Dual drug delivery of 5-fluorouracil (5-FU) and methotrexate (MTX) through random copolymeric nanomicelles of PLGA and polyethylenimine demonstrating enhanced cell uptake and cytotoxicity

Colloids and Surfaces B: Biointerfaces

Volumn 122, Issue , 2014, Pages 520-528

  Ashwanikumar, N ^a   Kumar, Nisha Asok ^a   Nair, S Asha ^a   Kumar, G S Vinod ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

Author keywords

5 Fluorouracil (5 FU); Methotrexate (MTX); Nanomicelles; Uptake

Indexed keywords

5-FLUOROURACIL (5-FU); CELL UPTAKE; METHOTREXATE (MTX); NANOMICELLES; POLYETHYLENIMINES; UPTAKE;

FLUOROURACIL; METHOTREXATE; POLYETHYLENEIMINE; POLYGLACTIN; ANTINEOPLASTIC AGENT; DRUG CARRIER; LACTIC ACID; MICELLE; NANOMATERIAL; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CELL TRANSPORT; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; HCT116 CELL LINE; PARTICLE SIZE; ZETA POTENTIAL; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SCREENING; HUMAN; INFRARED SPECTROSCOPY; MICELLE; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HCT116 CELLS; HUMANS; LACTIC ACID; METHOTREXATE; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; NANOSTRUCTURES; POLYETHYLENEIMINE; POLYGLYCOLIC ACID; PROTON MAGNETIC RESONANCE SPECTROSCOPY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 84909981815     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2014.07.024     Document Type: Article

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