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Volumn 99, Issue 11, 2014, Pages E2252-E2258

The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and wnt inhibitors in young women with hypothalamic amenorrhea

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; CALCIUM; CREATININE; DICKKOPF 1 PROTEIN; FIBROBLAST GROWTH FACTOR 23; LEPTIN; METRELEPTIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE; PHOSPHATE; PLACEBO; SCLEROSTIN; BONE MORPHOGENETIC PROTEIN; DKK1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; GENETIC MARKER; SIGNAL PEPTIDE; SOST PROTEIN, HUMAN;

EID: 84910018198     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2491     Document Type: Article
Times cited : (25)

References (37)
  • 1
    • 77954825540 scopus 로고    scopus 로고
    • Clinical practice. Functional hypothalamic amenorrhea
    • Gordon CM. Clinical practice. Functional hypothalamic amenorrhea. N Engl J Med. 2010;363: 365-371.
    • (2010) N Engl J Med , vol.363 , pp. 365-371
    • Gordon, C.M.1
  • 2
    • 34147150332 scopus 로고    scopus 로고
    • Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea
    • Miller KK, Lawson EA, Mathur V, et al. Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea. J Clin Endocrinol Metab. 2007;92: 1334-1339.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1334-1339
    • Miller, K.K.1    Lawson, E.A.2    Mathur, V.3
  • 3
    • 0004308696 scopus 로고
    • Identification of androgen receptors in normal human osteoblast-like cells
    • Colvard DS, Eriksen EF, Keeting PE, et al. Identification of androgen receptors in normal human osteoblast-like cells. Proc Natl Acad Sci USA. 1989;86: 854-857.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 854-857
    • Colvard, D.S.1    Eriksen, E.F.2    Keeting, P.E.3
  • 5
    • 84876284729 scopus 로고    scopus 로고
    • Bone metabolism markers in adolescent girls with eating disorders and weight loss: Effects of growth, weight trend, developmental and menstrual status
    • Swenne I, Stridsberg M. Bone metabolism markers in adolescent girls with eating disorders and weight loss: effects of growth, weight trend, developmental and menstrual status. Arch Osteoporos. 2012; 7: 125-133.
    • (2012) Arch Osteoporos , vol.7 , pp. 125-133
    • Swenne, I.1    Stridsberg, M.2
  • 7
    • 84862121497 scopus 로고    scopus 로고
    • Optimizing bone health in anorexia nervosa and hypothalamic amenorrhea: New trials and tribulations
    • Foo JP, Hamnvik OP, Mantzoros CS. Optimizing bone health in anorexia nervosa and hypothalamic amenorrhea: new trials and tribulations. Metabolism. 2012;61: 899-905.
    • (2012) Metabolism , vol.61 , pp. 899-905
    • Foo, J.P.1    Hamnvik, O.P.2    Mantzoros, C.S.3
  • 8
    • 0031759898 scopus 로고    scopus 로고
    • Decreased leptin levels in normal weightwomenwith hypothalamic amenorrhea: The effects of body composition and nutritional intake
    • Miller KK, Parulekar MS, Schoenfeld E, et al. Decreased leptin levels in normal weightwomenwith hypothalamic amenorrhea: the effects of body composition and nutritional intake. J Clin Endocrinol Metab. 1998;83: 2309-2312.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2309-2312
    • Miller, K.K.1    Parulekar, M.S.2    Schoenfeld, E.3
  • 9
    • 80051800457 scopus 로고    scopus 로고
    • Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women
    • Sienkiewicz E, Magkos F, Aronis KN, et al. Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women. Metabolism. 2011;60: 1211-1221.
    • (2011) Metabolism , vol.60 , pp. 1211-1221
    • Sienkiewicz, E.1    Magkos, F.2    Aronis, K.N.3
  • 10
    • 79955620729 scopus 로고    scopus 로고
    • Leptin is an effective treatment for hypothalamic amenorrhea
    • Chou SH, Chamberland JP, Liu X, et al. Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci USA. 2011; 108: 6585-6590.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6585-6590
    • Chou, S.H.1    Chamberland, J.P.2    Liu, X.3
  • 11
    • 0022578240 scopus 로고
    • Scoliosis and fractures in young ballet dancers. Relation to delayed menarche and secondary amenorrhea
    • Warren MP, Brooks-Gunn J, Hamilton LH, Warren LF, Hamilton WG. Scoliosis and fractures in young ballet dancers. Relation to delayed menarche and secondary amenorrhea.NEngl J Med. 1986; 314: 1348-1353.
    • (1986) NEngl J Med , vol.314 , pp. 1348-1353
    • Warren, M.P.1    Brooks-Gunn, J.2    Hamilton, L.H.3    Warren, L.F.4    Hamilton, W.G.5
  • 12
    • 0036785268 scopus 로고    scopus 로고
    • Relationship of serum leptin concentration with bone mineral density in the United States population
