Pathogenesis of post primary tuberculosis: Immunity and hypersensitivity in the development of cavities

Annals of Clinical and Laboratory Science

Volumn 44, Issue 4, 2014, Pages 365-387

  Hunter, Robert L ^a   Actor, Jeffrey K ^a   Hwang, Shen An ^a   Karev, Vadim ^b   Jagannath, Chinnaswamy ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b Scientific Research Institute of Childhood Diseases of the Federal Medical and Biological Agency   (Russian Federation)

Author keywords

Cavity and lung; Mycobacterium tuberculosis; Pathogenesis; Pathology; Pulmonary tuberculosis

Indexed keywords

ANTIBIOTIC AGENT; BCG VACCINE; CORD FACTOR; FAT DROPLET; LUNG SURFACTANT; MYCOBACTERIUM ANTIGEN; STEROID;

AGING; ARTICLE; ASPIRATION PNEUMONIA; BACTERIAL GROWTH; BACTERIAL INFECTION; BRONCHUS OBSTRUCTION; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DISEASE TRANSMISSION; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERSENSITIVITY; IMMUNE SYSTEM; IMMUNITY; INFECTION RESISTANCE; LUNG ALVEOLUS MACROPHAGE; LUNG CAVITY; LUNG PARENCHYMA; LUNG TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; POSTPRIMARY TUBERCULOSIS; STEROID THERAPY; THORAX RADIOGRAPHY; TUBERCULOSIS; ANIMAL; COMPLICATION; IMMUNOLOGY; LUNG; MICROBIOLOGY; NECROSIS; PATHOGENICITY; PATHOLOGY;

MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; HUMANS; IMMUNITY; LUNG; MYCOBACTERIUM TUBERCULOSIS; NECROSIS; TUBERCULOSIS;

EID: 84910018157     PISSN: 00917370     EISSN: 15508080     Source Type: Journal    
DOI: None     Document Type: Article

References (135)

1. World_Health_Organization. Global tuberculosis report 2013. 2013.
2. Russell, D. G., C. E. Barry, 3rd, and J. L. Flynn. Tuberculosis: what we don't know can, and does, hurt us. Science 2010. 328: 852-856.
3. Hunter, R. L. Pathology of post primary tuberculosis of the lung: An illustrated critical review. Tuberculosis (Edinb) E publication ahead of print July 4, 2011.
4. Russell, D. G. Who puts the tubercle in tuberculosis? Nat Rev Microbiol 2007. 5: 39-47.
5. den Boon, S., S. W. van Lill, M. W. Borgdorff, D. A. Enarson, S. Verver, E. D. Bateman, E. Irusen, C. J. Lombard, N. W. White, C. de Villiers, and N. Beyers. High prevalence of tuberculosis in previously treated patients, Cape Town, South Africa. Emerg Infect Dis 2007. 13: 1189-1194.
6. van Rie, A., T. C. Victor, M. Richardson, R. Johnson, G. D. van der Spuy, E. J. Murray, N. Beyers, N. C. Gey van Pittius, P. D. van Helden, and R. M. Warren. Reinfection and Mixed Infection Cause Changing Mycobacterium tuberculosis Drugresistance Patterns. Am J Respir Crit Care Med 2005.
7. Comas, I., J. Chakravartti, P. M. Small, J. Galagan, S. Niemann, K. Kremer, J. D. Ernst, and S. Gagneux. Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nature genetics 2010. 42: 498-503.
8. Brennan, M. J., and J. Thole. Tuberculosis vaccines: a strategic blueprint for the next decade. Tuberculosis (Edinb) 2012. 92 Suppl 1: S6-13.
9. Laennec, R. A treatise on diseases of the chest in which they are described according to their anatomical characters, and their diagnosis established on a new principle by means of acoustick instruments. 1821 T&G Underwood, London (reprinted 1979 by The Classics of Medicine Library. Birmingham AL).
10. Rich, A. The Pathogenesis of Tuberculosis, Second Edition. 1951 Charles C Thomas, Springfield, Illinois.
11. Canetti, G. The tubercle bacillus in the pulmonary lesion of man. Histobacteriology and its bearing on the therapy of pulmonary tuberculosis. 1955 Springer Publishing Compani Inc., New Yoyk.
