Heritability of cardiac vagal control in 24-h heart rate variability recordings: Influence of ceiling effects at low heart rates

Psychophysiology

Volumn 51, Issue 10, 2014, Pages 1023-1036

  Neijts, Melanie ^a,b   Van Lien, Rene ^a,b   Kupper, Nina ^a,c   Boomsma, Dorret ^a,b   Willemsen, Gonneke ^a,b   de Geus, Eco J C ^a,b  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c TILBURG UNIVERSITY   (Netherlands)

Author keywords

Ambulatory monitoring; Parasympathetic nervous system; RMSSD; RSA; Twins

Indexed keywords

ADULT; BREATHING RATE; CHOLINERGIC SYSTEM; FEMALE; GENETICS; HEART RATE; HUMAN; MALE; PHYSIOLOGY; REGISTER; SLEEP; TWINS; VAGUS NERVE; YOUNG ADULT;

ADULT; FEMALE; HEART RATE; HUMANS; MALE; PARASYMPATHETIC NERVOUS SYSTEM; REGISTRIES; RESPIRATORY RATE; SLEEP; TWINS; VAGUS NERVE; YOUNG ADULT;

EID: 84908644864     PISSN: 00485772     EISSN: 14698986     Source Type: Journal    
DOI: 10.1111/psyp.12246     Document Type: Article

References (83)