    • Ruhl CE, Everhart JE. Relationship of serum leptin concentration with bone mineral density in the United States population. J Bone Miner Res. 2002;17: 1896-1903.
    • (2002) J Bone Miner Res , vol.17 , pp. 1896-1903
    • Ruhl, C.E.1    Everhart, J.E.2
  • 13
    • 58549107572 scopus 로고    scopus 로고
    • Bone mineral density and bone turnover in relation to serum leptin, α-ketoglutarate and sex steroids in overweight and obese postmenopausal women
    • Filip R, Raszewski G. Bone mineral density and bone turnover in relation to serum leptin, α-ketoglutarate and sex steroids in overweight and obese postmenopausal women. Clin Endocrinol (Oxf). 2009;70: 214-220.
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 214-220
    • Filip, R.1    Raszewski, G.2
  • 14
    • 9444249827 scopus 로고    scopus 로고
    • Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women
    • Zhong N, Wu XP, Xu ZR, et al. Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta. 2005;351: 161-168.
    • (2005) Clin Chim Acta , vol.351 , pp. 161-168
    • Zhong, N.1    Wu, X.P.2    Xu, Z.R.3
  • 15
    • 0036847619 scopus 로고    scopus 로고
    • Leptin regulates bone formation via the sympathetic nervous system
    • Takeda S, Elefteriou F, Levasseur R, et al. Leptin regulates bone formation via the sympathetic nervous system. Cell. 2002;111: 305-317.
    • (2002) Cell , vol.111 , pp. 305-317
    • Takeda, S.1    Elefteriou, F.2    Levasseur, R.3
  • 16
    • 15844384047 scopus 로고    scopus 로고
    • Leptin regulation of bone resorption by the sympathetic nervous system and CART
    • Elefteriou F, Ahn JD, Takeda S, et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005;434: 514-520.
    • (2005) Nature , vol.434 , pp. 514-520
    • Elefteriou, F.1    Ahn, J.D.2    Takeda, S.3
  • 17
    • 33845624298 scopus 로고    scopus 로고
    • Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans
    • Chan JL, Mietus JE, Raciti PM, Goldberger AL, Mantzoros CS. Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans. Clin Endocrinol (Oxf). 2007;66: 49-57.
    • (2007) Clin Endocrinol (Oxf) , vol.66 , pp. 49-57
    • Chan, J.L.1    Mietus, J.E.2    Raciti, P.M.3    Goldberger, A.L.4    Mantzoros, C.S.5
  • 18
    • 3543089241 scopus 로고    scopus 로고
    • Estrogen prevents the reduction in fractional calcium absorption due to energy restriction in mature rats
    • Cifuentes M, Advis JP, Shapses SA. Estrogen prevents the reduction in fractional calcium absorption due to energy restriction in mature rats. J Nutr. 2004;134: 1929-1934.
    • (2004) J Nutr , vol.134 , pp. 1929-1934
    • Cifuentes, M.1    Advis, J.P.2    Shapses, S.A.3
  • 19
    • 12144265535 scopus 로고    scopus 로고
    • Effects of endogenous estrogen on renal calcium and phosphate handling in elderly women
    • Dick IM, Devine A, Beilby J, Prince RL. Effects of endogenous estrogen on renal calcium and phosphate handling in elderly women. Am J Physiol Endocrinol Metab. 2005;288: E430-E435.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E430-E435
    • Dick, I.M.1    Devine, A.2    Beilby, J.3    Prince, R.L.4
  • 20
    • 10744220420 scopus 로고    scopus 로고
    • Serum leptin in dialysis renal osteodystrophy
    • Coen G, Ballanti P, Fischer MS, et al. Serum leptin in dialysis renal osteodystrophy. Am J Kidney Dis. 2003;42: 1036-1042.
    • (2003) Am J Kidney Dis , vol.42 , pp. 1036-1042
    • Coen, G.1    Ballanti, P.2    Fischer, M.S.3
  • 21
    • 84874524601 scopus 로고    scopus 로고
    • Relationship between serum leptin levels and bone mineral density and bone metabolic markers in patients on hemodialysis
    • Ahmadi F, Salari S, Maziar S, Esfahanian F, Khazaeipour Z, Ranjbarnovin N. Relationship between serum leptin levels and bone mineral density and bone metabolic markers in patients on hemodialysis. Saudi J Kidney Dis Transpl. 2013;24: 41-47.
    • (2013) Saudi J Kidney Dis Transpl , vol.24 , pp. 41-47
    • Ahmadi, F.1    Salari, S.2    Maziar, S.3    Esfahanian, F.4    Khazaeipour, Z.5    Ranjbarnovin, N.6
  • 22
    • 84860783483 scopus 로고    scopus 로고
    • Serum leptin, parathyroid hormone, 1, 25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesity
    • Grethen E, Hill KM, Jones R, et al. Serum leptin, parathyroid hormone, 1, 25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesity. J Clin Endocrinol Metab. 2012;97: 1655-1662.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1655-1662
    • Grethen, E.1    Hill, K.M.2    Jones, R.3
  • 23
    • 78650371013 scopus 로고    scopus 로고
    • Associations between serum leptin level and bone turnover in kidney transplant recipients