12. Medlar, E. M. The behavior of pulmonary tuberculous lesions; a pathological study. Am Rev Tuberc 1955. 71: 1-244.
13. Levine, E. R. Chapter 7, Classification of reinfection pulmonary tuberculosis. In The Fundamentals of Pulmonary Tuberculosis and its Complications for Students, Teachers and Practicing Physicians. E. Hayes, ed. Charles C Thomas, Springfield. 1949. 97-113.
14. Pagel, W., F. Simmonds, N. MacDonald, and E. Nassau. Chapter 3.TheMorbidAnatomy and Histology of Tuberculosis, An Introduction in Simple Terms. In In Pulmonary Tuberculosis, Bacteriology, Pathology, Management, Epidemiology and Prevention. Oxford University Press, London. 1964. 36-63.
15. Dannenberg, A. M., Jr. Pathogenisis of human pulmonary tuberculosis. Insights from the rabbit model. 2006 ASM press, Washington, DC.
16. Creighton, C. Bovine Tubercuosis in Man: An account of the Pathology of Suspected Cases. 1881 MacMillan and Co., London.
17. Liebana, E., L. Johnson, J. Gough, P. Durr, K. Jahans, R. Clifton-Hadley, Y. Spencer, R. G. Hewinson, and S. H. Downs. Pathology of naturally occurring bovine tuberculosis in England and Wales. Vet J 2008. 176: 354-360.
18. Hunter, R. L., M. Olsen, C. Jagannath, and J. K. Actor. Trehalose 6,6'-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice. Am J Pathol 2006. 168: 1249-1261.
19. Guidry, T. V., R. L. Hunter, Jr., and J. K. Actor. Mycobacterial glycolipid trehalose 6,6'-dimycolate-induced hypersensitive granulomas: contribution ofCD4+ lymphocytes. Microbiology 2007. 153: 3360-3369.
20. Guidry, T. V., M. Olsen, K. S. Kil, R. L. Hunter, Jr., Y. J. Geng, and J. K. Actor. Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6'-dimycolate. J Interferon Cytokine Res 2004. 24: 362-371.
21. Hunter, R. L., C. Jagannath, and J. K. Actor. Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs. Tuberculosis (Edinb) 2007. 87: 267-278.
22. Ehlers, S. Lazy, dynamic or minimally recrudescent? On the elusive nature and location of the mycobacterium responsible for latent tuberculosis. Infection 2009. 37: 87-95.
23. Lin, P. L., C. B. Ford, M. T. Coleman, A. J. Myers, R. Gawande, T. Ioerger, J. Sacchettini, S. M. Fortune, and J. L. Flynn. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nat Med 2014. 20: 75-79.
24. Neyrolles, O., R. Hernandez-Pando, F. Pietri-Rouxel, P. Fornes, L. Tailleux, J. A. Barrios Payan, E. Pivert, Y. Bordat, D. Aguilar, M. C. Prevost, C. Petit, and B. Gicquel. Is adipose tissue a place for Mycobacterium tuberculosis persistence? PloS one 2006. 1: e43.
25. Agarwal, P., S. R. Khan, S. C. Verma, M. Beg, K. Singh, K. Mitra, A. N. Gaikwad, M. S. Akhtar, and M. Y. Krishnan. Mycobacterium tuberculosis persistence in various adipose depots of infected mice and the effect of anti-tubercular therapy. Microbes Infect 2014. 16: 571-580.
26. Hadda, V., and G. C. Khilnani. Lipoid pneumonia: an overview. Expert review of respiratory medicine 2010. 4: 799-807.
27. Osler, W. Chapter 26, Tuberculosis. In The principles and practice of medicine. D. Appleton and Company, New York. 1892. 184-255.
28. Dubos, R., and G. Dubos. The White Plague. Tuberculosis, Man, and Society. 1987 Rutgers Univesity Press, Brunswick, NJ.
29. Erokhin, V. V., V. Y. Mishin, V. I. Chukanov, and D. V. Guiller. Caseous pneumonia, Pathologic anatomy, pathogenesis, diagnosis, clinical course and treatment, A manual for practitioners 2008 Meditsina Publishers, Moscow.
