Ectopic activation of Wnt/β-catenin signaling in lens fiber cells results in cataract formation and aberrant fiber cell differentiation

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Antosova, Barbora ^a,b   Smolikova, Jana ^a   Borkovcova, Romana ^a   Strnad, Hynek ^a   Lachova, Jitka ^a   Machon, Ondrej ^a   Kozmik, Zbynek ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; BETA CATENIN; GAMMA CRYSTALLIN; LYMPHOID ENHANCER FACTOR 1; WNT PROTEIN; CRYSTALLIN; DNA BINDING PROTEIN; LEF1 PROTEIN, MOUSE;

ADULT; ADULT ANIMAL; ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CATARACT; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EYE DEVELOPMENT; GENE EXPRESSION; LENS EPITHELIUM CELL; LENS FIBER; MALE; MICROPHTHALMIA; MOUSE; MOUSE MODEL; NONHUMAN; PROMOTER REGION; PROTEIN DOMAIN; TRANSACTIVATION; TRANSCRIPTION REGULATION; TRANSGENE; TRANSGENIC MOUSE; WNT SIGNALING PATHWAY; ANIMAL; C57BL MOUSE; CELL CYCLE; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LENS; METABOLISM; SIGNAL TRANSDUCTION;

MUS; MUS MUSCULUS;

ANIMALS; BETA CATENIN; CATARACT; CELL CYCLE; CELL DIFFERENTIATION; CRYSTALLINS; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LENS, CRYSTALLINE; LYMPHOID ENHANCER-BINDING FACTOR 1; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROPHTHALMOS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY;

EID: 84908685405     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078279     Document Type: Article

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