1. Akaike, H. (1987). Factor analysis and AIC. Psychometrika, 52, 317-332. doi: 10.1007/BF02294359
2. Baccarelli, A., Cassano, P. A., Litonjua, A., Park, S. K., Suh, H., Sparrow, D.,Schwartz, J. (2008). Cardiac autonomic dysfunction: Effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation, 117, 1802-1809. doi: 10.1161/CIRCULATIONAHA.107.726067
3. Berntson, G. G., Bigger, J. T., Jr., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., van der Molen, M. W. (1997). Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology, 34, 623-648. doi: 10.1111/j.1469-8986.1997.tb02140.x
4. Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1993). Respiratory sinus arrhythmia: Autonomic origins, physiological mechanisms, and psychophysiological implications. Psychophysiology, 30, 183-196. doi: 10.1111/j.1469-8986.1993.tb01731.x
5. Bigger, J. T., Jr., Fleiss, J. L., Rolnitzky, L. M., & Steinman, R. C. (1993). Frequency domain measures of heart period variability to assess risk late after myocardial infarction. Journal of the American College of Cardiology, 21, 729-736. doi: 10.1016/0735-1097(93)90106-B
6. Bigger, J. T., Jr., Fleiss, J. L., Steinman, R. C., Rolnitzky, L. M., Kleiger, R. E., & Rottman, J. N. (1992). Correlations among time and frequency domain measures of heart period variability two weeks after acute myocardial infarction. American Journal of Cardiology, 69, 891-898. doi: 10.1016/0002-9149(92)90788-Z
7. Bigger, J. T., Jr., Hoover, C. A., Steinman, R. C., Rolnitzky, L. M., & Fleiss, J. L. (1990). Autonomic nervous system activity during myocardial ischemia in man estimated by power spectral analysis of heart period variability. The Multicenter Study of Silent Myocardial Ischemia Investigators. American Journal of Cardiology, 66, 497-498. doi: 10.1016/0002-9149(90)90712-A
8. Boomsma, D. I., & Gabrielli, W. F., Jr. (1985). Behavioral genetic approaches to psychophysiological data. Psychophysiology, 22, 249-260. doi: 10.1111/j.1469-8986.1985.tb01596.x
9. Boomsma, D. I., van Baal, G. C., & Orlebeke, J. F. (1990). Genetic influences on respiratory sinus arrhythmia across different task conditions. Acta Geneticae Medicae et Gemellologiae (Roma), 39, 181-191.
10. Buccelletti, E., Gilardi, E., Scaini, E., Galiuto, L., Persiani, R., Biondi, A., Silveri, N. G. (2009). Heart rate variability and myocardial infarction: Systematic literature review and metanalysis. European Review for Medical and Pharmacological Sciences, 13, 299-307.
11. Busjahn, A., Voss, A., Knoblauch, H., Knoblauch, M., Jeschke, E., Wessel, N., Luft, F. C. (1998). Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins. American Journal of Cardiology, 81, 755-760. doi: 10.1016/S0002-9149(97)01019-9
12. Christov, I. I. (2004). Real time electrocardiogram QRS detection using combined adaptive threshold. Biomedical Engineering Online, 3, 28. doi: 10.1186/1475-925X-3-28
13. Cui, J. S., Hopper, J. L., & Harrap, S. B. (2003). Antihypertensive treatments obscure familial contributions to blood pressure variation. Hypertension, 41, 207-210. doi: 10.1161/01.HYP.0000044938.94050.E3
14. de Geus, E. J. C. (2010). Quantitative genetics in behavioral medicine. In A. Steptoe (Ed.), Handbook of behavioral medicine (pp. 399-422). London, UK: Springer. doi: 10.1007/978-0-387-09488-5-28
15. de Geus, E. J., Boomsma, D. I., & Snieder, H. (2003). Genetic correlation of exercise with heart rate and respiratory sinus arrhythmia. Medicine and Science in Sports and Exercise, 35, 1287-1295. doi: 10.1249/01.MSS.0000079073.20399.11
16. de Geus, E. J., Kupper, N., Boomsma, D. I., & Snieder, H. (2007). Bivariate genetic modeling of cardiovascular stress reactivity: Does stress uncover genetic variance? Psychosomatic Medicine, 69, 356-364. doi: 10.1097/PSY.0b013e318049cc2d
17. de Geus, E. J., Willemsen, G. H., Klaver, C. H., & van Doornen, L. J. (1995). Ambulatory measurement of respiratory sinus arrhythmia and respiration rate. Biological Psychology, 41, 205-227. doi: 10.1016/0301-0511(95)05137-6
