BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 153, Issue 5, 2010, Pages 1024-1030

  Yang, Albert C ^a,b   Chen, Tai Jui ^c   Tsai, Shih Jen ^c,d   Hong, Chen Jee ^b,d   Kuo, Chung Hsun ^b   Yang, Cheng Hung ^b,d   Kao, Ko Pei ^a  

^a Chutung Veterans Hospital   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Autonomic nervous system; Brain derived neurotrophic factor; Heart rate variability

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CHINESE; CONTROLLED STUDY; FEMALE; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HEART RATE VARIABILITY; HUMAN; MALE; MOOD; NORMAL HUMAN; PARASYMPATHETIC FUNCTION; PERSONALITY; PRIORITY JOURNAL; SYMPATHETIC FUNCTION; VAGUS TONE; ADRENERGIC SYSTEM; AFFECT; AMINO ACID SUBSTITUTION; DEMOGRAPHY; GENETICS; HEALTH; HEART RATE; PERSONALITY TEST; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; VAGUS NERVE;

ADULT; AFFECT; AMINO ACID SUBSTITUTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEMOGRAPHY; FEMALE; GENOTYPE; HEALTH; HEART RATE; HUMANS; MALE; METHIONINE; PERSONALITY; PERSONALITY TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; SYMPATHETIC NERVOUS SYSTEM; VAGUS NERVE; VALINE;

EID: 77954369069     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31069     Document Type: Article

References (44)

1. Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ. 1981. Power spectrum analysis of heart rate fluctuation: A quantitative probe of beat-to-beat cardiovascular control. Science 213(4504):220-222. (Pubitemid 11060568)
2. Berntson GG, Bigger JT Jr, Eckberg DL, Grossman P, Kaufmann PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, et al. 1997. Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology 34(6):623-648.
3. Bornas X, Llabres J, Noguera M, Lopez AM, Barcelo F, Tortella-Feliu M, Fullana MA. 2005. Looking at the heart of low and high heart rate variability fearful flyers: Self-reported anxiety when confronting feared stimuli. Biol Psychol 70(3):182-187.
4. Burgess A, Aubert I. 2006. Polysialic acid limits choline acetyltransferase activity induced by brain-derived neurotrophic factor. J Neurochem 99(3):797-806.
5. Camm AJ, Pratt CM, Schwartz PJ, Al-Khalidi HR, Spyt MJ, Holroyde MJ, Karam R, Sonnenblick EH, Brum JM. 2004. Mortality in patients after a recent myocardial infarction: A randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification. Circulation 109(8):990-996.
6. Carney RM, Freedland KE, Stein PK. 2000. Anxiety, depression, and heart rate variability. Psychosom Med 62(1):84-87.
7. Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, Kuchel G, Miller FD. 1997. Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18(2):257-267.
8. Chaldakov GN, Fiore M, Stankulov IS, Manni L, Hristova MG, Antonelli A, Ghenev PI, Aloe L. 2004. Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: A role for NGF and BDNF in cardiovascular disease? Prog Brain Res 146:279-289.
9. Chen WJ, Chen HM, Chen CC, Chen CC, Yu WY, Cheng AT. 2002. Cloninger's Tridimensional Personality Questionnaire: Psychometric properties and construct validity in Taiwanese adults. Compr Psychiatry 43(2):158-166.
10. Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, et al. 2006. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314(5796): 140-143.
11. Cloninger CR. 1987. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 44(6):573-588.
12. Deng YS, Zhong JH, Zhou XF. 2000. BDNF is involved in sympathetic sprouting in the dorsal root ganglia following peripheral nerve injury in rats. Neurotox Res 1(4):311-322.
13. Dishman RK, Nakamura Y, Garcia ME, Thompson RW, Dunn AL, Blair SN. 2000. Heart rate variability, trait anxiety, and perceived stress among physically fit men and women. Int J Psychophysiol 37(2):121-133.
14. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, et al. 2003. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112(2):257-269.
15. Fei L, Copie X, Malik M, Camm AJ. 1996. Short- and long-term assessment of heart rate variability for risk stratification after acute myocardial infarction. Am J Cardiol 77(9):681-684. (Pubitemid 26116680)
16. Friedman BH, Thayer JF. 1998. Autonomic balance revisited: Panic anxiety and heart rate variability. J Psychosom Res 44(1):133-151.
17. Frustaci A, Pozzi G, Gianfagna F, Manzoli L, Boccia S. 2008. Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. Neuropsychobiology 58(3-4):163-170.
18. Goldberger AL, Amaral LA, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE. 2000. PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals. Circulation 101(23):E215-E220.
19. Goldberger JJ, Challapalli S, Tung R, Parker MA, Kadish AH. 2001. Relationship of heart rate variability to parasympathetic effect. Circulation 103(15):1977-1983. (Pubitemid 32322226)
20. Gorman JM, Sloan RP. 2000. Heart rate variability in depressive and anxiety disorders. Am Heart J 140:77-83.
21. Jiang X, Xu K, Hoberman J, Tian F, Marko AJ, Waheed JF, Harris CR, Marini AM, Enoch MA, Lipsky RH. 2005. BDNF variation and mood disorders:Anovel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30(7):1353-1361.
22. Kasselman LJ, Sideris A, Bruno C, Perez WR, Cai N, Nicoletti JN, Wiegand SJ, Croll SD. 2006. BDNF: A missing link between sympathetic dysfunction and inflammatory disease? J Neuroimmunol 175(1-2):118-127.
23. Katona PG, Jih F. 1975. Respiratory sinus arrhythmia: Noninvasive measure of parasympathetic cardiac control. J Appl Physiol 39(5):801-805.
24. Kleiger RE, Stein PK, Bigger JT Jr. 2005. Heart rate variability: Measurement and clinical utility. Ann Noninvasive Electrocardiol 10(1):88-101.
25. Liu Y, Sun L, Huan Y, Zhao H, Deng J. 2006. Application of bFGF and BDNF to improve angiogenesis and cardiac function. J Surg Res 136(1): 85-91.
26. Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM, Yancopoulos GD. 1990. NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression. Neuron 5(4):501-509.
27. Malliani A, Lombardi F, Pagani M. 1994. Power spectrum analysis of heart rate variability: Atool to explore neural regulatory mechanisms. Br Heart J 71(1):1-2. (Pubitemid 24061000)
28. Martinowich K, Manji H, Lu B. 2007. New insights into BDNF function in depression and anxiety. Nat Neurosci 10(9):1089-1093.
29. Mellman TA, Knorr BR, Pigeon WR, Leiter JC, Akay M. 2004. Heart rate variability during sleep and the early development of posttraumatic stress disorder. Biol Psychiatry 55(9):953-956.
30. Mietus JE, Peng CK, Henry I, Goldsmith RL, Goldberger AL. 2002. The pNNx files: Re-examining a widely used heart rate variability measure. Heart 88(4):378-380.
31. Miu AC, Heilman RM, Miclea M. 2009. Reduced heart rate variability and vagal tone in anxiety: Trait versus state, and the effects of autogenic training. Auton Neurosci. 145(1):99-103.
32. Mujica-Parodi LR, Korgaonkar M, Ravindranath B, Greenberg T, Tomasi D, Wagshul M, Ardekani B, Guilfoyle D, Khan S, Zhong Y, et al. 2009. Limbic dysregulation is associated with lowered heart rate variability and increased trait anxiety in healthy adults. Hum Brain Mapp 30(1):47-58.
33. Passik SD, Lundberg JC, Rosenfeld B, Kirsh KL, Donaghy K, Theobald D, Lundberg E, Dugan W. 2000. Factor analysis of the Zung Self-Rating Depression Scale in a large ambulatory oncology sample. Psychosomatics 41(2):121-127.
34. Pomeranz B, Macaulay RJ, Caudill MA, Kutz I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ, et al. 1985. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol 248:H151-H153. (Pubitemid 15170666)
35. Shinba T, Kariya N, Matsui Y, Ozawa N, Matsuda Y, Yamamoto K. 2008. Decrease in heart rate variability response to task is related to anxiety and depressiveness in normal subjects. Psychiatry Clin Neurosci 62(5): 603-609.
36. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Evans JC, Levy D. 1999. Heritability of heart rate variability: The Framingham Heart Study. Circulation 99(17):2251-2254. (Pubitemid 29201130)
37. Slonimsky JD, Yang B, Hinterneder JM, Nokes EB, Birren SJ. 2003. BDNF and CNTF regulate cholinergic properties of sympathetic neurons through independent mechanisms. Mol Cell Neurosci 23(4):648-660.
38. Task-Force. 1996. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Circulation 93(5):1043-1065.
39. Taylor JA, Carr DL, Myers CW, Eckberg DL. 1998. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation 98(6):547-555.
40. Tsai SJ, Hong CJ, Yu YW, Chen TJ. 2004. Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females. Neuropsychobiology 49(1):13-16.
41. Tsuji H, Larson MG, Venditti FJ Jr, Manders ES, Evans JC, Feldman CL, Levy D. 1996. Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 94(11): 2850-2855.
42. Tuszynski MH, Gage FH. 1994. Neurotrophic factors and diseases of the nervous system. Ann Neurol 35(Suppl): S9-S12.
43. Zhou X, Nai Q, Chen M, Dittus JD, Howard MJ, Margiotta JF. 2004. Brain-derived neurotrophic factor and trkB signaling in parasympathetic neurons: Relevance to regulating alpha7-containing nicotinic receptors and synaptic function. J Neurosci 24(18):4340-4350.
44. Zung WW. 1965. A Self-Rating Depression Scale. Arch Gen Psychiatry 12:63-70.