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Volumn 1132, Issue , 2014, Pages 93-106

Engineering chloroplasts for high-level foreign protein expression

(1)  Bock, Ralph a  

a NONE

Author keywords

3 UTR; 5 UTR; Chloroplast; Codon optimization; Downstream box; Integration site; Operon expression; Plastid; Plastid transformation; Promoter strength; Protein localization; Protein stability; Transcription; Translational regulation

Indexed keywords

5' UNTRANSLATED REGION; ARTICLE; CELL ENGINEERING; CHLOROPLAST; CODON USAGE; CONCENTRATION (PARAMETERS); GENE EXPRESSION; NONHUMAN; OPERON; PLASTID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN STABILITY; TRANSGENE; 3' UNTRANSLATED REGION; BIOTECHNOLOGY; CHLOROPLAST GENOME; GENETICS; PLANT; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REVIEW; TRANSGENIC PLANT;

EID: 84909647224     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-995-6_5     Document Type: Article
Times cited : (29)

References (67)
  • 1
    • 1542368230 scopus 로고    scopus 로고
    • Plastid transformation in higher plants
    • Maliga P (2004) Plastid transformation in higher plants. Annu Rev Plant Biol 55:289–313
    • (2004) Annu Rev Plant Biol , vol.55 , pp. 289-313
    • Maliga, P.1
  • 3
    • 34147158443 scopus 로고    scopus 로고
    • Plastid biotechnology: Prospects for herbicide and insect resistance, metabolic engineering and molecular farming
    • Bock R (2007) Plastid biotechnology: prospects for herbicide and insect resistance, metabolic engineering and molecular farming. Curr Opin Biotechnol 18:100–106
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 100-106
    • Bock, R.1
  • 5
    • 34249860016 scopus 로고    scopus 로고
    • Determining the transgene containment level provided by chloroplast transformation
    • Ruf S, Karcher D, Bock R (2007) Determining the transgene containment level provided by chloroplast transformation. Proc Natl Acad Sci U S A 104:6998–7002
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6998-7002
    • Ruf, S.1    Karcher, D.2    Bock, R.3
  • 6
    • 34249860848 scopus 로고    scopus 로고
    • Exceptional transmission of plastids and mitochondria from the transplastomic pollen parent and its impact on transgene containment
    • Svab Z, Maliga P (2007) Exceptional transmission of plastids and mitochondria from the transplastomic pollen parent and its impact on transgene containment. Proc Natl Acad Sci U S A 104:7003–7008
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7003-7008
    • Svab, Z.1    Maliga, P.2
  • 7
    • 34147153529 scopus 로고    scopus 로고
    • Production of biopharmaceuticals and vaccines in plants via the chloroplast genome
    • Daniell H (2006) Production of biopharmaceuticals and vaccines in plants via the chloroplast genome. Biotechnol J 1:1071–1079
    • (2006) Biotechnol J , vol.1 , pp. 1071-1079
    • Daniell, H.1
  • 8
    • 77951975776 scopus 로고    scopus 로고
    • Solar-powered factories for new vaccines and antibiotics
    • Bock R, Warzecha H (2010) Solar-powered factories for new vaccines and antibiotics. Trends Biotechnol 28:246–252
    • (2010) Trends Biotechnol , vol.28 , pp. 246-252
    • Bock, R.1    Warzecha, H.2
  • 10
    • 28244477465 scopus 로고    scopus 로고
    • Development of novel types of plastid transformation vectors and evaluation of factors controlling expression
    • Herz S, Füßl M, Steiger S, Koop H-U (2005) Development of novel types of plastid transformation vectors and evaluation of factors controlling expression. Transgenic Res 14:969–982
    • (2005) Transgenic Res , vol.14 , pp. 969-982
    • Herz, S.1    Füßl, M.2    Steiger, S.3    Koop, H.-U.4
  • 12
    • 13444271887 scopus 로고    scopus 로고
    • Accumulation of rotavirus VP6 protein in chloroplasts of transplastomic tobacco is limited by protein stability
    • Birch-Machin I, Newell CA, Hibberd JM, Gray JC (2004) Accumulation of rotavirus VP6 protein in chloroplasts of transplastomic tobacco is limited by protein stability. Plant Biotechnol J 2:261–270
    • (2004) Plant Biotechnol J , vol.2 , pp. 261-270
    • Birch-Machin, I.1    Newell, C.A.2    Hibberd, J.M.3    Gray, J.C.4
  • 13
    • 34648834872 scopus 로고    scopus 로고
    • Transcription and transcriptional regulation in plastids
    • Liere K, Börner T (2007) Transcription and transcriptional regulation in plastids. Top Curr Genet 19:121–174
    • (2007) Top Curr Genet , vol.19 , pp. 121-174
    • Liere, K.1    Börner, T.2
  • 14
    • 27144476509 scopus 로고    scopus 로고
    • Viral proteins functioning in organelles: A cryptic origin?
