Development of metabolic indicators of burn injury: Very low density lipoprotein (VLDL) and acetoacetate are highly correlated to severity of burn injury in rats

Metabolites

Volumn 2, Issue 3, 2012, Pages 458-478

  Izamis, Maria Louisa ^a   Uygun, Korkut ^a   Sharma, Nripen S ^a   Uygun, Basak ^a   Yarmush, Martin L ^a,b   Berthiaume, Francois ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Burn injury; Cluster analysis; Flux analysis; Hypermetabolism; Metabonomics; Regression; Variable selection

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; AMMONIA; ASPARAGINE; ASPARTATE AMINOTRANSFERASE; ASPARTIC ACID; BILIRUBIN; CHOLESTEROL; CREATININE; CYSTEINE; CYTOKINE; GLUCOSE; GLUTAMIC ACID; HIGH DENSITY LIPOPROTEIN; HISTIDINE; INSULIN; LACTIC ACID; LOW DENSITY LIPOPROTEIN; METHIONINE; ORNITHINE; OXYHEMOGLOBIN; SERINE; TRIACYLGLYCEROL; UREA; VERY LOW DENSITY LIPOPROTEIN;

ALGORITHM; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GAS ANALYSIS; BURN; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMATOCRIT; HYPERMETABOLISM; MALE; MEASUREMENT ERROR; METABOLOMICS; NONHUMAN; PH; RAT; UREA NITROGEN BLOOD LEVEL; VALIDATION PROCESS;

EID: 84909631074     PISSN: None     EISSN: 22181989     Source Type: Journal    
DOI: 10.3390/metabo2030458     Document Type: Article

References (48)