30. Goodwin, R. A., and R. M. Des Prez. Apical localization of pulmonary tuberculosis, chronic pulmonary histoplasmosis, and progressive massive fibrosis of the lung. Chest 1983. 83: 801-805.
31. Pai, M., A. Mohan, K. Dheda, C. C. Leung, W. W. Yew, D. J. Christopher, and S. K. Sharma. Lethal interaction: the colliding epidemics of tobacco and tuberculosis. Expert review of anti-infective therapy 2007. 5: 385-391.
32. Murray, J. F. Bill Dock and the location of pulmonary tuberculosis: how bed rest might have helped consumption. Am J Respir Crit Care Med 2003. 168: 1029-1033.
33. Broch, B. L. Chapter 14, The role of the bronchial tree in the pathogenesis of pulmonary tuberculosis. In The Fundamentals of Pulmonary Tuberculosis and its Complications for Students, Teachers and Practicing Physicians. E. Hayes, ed. Charles C Thomas, Springfield. 1949. 245-253.
34. Ehrhardt, J., R. Werner, A. Schmidt-Richberg, and H. Handels. Statistical modeling of 4D respiratory lung motion using diffeomorphic image registration. IEEE transactions on medical imaging 2011. 30: 251-265.
35. Du, K., J. E. Bayouth, K. Cao, G. E. Christensen, K. Ding, and J. M. Reinhardt. Reproducibility of registration-based measures of lung tissue expansion. Medical physics 2012. 39: 1595-1608.
36. Lam, C. W., J. T. James, R. McCluskey, and R. L. Hunter. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 2004. 77: 126-134.
37. O'Garra, A., P. S. Redford, F. W. McNab, C. I. Bloom, R. J. Wilkinson, and M. P. Berry. The immune response in tuberculosis. Annu Rev Immunol 2013. 31: 475-527.
38. Korf, J., A. Stoltz, J. Verschoor, P. De Baetselier, and J. Grooten. The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses. Eur J Immunol 2005. 35: 890-900.
39. Peyron, P., J. Vaubourgeix, Y. Poquet, F. Levillain, C. Botanch, F. Bardou, M. Daffe, J. F. Emile, B. Marchou, P. J. Cardona, C. de Chastellier, and F. Altare. Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. PLoS Pathog 2008. 4: e1000204.
40. Korf, J. E., G. Pynaert, K. Tournoy, T. Boonefaes, A. Van Oosterhout, D. Ginneberge, A. Haegeman, J. A. Verschoor, P. De Baetselier, and J. Grooten. Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma. Am J Respir Crit Care Med 2006. 174: 152-160.
41. Melo, R. C., and A. M. Dvorak. Lipid body-phagosome interaction in macrophages during infectious diseases: host defense or pathogen survival strategy? PLoS Pathog 2012. 8: e1002729.
42. North, R. J., and Y. J. Jung. Immunity to tuberculosis. Annu Rev Immunol 2004. 22: 599-623.
43. Nuermberger, E. L., T. Yoshimatsu, S. Tyagi, W. R. Bishai, and J. H. Grosset. Paucibacillary tuberculosis in mice after prior aerosol immunization with Mycobacterium bovis BCG. Infect Immun 2004. 72: 1065-1071.
44. Kondo, A., N. Oketani, M. Maruyama, Y. Taguchi, Y. Yamaguchi, H. Miyao, I. Mashima, M. Oono, K. Wada, T. Tsuchiya, H. Takahashi, and S. Abe. [Significance of serum surfactant protein-D (SP-D) level in patients with pulmonary tuberculosis]. Kekkaku 1998. 73: 585-590.
45. Chroneos, Z. C., K. Midde, Z. Sever-Chroneos, and C. Jagannath. Pulmonary surfactant and tuberculosis. Tuberculosis (Edinb) 2009. 89 Suppl 1: S10-14.
46. Wang, Z., U. Schwab, E. Rhoades, P. R. Chess, D. G. Russell, and R. H. Notter. Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant function. Tuberculosis (Edinb) 2008. 88: 178-186.