    • Filée J, Forterre P (2005) Viral proteins functioning in organelles: a cryptic origin? Trends Microbiol 13:510–513
    • (2005) Trends Microbiol , vol.13 , pp. 510-513
    • Filée, J.1    Forterre, P.2
  • 15
    • 0031011722 scopus 로고    scopus 로고
    • The two RNA polymerases encoded by the nuclear and the plastid compartments transcribe distinct groups of genes in tobacco plastids
    • Hajdukiewicz PTJ, Allison LA, Maliga P (1997) The two RNA polymerases encoded by the nuclear and the plastid compartments transcribe distinct groups of genes in tobacco plastids. EMBO J 16:4041–4048
    • (1997) EMBO J , vol.16 , pp. 4041-4048
    • Hajdukiewicz, P.1    Allison, L.A.2    Maliga, P.3
  • 16
    • 0035162968 scopus 로고    scopus 로고
    • Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals
    • De Cosa B, Moar W, Lee S-B, Miller M, Daniell H (2001) Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals. Nat Biotechnol 19:71–74
    • (2001) Nat Biotechnol , vol.19 , pp. 71-74
    • De Cosa, B.1    Moar, W.2    Lee, S.-B.3    Miller, M.4    Daniell, H.5
  • 18
    • 58849157867 scopus 로고    scopus 로고
    • Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic
    • Oey M, Lohse M, Kreikemeyer B, Bock R (2009) Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic. Plant J 57:436–445
    • (2009) Plant J , vol.57 , pp. 436-445
    • Oey, M.1    Lohse, M.2    Kreikemeyer, B.3    Bock, R.4
  • 19
    • 0142040170 scopus 로고    scopus 로고
    • Expression of green fl uorescent protein from bacterial and plastid promoters in tobacco chloroplasts
    • Newell CA, Birch-Machin I, Hibberd JM, Gray JC (2003) Expression of green fl uorescent protein from bacterial and plastid promoters in tobacco chloroplasts. Transgenic Res 12:631–634
    • (2003) Transgenic Res , vol.12 , pp. 631-634
    • Newell, C.A.1    Birch-Machin, I.2    Hibberd, J.M.3    Gray, J.C.4
  • 20
    • 37249060192 scopus 로고    scopus 로고
    • Faithful transcription initiation from a mitochondrial promoter in transgenic plastids
    • Bohne A-V, Ruf S, Börner T, Bock R (2007) Faithful transcription initiation from a mitochondrial promoter in transgenic plastids. Nucleic Acids Res 35:7256–7266
    • (2007) Nucleic Acids Res , vol.35 , pp. 7256-7266
    • Bohne, A.-V.1    Ruf, S.2    Börner, T.3    Bock, R.4
  • 21
    • 0036324267 scopus 로고    scopus 로고
    • Searching limiting steps in the expression of chloroplast-encoded proteins: Relations between gene copy number, transcription, transcript abundance and translation rate in the chloroplast of Chlamydomonas reinhardtii
    • Eberhard S, Drapier D, Wollman F-A (2002) Searching limiting steps in the expression of chloroplast-encoded proteins: relations between gene copy number, transcription, transcript abundance and translation rate in the chloroplast of Chlamydomonas reinhardtii. Plant J 31:149–160
    • (2002) Plant J , vol.31 , pp. 149-160
    • Eberhard, S.1    Drapier, D.2    Wollman, F.-A.3
  • 22
    • 48549095295 scopus 로고    scopus 로고
    • Plastid transcriptomics and translatomics of tomato fruit development and chloroplast-to-chromoplast differentiation: Chromoplast gene expression largely serves the production of a single protein
    • Kahlau S, Bock R (2008) Plastid transcriptomics and translatomics of tomato fruit development and chloroplast-to-chromoplast differentiation: chromoplast gene expression largely serves the production of a single protein. Plant Cell 20:856–874
    • (2008) Plant Cell , vol.20 , pp. 856-874
    • Kahlau, S.1    Bock, R.2
  • 23
    • 0028518530 scopus 로고