18. de Geus, E. J. C., & van Doornen, L. J. P. (1996). Ambulatory assessment of parasympathetic/sympathetic balance by impedance cardiography. In J. Fahrenberg & M. Myrtek (Eds.), Ambulatory assessment: Computer-assisted psychological and psychophysiological methods in monitoring and field studies (pp. 141-163). Gottingen, Germany: Hogrefe & Huber.
19. De Meersman, R. E., & Stein, P. K. (2007). Vagal modulation and aging. Biological Psychology, 74, 165-173. doi: 10.1016/j.biopsycho.2006.04.008
20. Dekker, J. M., Crow, R. S., Folsom, A. R., Hannan, P. J., Liao, D., Swenne, C. A., Schouten, E. G. (2000). Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: The ARIC Study. Atherosclerosis Risk in Communities. Circulation, 102, 1239-1244. doi: 10.1161/01.CIR.102.11.1239
21. Dekker, J. M., Schouten, E. G., Klootwijk, P., Pool, J., Swenne, C. A., & Kromhout, D. (1997). Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. American Journal of Epidemiology, 145, 899-908. doi: 10.1093/oxfordjournals.aje.a009049
22. Eckberg, D. L. (2003). The human respiratory gate. Journal of Physiology, 548, 339-352. doi: 10.1113/jphysiol.2002.037192
23. Goedhart, A. D., Kupper, N., Willemsen, G., Boomsma, D. I., & de Geus, E. J. (2006). Temporal stability of ambulatory stroke volume and cardiac output measured by impedance cardiography. Biological Psychology, 72, 110-117. doi: 10.1016/j.biopsycho.2005.08.004
24. Goedhart, A. D., van der Sluis, S., Houtveen, J. H., Willemsen, G., & de Geus, E. J. (2007). Comparison of time and frequency domain measures of RSA in ambulatory recordings. Psychophysiology, 44, 203-215. doi: 10.1111/j.1469-8986.2006.00490.x
25. Goldberger, J. J., Challapalli, S., Tung, R., Parker, M. A., & Kadish, A. H. (2001). Relationship of heart rate variability to parasympathetic effect. Circulation, 103, 1977-1983. doi: 10.1161/01.CIR.103.15.1977
26. Grossman, P., & Kollai, M. (1993). Respiratory sinus arrhythmia, cardiac vagal tone, and respiration: Within- and between-individual relations. Psychophysiology, 30, 486-495. doi: 10.1111/j.1469-8986.1993.tb02072.x
27. Grossman, P., van Beek, J., & Wientjes, C. (1990). A comparison of three quantification methods for estimation of respiratory sinus arrhythmia. Psychophysiology, 27, 702-714. doi: 10.1111/j.1469-8986.1990.tb03198.x
28. Grossman, P., & Wientjes, K. (1986). Respiratory sinus arrythmia and parasympathetic cardiac control: Some basic issues concerning quantification, applications and implications. In R. Grossman, K. H. L. Janssen, & D. Vital (Eds.), Cardiorespiratory and cardiosomatic psychophysiology (pp. 117-138). New York, NY: Plenum Press. doi: 10.1007/978-1-4757-0360-3_8
29. Grossman, P., Wilhelm, F. H., & Spoerle, M. (2004). Respiratory sinus arrhythmia, cardiac vagal control, and daily activity. American Journal of Physiology, Heart and Circulatory Physiology, 287, H728-H734. doi: 10.1152/ajpheart.00825.2003
30. Hohnloser, S. H., Klingenheben, T., Zabel, M., Schroder, F., & Just, H. (1992). Intraindividual reproducibility of heart rate variability. Pacing and Clinical Electrophysiology, 15, 2211-2214. doi: 10.1111/j.1540-8159.1992.tb03049.x
31. Houtveen, J. H., Groot, P. F., & de Geus, E. J. (2005). Effects of variation in posture and respiration on RSA and pre-ejection period. Psychophysiology, 42, 713-719. doi: 10.1111/j.1469-8986.2005.00363.x
32. Katona, P. G., & Jih, F. (1975). Respiratory sinus arrhythmia: Noninvasive measure of parasympathetic cardiac control. Journal of Applied Physiology, 39, 801-805.
33. Kleiger, R. E., Bigger, J. T., Bosner, M. S., Chung, M. K., Cook, J. R., Rolnitzky, L. M., Fleiss, J. L. (1991). Stability over time of variables measuring heart rate variability in normal subjects. American Journal of Cardiology, 68, 626-630. doi: 10.1016/0002-9149(91)90355-O