1. Herndon, D.N.; Tompkins, R.G. Support of the metabolic response to burn injury. Lancet 2004, 363, 1895-1902.
2. Bosaeus, I. Nutritional support in multimodal therapy for cancer cachexia. Support. Care Cancer 2008, 16, 447-451.
3. Hart, D.W.; Wolf, S.E.; Herndon, D.N.; Chinkes, D.L.; Lal, S.O.; Obeng, M.K.; Beauford, R.B.; Mlcak, R.P. Energy expenditure and caloric balance after burn. Increased feeding leads to fat rather than lean mass accretion. Ann. Surg. 2002, 235, 152-161.
4. Patterson, B.W.; Nguyen, T.; Pierre, E.; Herndon, D.N.; Wolfe, R.R. Urea and protein metabolism in burned children: Effect of dietary protein intake. Metabolism 1997, 46, 573-578.
5. Windle, E.M. Glutamine supplementation in critical illness: Evidence, recommendations, and implications for clinical practice in burn care. J. Burn Care Res. 2006, 27, 764-772.
6. Yu, Y.M.; Young, V.R.; Tompkins, R.G.; Burke, J.F. Relationships among arginine, citrulline, ornithine, and leucine kinetics in adult burn patients. Am. J. Clin. Nutr. 1995, 62, 960-968.
7. Jeschke, M.G.; Herndon, D.N.; Ebener, C.; Barrow, R.E.; Jauch, K.-W. Nutritional intervention high in vitamins, protein, amino acids, and omega-3 fatty acids improves protein metabolism during the hypermetabolic state after thermal injury. Arch. Surg. 2001, 136, 1301-1306.
8. Cree, M.G.; Newcomer, B.R.; Herndon, D.N.; Qian, T.; Sun, D.Y.; Morio, B.; Zwetsloot, J.J.; Dohm, G.L.; Fram, R.Y.; Aarsland, A.; et al. PPAR-alpha agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children. Fed. Am. Soc. Exp. Biol. 2007, A839.
9. Cree, M.G.; Wolfe, R.R. Postburn trauma insulin resistance and fat metabolism. Am. J. Physiol. Endocrinol. Metab. 2008, 294, E1-E9.
10. Gore, D.C.; Herndon, D.N.; Wolfe, R.R. Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury. J. Trauma 2005, 59, 316-322.
11. Pierre, E.J.; Barrow, R.E.; Hawkins, H.K.; Nguyen, T.T.; Sakurai, Y.; Desai, M.; Wolfe, R.R.; Herndon, D.N. Effects of insulin on wound healing. J. Trauma 1998, 44, 342-345.
12. Van den Berghe, G.; Wouters, P.; Weekers, F.; Verwaest, C.; Bruyninckx, F.; Schetz, M.; Vlasselaers, D.; Ferdinande, P.; Lauwers, P.; Bouillon, R. Intensive insulin therapy in critically ill patients. N. Engl. J. Med. 2001, 345, 1359-1367.
13. Wanek, S.; Wolf, S.E. Metabolic response to injury and role of anabolic hormones. Curr. Opin. Clin. Nutr. Metab. Care 2007, 10, 272-277.
14. Herndon, D.N.; Hart, D.W.; Wolf, S.E.; Chinkes, D.L.; Wolfe, R.R. Reversal of catabolism by beta-blockade after severe burns. N. Engl. J. Med.2001, 345, 1223-1229.
15. De-Souza, D.A.; Greene, L.J. Pharmacological nutrition after burn injury. J. Nutr. 1998, 128, 797-803.
16. Cioffi, W.G. What's new in burns and metabolism. J. Am. Coll. Surg. 2001, 192, 241-254.
17. Steuer, R. Review: On the analysis and interpretation of correlations in metabolomic data. Brief. Bioinform. 2006, 7, 151-158.
18. Yarmush, D.M.; MacDonald, A.D.; Foy, B.D.; Berthiaume, F.; Tompkins, R.G.; Yarmush, M.L. Cutaneous burn injury alters relative tricarboxylic acid cycle fluxes in rat liver. J. Burn Care Rehabil. 1999, 20, 292-302.
19. Yamaguchi, Y.; Yu, Y.M.; Zupke, C.; Yarmush, D.M.; Berthiaume, F.; Tompkins, R.G.; Yarmush, M.L. Effect of burn injury on glucose and nitrogen metabolism in the liver: Preliminary studies in a perfused liver system. Surgery 1997, 121, 295-303.
20. Chen, C.L.; Fei, Z.; Carter, E.A.; Lu, X.M.; Hu, R.H.; Young, V.R.; Tompkins, R.G.; Yu, Y.M. Metabolic fate of extrahepatic arginine in liver after burn injury. Metabolism 2003, 52, 1232-1239.
21. Izamis, M.L.; Sharma, N.S.; Uygun, B.; Bieganski, R.; Saeidi, N.; Nahmias, Y.; Uygun, K.; Yarmush, M.L.; Berthiaume, F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol. Bioeng. 2011, 108, 839-852.
22. Kaddurah-Daouk, R.; Kristal, B.S.; Weinshilboum, R.M. Metabolomics: A global biochemical approach to drug response and disease. Annu. Rev. Pharmacol. Toxicol. 2008, 48, 653-683.
23. Beger, R.; Holland, R.; Sun, J.; Schnackenberg, L.; Moore, P.; Dent, C.; Devarajan, P.; Portilla, D. Metabonomics of acute kidney injury in children after cardiac surgery. Pediatr. Nephrol. 2008, 23, 977-984.
24. Keun, H.C.; Athersuch, T.J. Application of metabonomics in drug development. Pharmacogenomics 2007, 8, 731-741.