47. Lovacheva, O. V., V. V. Erokhin, N. V. Chernichenko, G. V. Evgushchenko, L. N. Lepekha, and O. A. Rozenberg. [Results of use of surfactant in complex therapy of patients with destructive pulmonary tuberculosis]. Probl Tuberk Bolezn Legk 2006. 12-17.
48. Hektoen, L., and D. Reisman. A Text-Book of Pathology for the use of students and practitoners of medicine and surgery. 1901 W.B. Saunders & Company, London and Philadelphia.
49. Coats, J., and L. K. Sutherland. Manual Of Pathology, Chapter 5. Healing Of Phthisis. 1900 Longmans, Green, And Co, London.
50. Im, J. G., H. Itoh, K. S. Lee, and M. C. Han. CT-pathology correlation of pulmonary tuberculosis. Crit Rev Diagn Imaging 1995. 36: 227-285.
51. Lee, J. Y., K. S. Lee, K. J. Jung, J. Han, O. J. Kwon, J. Kim, and T. S. Kim. Pulmonary tuberculosis: CT and pathologic correlation. J Comput Assist Tomogr 2000. 24: 691-698.
52. Kondo, S., T. Miyagawa, and M. Ito. [Reevaluation of pathogenesis of epituberculosis in infants and children with tuberculosis]. Kekkaku 2007. 82: 569-575.
53. Fish, R., and W. Pagel. The morbid anatomy of epituberculosis. J Path Bact 1938. 47: 593-601.
54. Amita, R., S. Sandhyamani, and M. Unnikrishnan. Extensive unilateral pulmonary tuberculosis with segmental atresia of principal bronchus. Lung India: official organ of Indian Chest Society 2014. 31: 94-95.
55. Ahonen, A., and K. Valavirta. Ultrastructure of cilia in pulmonary tuberculosis. European journal of respiratory diseases. Supplement 1983. 128 (Pt 2): 460-463.
56. Reed, G. W., H. Choi, S. Y. Lee, M. Lee, Y. Kim, H. Park, J. Lee, X. Zhan, H. Kang, S. Hwang, M. Carroll, Y. Cai, S. N. Cho, C. E. Barry, 3rd, L. E. Via, and H. Kornfeld. Impact of diabetes and smoking on mortality in tuberculosis. PloS one 2013. 8: e58044.
57. Davies, P. D., W. W. Yew, D. Ganguly, A. L. Davidow, L. B. Reichman, K. Dheda, and G. A. Rook. Smoking and tuberculosis: the epidemiological association and immunopathogenesis. Trans R Soc Trop Med Hyg 2006. 100: 291-298.
58. Farver, C., A. E. Fraire, and J. F. Tomashefski. Dail and Hammar's Pulmonary Pathology, Volume 1: Nonneoplastic Lung Disease 1998 Springer Verlag New York
59. Pagel W, and P. W. Zur Histochemie der Lungentuberkulose, mit besonderer Berucksichtung der Fettsubstanzen und Lipoide. (Fat and lipoid content to tuberculous tissue. Histochemical investigation.). Virchows Arch Pathol Anat 1925. 256: 629-640.
60. Johnson, J. L., and J. J. Ellner. Chapter 57. Cavitary Pulmonary Disease. In Clinical Infectious Diseases: A Practical Approach. R. K. Root, ed. Oxford University Press, New Hork. 1999. 539-549.
61. Akinosoglou, K. S., K. Karkoulias, and M. Marangos. Infectious complications in patients with lung cancer. European review for medical and pharmacological sciences 2013. 17: 8-18.
62. Hunter, R. L. On the pathogenesis of post primary tuberculosis: the role of bronchial obstruction in the pathogenesis of cavities. Tuberculosis (Edinb) 2011. 91 Suppl 1: S6-10.
63. Pattnaik, M. K., P. C. Majhi, A. K. Nayak, and D. Senapati. A rare presentation of a huge mature mediastinal teratoma with right lung cavitation. BMJ case reports 2014. 2014.
64. Humphrey, D. M., and M. H. Weiner. Mycobacterial antigen detection by immunohistochemistry in pulmonary tuberculosis. Hum Pathol 1987. 18: 701-708.