34. Kleiger, R. E., Miller, J. P., Bigger, J. T., Jr., & Moss, A. J. (1987). Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. American Journal of Cardiology, 59, 256-262. doi: 10.1016/0002-9149(87)90795-8
35. Kupper, N., Willemsen, G., Posthuma, D., de Boer, D., Boomsma, D. I., & de Geus, E. J. (2005). A genetic analysis of ambulatory cardiorespiratory coupling. Psychophysiology, 42, 202-212. doi: 10.1111/j.1469-8986.2005.00276.x
36. Kupper, N. H., Willemsen, G., van den Berg, M., de Boer, D., Posthuma, D., Boomsma, D. I., de Geus, E. J. C. (2004). Heritability of ambulatory heart rate variability. Circulation, 110, 2792-2796. doi: 10.1161/01.CIR.0000146334.96820.6E
37. La Rovere, M. T., Pinna, G. D., Hohnloser, S. H., Marcus, F. I., Mortara, A., Nohara, R., Schwartz, P. J. (2001). Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: Implications for clinical trials. Circulation, 103, 2072-2077. doi: 10.1161/01.CIR.103.16.2072
38. Malik, M., & Camm, A. J. (1993). Components of heart rate variability-What they really mean and what we really measure. American Journal of Cardiology, 72, 821-822. doi: 10.1016/0002-9149(93)91070-X
39. Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., Visscher, P. M. (2009). Finding the missing heritability of complex diseases. Nature, 461, 747-753. doi: 10.1038/nature08494
40. Martinmaki, K., Rusko, H., Kooistra, L., Kettunen, J., & Saalasti, S. (2006). Intraindividual validation of heart rate variability indexes to measure vagal effects on hearts. American Journal of Physiology, Heart and Circulatory Physiology, 290, H640-H647. doi: 10.1152/ajpheart.00054.2005
41. McNarry, M. A., & Lewis, M. J. (2012). Interaction between age and aerobic fitness in determining heart rate dynamics. Physiological Measurement, 33, 901-914. doi: 10.1088/0967-3334/33/6/901
42. Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2006). Mx: Statistical Modeling (7th ed.) Richmond, VA: VCU.
43. Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-94-015-8018-2
44. Neumann, S. A., Tingley, W. G., Conklin, B. R., Shrader, C. J., Peet, E., Muldoon, M. F., Manuck, S. B.(2009). AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans. Psychophysiology, 46, 466-472. doi: 10.1111/j.1469-8986.2009.00802.x
45. Newton-Cheh, C., Guo, C. Y., Wang, T. J., O'Donnell, C. J., Levy, D., & Larson, M. G. (2007). Genome-wide association study of electrocardiographic and heart rate variability traits: The Framingham Heart Study [Supplement 1]. BMC Medical Genetics, 8, S1-S7. doi: 10.1186/1471-2350-8-S1-S7
46. Nolte, I., Tragante do Ó, V., Whitsel, E., Penninx, B. W., Oldehinkel, A., Bis, J., de Geus, E. J. C. (2011). Meta-analysis of genome wide association studies on heart rate variability. Behavior Genetics, 41, 927.
47. Pitzalis, M. V., Mastropasqua, F., Massari, F., Forleo, C., Di, M. M., Passantino, A., Rizzon, P. (1996). Short- and long-term reproducibility of time and frequency domain heart rate variability measurements in normal subjects. Cardiovascular Research, 32, 226-233. doi: 10.1016/0008-6363(96)00086-7
48. Quilliot, D., Fluckiger, L., Zannad, F., Drouin, P., & Ziegler, O. (2001). Impaired autonomic control of heart rate and blood pressure in obesity: Role of age and of insulin-resistance. Clinical Autonomic Research, 11, 79-86. doi: 10.1007/BF02322050
49. Rekling, J. C., & Feldman, J. L. (1998). PreBotzinger complex and pacemaker neurons: Hypothesized site and kernel for respiratory rhythm generation. Annual Review of Physiology, 60, 385-405. doi: 10.1146/annurev.physiol.60.1.385
50. Riese, H., Groot, P. F., van den Berg, M., Kupper, N. H., Magnee, E. H., Rohaan, E. J., de Geus, E. J. (2003). Large-scale ensemble averaging of ambulatory impedance cardiograms. Behavior Research Methods, Instruments, and Computers, 35, 467-477. doi: 10.3758/BF03195525
