IL-17-producing double-negative T cells are expanded in the peripheral blood, infiltrate the salivary gland and are partially resistant to corticosteroid therapy in patients with Sjögren's syndrome

Reumatismo

Volumn 65, Issue 4, 2013, Pages 192-198

  Alunno, A ^a   Bistoni, O ^a   Bartoloni Bocci, E ^a   Caterbi, S ^a   Bigerna, B ^a   Pucciarini, A ^a   Tabarrini, A ^a   Mannucci, R ^a   Beghelli, D ^b   Falini, B ^a   Gerli, R ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Dexamethasone; Sj gren's syndrome; T helper 17 cells

Indexed keywords

DEXAMETHASONE; INTERLEUKIN 17;

ADULT; ARTICLE; CELL EXPANSION; CELL ISOLATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE NEGATIVE T LYMPHOCYTE; DOWN REGULATION; DRUG RESISTANCE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; IN VITRO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PHENOTYPE; SALIVARY GLAND DISEASE; SJOEGREN SYNDROME; T CELL CULTURE; T LYMPHOCYTE; TH17 CELL;

ANTIGENS, CD3; ANTIGENS, CD8; CELLS, CULTURED; DEXAMETHASONE; DRUG RESISTANCE; FEMALE; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-17; MALE; MIDDLE AGED; SALIVARY GLANDS; SJOGREN'S SYNDROME; T-LYMPHOCYTES;

EID: 84887048365     PISSN: 00487449     EISSN: None     Source Type: Journal    
DOI: 10.4081/reumatismo.2013.192     Document Type: Article

References (39)

1. Voulgarelis M, Tzioufas AG. Pathogenetic mechanisms in the initiation and perpetuation of Sjogren's syndrome. Nat Rev Rheumatol. 2010; 6: 529-37
2. Mavragani CP, Moutsopoulos HM. Conventional therapy of Sjogren's syndrome. Clin Rev Allerg Immunol. 2007; 32: 284-91
3. Cua DJ, Sherlock J, Chen Y, et al. Interleukin- 23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003; 421: 744-8
4. Murphy CA, Langrish CN, Chen Y, et al. Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med. 2003; 198: 1951-7
5. Abdulahad WH, Boots AM, Kallenger CG. FoxP3+ CD4+ T cells in systemic autoimmune diseases: the delicate balance between true regulatory T cells and effector Th-17 cells. Rheumatology. 2011; 50: 646-56
6. Sakai A, Sugawara Y, Kuroishi T, et al. Identification of IL-18 and Th17 cells in salivary glands of patients with Sjogren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol. 2008; 181: 2898-906
7. Katsifis GE, Rekka S, Moutsopoulos NM, et al. Systemic and local interleukin-17 and linked cytokines associated with Sjogren's syndrome immunopathogenesis. Am J Pathol. 2009; 175: 1167-77
8. Nguyen CG, Yin H, Lee BH, et al. Pathogenic effect of interleukin-17A in induction of Sjogren's syndrome-like disease using adenovirus- mediated gene transfer. Arthritis Res Ther 2010; 12: R220
9. Nguyen CG, Yin H, Lee BH, et al. IL17: potential therapeutic target in Sjogren's syndrome using adenovirus-mediated gene transfer. Lab Invest. 2011; 91: 54-62
10. Weaver CT, Hatton RD, Mangan PR, et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol. 2007; 25: 821-52
11. Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004; 21: 467-76
12. Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005; 6: 1123-32
13. Crispin JC, Tsokos GC. Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol. 2009; 183: 4675-81
14. Zhang ZX Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med. 2000; 6: 782-9
15. Fisher KS, Voelkl S, Heymann J, et al. Isolation and characterization of human antigenspecific TCR alpha beta+ CD4(-)CD8- double- negative regulatory T cells. Blood. 2005; 105: 2828-35
16. Zhang D, Yang W, Degauque N, et al. New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses. Blood. 2007; 109: 4071-79
17. Shivakumar SJ, Tsokos GK, Datta SK. T cell receptor alpha/beta expressing doublenegative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol. 1989; 143: 103-12
18. Anand A, Dean GS, Quereshi K, et al. Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: activation markers. Lupus. 2002; 11: 493-500
19. Crispin JC, Oukka M, Bayliss G, et al. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol. 2008; 181: 8761-6
20. Moutsopoulos NM, Katsifis GE, Angelov N, et al. Lack of efficacy of etanercept in Sjogren syndrome correlates with failed suppression of tumour necrosis factor alpha and systemic immune activation. Ann Rheum Dis. 2008; 67: 1437-43
21. Vitali C, Bombardieri S, Johnsson R, et al. Classification criteria for Sjogren's Syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002; 61: 554-8
22. Tassone P, Forciniti S, Galea E, et al. Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines Leukemia. 2000; 14: 841-4
23. Tassone P, Neri P, Burger R, et al. Human multiple myeloma antitumor effects in a novel SCID-hu in vivo model of superantagonist Sant7 and dexamethasone induces combination therapy with interleukin-6 receptor. Clin Cancer Res. 2005; 11: 4251-8
24. Bertini R, Bianchi M, Erroi A, et al. Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin- 1 on liver cytochrome P-450, plasma fibrinogen, and serum iron. J Leuk Biol. 1989; 46: 254-62
25. Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjogren's disease. J Clin Pathol. 1968; 21: 656-60
26. Greenspan JS, Daniels TE, Talal N, et al. The histopathology of Sjogren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974; 37: 217-29
27. D'Acquisto F, Crompton T. CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response? Biochem Pharmacol. 2011; 82: 333-40
28. Reinhardt C, Melms A. Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. Ann Neurol. 2000; 48: 603-8
29. Shin MS, Lee N, Kang I. Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells. Curr Opin Rheumatol. 2011; 23: 444-8
30. Marodon G, Warren D, Filomio MC, et al. Productive infection of double-negative T cells with HIV in vivo. Proc Natl Acad Sci USA. 1999; 96: 11958-63
31. Lin Y, Ritchea S, Logar A, et al. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity. 2009; 31: 799-810
32. Cowley SC, Meierovics AI, Frelinger JA, et al. Lung CD4-CD8- double-negative T cells are prominent producers of IL-17A and IFNgamma during primary respiratory murine infection with Francisella tularensis live vaccine strain. J Immunol. 2010; 184: 5791-801
33. Fox PC, Datiles M, Atkinson JC, et al. Prednisone and piroxicam for treatment of primary Sjogren's syndrome. Clin Exp Rheumatol. 1993; 11: 149-56
34. Zandbelt MM, van den Hoogen FH, de Wilde PC, et al. Reversibility of histological and immunohistological abnormalities in sublabial salivary gland biopsy specimens following treatment with corticosteroids in Sjogren's syndrome. Ann Rheum Dis. 2001; 60: 511-3
35. Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet. 2009; 373: 1905-17
36. Chikanza IC, Kozachi DL. Corticosteroid resistance in rheumatoid arthritis: molecular and cellular perspectives. Rheumatology. 2004; 43: 1337-45
37. Seki M, Ushiyama C, Seta N, et al. Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus. Arthritis Rheum. 1998; 41: 823-30
38. McKinley LJ, Alcorn JF, Peterson A, et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. Immunol. 2008; 181: 4089-97
39. Vazquez-Tello A, Semlali A, Chakir J, et al. Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines. Clin Exp Allergy. 2010; 40: 1312-22.