65. Ridley, M. J., and D. S. Ridley. Histochemical demonstration of mycobacterial antigen, specific antibody and complement in the lesions of tuberculosis. The Histochemical journal 1986. 18: 551-556.
66. Pedersen, J. S., I. Clarke, and J. Mills. Improved detection of mycobacteria species in formalin-fixed tissue sections. Histopathology 2011. 59: 993-1005.
67. Guerardel, Y., E. Maes, V. Briken, F. Chirat, Y. Leroy, C. Locht, G. Strecker, and L. Kremer. Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties. J Biol Chem 2003. 278: 36637-36651.
68. Chan, J., X. D. Fan, S. W. Hunter, P. J. Brennan, and B. R. Bloom. Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun 1991. 59: 1755-1761.
69. Talaat, A. M., S. K. Ward, C. W. Wu, E. Rondon, C. Tavano, J. P. Bannantine, R. Lyons, and S. A. Johnston. Mycobacterial bacilli are metabolically active during chronic tuberculosis in murine lungs: insights from genome-wide transcriptional profiling. J Bacteriol 2007. 189: 4265-4274.
70. Rogerson, B. J., Y. J. Jung, R. LaCourse, L. Ryan, N. Enright, and R. J. North. Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen- specific T cells during stationary level lung infection in mice. Immunology 2006. 118: 195-201.
71. Bhalla, A., M. Mahapatra, R. Singh, and S. D'Cruz. Acute lung injury in miliary tuberculosis. Indian Journal of Tuberculosis 2002. 49: 125-128.
72. Lincoln, E. M., and W. Grethmann. The potetial dangers of tuberculin tests. J Pediatrics 1939. 15: 682-696.
73. Massaro, D., and S. Katz. Rapid Clearing in Hematogenous Pulmonary Tuberculosis. Archives of internal medicine 1964. 113: 573-577.
74. Trapnell, B. C., B. C. Carey, K. Uchida, and T. Suzuki. Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages. Current opinion in immunology 2009. 21: 514-521.
75. Carey, B., and B. C. Trapnell. The molecular basis of pulmonary alveolar proteinosis. Clin Immunol 2010. 135: 223-235.
76. Ramirez, J. Pulmonary alveolar proteinosis. Treatment in a case complicated by tuberculosis. Am Rev Respir Dis 1967. 95: 491-495.
77. Huang, X. Y., C. Yu, X. M. Xu, W. T. Yang, X. Zhang, P. P. Liu, and L. X. Wang. Pulmonary alveolar proteinosis associated with tuberculosis and aspergilloma formation. Chinese medical journal 2012. 125: 3191-3192.
78. Betancourt, S. L., S. Martinez-Jimenez, S. E. Rossi, M. T. Truong, J. Carrillo, and J. J. Erasmus. Lipoid pneumonia: spectrum of clinical and radiologic manifestations. AJR Am J Roentgenol 2010. 194: 103-109.
79. Sulkowska, M., and S. Sulkowski. Endogenous lipid pneumonia- and alveolar proteinosis-type changes in the vicinity of non-small cell lung cancer: histiopathologic, immunohistochemical, and ultrastructural evaluation. Ultrastructural pathology 1998. 22: 109-119.
80. Mustafa, T., S. Phyu, R. Nilsen, R. Jonsson, and G. Bjune. A mouse model for slowly progressive primary tuberculosis. Scand J Immunol 1999. 50: 127-136.
81. Chapman, R. C., and S. M. Claydon. Mycobacterium tuberculosis: a continuing cause of sudden and unexpected death in west London. Journal of clinical pathology 1992. 45: 713-715.
82. Alzeer, A., A. Mashlah, N. Fakim, N. Al-Sugair, M. Al- Hedaithy, S. Al-Majed, and G. Jamjoom. Tuberculosis is the commonest cause of pneumonia requiring hospitalization during Hajj (pilgrimage to Makkah). J Infect 1998. 36: 303-306.
83. Gonzalez Saldana, N., M. Macias Parra, M. Hernandez Porras, P. Gutierrez Castrellon, V. Gomez Toscano, and H. Juarez Olguin. Pulmonary Tuberculous: Symptoms, diagnosis and treatment. 19-year experience in a third level pediatric hospital. BMC infectious diseases 2014. 14: 401.