51. Riese, H., Rijsdijk, F. V., Ormel, J., van Roon, A. M., Neeleman, J., & Rosmalen, J. G. (2006). Genetic influences on baroreflex sensitivity during rest and mental stress. Journal of Hypertension, 24, 1779-1786. doi: 10.1097/01.hjh.0000242402.83709.27
52. Riese, H., Rosmalen, J. G., Ormel, J., van Roon, A. M., Oldehinkel, A. J., & Rijsdijk, F. V. (2007). The genetic relationship between neuroticism and autonomic function in female twins. Psychological Medicine, 37, 257-267. doi: 10.1017/S0033291706009160
53. Ritz, T., & Dahme, B. (2006). Implementation and interpretation of respiratory sinus arrhythmia measures in psychosomatic medicine: Practice against better evidence? Psychosomatic Medicine, 68, 617-627. doi: 10.1097/01.psy.0000228010.96408.ed
54. Sacknoff, D. M., Gleim, G. W., Stachenfeld, N., & Coplan, N. L. (1994). Effect of athletic training on heart rate variability. American Heart Journal, 127, 1275-1278. doi: 10.1016/0002-8703(94)90046-9
55. Schwartz, P. J., Billman, G. E., & Stone, H. L. (1984). Autonomic mechanisms in ventricular fibrillation induced by myocardial ischemia during exercise in dogs with healed myocardial infarction. An experimental preparation for sudden cardiac death. Circulation, 69, 790-800. doi: 10.1161/01.CIR.69.4.790
56. Schwartz, P. J., Vanoli, E., Stramba-Badiale, M., De Ferrari, G. M., Billman, G. E., & Foreman, R. D. (1988). Autonomic mechanisms and sudden death. New insights from analysis of baroreceptor reflexes in conscious dogs with and without a myocardial infarction. Circulation, 78, 969-979. doi: 10.1161/01.CIR.78.4.969
57. Singer, D. H., Martin, G. J., Magid, N., Weiss, J. S., Schaad, J. W., Kehoe, R., Lesch, M. (1988). Low heart rate variability and sudden cardiac death [Supplement]. Journal of Electrocardiology, 21, S46-S55. doi: 10.1016/0022-0736(88)90055-6
58. Sinnreich, R., Kark, J. D., Friedlander, Y., Sapoznikov, D., & Luria, M. H. (1998). Five minute recordings of heart rate variability for population studies: Repeatability and age-sex characteristics. Heart, 80, 156-162.
59. Snieder, H., Boomsma, D. I., van Doornen, L. J., & de Geus, E. J. (1997). Heritability of respiratory sinus arrhythmia: Dependency on task and respiration rate. Psychophysiology, 34, 317-328. doi: 10.1111/j.1469-8986.1997.tb02402.x
60. Stein, P. K., Rich, M. W., Rottman, J. N., & Kleiger, R. E. (1995). Stability of index of heart rate variability in patients with congestive heart failure. American Heart Journal, 129, 975-981. doi: 10.1016/0002-8703(95)90119-1
61. Su, S., Lampert, R., Lee, F., Bremner, J. D., Snieder, H., Jones, L., Vaccarino, V. (2010). Common genes contribute to depressive symptoms and heart rate variability: The Twins Heart Study. Twin Research and Human Genetics, 13, 1-9. doi: 10.1375/twin.13.1.1
62. Sullivan, P. F. (2007). Spurious genetic associations. Biological Psychiatry, 61, 1121-1126. doi: 10.1016/j.biopsych.2006.11.010
63. Tabor, H. K., Risch, N. J., & Myers, R. M. (2002). Candidate-gene approaches for studying complex genetic traits: Practical considerations. Nature Reviews Genetics, 3, 391-397. doi: 10.1038/nrg796
64. Tank, J., Jordan, J., Diedrich, A., Stoffels, M., Franke, G., Faulhaber, H. D., Busjahn, A. (2001). Genetic influences on baroreflex function in normal twins. Hypertension, 37, 907-910. doi: 10.1161/01.HYP.37.3.907
65. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. Circulation, 93, 1043-1065.
66. Tingley, W. G., Pawlikowska, L., Zaroff, J. G., Kim, T., Nguyen, T., Young, S. G.Conklin, B. R. (2007). Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proceedings of the National Academy of Sciences of the United States of America, 104, 8461-8466. doi: 10.1073/pnas.0610393104
67. Tsuji, H., Larson, M. G., Venditti, F. J., Jr., Manders, E. S., Evans, J. C., Feldman, C. L., Levy, D. (1996). Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation, 94, 2850-2855. doi: 10.1161/01.CIR.94.11.2850
