The DNA methylation signature of human TCRαβ+CD4-CD8- double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response

Clinical Immunology

Volumn 156, Issue 1, 2015, Pages 19-27

  Renauer, Paul A ^a   Coit, Patrick ^a   Sawalha, Amr H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

DNA methylation; Double negative; Epigenome; Methylome; T cell

Indexed keywords

DNA; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GAMMA INTERFERON; INTERLEUKIN 12P40; INTERLEUKIN 17F; INTERLEUKIN 18; INTERLEUKIN 5; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; CYTOSINE; DMAP1 PROTEIN, HUMAN; DNA (CYTOSINE 5) METHYLTRANSFERASE; GUANINE; LYMPHOCYTE ANTIGEN RECEPTOR; REPRESSOR PROTEIN;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BIOINFORMATICS; BLOOD SAMPLING; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ADHESION; CELL INTERACTION; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; EPIGENETIC REPRESSION; FEMALE; FLOW CYTOMETRY; GENE LOCUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PERIPHERAL BLOOD MONONUCLEAR CELL; T LYMPHOCYTE ACTIVATION; BIOLOGY; CHEMISTRY; DOWN REGULATION; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; T LYMPHOCYTE;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COMPUTATIONAL BIOLOGY; CYTOSINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; FLOW CYTOMETRY; GUANINE; HUMANS; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; REPRESSOR PROTEINS; T-LYMPHOCYTES;

EID: 84909619773     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2014.10.007     Document Type: Article

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