84. Eldour, A. A. A., M. Elfatih, R. A. A. Salih, and H. G. Ahmed. Blood Coagulation Changes among Sudanese Patients with Pulmonary Tuberculosis. International Journal of Science and Research 2014. 3: 176-719.
85. Birnbaum, M. Prof. Koch's Method to Cure Tuberculosis Popularly Treated. In PROJECT GUTENBERG EBOOK METHOD TO CURE TUBERCULOSIS. http://www. gutenberg.net EBook #27181. 2008.
86. Moreira, A. L., L. Tsenova, M. H. Aman, L. G. Bekker, S. Freeman, B. Mangaliso, U. Schroder, J. Jagirdar, W. N. Rom, M. G. Tovey, V. H. Freedman, and G. Kaplan. Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice. Infect Immun 2002. 70: 2100-2107.
87. Medlar, E. M. The pathogenesis of minimal pulmonary tuberculosis; a study of 1,225 necropsies in cases of sudden and unexpected death. Am Rev Tuberc 1948. 58: 583-611.
88. Wayne, L. G., and C. D. Sohaskey. Nonreplicating persistence of mycobacterium tuberculosis. Annu Rev Microbiol 2001. 55: 139-163.
89. Hurford, J. V., and W. H. Valentine. Viable tubercle bacilli in closed lesions. Tubercle 1957. 38: 194-198.
90. Hunter, R. L., M. R. Olsen, C. Jagannath, and J. K. Actor. Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease. Ann Clin Lab Sci 2006. 36: 371-386.
91. Rook, G. A., K. Dheda, and A. Zumla. Immune responses to tuberculosis in developing countries: implications for new vaccines. Nat Rev Immunol 2005. 5: 661-667.
92. Dheda, K., H. Booth, J. F. Huggett, M. A. Johnson, A. Zumla, and G. A. Rook. Lung remodeling in pulmonary tuberculosis. J Infect Dis 2005. 192: 1201-1209.
93. Chapel, H. M., and P. J. August. Report of nine cases of accidental injury to man with Freund's complete adjuvant. Clin Exp Immunol 1976. 24: 538-541.
94. Freedman, D. H. Why Scientific Studies Are So Often Wrong: The Streetlight Effect. Discover 2010. July-August.
95. Hatipoglu, O. N., E. Osma, M. Manisali, E. S. Ucan, P. Balci, A. Akkoclu, O. Akpinar, C. Karlikaya, and C. Yuksel. High resolution computed tomographic findings in pulmonary tuberculosis. Thorax 1996. 51: 397-402.
96. Collins, J., D. Blankenbaker, and E. J. Stern. CT patterns of bronchiolar disease: what is "tree-in-bud"? AJR Am J Roentgenol 1998. 171: 365-370.
97. Karimi, S., M. Shamaei, M. Pourabdollah, M. Sadr, M. Karbasi, A. Kiani, and M. Bahadori. Histopathological findings in immunohistological staining of the granulomatous tissue reaction associated with tuberculosis. Tuberculosis research and treatment 2014. 2014: 858396.
98. Corbett, E. L., A. Zezai, Y. B. Cheung, T. Bandason, E. Dauya, S. S. Munyati, A. E. Butterworth, S. Rusikaniko, G. J. Churchyard, S. Mungofa, R. J. Hayes, and P. R. Mason. Provider-initiated symptom screening for tuberculosis in Zimbabwe: diagnostic value and the effect of HIV status. Bull World Health Organ 2010. 88: 13-21.
99. van Rie, A., R. Warren, M. Richardson, T. C. Victor, R. P. Gie, D. A. Enarson, N. Beyers, and P. D. van Helden. Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. N Engl J Med 1999. 341: 1174-1179.
100. Huaman, M. A., C. T. Fiske, T. F. Jones, J. Warkentin, B. E. Shepherd, L. A. Ingram, F. Maruri, and T. R. Sterling. Tuberculosis and the risk of infection with other intracellular bacteria: a population-based study. Epidemiology and infection 2014. 1-9.
101. Ledru, E., S. Ledru, and A. Zoubga. Granuloma formation and tuberculosis transmission in HIV-infected patients. Immunol Today 1999. 20: 336-337.