68. Tuvblad, C., Isen, J., Baker, L. A., Raine, A., Lozano, D. I., & Jacobson, K. C. (2010). The genetic and environmental etiology of sympathetic and parasympathetic activity in children. Behavior Genetics, 40, 452-466. doi: 10.1007/s10519-010-9346-0
69. Umetani, K., Singer, D. H., McCraty, R., & Atkinson, M. (1998). Twenty-four hour time domain heart rate variability and heart rate: Relations to age and gender over nine decades. Journal of the American College of Cardiology, 31, 593-601. doi: 10.1016/S0735-1097(97)00554-8
70. Uusitalo, A. L., Vanninen, E., Levalahti, E., Battie, M. C., Videman, T., & Kaprio, J. (2007). Role of genetic and environmental influences on heart rate variability in middle-aged men. American Journal of Physiology, Heart and Circulatory Physiology, 293, H1013-H1022. doi: 10.1152/ajpheart.00475.2006
71. Valentini, M., & Parati, G. (2009). Variables influencing heart rate. Progress in Cardiovascular Diseases, 52, 11-19. doi: 10.1016/j.pcad.2009.05.004
72. Vallejo, M., Marquez, M. F., Borja-Aburto, V. H., Cardenas, M., & Hermosillo, A. G. (2005). Age, body mass index, and menstrual cycle influence young women's heart rate variability-A multivariable analysis. Clinical Autonomic Research, 15, 292-298. doi: 10.1007/s10286-005-0272-9
73. van Dijk, A. E., van Lien, R., van, Eijsden, M., Gemke, R. J., Vrijkotte, T. G., & de Geus, E. J. (2013). Measuring cardiac autonomic nervous system (ANS) activity in children. Journal of Visualized Experiments, 74, e50073. doi: 10.3791/50073
74. van Lien, R., Goedhart, A., Kupper, N., Boomsma, D., Willemsen, G., & de Geus, E. J. (2011). Underestimation of cardiac vagal control in regular exercisers by 24-hour heart rate variability recordings. International Journal of Psychophysiology, 81, 169-176. doi: 10.1016/j.ijpsycho.2011.06.007
75. Vikman, S., Makikallio, T. H., Yli-Mayry, S., Nurmi, M., Airaksinen, K. E., & Huikuri, H. V. (2003). Heart rate variability and recurrence of atrial fibrillation after electrical cardioversion. Annals of Medicine, 35, 36-42. doi: 10.1080/07853890310004110
76. Viola, A. U., James, L. M., Archer, S. N., & Dijk, D. J. (2008). PER3 polymorphism and cardiac autonomic control: Effects of sleep debt and circadian phase. American Journal of Physiology, Heart and Circulatory Physiology, 295, H2156-H2163. doi: 10.1152/ajpheart.00662.2008
77. Wang, X., Ding, X., Su, S., Li, Z., Riese, H., Thayer, J. F., Snieder, H. (2009). Genetic influences on heart rate variability at rest and during stress. Psychophysiology, 46, 458-465. doi: 10.1111/j.1469-8986.2009.00793.x
78. Wang, X., Thayer, J. F., Treiber, F., & Snieder, H. (2005). Ethnic differences and heritability of heart rate variability in African- and European American youth. American Journal of Cardiology, 96, 1166-1172. doi: 10.1016/j.amjcard.2005.06.050
79. Wilhelm, F. H., Roth, W. T., & Sackner, M. A. (2003). The lifeShirt. An advanced system for ambulatory measurement of respiratory and cardiac function. Behavior Modification, 27, 671-691. doi: 10.1177/0145445503256321
80. Willemsen, G., Vink, J. M., Abdellaoui, A., den, Braber, A., van Beek, J. H., Draisma, H. H., Boomsma, D. I. (2013). The adult Netherlands twin register: Twenty-five years of survey and biological data collection. Twin Research and Human Genetics, 16, 271-281. doi: 10.1017/thg.2012.140
81. Yang, A. C., Chen, T. J., Tsai, S. J., Hong, C. J., Kuo, C. H., Yang, C. H., Kao, K. P. (2010). BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 153B, 1024-1030. doi: 10.1002/ajmg.b.31069
82. Zanstra, Y. J., & Johnston, D. W. (2011). Cardiovascular reactivity in real life settings: Measurement, mechanisms and meaning. Biological Psychology, 86, 98-105. doi: 10.1016/j.biopsycho.2010.05.002
83. Zhang, L., Rao, F., Zhang, K., Khandrika, S., Das, M., Vaingankar, S. M., O'Connor, D. T. (2007). Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. Journal of Clinical Investigation, 117, 2658-2671. doi: 10.1172/JCI31093