Synovial sarcoma is a stem cell malignancy

Stem Cells

Volumn 28, Issue 7, 2010, Pages 1119-1131

  Naka, Norifumi ^a   Takenaka, Satoshi ^a,b   Araki, Nobuhito ^a   Miwa, Toshitada ^c   Hashimoto, Nobuyuki ^b   Yoshioka, Kiyoko ^a   Joyama, Susumu ^a   Hamada, Ken Ichiro ^a   Tsukamoto, Yoshitane ^d   Tomita, Yasuhiko ^a   Ueda, Takafumi ^e   Yoshikawa, Hideki ^b   Itoh, Kazuyuki ^a  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA KOSEI NENKIN HOSPITAL   (Japan)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

^e OSAKA NATIONAL HOSPITAL   (Japan)

Author keywords

Cancer initiating ability; Cell of origin; Mesenchymal stem cell; SS18 SSX; Synovial sarcoma

Indexed keywords

HYBRID PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CARTILAGE CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL RENEWAL; CONTROLLED STUDY; GENE FUSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OSTEOCYTE; PROTEIN EXPRESSION; SYNOVIAL SARCOMA; TUMOR XENOGRAFT;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; NEOPLASTIC STEM CELLS; ONCOGENE PROTEINS, FUSION; RNA, SMALL INTERFERING; SARCOMA, SYNOVIAL; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77954823179     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.452     Document Type: Article

References (47)

1. Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors, 5th ed. St. Louis MO: Mosby Inc, 2008:1161-1182.
2. Clark J, Rocques PJ, Crew AJ et al. Identification of novel genes, Syt And SSX, involved in the t(X;18)(p112;q112) translocation found in human synovial sarcoma. Nat Genet 1994;7:502-508.
3. Crew AJ, Clark J, Fisher C et al. Fusion of SYT to two genes, SSX1 And SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 1995;14:2333-2340.
4. Skytting B, Nilsson G, Brodin B et al. A novel fusion gene, SYTSSX4, in synovial sarcoma. J Natl Cancer Inst 1999;91:974-975. (Pubitemid 29275883)
5. Nagai M, Tanaka S, Tsuda M et al. Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha. Proc Natl Acad Sci USA 2001;98:3843-3848.
6. Haldar M, Hancock JD, Coffin CM et al. A conditional mouse model of synovial sarcoma: Insights into a myogenic origin. Cancer Cell 2007;11:375-388.
7. Fletcher CDM, Unni KK, Mertens F. Tumours of Soft Tissue and Bone. Lyon, FR: IARC Press, 2002:200-204.
8. Lapidot T, Sirard C, Vormoor J et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994;367:645-648.
9. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-737.
10. Al-Hajj M, Wicha MS, Benito-Hernandez A et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100:3983-3988. (Pubitemid 36418143)
11. Hemmati HD, Nakano I, Lazareff JA et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 2003;100:15178-15183.
12. Dontu G, Abdallah WM, Foley JM et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003;17:1253-1270.
13. Yano J, Hirabayashi K, Nakagawa S et al. Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer. Clin Cancer Res 2004;10:7721-7726.
14. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
15. Johnstone B, Hering TM, Caplan AI et al. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998;238:265-272.
16. Singh SK, Hawkins C, Clarke ID et al. Identification of human brain tumour initiating cells. Nature 2004;432:396-401.
17. Kondo T, Setoguchi T, Taga T. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA 2004;101:781-786.
18. Ponti D, Costa A, Zaffaroni N et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65:5506-5511. (Pubitemid 40911148)
19. Singh SK, Clarke ID, Terasaki M et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-5828.
20. Clarke MF, Dick JE, Dirks PB et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006;66:9339-9344.
21. Mani SA, Guo W, Liao MJ et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008;133:704-715.
22. Gidekel S, Pizov G, Bergman Y, Pikarsky E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003;4:361-370.
23. Santagata S, Ligon KL, Hornick JL. Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am J Surg Pathol 2007;31:836-845.
24. Ben-Porath I, Thomson MW, Carey VJ et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499-507.
25. Glinsky GV. "Stemness" genomics law governs clinical behavior of human cancer: Implications for decision making in disease management. J Clin Oncol 2008;26:2846-2853.
26. Fang D, Nguyen TK, Leishear K et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005;65:9328-9337.
27. Schatton T, Murphy GF, Frank NY et al. Identification of cells initiating human melanomas. Nature 2008;451:345-349.
28. Majumdar MK, Thiede MA, Haynesworth SE et al. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res 2000;9:841-848.
29. Kim DH, Yoo KH, Choi KS et al. Gene expression profile of cytokine and growth factor during differentiation of bone marrow-derived mesenchymal stem cell. Cytokine 2005;31:119-126.
30. Wong GG, Witek-Giannotti JS, Temple PA et al. Stimulation of murine hemopoietic colony formation by human IL-6. J Immunol 1988; 140:3040-3044.
31. Kishimoto T. The biology of interleukin-6. Blood 1989;74:1-10.
32. Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008;132:567-582.
33. Lengner CJ, Camargo FD, Hochedlinger K et al. Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 2007;1:403-415.
34. Li XL, Eishi Y, Bai YQ et al. Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int J Oncol 2004;24:257-263.
35. Rodriguez-Pinilla SM, Sarrio D, Moreno-Bueno G et al. Sox2: A possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol 2007;20:474-481.
36. Riggi N, Cironi L, Provero P et al. Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res 2005;65:11459-11468.
37. Riggi N, Cironi L, Provero P et al. Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res 2006;66:7016-7023.
38. Tirode F, Laud-Duval K, Prieur A et al. Mesenchymal stem cell features of Ewing tumors. Cancer Cell 2007;11:421-429. (Pubitemid 46680428)
39. Milchgrub S, Ghandur-Mnaymneh L, Dorfman HD et al. Synovial sarcoma with extensive osteoid and bone formation. Am J Surg Pathol 1993;17:357-363. (Pubitemid 23096826)
40. Nagayama S, Katagiri T, Tsunoda T et al. Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res 2002;62:5859-5866. (Pubitemid 35204746)
41. Ishibe T, Nakayama T, Aoyama T et al. Neuronal differentiation of synovial sarcoma and its therapeutic application. Clin Orthop Relat Res 2008;466:2147-2155.
42. Smith R, Owen LA, Trem DJ et al. Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 2006;9:405-416.
43. Hu-Lieskovan S, Zhang J, Wu L et al. EWS-FLI1 fusion protein upregulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res 2005;65:4633-4644.
44. Krawisz BR, Florine DL, Scott RE. Differentiation of fibroblast-like cells into macrophages. Cancer Res 1981;41:2891-2899.
45. Sparks RL, Seibel-Ross EI, Wier ML et al. Differentiation, dedifferentiation, and transdifferentiation of BALB/c 3T3 T mesenchymal stem cells: Potential significance in metaplasia and neoplasia. Cancer Res 1986;46:5312-5319.
46. Feng R, Desbordes SC, Xie H et al. PU. 1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci USA 2008;105:6057-6062.
47. Reuter U, Champion C, Kain HL. Transdifferentiation of human monocytes into fibroblast-like cells in vitro. Ger J Ophthalmol 1995;4:182-187.