    • Translation of the psbA mRNA is regulated by light via the 5′-untranslated region in tobacco plastids
    • Staub JM, Maliga P (1994) Translation of the psbA mRNA is regulated by light via the 5′-untranslated region in tobacco plastids. Plant J 6:547–553
    • (1994) Plant J , vol.6 , pp. 547-553
    • Staub, J.M.1    Maliga, P.2
  • 24
    • 0035112076 scopus 로고    scopus 로고
    • Plastidexpressed 5-enolpyruvylshikimate- 3-phosphate synthase genes provide high level glyphosate tolerance in tobacco
    • Ye G-N, Hajdukiewicz PTJ, Broyles D, Rodriguez D, Xu CW, Nehra N, Staub JM (2001) Plastidexpressed 5-enolpyruvylshikimate- 3-phosphate synthase genes provide high level glyphosate tolerance in tobacco. Plant J 25:261–270
    • (2001) Plant J , vol.25 , pp. 261-270
    • Ye, G.-N.1    Hajdukiewicz, P.2    Broyles, D.3    Rodriguez, D.4    Xu, C.W.5    Nehra, N.6    Staub, J.M.7
  • 25
    • 0032837715 scopus 로고    scopus 로고
    • In vivo analysis of plastid psbA, rbcL and rpl32 UTR elements by chloroplast transformation: Tobacco plastid gene expression is controlled by modulation of transcript levels and translation effi ciency
    • Eibl C, Zou Z, Beck A, Kim M, Mullet J, Koop H-U (1999) In vivo analysis of plastid psbA, rbcL and rpl32 UTR elements by chloroplast transformation: tobacco plastid gene expression is controlled by modulation of transcript levels and translation effi ciency. Plant J 19:333–345
    • (1999) Plant J , vol.19 , pp. 333-345
    • Eibl, C.1    Zou, Z.2    Beck, A.3    Kim, M.4    Mullet, J.5    Koop, H.-U.6
  • 26
    • 0035865938 scopus 로고    scopus 로고
    • Complementarity of the 16S rRNA penultimate stem with sequences downstream of the AUG destabilizes the plastid mRNAs
    • Kuroda H, Maliga P (2001) Complementarity of the 16S rRNA penultimate stem with sequences downstream of the AUG destabilizes the plastid mRNAs. Nucleic Acids Res 29:970–975
    • (2001) Nucleic Acids Res , vol.29 , pp. 970-975
    • Kuroda, H.1    Maliga, P.2
  • 27
    • 79952296790 scopus 로고    scopus 로고
    • Selection of Shine- Dalgarno sequences in plastids
    • Drechsel O, Bock R (2011) Selection of Shine- Dalgarno sequences in plastids. Nucleic Acids Res 39:1427–1438
    • (2011) Nucleic Acids Res , vol.39 , pp. 1427-1438
    • Drechsel, O.1    Bock, R.2
  • 28
    • 78651384689 scopus 로고    scopus 로고
    • High effi ciency plastid transformation in potato and regulation of transgene expression in leaves and tubers by alternative 5′ and 3′ regulatory sequences
    • Valkov VT, Gargano D, Manna C, Formisano G, Dix PJ, Gray JC, Scotti N, Cardi T (2011) High effi ciency plastid transformation in potato and regulation of transgene expression in leaves and tubers by alternative 5′ and 3′ regulatory sequences. Transgenic Res 20:137–151
    • (2011) Transgenic Res , vol.20 , pp. 137-151
    • Valkov, V.T.1    Gargano, D.2    Manna, C.3    Formisano, G.4    Dix, P.J.5    Gray, J.C.6    Scotti, N.7    Cardi, T.8
  • 29
    • 84866730262 scopus 로고    scopus 로고
    • Identifi cation of cis-elements conferring high levels of gene expression in non-green plastids
    • Zhang J, Ruf S, Hasse C, Childs L, Scharff LB, Bock R (2012) Identifi cation of cis-elements conferring high levels of gene expression in non-green plastids. Plant J 72:115–128
    • (2012) Plant J , vol.72 , pp. 115-128
    • Zhang, J.1    Ruf, S.2    Hasse, C.3    Childs, L.4    Scharff, L.B.5    Bock, R.6
  • 30
    • 84873051879 scopus 로고    scopus 로고
    • Design of chimeric expression elements that confer high-level gene activity in chromoplasts
