 474-479
    • Bruno, C.J.1    Greco, T.M.2    Ischiropoulos, H.3
  • 27
    • 84859717206 scopus 로고    scopus 로고
    • Innate immunity in the central nervous system
    • 22466658
    • Ransohoff RM, Brown MA. Innate immunity in the central nervous system. J Clin Invest 2012, 122:1164-1171. 10.1172/JCI58644, 22466658.
    • (2012) J Clin Invest , vol.122 , pp. 1164-1171
    • Ransohoff, R.M.1    Brown, M.A.2
  • 29
    • 33845366469 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors
    • 17125260
    • El-Tayeb A, Qi A, Muller CE. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem 2006, 49:7076-7087. 10.1021/jm060848j, 17125260.
    • (2006) J Med Chem , vol.49 , pp. 7076-7087
    • El-Tayeb, A.1    Qi, A.2    Muller, C.E.3
  • 31
    • 1842634568 scopus 로고    scopus 로고
    • Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors
    • 15081875
    • Mamedova LK, Joshi BV, Gao ZG, von Kugelgen I, Jacobson KA. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol 2004, 67:1763-1770. 10.1016/j.bcp.2004.01.011, 15081875.
    • (2004) Biochem Pharmacol , vol.67 , pp. 1763-1770
    • Mamedova, L.K.1    Joshi, B.V.2    Gao, Z.G.3    von Kugelgen, I.4    Jacobson, K.A.5
  • 32
    • 33646424353 scopus 로고    scopus 로고
    • Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
    • von Kugelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 2006, 110:415-432. 10.1016/j.pharmthera.2005.08.014.
    • (2006) Pharmacol Ther , vol.110 , pp. 415-432
    • von Kugelgen, I.1
  • 33
    • 0034515728 scopus 로고    scopus 로고
    • Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain
    • 11122346
    • Braun N, Sevigny J, Robson SC, Enjyoji K, Guckelberger O, Hammer K, Di Virgilio F, Zimmermann H. Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain. Eur J Neurosci 2000, 12:4357-4366. 11122346.
    • (2000) Eur J Neurosci , vol.12 , pp. 4357-4366
    • Braun, N.1    Sevigny, J.2    Robson, S.C.3    Enjyoji, K.4    Guckelberger, O.5    Hammer, K.6    Di Virgilio, F.7    Zimmermann, H.8
  • 35
    • 84885961048 scopus 로고    scopus 로고
    • Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro
    • 23990338
    • Brisevac D, Bajic A, Bjelobaba I, Milosevic M, Stojiljkovic M, Beyer C, Clarner T, Kipp M, Nedeljkovic N. Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro. J Mol Neurosci 2013, 51:871-879. 10.1007/s12031-013-0088-3, 23990338.
    • (2013) J Mol Neurosci , vol.51 , pp. 871-879
    • Brisevac, D.1    Bajic, A.2    Bjelobaba, I.3    Milosevic, M.4    Stojiljkovic, M.5    Beyer, C.6    Clarner, T.7    Kipp, M.8    Nedeljkovic, N.9
  • 37
    • 84884671968 scopus 로고    scopus 로고
    • Lack of specificity shown by P2Y6 receptor antibodies
    • 23793102
    • Yu W, Hill WG. Lack of specificity shown by P2Y6 receptor antibodies. Naunyn Schmiedebergs Arch Pharmacol 2013, 386:885-891. 10.1007/s00210-013-0894-8, 23793102.
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , pp. 885-891
    • Yu, W.1    Hill, W.G.2
  • 38
    • 17844385044 scopus 로고    scopus 로고
    • Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia
    • 15850653
    • Bianco F, Fumagalli M, Pravettoni E, D'Ambrosi N, Volonte C, Matteoli M, Abbracchio MP, Verderio C. Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia. Brain Res Brain Res Rev 2005, 48:144-156. 10.1016/j.brainresrev.2004.12.004, 15850653.
    • (2005) Brain Res Brain Res Rev , vol.48 , pp. 144-156
    • Bianco, F.1    Fumagalli, M.2    Pravettoni, E.3    D'Ambrosi, N.4    Volonte, C.5    Matteoli, M.6    Abbracchio, M.P.7    Verderio, C.8
  • 39
    • 79954620950 scopus 로고    scopus 로고
    • Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells
    • 21510893
    • Wen J, Ribeiro R, Zhang Y. Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells. J Neuroinflammation 2011, 8:38. 10.1186/1742-2094-8-38, 21510893.
    • (2011) J Neuroinflammation , vol.8 , pp. 38
    • Wen, J.1    Ribeiro, R.2    Zhang, Y.3
  • 41
    • 0032735975 scopus 로고    scopus 로고
    • Neuronal protection and destruction by NO
    • 10556970
    • Lipton SA. Neuronal protection and destruction by NO. Cell Death Differ 1999, 6:943-951. 10.1038/sj.cdd.4400580, 10556970.
    • (1999) Cell Death Differ , vol.6 , pp. 943-951
    • Lipton, S.A.1
  • 42
    • 33646697351 scopus 로고    scopus 로고
    • Nitric oxide and cell proliferation
    • 16704409
    • Villalobo A. Nitric oxide and cell proliferation. FEBS J 2006, 273:2329-2344. 10.1111/j.1742-4658.2006.05250.x, 16704409.
    • (2006) FEBS J , vol.273 , pp. 2329-2344
    • Villalobo, A.1
  • 43
    • 0024571578 scopus 로고
    • Lipopolysaccharide-free conditions in primary astrocyte cultures allow growth and isolation of microglial cells
    • 2643682
    • Gebicke-Haerter PJ, Bauer J, Schobert A, Northoff H. Lipopolysaccharide-free conditions in primary astrocyte cultures allow growth and isolation of microglial cells. J Neurosci 1989, 9:183-194. 2643682.
    • (1989) J Neurosci , vol.9 , pp. 183-194
    • Gebicke-Haerter, P.J.1    Bauer, J.2    Schobert, A.3    Northoff, H.4
  • 44
    • 84893200802 scopus 로고    scopus 로고
    • Exposure to inflammatory cytokines IL-1beta and TNFalpha induces compromise and death of astrocytes; implications for chronic neuroinflammation
    • 24367648
    • van Kralingen C, Kho DT, Costa J, Angel CE, Graham ES. Exposure to inflammatory cytokines IL-1beta and TNFalpha induces compromise and death of astrocytes; implications for chronic neuroinflammation. PLoS One 2013, 8:e84269. 10.1371/journal.pone.0084269, 24367648.
    • (2013) PLoS One , vol.8 , pp. e84269
    • van Kralingen, C.1    Kho, D.T.2    Costa, J.3    Angel, C.E.4    Graham, E.S.5
  • 45
    • 84855973883 scopus 로고    scopus 로고
    • Heterogeneity of Astrocytic Form and Function
    • 22144298
    • Oberheim NA, Goldman SA, Nedergaard M. Heterogeneity of Astrocytic Form and Function. Methods Mol Biol 2012, 814:23-45. 10.1007/978-1-61779-452-0_3, 22144298.
    • (2012) Methods Mol Biol , vol.814 , pp. 23-45
    • Oberheim, N.A.1    Goldman, S.A.2    Nedergaard, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.