Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 20, 2007, Pages 8461-8466

  Tingley, Whittemore G ^a,c,g   Pawlikowska, Ludmila ^b   Zaroff, Jonathan G ^c   Kim, Taeryn ^a   Nguyen, Trieu ^a   Young, Stephen G ^d   Vranizan, Karen ^a,e   Kwok, Pui Yan ^b   Whooley, Mary A ^c,f   Conklin, Bruce R ^a,c  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g CardioDx Inc   (United States)

Author keywords

G protein; Receptor; Signaling

Indexed keywords

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE; CONTROLLED STUDY; EMBRYONIC STEM CELL; FEMALE; GENE; GENE AKAP10; GENE DISRUPTION; GENE MUTATION; GENETIC REGULATION; HEART ARRHYTHMIA; HEART DEATH; HEART MUSCLE CELL; HEART RATE VARIABILITY; HEART RHYTHM; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN GENETICS; MAJOR CLINICAL STUDY; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SUDDEN DEATH; VAGUS NERVE; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG EFFECT; GENETICS; GENOTYPE; HEART RATE; MEDICAL GENETICS; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL;

MUS;

AKAP10 PROTEIN, HUMAN; AKAP10 PROTEIN, MOUSE; CHOLINERGIC RECEPTOR STIMULATING AGENT; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UNCLASSIFIED DRUG;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CHOLINERGIC AGONISTS; EMBRYONIC STEM CELLS; FEMALE; GENETICS, MEDICAL; GENOTYPE; HEART RATE; HUMANS; MALE; MICE; MICE, MUTANT STRAINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; MYOCYTES, CARDIAC; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; VAGUS NERVE;

EID: 34347263788     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610393104     Document Type: Article

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