Complex regulatory element within the γE- and γF-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid

Gene

Volumn 286, Issue 2, 2002, Pages 271-282

  Králová, Jarmila ^a   Czerny, Thomas ^b   Španielová, Hana ^c   Ratajová, Veronika ^a   Kozmik, Zbynek ^a,d  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c Department of Genetics and Microbiology ^*  (Czech Republic)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

DNA binding; Lens; Paired box; Retinoic acid receptor; Transcription

Indexed keywords

CRYSTALLIN; RECEPTOR PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR; TRANSCRIPTION FACTOR PAX6;

ANIMAL CELL; ARTICLE; BINDING SITE; CHICK EMBRYO; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; EMBRYO; ENHANCER REGION; FIBROBLAST; GENE CONTROL; GENE INDUCTION; INSECT CELL; LENS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN INDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CELLS, CULTURED; CHICK EMBRYO; CRYSTALLINS; DNA-BINDING PROTEINS; DOWN-REGULATION; ENHANCER ELEMENTS (GENETICS); EPITHELIAL CELLS; EYE PROTEINS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; LENS, CRYSTALLINE; LUCIFERASES; PAIRED BOX TRANSCRIPTION FACTORS; PLASMIDS; PROMOTER REGIONS (GENETICS); RECEPTORS, RETINOIC ACID; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; RETINOID X RECEPTORS; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION FACTORS; TRANSFECTION; TRETINOIN;

GALLUS GALLUS;

EID: 0037139578     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)00425-0     Document Type: Article

References (42)

1. Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila
2. Activation of the gamma E-crystallin pseudogene in the human hereditary Coppock-like cataract
3. A frameshift mutation in the gamma E-crystallin gene of the Elo mouse
4. Lens development and crystallin gene expression: Many roles for Pax-6
5. Transcriptional regulation of the mouse alpha A-crystallin gene: Activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site
6. DNA-binding and transactivation properties of Pax-6: Three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5)
7. DNA sequence recognition by Pax proteins: Bipartite structure of the paired domain and its binding site
8. Role of Olf-1 and Pax-6 transcription factors in neurodevelopment
9. Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region
10. Dual roles for Pax-6: A transcriptional repressor of lens fiber cell-specific beta-crystallin genes
11. Immunodepletion EMSA: A novel method to identify proteins in a protein-DNA complex
12. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
13. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing
14. Involvement of retinoic acid/retinoid receptors in the regulation of murine alphaB-crystallin/small heat shock protein gene expression in the lens
15. Temporal regulation of six crystallin transcripts during mouse lens development
16. Developmental regulation and cell type-specific expression of the murine gamma F-crystallin gene is mediated through a lens-specific element containing the gamma F-1 binding site
17. Murine gamma E-crystallin is distinct from murine gamma 2-crystallin
18. Retinal expression of gamma-crystallins in the mouse
19. Cooperative interactions between paired domain and homeodomain
20. Involvement of SOX proteins in lens-specific activation of crystallin genes
21. Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development
22. Genetic analysis of RXR alpha developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis
23. Regulation of lens fiber cell differentiation by transcription factor c-Maf
24. The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia
25. Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8
26. Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter
27. Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate: Implications for stepwise determination of the lens
28. Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants
29. Lens-specific promoter activity of a mouse gamma-crystallin gene
30. Multiple regulatory elements of the murine gamma 2-crystallin promoter
31. Structural and evolutionary relationships among five members of the human gamma-crystallin gene family
32. Gamma-crystallins of the human eye lens: Expression analysis of five members of the gene family
33. Differential regulation of gamma-crystallin genes during mouse lens development
34. Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice
35. Induction of lens differentiation by activation of a bZIP transcription factor, L-Maf
36. An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: Evidence of a role for retinoids in lens development
37. Heterodimeric interaction of the retinoic acid and thyroid hormone receptors in transcriptional regulation on the gamma F-crystallin everted retinoic acid response element
38. Lens crystallins of invertebrates - Diversity and recruitment from detoxification enzymes and novel proteins
39. Pax-6, a murine paired box gene, is expressed in the developing CNS
40. Lens crystallins: Gene recruitment and evolutionary dynamism
41. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding
42. Homologous and heterologous enhancers modulate spatial expression but not cell-type specificity of the murine gamma F-crystallin promoter