102. Kenyon, T. A., T. Creek, K. Laserson, M. Makhoa, N. Chimidza, M. Mwasekaga, J. Tappero, S. Lockman, T. Moeti, and N. Binkin. Risk factors for transmission of Mycobacterium tuberculosis from HIV-infected tuberculosis patients, Botswana. Int J Tuberc Lung Dis 2002. 6: 843-850.
103. Wang, C. S., H. C. Chen, C. J. Yang, W. Y. Wang, I. W. Chong, J. J. Hwang, and M. S. Huang. The impact of age on the demographic, clinical, radiographic characteristics and treatment outcomes of pulmonary tuberculosis patients in Taiwan. Infection 2008. 36: 335-340.
104. Dannenberg, A. M., Jr., and F. M. Collins. Progressive pulmonary tuberculosis is not due to increasing numbers of viable bacilli in rabbits, mice and guinea pigs, but is due to a continuous host response to mycobacterial products. Tuberculosis (Edinb) 2001. 81: 229-242.
105. McGrath, J. W. Social networks of disease spread in the lower Illinois valley: a simulation approach. Am J Phys Anthropol 1988. 77: 483-496.
106. Musser, J. M., A. Amin, and S. Ramaswamy. Negligible genetic diversity of mycobacterium tuberculosis host immune system protein targets: evidence of limited selective pressure. Genetics 2000. 155: 7-16.
107. Rook, G. A., and R. Hernandez-Pando. The pathogenesis of tuberculosis. Annu Rev Microbiol 1996. 50: 259-284.
108. Fujita, Y., Y. Okamoto, Y. Uenishi, M. Sunagawa, T. Uchiyama, and I. Yano. Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice. Microb Pathog 2007. 43: 10-21.
109. McMullen, A. M., S. A. Hwang, K. O'Shea, M. L. Aliru, and J. K. Actor. Evidence for a unique species-specific hypersensitive epitope in Mycobacterium tuberculosis derived cord factor. Tuberculosis (Edinb) 2013. 93 Suppl: S88-93.
110. Okamoto, Y., Y. Fujita, T. Naka, M. Hirai, I. Tomiyasu, and I. Yano. Mycobacterial sulfolipid shows a virulence by inhibiting cord factor induced granuloma formation and TNF-alpha release. Microb Pathog 2006. 40: 245-253.
111. Middlebrook, G., R. G. Dubos, and C. Pierce. Virulence and morphological characteristics of mammalian tubercle bacilli. J. Exp. Med. 1947. 86: 175-184.
112. Bloch, H. Studies on the virulence of tubercle bacilli: Isolation and biological properties of a constituent of virulent organisms. J. Exp. Med. 1950. 91: 197-219.
113. Hunter, R. L., N. Venkataprasad, and M. R. Olsen. The role of trehalose dimycolate (cord factor) on morphology of virulent M. tuberculosis in vitro. Tuberculosis (Edinb) 2006. 86: 349-356.
114. Goren, M., O. Brokl, B. Das, and E. Lederer. Sulfolipid I of Mycobacterium tuberculosis, strain H37Rv. Nature of the acyl substituents. Biochemistry 1971. 10: 72-81.
115. Andreu, N., I. Gibert, M. Luquin, P. E. Kolattukudy, and T. Sirakova. Neutral red staining of cells of a sulfolipid-deficient Mycobacterium tuberculosis pks2 mutant proves that sulfolipids are not responsible for this cytochemical reaction. J Clin Microbiol 2004. 42: 1379-1380.
116. Goren, M. Cord Factor Revisited: A tribute to the late Hubert Bloch. Tubercle 1975. 56: 65-71.
117. Goren, M. B., and P. J. Brennan. Chapter 4. Mycobacterial lipids: chemistry and biologic activities. In Tuberculosis. G. P. Youmans, ed. W.B. Saunders, Philadelphia, PA. 1979. 63-193.
118. Indrigo, J., R. L. Hunter, Jr., and J. K. Actor. Influence of trehalose 6,6'-dimycolate (TDM) during mycobacterial infection of bone marrow macrophages. Microbiology 2002. 148: 1991-1998.