    • Caroca R, Howell KA, Hasse C, Ruf S, Bock R (2012) Design of chimeric expression elements that confer high-level gene activity in chromoplasts. Plant J 73:368–379
    • (2012) Plant J , vol.73 , pp. 368-379
    • Caroca, R.1    Howell, K.A.2    Hasse, C.3    Ruf, S.4    Bock, R.5
  • 32
    • 79957844129 scopus 로고    scopus 로고
    • The effect of different 3′ untranslated regions on the accumulation and stability of transcripts of a gfp transgene in chloroplasts of transplastomic tobacco
    • Tangphatsornruang S, Birch-Machin I, Newell CA, Gray JC (2011) The effect of different 3′ untranslated regions on the accumulation and stability of transcripts of a gfp transgene in chloroplasts of transplastomic tobacco. Plant Mol Biol 76:385–396
    • (2011) Plant Mol Biol , vol.76 , pp. 385-396
    • Tangphatsornruang, S.1    Birch-Machin, I.2    Newell, C.A.3    Gray, J.C.4
  • 33
    • 0020486135 scopus 로고
    • A role for mRNA secondary structure in the control of translation initiation
    • Hall MN, Gabay J, Debarbouille M, Schwartz M (1982) A role for mRNA secondary structure in the control of translation initiation. Nature 295:616–618
    • (1982) Nature , vol.295 , pp. 616-618
    • Hall, M.N.1    Gabay, J.2    Debarbouille, M.3    Schwartz, M.4
  • 34
    • 56049106809 scopus 로고    scopus 로고
    • Design of simple synthetic RNA thermometers fortemperature-controlled gene expression in Escherichia coli
    • Neupert J, Karcher D, Bock R (2008) Design of simple synthetic RNA thermometers fortemperature-controlled gene expression in Escherichia coli. Nucleic Acids Res 36:e124
    • (2008) Nucleic Acids Res , vol.36
    • Neupert, J.1    Karcher, D.2    Bock, R.3
  • 35
    • 64849114915 scopus 로고    scopus 로고
    • Coding-sequence determinants of gene expression in Escherichia coli
    • Kudla G, Murray AW, Tollervey D, Plotkin JB (2009) Coding-sequence determinants of gene expression in Escherichia coli. Science 324:255–258
    • (2009) Science , vol.324 , pp. 255-258
    • Kudla, G.1    Murray, A.W.2    Tollervey, D.3    Plotkin, J.B.4
  • 36
    • 77950885839 scopus 로고    scopus 로고
    • Inducible gene expression from the plastid genome by a synthetic riboswitch
    • Verhounig A, Karcher D, Bock R (2010) Inducible gene expression from the plastid genome by a synthetic riboswitch. Proc Natl Acad Sci U S A 107:6204–6209
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6204-6209
    • Verhounig, A.1    Karcher, D.2    Bock, R.3
  • 37
    • 0029917715 scopus 로고    scopus 로고
    • Chloroplast mRNA 3′-end processing by a high molecular weight protein complex is regulated by nuclear encoded RNA binding proteins
    • Hayes R, Kudla J, Schuster G, Gabay L, Maliga P, Gruissem W (1996) Chloroplast mRNA 3′-end processing by a high molecular weight protein complex is regulated by nuclear encoded RNA binding proteins. EMBO J 15:1132–1141
    • (1996) EMBO J , vol.15 , pp. 1132-1141
    • Hayes, R.1    Kudla, J.2    Schuster, G.3    Gabay, L.4    Maliga, P.5    Gruissem, W.6
  • 38
    • 36349016215 scopus 로고    scopus 로고
    • Identifi cation of a plastid Intercistronic Expression Element (IEE) facilitating the expression of stable translatable monocistronic mRNAs from operons
    • Zhou F, Karcher D, Bock R (2007) Identifi cation of a plastid Intercistronic Expression Element (IEE) facilitating the expression of stable translatable monocistronic mRNAs from operons. Plant J 52:961–972
    • (2007) Plant J , vol.52 , pp. 961-972
    • Zhou, F.1    Karcher, D.2    Bock, R.3