25. Clayton, A.T.; Lindon, J.C.; Cloarec, O.; Antti, H.; Charuel, C.; Hanton, G.; Provost, J.-P.; Le Net, J.-L.c.; Baker, D.; Walley, R.J.; et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 2006, 440, 1073-1077.
26. Erb, G.; Elbayed, K.; Piotto, M.; Raya, J.; Neuville, A.; Mohr, M.; Maitrot, D.; Kehrli, P.; Namer, I.J. Toward improved grading of malignancy in oligodendrogliomas using metabolomics. Magn. Reson. Med. 2008, 59, 959-965.
27. Banta, S.; Vemula, M.; Yokoyama, T.; Jayaraman, A.; Berthiaume, F.; Yarmush, M.L. Contribution of gene expression to metabolic fluxes in hypermetabolic livers induced through burn injury and cecal ligation and puncture in rats. Biotechnol. Bioeng. 2007, 97, 118-137.
28. Banta, S.; Yokoyama, T.; Berthiaume, F.; Yarmush, M.L. Quantitative effects of thermal injury and insulin on the metabolism of the skeletal muscle using the perfused rat hindquarter preparation. Biotechnol. Bioeng. 2004, 88, 613-629.
29. Uygun, K.; Matthew, H.W.T.; Huang, Y.L. DFBA-LQR: An optimal control approach to flux balance analysis. Ind. Eng. Chem. Res. 2006, 45, 8554-8564.
30. Uygun, K.; Matthew, H.W.T.; Huang, Y. Investigation of metabolic objectives in cultured hepatocytes. Biotechnol. Bioeng. 2007, 97, 622-637.
31. Barber, R.C.; Maass, D.L.; White, J.; Horton, J.W. Increasing percent burn is correlated with increasing inflammation in an adult rodent model. Shock 2008, 30, 388-393.
32. Barrow, R.E.; Meyer, N.A.; Jeschke, M.G. Effect of varying burn sizes and ambient temperature on the hypermetabolic rate in thermally injured rats. J. Surg. Res. 2001, 99, 253-257.
33. Kaufman, L.; Rousseeuw, P. Finding Groups in Data: An Introduction to Cluster Analysis; Wiley: New York, NY, USA, 1990.
34. Yang, E.; Maguire, T.; Yarmush, M.L.; Berthiaume, F.; Androulakis, I.P. Bioinformatics analysis of the early inflammatory response in a rat thermal injury model. BMC Bioinform. 2007, 8, 10.
35. Picard, R.R.; Cook, R.D. Cross-validation of regression-models. J. Am. Stat. Assoc. 1984, 79, 575-583.
36. Witten, I.H.; Frank, E. Data Mining: Practical Machine Learning Tools and Techniques, 2nd ed.; Morgan Kaufmann: San Francisco, CA, USA, 2005.
37. Tukey, J.W. Exploratory Data Analysis; Addison-Wesley: Reading, MA, USA, 1977.
38. Laun, R.A.; Rapsch, B.; Abel, W.; Schroder, O.; Roher, H.D.; Ekkernkamp, A.; Schulte, K.M. The determination of ketone bodies: Preanalytical, analytical and physiological considerations. Clin. Exp. Med. 2001, 1, 201-209.
39. Oda, S.; Hirasawa, H.; Sugai, T.; Shiga, H.; Matsuda, K.; Ueno, H. Cellular injury score for multiple organ failure severity scoring system. J. Trauma 1998, 45, 304-310; discussion 310-311.
40. Martini, W.Z.; Irtun, O.; Chinkes, D.L.; Rasmussen, B.; Traber, D.L.; Wolfe, R.R. Alteration of hepatic fatty acid metabolism after burn injury in pigs. JPEN J. Parenter. Enteral Nutr. 2001, 25, 310-316.
41. Yu, Y.-M.; Young, V.R.; Castillo, L.; Chapman, T.E.; Tompkins, R.G.; Ryan, C.M.; Burke, J.F. Plasma arginine and leucine kinetics and urea production rates in burn patients. Metabolism 1995, 44, 659-666.
42. Yu, Y.M.; Ryan, C.M.; Castillo, L.; Lu, X.M.; Beaumier, L.; Tompkins, R.G.; Young, V.R. Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal. Am. J. Physiol. Endocrinol. Metab. 2001, 280, E509-E517.
43. Nakatani, T.; Spolter, L.; Kobayashi, K. Arterial ketone body ratio as a parameter of hepatic mitochondrial redox state during and after hemorrhagic shock. World J. Surg. 1995, 19, 592-596.
44. Ozawa, K.; Mori, K.; Morimoto, T. Evaluation of hepatic function. Curr. Opin. Gen. Surg. 1994, 17-23.
45. Dong, Y.L.; Sheng, C.Y.; Herndon, D.N.; Waymack, J.P. Metabolic abnormalities of mitochondrial redox potential in postburn multiple system organ failure. Burns 1992, 18, 283-286.
46. Gore, D.C.; Rinehart, A.; Asimakis, G. Temporal changes in cellular energy following burn injury. Burns 2005, 31, 998-1002.
47. Banta, S.; Yokoyama, T.; Berthiaume, F.; Yarmush, M.L. Effects of dehydroepiandrosterone administration on rat hepatic metabolism following thermal injury. J. Surg. Res. 2005, 127, 93-105.
48. Izamis, M.; Uygun, K.; Uygun, B.; Yarmush, M.; Berthiaume, F. Effects of burn injury on markers of hypermetabolism in rats. J. Burn Care Res. 2009, 30, 993-1001.