Adenanthin targets proteins involved in the regulation of disulphide bonds

Biochemical Pharmacology

Volumn 89, Issue 2, 2014, Pages 210-216

  Muchowicz, Angelika ^a   Firczuk, Małgorzata ^a   Chlebowska, Justyna ^a   Nowis, Dominika ^a,b   Stachura, Joanna ^a   Barankiewicz, Joanna ^a   Trzeciecka, Anna ^a   Kłossowski, Szymon ^c   Ostaszewski, Ryszard ^c   Zagozdzon, Radosław ^a   Pu, Jian Xin ^d   Sun, Han Dong ^d   Golab, Jakub ^a,e  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c INSTITUTE OF ORGANIC CHEMISTRY   (Poland)

^d KUNMING INSTITUTE OF BOTANY   (China)

^e INSTITUTE OF PHYSICAL CHEMISTRY   (Poland)

Author keywords

Adenanthin; Cancer; Peroxiredoxin; Protein disulphide isomerase; Thioredoxin

Indexed keywords

ADENANTHIN; BINDING PROTEIN; DITERPENOID; INSULIN; PEROXIREDOXIN; PEROXIREDOXIN 1; PEROXIREDOXIN 2; PROTEIN DISULFIDE ISOMERASE; THIOREDOXIN; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOTINYLATION; CELL CULTURE; DISULFIDE BOND; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN TARGETING;

ADENANTHIN; CANCER; PEROXIREDOXIN; PROTEIN DISULPHIDE ISOMERASE; THIOREDOXIN;

CELL LINE, TUMOR; DISULFIDES; DITERPENES; HEK293 CELLS; HUMANS; ISODON; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PROTEIN TRANSPORT; THIOREDOXINS;

EID: 84899427005     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.02.022     Document Type: Article

References (18)

1. C.X. Liu, Q.Q. Yin, H.C. Zhou, Y.L. Wu, J.X. Pu, and L. Xia et al. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells Nat Chem Biol 8 2012 486 493
2. Q.Q. Yin, C.X. Liu, Y.L. Wu, S.F. Wu, Y. Wang, and X. Zhang et al. Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-kappaB signaling J Immunol 191 2013 2115 2125
3. S. Klossowski, A. Muchowicz, M. Firczuk, M. Swiech, A. Redzej, and J. Golab et al. Studies toward novel peptidomimetic inhibitors of thioredoxin-thioredoxin reductase system J Med Chem 55 2012 55 67
4. J.E. Biaglow, and R.A. Miller The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy Cancer Biol Ther 4 2005 6 13
5. G. Fujino, T. Noguchi, K. Takeda, and H. Ichijo Thioredoxin and protein kinases in redox signaling Semin Cancer Biol 16 2006 427 435
6. J.R. Matthews, N. Wakasugi, J.L. Virelizier, J. Yodoi, and R.T. Hay Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62 Nucleic Acids Res 20 1992 3821 3830
7. S.G. Rhee, H.A. Woo, I.S. Kil, and S.H. Bae Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides J Biol Chem 287 2012 4403 4410
8. A. Holmgren Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide Structure 3 1995 239 243
9. B.F. Jordan, M. Runquist, N. Raghunand, R.J. Gillies, W.R. Tate, and G. Powis et al. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging Clin Cancer Res 11 2005 529 536
10. A. Holmgren Reduction of disulfides by thioredoxin. Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action J Biol Chem 254 1979 9113 9119
11. A. Malenda, A. Skrobanska, T. Issat, M. Winiarska, J. Bil, and B. Oleszczak et al. Statins impair glucose uptake in tumor cells Neoplasia 14 2012 311 323
12. E. Pedone, D. Limauro, K. D'Ambrosio, G. De Simone, and S. Bartolucci Multiple catalytically active thioredoxin folds: a winning strategy for many functions Cell Mol Life Sci 67 2010 3797 3814
13. S. Lee, S.M. Kim, and R.T. Lee Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance Antioxid Redox Signal 18 2013 1165 1207
14. B. Luo, and A.S. Lee The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies Oncogene 32 2013 805 818
15. P.J. Hogg Targeting allosteric disulphide bonds in cancer Nat Rev Cancer 13 2013 425 431
16. K.M. Cook, and P.J. Hogg Post-translational control of protein function by disulfide bond cleavage Antioxid Redox Signal 18 2013 1987 2015
17. I. Azimi, J.W. Wong, and P.J. Hogg Control of mature protein function by allosteric disulfide bonds Antioxid Redox Signal 14 2011 113 126
18. K. Reiser, K.O. Francois, D. Schols, T. Bergman, H. Jornvall, and J. Balzarini et al. Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120 Int J Biochem Cell Biol 44 2012 556 562