  • 40
    • 33846050084 scopus 로고    scopus 로고
    • Contained metabolic engineering in tomatoes by expression of carotenoid biosynthesis genes from the plastid genome
    • Wurbs D, Ruf S, Bock R (2007) Contained metabolic engineering in tomatoes by expression of carotenoid biosynthesis genes from the plastid genome. Plant J 49:276–288
    • (2007) Plant J , vol.49 , pp. 276-288
    • Wurbs, D.1    Ruf, S.2    Bock, R.3
  • 41
    • 66149136008 scopus 로고    scopus 로고
    • Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins
    • Oey M, Lohse M, Scharff LB, Kreikemeyer B, Bock R (2009) Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins. Proc Natl Acad Sci U S A 106:6579–6584
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 6579-6584
    • Oey, M.1    Lohse, M.2    Scharff, L.B.3    Kreikemeyer, B.4    Bock, R.5
  • 42
    • 0035144228 scopus 로고    scopus 로고
    • Sequences downstream of the translation initiation codon are important determinants of translation effi ciency in chloroplasts
    • Kuroda H, Maliga P (2001) Sequences downstream of the translation initiation codon are important determinants of translation effi ciency in chloroplasts. Plant Physiol 125:430–436
    • (2001) Plant Physiol , vol.125 , pp. 430-436
    • Kuroda, H.1    Maliga, P.2
  • 44
    • 60549093369 scopus 로고    scopus 로고
    • High-level bacterial cellulase accumulation in chloroplast-transformed tobacco mediated by downstream box fusions
    • Gray BN, Ahner BA, Hanson MR (2009) High-level bacterial cellulase accumulation in chloroplast-transformed tobacco mediated by downstream box fusions. Biotechnol Bioeng 102:1045–1054
    • (2009) Biotechnol Bioeng , vol.102 , pp. 1045-1054
    • Gray, B.N.1    Ahner, B.A.2    Hanson, M.R.3
  • 45
    • 77955686870 scopus 로고    scopus 로고
    • Identifi cation of protein stability determinants in chloroplasts
    • Apel W, Schulze WX, Bock R (2010) Identifi cation of protein stability determinants in chloroplasts. Plant J 63:636–650
    • (2010) Plant J , vol.63 , pp. 636-650
    • Apel, W.1    Schulze, W.X.2    Bock, R.3
  • 46
    • 17144390262 scopus 로고    scopus 로고
    • Cytoplasm and chloroplasts are not suitable subcellular locations for ß-zein accumulation in transgenic plants
    • Bellucci M, de Marchis F, Mannucci R, Bock R, Arcioni S (2005) Cytoplasm and chloroplasts are not suitable subcellular locations for ß-zein accumulation in transgenic plants. J Exp Bot 56:1205–1212
    • (2005) J Exp Bot , vol.56 , pp. 1205-1212
    • Bellucci, M.1    De Marchis, F.2    Mannucci, R.3    Bock, R.4    Arcioni, S.5
  • 47
    • 34548814736 scopus 로고    scopus 로고
    • Protein stability and degradation in plastids
    • Adam Z (2007) Protein stability and degradation in plastids. Top Curr Genet 19:315–338
    • (2007) Top Curr Genet , vol.19 , pp. 315-338
    • Adam, Z.1
  • 48
    • 33745645551 scopus 로고    scopus 로고
    • Protein degradation machineries in plastids
    • Sakamoto W (2006) Protein degradation machineries in plastids. Annu Rev Plant Biol 57:599–621
    • (2006) Annu Rev Plant Biol , vol.57 , pp. 599-621
    • Sakamoto, W.1
  • 50
    • 36849027691 scopus 로고    scopus 로고
    • Both the stroma and thylakoid lumen of tobacco chloroplasts are competent for the formation of disulphide bonds in recombinant proteins
    • Bally J, Paget E, Droux M, Job C, Job D, Dubald M (2008) Both the stroma and thylakoid lumen of tobacco chloroplasts are competent for the formation of disulphide bonds in recombinant proteins. Plant Biotechnol J 6:46–61