    • Kovesdy CP, Molnar MZ, Czira ME, et al. Associations between serum leptin level and bone turnover in kidney transplant recipients. Clin J Am Soc Nephrol. 2010;5: 2297-2304.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 2297-2304
    • Kovesdy, C.P.1    Molnar, M.Z.2    Czira, M.E.3
  • 24
    • 83755172875 scopus 로고    scopus 로고
    • Changes in serum leptin and adiponectin concentrations and insulin resistance after curative parathyroidectomy in moderate to severe primary hyperparathyroidism
    • Bhadada SK, Bhansali A, ShahVN, RaoDS. Changes in serum leptin and adiponectin concentrations and insulin resistance after curative parathyroidectomy in moderate to severe primary hyperparathyroidism. Singapore Med J. 2011;52: 890-893.
    • (2011) Singapore Med J , vol.52 , pp. 890-893
    • Bhadada, S.K.1    Bhansali, A.2    Shah, V.N.3    Rao, D.S.4
  • 25
    • 84901192783 scopus 로고    scopus 로고
    • Leptin signaling and hyperparathyroidism: Clinical and genetic associations
    • Hoang D, Broer N, Roman SA, et al. Leptin signaling and hyperparathyroidism: clinical and genetic associations. J Am Coll Surg. 2014;218: 1239-1250.
    • (2014) J Am Coll Surg , vol.218 , pp. 1239-1250
    • Hoang, D.1    Broer, N.2    Roman, S.A.3
  • 27
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423: 337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 28
    • 0033984313 scopus 로고    scopus 로고
    • The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
    • Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res. 2000; 15: 2-12.
    • (2000) J Bone Miner Res , vol.15 , pp. 2-12
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3    Lacey, D.L.4    Boyle, W.J.5    Riggs, B.L.6
  • 29
    • 0034878897 scopus 로고    scopus 로고
    • Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation
    • MaYL, Cain RL, Halladay DL, et al. Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology. 2001;142: 4047-4054.
    • (2001) Endocrinology , vol.142 , pp. 4047-4054
    • Mayl Cain, R.L.1    Halladay, D.L.2
  • 30
    • 34250211442 scopus 로고    scopus 로고
    • Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa
    • Munoz-Calvo MT, Barrios V, Garcia de Alvaro MT, et al. Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa. Scand J Clin Lab Invest. 2007;67: 387-393.
    • (2007) Scand J Clin Lab Invest , vol.67 , pp. 387-393
    • Munoz-Calvo, M.T.1    Barrios, V.2    De Garcia Alvaro, M.T.3
  • 32
    • 0033984390 scopus 로고    scopus 로고
    • Serum CTX: A new marker of bone resorption that shows treatment effect more often than other markers because of low coefficient of variability and large changes with bisphosphonate therapy
    • Rosen HN, Moses AC, Garber J, et al. Serum CTX: a new marker of bone resorption that shows treatment effect more often than other markers because of low coefficient of variability and large changes with bisphosphonate therapy. Calcif Tissue Int. 2000;66: 100-103.
    • (2000) Calcif Tissue Int , vol.66 , pp. 100-103
    • Rosen, H.N.1    Moses, A.C.2    Garber, J.3
  • 33
    • 2942715123 scopus 로고    scopus 로고
    • Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-κB ligand mRNA levels in primary hyperparathyroidism: Effect of parathyroidectomy and association with bone metabolism
    • Stilgren L, Rettmer E, Eriksen E, Hegedus L, Beck-Nielsen H, Abrahamsen B. Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-κB ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Bone. 2004;35: 256-265.
    • (2004) Bone , vol.35 , pp. 256-265
    • Stilgren, L.1    Rettmer, E.2    Eriksen, E.3    Hegedus, L.4    Beck-Nielsen, H.5    Abrahamsen, B.6
  • 34
  • 35
    • 80053938104 scopus 로고    scopus 로고
    • Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    • Nakashima T, HayashiM, Fukunaga T, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 2011;17: 1231-1234.
    • (2011) Nat Med , vol.17 , pp. 1231-1234
    • Nakashima, T.1    Hayashi, M.2    Fukunaga, T.3
  • 36
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li X, Zhang Y, Kang H, et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem. 2005;280: 19883-19887.
    • (2005) J Biol Chem , vol.280 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3
  • 37
    • 33748156090 scopus 로고    scopus 로고
    • Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
    • Li J, Sarosi I, Cattley RC, et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone. 2006;39: 754-766.
    • (2006) Bone , vol.39 , pp. 754-766
    • Li, J.1    Sarosi, I.2    Cattley, R.C.3


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