Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 16, 2009, Pages 6579-6584

  Oey, Melanie ^a   Lohse, Marc ^a   Scharff, Lars B ^a   Kreikemeyer, Bernd ^b   Bock, Ralph ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PLANT PHYSIOLOGY   (Germany)

^b ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

Chloroplast; Molecular farming; Phage lysin; Plastid transformation; Site specific recombination

Indexed keywords

ANTIBIOTIC AGENT; CPL 1 PROTEIN; PAL PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; MESSENGER RNA; TOXIN;

ARTICLE; BACTERICIDAL ACTIVITY; CELL TRANSFORMATION; CONTROLLED STUDY; ESCHERICHIA COLI; GENETIC TRANSCRIPTION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASTID; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STREPTOCOCCUS PNEUMONIAE; BACTERIOLYSIS; BIOSYNTHESIS; BIOTECHNOLOGY; DRUG EFFECT; GENE VECTOR; GENETIC TRANSFORMATION; GENETICS; METABOLISM; METHODOLOGY; MICROBIAL VIABILITY; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; PLASTID GENOME; TOBACCO;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PROKARYOTA; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIOLYSIS; BIOTECHNOLOGY; GENETIC VECTORS; GENOME, PLASTID; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; MOLECULAR SEQUENCE DATA; PLASTIDS; PNEUMONIA; RNA, MESSENGER; STREPTOCOCCUS PNEUMONIAE; TOBACCO; TOXINS, BIOLOGICAL; TRANSCRIPTION, GENETIC; TRANSFORMATION, GENETIC;

EID: 66149136008     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813146106     Document Type: Article

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