    • (2008) Plant Biotechnol J , vol.6 , pp. 46-61
    • Bally, J.1    Paget, E.2    Droux, M.3    Job, C.4    Job, D.5    Dubald, M.6
  • 52
    • 35448994846 scopus 로고    scopus 로고
    • Expression of the recombinant bacterial outer surface protein A in tobacco chloroplasts leads to thylakoid localization and loss of photosynthesis
    • Hennig A, Bonfi g K, Roitsch T, Warzecha H (2007) Expression of the recombinant bacterial outer surface protein A in tobacco chloroplasts leads to thylakoid localization and loss of photosynthesis. FEBS J 274:5749–5758
    • (2007) FEBS J , vol.274 , pp. 5749-5758
    • Hennig, A.1    Bonfi G, K.2    Roitsch, T.3    Warzecha, H.4
  • 53
    • 77957773846 scopus 로고    scopus 로고
    • Y3IP1, a nucleus-encoded thylakoid protein, co-operates with the plastidencoded Ycf3 protein in photosystem I assembly
    • Albus C, Ruf S, Schöttler MA, Lein W, Kehr J, Bock R (2010) Y3IP1, a nucleus-encoded thylakoid protein, co-operates with the plastidencoded Ycf3 protein in photosystem I assembly. Plant Cell 22:2838–2855
    • (2010) Plant Cell , vol.22 , pp. 2838-2855
    • Albus, C.1    Ruf, S.2    Schöttler, M.A.3    Lein, W.4    Kehr, J.5    Bock, R.6
  • 55
    • 43049156431 scopus 로고    scopus 로고
    • Molecular crowding and order in photosynthetic membranes
    • Kirchhoff H (2008) Molecular crowding and order in photosynthetic membranes. Trends Plant Sci 13:201–207
    • (2008) Trends Plant Sci , vol.13 , pp. 201-207
    • Kirchhoff, H.1
  • 56
    • 40349091373 scopus 로고    scopus 로고
    • Translocation of aprotinin, a therapeutic protease inhibitor, into the thylakoid lumen of genetically engineered tobacco chloroplasts
    • Tissot G, Canard H, Nadai M, Martone A, Botterman J, Dubald M (2008) Translocation of aprotinin, a therapeutic protease inhibitor, into the thylakoid lumen of genetically engineered tobacco chloroplasts. Plant Biotechnol J 6:309–320
    • (2008) Plant Biotechnol J , vol.6 , pp. 309-320
    • Tissot, G.1    Canard, H.2    Nadai, M.3    Martone, A.4    Botterman, J.5    Dubald, M.6
  • 57
    • 0030729775 scopus 로고    scopus 로고
    • Both RNA editing and RNA cleavage are required for translation of tobacco chloroplast ndhD mRNA: A possible regulatory mechanism for the expression of a chloroplast operon consisting of functionally unrelated genes
    • Hirose T, Sugiura M (1997) Both RNA editing and RNA cleavage are required for translation of tobacco chloroplast ndhD mRNA: a possible regulatory mechanism for the expression of a chloroplast operon consisting of functionally unrelated genes. EMBO J 16:6804–6811
    • (1997) EMBO J , vol.16 , pp. 6804-6811
    • Hirose, T.1    Sugiura, M.2
  • 58
    • 0029294593 scopus 로고
    • Expression of a chimeric uidA gene indicates that polycistronic mRNAs are effi ciently translated in tobacco plastids
    • Staub JM, Maliga P (1995) Expression of a chimeric uidA gene indicates that polycistronic mRNAs are effi ciently translated in tobacco plastids. Plant J 7:845–848
    • (1995) Plant J , vol.7 , pp. 845-848
    • Staub, J.M.1    Maliga, P.2
  • 59
    • 27244432790 scopus 로고    scopus 로고
    • Characterization of heterologous multigene operons in transgenic chloroplasts. Transcription, processing, and translation
    • Quesada-Vargas T, Ruiz ON, Daniell H (2005) Characterization of heterologous multigene operons in transgenic chloroplasts. Transcription, processing, and translation. Plant Physiol 138:1746–1762
    • (2005) Plant Physiol , vol.138 , pp. 1746-1762
    • Quesada-Vargas, T.1    Ruiz, O.N.2    Daniell, H.3
  • 60
