Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling

Free Radical Biology and Medicine

Volumn 77, Issue , 2014, Pages 331-339

  Soethoudt, Marjolein ^a,b   Peskin, Alexander V ^a   Dickerhof, Nina ^a   Paton, Louise N ^a   Pace, Paul E ^a   Winterbourn, Christine C ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Adenanthin; Electrophile; Glutaredoxin; Glutathione; Glutathione reductase; Peroxiredoxin; Thioredoxin reductase

Indexed keywords

ADENANTHIN; DITERPENOID; GLUTATHIONE; PEROXIREDOXIN; PEROXIREDOXIN 1; PEROXIREDOXIN 2; THIOREDOXIN; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GLUTAREDOXIN; HOMEODOMAIN PROTEIN; KAURANE DERIVATIVE; PRRX2 PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DIMERIZATION; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; JURKAT CELL LINE; MICHAEL ADDITION; OXIDATION; REDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION;

DITERPENES, KAURANE; ENZYME INHIBITORS; ERYTHROCYTES; GLUTAREDOXINS; GLUTATHIONE; HOMEODOMAIN PROTEINS; HUMANS; JURKAT CELLS; KINETICS; OXIDATION-REDUCTION; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84909580285     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.09.025     Document Type: Article

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