119. Spitznagel, J. K., and R. J. Dubos. A fraction of tubercle bacilli possessing primary toxicity. J Exp Med 1955. 101: 291-311.
120. Indrigo, J., R. L. Hunter, Jr., and J. K. Actor. Cord factor trehalose 6,6'-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. Microbiology 2003. 149: 2049-2059.
121. Kan-Sutton, C., C. Jagannath, and R. L. Hunter, Jr. Trehalose 6,6'-dimycolate on the surface of Mycobacterium tuberculosis modulates surface marker expression for antigen presentation and costimulation in murine macrophages. Microbes Infect 2009. 11: 40-48.
122. Behling, C. A., B. Bennett, K. Takayama, and R. L. Hunter. Development of a trehalose 6,6'-dimycolate model which explains cord formation by Mycobacterium tuberculosis. Infect Immun 1993. 61: 2296-2303.
123. Retzinger, G. S., S. C. Meredith, R. L. Hunter, K. Takayama, and F. J. Kezdy. Identification of the physiologically active state of the mycobacterial glycolipid trehalose 6,6'-dimycolate and the role of fibrinogen in the biologic activities of trehalose 6,6'-dimycolate monolayers. J Immunol 1982. 129: 735-744.
124. Retzinger, G. S., S. C. Meredith, K. Takayama, R. L. Hunter, and F. J. Kezdy. The role of surface in the biological activities of trehalose 6,6'- dimycolate. Surface properties and development of a model system. J Biol Chem 1981. 256: 8208-8216.
125. Schabbing, R.W., A.Garcia,andR. L.Hunter.Characterization of the trehalose 6,6'-dimycolate surface monolayer by scanning tunneling microscopy. Infect Immun 1994. 62: 754-756.
126. Bekierkunst, A. Acute granulomatous response produced in mice by trehalose-6,6-dimycolate. J Bacteriol 1968. 96: 958-961.
127. Bekierkunst, A., and E. Yarkoni. Granulomatous hypersensitivity to trehalose 6,6'-dimycolate (cord factor) in mice infected with BCG. Infect Immun 1973. 7: 631-638.
128. Geisel, R. E., K. Sakamoto, D. G. Russell, and E. R. Rhoades. In Vivo Activity of Released Cell Wall Lipids of Mycobacterium bovis Bacillus Calmette-Guerin Is Due Principally to Trehalose Mycolates. J Immunol 2005. 174: 5007-5015.
129. Yarkoni, E., and H. J. Rapp. Toxicity of emulsified trehalose 6,6' dimycolate (cord factor) in mice depends on size distribution of mineral oil droplets. Infect. Immun. 1978. 20: 856-860.
130. Syed, S. S., and R. L. Hunter, Jr. Studies on the toxic effects of quartz and a mycobacterial glycolipid, trehalose 6,6'-dimycolate. Ann Clin Lab Sci 1997. 27: 375-383.
131. Ashenafi, S., G. Aderaye, A. Bekele, M. Zewdie, G. Aseffa, A. T. Hoang, B. Carow, M. Habtamu, M. Wijkander, M. Rottenberg, A. Aseffa, J. Andersson, M. Svensson, and S. Brighenti. Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3. Clin Immunol 2014. 151: 84-99.
132. Young, D. Animal models of tuberculosis. Eur J Immunol 2009. 39: 2011-2014.
133. Kubler, A., B. Luna, C. Larsson, N. C. Ammerman, B. B. Andrade, M. Orandle, K. W. Bock, Z. Xu, U. Bagci, D. J. Molura, J. Marshall, J. Burns, K. Winglee, B. A. Ahidjo, L. S. Cheung, M. Klunk, S. K. Jain, N. P. Kumar, S. Babu, A. Sher, J. S. Friedland, P. T. Elkington, and W. R. Bishai. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J Pathol 2014 Sept epub ahead of print.
134. Frick, M. The TB Vaccines Pipeline. In HIV.HCV.TB Pipeline Report. Treatment Action Group http://www.pipelinereport. org, New York. 2013. 263-283.
135. Kondratieva, T., T. Azhikina, B. Nikonenko, A. Kaprelyants, and A. Apt. Latent tuberculosis infection: What we know about its genetic control? Tuberculosis (Edinb) 2014.