    • 84874228036 scopus 로고    scopus 로고
    • Effi cient metabolic pathway engineeringin transgenic tobacco and tomato plastids with synthetic multigene operons
    • Lu Y, Rijzaani H, Karcher D, Ruf S, Bock R (2013) Effi cient metabolic pathway engineeringin transgenic tobacco and tomato plastids with synthetic multigene operons. Proc Natl Acad Sci U S A 110:E623–E632
    • (2013) Proc Natl Acad Sci U S A , vol.110
    • Lu, Y.1    Rijzaani, H.2    Karcher, D.3    Ruf, S.4    Bock, R.5
  • 61
    • 4444319506 scopus 로고    scopus 로고
    • T7 RNA polymerase-directed expression of an antibody fragment transgene in plastids causes a semi-lethal pale-green seedling phenotype
    • Magee AM, Coyne S, Murphy D, Horvath EM, Medgyesy P, Kavanagh TA (2004) T7 RNA polymerase-directed expression of an antibody fragment transgene in plastids causes a semi-lethal pale-green seedling phenotype. Transgenic Res 13:325–337
    • (2004) Transgenic Res , vol.13 , pp. 325-337
    • Magee, A.M.1    Coyne, S.2    Murphy, D.3    Horvath, E.M.4    Medgyesy, P.5    Kavanagh, T.A.6
  • 62
    • 79957877550 scopus 로고    scopus 로고
    • High-level expression of a suite of thermostable cell walldegrading enzymes from the chloroplast genome
    • Petersen K, Bock R (2011) High-level expression of a suite of thermostable cell walldegrading enzymes from the chloroplast genome. Plant Mol Biol 76:311–321
    • (2011) Plant Mol Biol , vol.76 , pp. 311-321
    • Petersen, K.1    Bock, R.2
  • 63
    • 0033768431 scopus 로고    scopus 로고
    • Removal of antibiotic resistance genes from transgenic tobacco plastids
    • Iamtham S, Day A (2000) Removal of antibiotic resistance genes from transgenic tobacco plastids. Nat Biotechnol 18:1172–1176
    • (2000) Nat Biotechnol , vol.18 , pp. 1172-1176
    • Iamtham, S.1    Day, A.2
  • 64
    • 33749998424 scopus 로고    scopus 로고
    • Tobacco plastid ribosomal protein S18 is essential for cell survival
    • Rogalski M, Ruf S, Bock R (2006) Tobacco plastid ribosomal protein S18 is essential for cell survival. Nucleic Acids Res 34:4537–4545
    • (2006) Nucleic Acids Res , vol.34 , pp. 4537-4545
    • Rogalski, M.1    Ruf, S.2    Bock, R.3
  • 65
    • 38849159102 scopus 로고    scopus 로고
    • Superwobbling facilitates translation with reduced tRNA sets
    • Rogalski M, Karcher D, Bock R (2008) Superwobbling facilitates translation with reduced tRNA sets. Nat Struct Mol Biol 15:192–198
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 192-198
    • Rogalski, M.1    Karcher, D.2    Bock, R.3
  • 66
    • 57749098695 scopus 로고    scopus 로고
    • Rpl33, a nonessential plastid- encoded ribosomal protein in tobacco, is required under cold stress conditions
    • Rogalski M, Schöttler MA, Thiele W, Schulze WX, Bock R (2008) Rpl33, a nonessential plastid- encoded ribosomal protein in tobacco, is required under cold stress conditions. Plant Cell 20:2221–2237
    • (2008) Plant Cell , vol.20 , pp. 2221-2237
    • Rogalski, M.1    Schöttler, M.A.2    Thiele, W.3    Schulze, W.X.4    Bock, R.5
  • 67
    • 69449105603 scopus 로고    scopus 로고
    • Extensive homologous recombination between introduced and native regulatory plastid DNA elements in transplastomic plants
    • Gray BN, Ahner BA, Hanson MR (2009) Extensive homologous recombination between introduced and native regulatory plastid DNA elements in transplastomic plants. Transgenic Res 18:559–572
    • (2009) Transgenic Res , vol.18 , pp. 559-572
    • Gray, B.N.1    Ahner, B.A.2    Hanson, M.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.