Equol induces mitochondria-mediated apoptosis of human cervical cancer cells

Anticancer Research

Volumn 34, Issue 9, 2014, Pages 4985-4992

  Kim, Eun Young ^a   Shin, Jin Young ^a   Park, Young Ja ^a   Kim, An Keun ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

Apoptosis; Caspase; Cervical cancer cells; Equol; Mitochondria

Indexed keywords

ACETYLCYSTEINE; CASPASE 8; EQUOL; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; CASPASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; HELA CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MTT ASSAY; PRIORITY JOURNAL; UTERINE CERVIX CANCER; WESTERN BLOTTING; CERVICAL CANCER CELLS; DOSE RESPONSE; DRUG EFFECT; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UTERINE CERVIX TUMOR;

APOPTOSIS; CASPASE; CERVICAL CANCER CELLS; EQUOL; MITOCHONDRIA;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EQUOL; FEMALE; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UTERINE CERVICAL NEOPLASMS;

EID: 84908681867     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Akinyemiju TF: Socio-economic and health access determinants of breast and cervical cancer screening in low-income countries: analysis of the world health survey. PLoS One 7: e48834, 2012.
2. Markowitz LE, Tsu V, Deeks SL, Cubie H, Wang SA, Vicari AS, and Brotherton JM: Human papillomavirus vaccine introduction - the first five years. Vaccine 30(Suppl 5): F139-148, 2012.
3. Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJ and Naghavi M: Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet 378: 1461-1484, 2011.
4. Rob L, Robova H, Chmel R, Komar M, Halaska M and Skapa P: Surgical options in early cervical cancer. Int J Hyperthermia 28: 489-500, 2012.
5. Fujimoto J: Novel strategy of anti-angiogenic therapy for uterine cervical carcinomas. Anticancer Res 29: 2665-2669, 2009.
6. Myung SK, Ju W, Choi HJ and Kim SC: Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis. Brit J Obstet Gynaecol 116: 1697-705, 2009.
7. Yang G, Shu XO, Li HL, Chow WH, Wen W, Xiang YB, Zhang X, Cai H, Ji BT, Gao YT and Zheng W: Prediagnosis soy food consumption and lung cancer survival in women. J Clin Oncol 31: 1548-1553, 2013.
8. Kang HB, Zhang YF, Yang JD and Lu KL: Study on soy isoflavone consumption and risk of breast cancer and survival. Asian Pac J Cancer Prev 13: 995-998, 2012.
9. Dong J-Y and Qin L-Q: Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 125: 315-323, 2011.
10. Hussain A, Harish G, Prabhu SA, Mohsin J, Khan MA, Rizvi TA and Sharma C: Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 expression. Cancer Epidemiol 36: e387-393, 2012.
11. Wang J, Eltoum IE, Carpenter M and Lamartiniere CA: Genistein mechanisms and timing of prostate cancer chemoprevention in Lobund-Wistar rats. Asian Pac J Cancer Prev 10: 143-150, 2009.
12. Liu X, Suzuki N, Santosh Laxmi YR, Okamoto Y and Shibutani S: Anti-breast cancer potential of daidzein in rodents. Life Sci 91: 415-419, 2012.
13. Hedlund TE, Johannes WU and Miller GJ: Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro. Prostate 54: 68-78, 2003.
14. Shi J, Ji A, Cao Z, Cao R, Li D, Yang R and Wang F: Equol induced apoptosis of human breast cancer MDA-MB-231 cell by inhibiting the expression of nuclear factor-kappaB. Wei Sheng Yan Jiu 40: 95-98, 2011 [Article in Chinese].
15. Choi EJ, Ahn WS and Bae SM: Equol induces apoptosis through cytochrome c-mediated caspases cascade in human breast cancer MDA-MB-453 cells. Chem Biol Interact 177: 7-11, 2009.
16. Szliszka E and Krol W: Soy isoflavones augment the effect of TRAIL-mediated apoptotic death in prostate cancer cells. Oncol Rep 26: 533-541, 2011.
17. Kim EY and Kim AK: Combination effect of equol and TRAIL against human cervical cancer cells. Anticancer Res 33: 903-912, 2013.
18. Charalambous C, Pitta CA and Constantinou AI: Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells. BMC Cancer 13: 238-247, 2013.
19. Taghizadeh B, Ghavami L, Nikoofar A and Goliaei B: Equol as a potent radiosensitizer in estrogen receptor-positive and -negative human breast cancer cell lines. Breast Cancer, Sep 2013 [Epub ahead of print].
20. Harvey NL and Kumar S: The role of caspases in apoptosis. Adv Biochem Eng Biotechnol 62: 107-128, 1998.
21. Chalah A and Khosravi-Far R: The mitochondrial death pathway. Adv Exp Med Biol 615: 25-45, 2008.
22. Azad N, Iyer A, Vallyathan V, Wang L, Castranova V, Stehlik C and Rojanasakul Y: Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation. Ann NY Acad Sci 1203: 1-6, 2010.
23. Herrera B, Alvarez AM, Sanchez A, Fernandez M, Roncero C, Benito M and Fabregat I: Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes. FASEB J 15: 741-751, 2001.
24. Moungjaroen J, Nimmannit U, Callery PS, Wang L, Azad N, Lipipun V, Chanvorachote P and Rojanasakul Y: Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through BCL-2 down-regulation. J Pharmacol Exp Ther 319: 1062-1069, 2006.
25. Elmore S: Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516, 2007.
26. Oliver L and Vallette FM: The role of caspases in cell death and differentiation. Drug Resist Updat 8: 163-170, 2005.
27. Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999.
28. Kruidering M and Evan GI: Caspase-8 in apoptosis: The beginning of "The End"? IUBMB Life 50: 85-90, 2000.
29. Mates JM and Sanchez-Jimenez FM: Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 32: 157-170, 2000.
30. Martindale JL and Holbrook NJ: Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192: 1-15, 2002.
31. Jing XB, Cai XB, Hu H, Chen SZ, Chen BM and Cai JY: Reactive oxygen species and mitochondrial membrane potential are modulated during CDDP-induced apoptosis in EC-109 cells. Biochem Cell Biol 85: 265-271, 2007.
32. Wang YF, Chen CY, Chung SF, Chiou YH and Lo HR: Involvement of oxidative stress and caspase activation in paclitaxel-induced apoptosis of primary effusion lymphoma cells. Cancer Chemother Pharmacol 54: 322-330, 2004.
33. Ling YH, Liebes L, Zou Y and Perez-Soler R: Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 278: 33714-33723, 2003.
34. Ozben T: Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 96: 2181-2196, 2007.