Role of genetic and environmental influences on heart rate variability in middle-aged men

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 2, 2007, Pages

  Uusitalo, A L T ^a,e   Vanninen, E ^a   Levalahti E ^b,c   Battie M C ^d   Videman, T ^d   Kaprio, J ^b,c  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF ALBERTA   (Canada)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Autonomic function; Coffee; Heredity; Physical activity; Smoking; Twins

Indexed keywords

ADULT; AGED; ARTICLE; BEHAVIOR; BODY FAT; BODY MASS; CHRONIC DISEASE; COFFEE; CONTROLLED STUDY; DIZYGOTIC TWINS; ELECTROCARDIOGRAM; ENVIRONMENTAL FACTOR; HEALTH STATUS; HEART RATE VARIABILITY; HEREDITY; HUMAN; INTERVIEW; LEISURE; LIFESPAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MONOZYGOTIC TWINS; MULTIVARIATE ANALYSIS; OCCUPATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SMOKING; SPORT; STATISTICAL ANALYSIS; SUPINE POSITION; UNIVARIATE ANALYSIS;

ADULT; AGE FACTORS; AGED; AGING; AUTONOMIC NERVOUS SYSTEM; BODY COMPOSITION; BODY MASS INDEX; COFFEE; COHORT STUDIES; DISEASES IN TWINS; DRUG THERAPY; ELECTROCARDIOGRAPHY; HEALTH STATUS INDICATORS; HEART; HEART RATE; HUMANS; LIFE STYLE; MALE; MIDDLE AGED; MODELS, GENETIC; QUESTIONNAIRES; SMOKING; TWIN STUDIES; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; VARIATION (GENETICS);

EID: 34547913801     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00475.2006     Document Type: Article

References (62)

1. Agelink MW, Malessa R, Baumann B, Majewski T, Akila F, Zeit T, Ziegler D. Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate. Clin Auton Res 11: 99-108, 2001.
2. Antelmi I, de Paula RS, Shinzato AR, Peres CA, Mansur AJ, Grupi CJ. Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease. Am J Cardiol 93: 381-385, 2004.
3. Aronson D, Burger AJ. Effect of β-blockade on heart rate variability in decompensated heart failure. Int J Cardiol 79: 31-39, 2001.
4. Badilini F, Maison-Blanche P, Champomier P, Provost JC, Coumel P, Milon H. Frequency-domain heart rate variability in 24-hour Holter recordings: role of spectral method to assess circadian patterns and pharmacological autonomic modulation. J Electrocardiol 33: 147-157, 2000.
5. Battie MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K. 1995 Volvo Award in Clinical Sciences. Determinants of lumbar disc degeneration: a study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 20: 2601-2612, 1995.
6. Boomsma DI, van Baal GC, Orlebeke JF. Genetic influences on respiratory sinus arrhythmia across different task conditions. Acta Genet Med Gemellol (Roma) 39: 181-191, 1990.
7. Busjahn A, Voss A, Knoblauch H, Knoblauch M, Jeschke E, Wessel N, Bohlender J, McCarron J, Faulhaber HD, Schuster H, Dietz R, Luft FC. Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins. Am J Cardiol 81: 755-760, 1998.
8. Carney RM, Freedland KE, Veith RC. Depression, the autonomic nervous system, and coronary heart disease. Psychosom Med 67 Suppl 1: S29-S33, 2005.
9. Cohen H, Loewenthal U, Matar M, Kotler M. Association of autonomic dysfunction and clozapine. Heart rate variability and risk for sudden death in patients with schizophrenia on long-term psychotropic medication. Br J Psychiatry 179: 167-171, 2001.
10. Corrada MM, Kawas CH, Mozaffar F, Paganini-Hill A. Association of body mass index and weight change with all-cause mortality in the elderly. Am J Epidemiol 163: 938-949, 2006.
11. De Geus EJ, Boomsma DI, Snieder H. Genetic correlation of exercise with heart rate and respiratory sinus arrhythmia. Med Sci Sports Exerc 35: 1287-1295, 2003.
12. Fagard RH, Pardaens K, Staessen JA. Influence of demographic, anthropometric and lifestyle characteristics on heart rate and its variability in the population. J Hypertens 17: 1589-1599, 1999.
13. Gerhardt U, Vorneweg P, Riedasch M, Hohage H. Acute and persistent effects of smoking on the baroreceptor function. J Auton Pharmacol 19: 105-108, 1999.
14. Gottsater A, Ahlgren AR, Taimour S, Sundkvist G. Decreased heart rate variability may predict the progression of carotid atherosclerosis in type 2 diabetes. Clin Auton Res 16: 228-234, 2006.
15. Gutin B, Barbeau P, Litaker MS, Ferguson M, Owens S. Heart rate variability in obese children: relations to total body and visceral adiposity, and changes with physical training and detraining. Obes Res 8: 12-19, 2000.
16. Jartti TT, Tahvanainen KU, Kaila TJ, Kuusela TA, Koivikko AS, Vanto TT, Valimaki IA. Cardiovascular autonomic regulation in asthmatic children evidenced by spectral analysis of heart rate and blood pressure variability. Scand J Clin Lab Invest 56: 545-554, 1996.
17. Kaprio J, Koskenvuo M. Genetic and environmental factors in complex diseases: the older Finnish Twin Cohort. Twin Res 5: 358-365, 2002.
18. Karpansalo M, Manninen P, Lakka TA, Kauhanen J, Rauramaa R, Salonen JT. Physical workload and risk of early retirement: prospective population-based study among middle-aged men. J Occup Environ Med 44: 930-939, 2002.
19. Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 59: 256-262, 1987.
20. Kop WJ, Verdino RJ, Gottdiener JS, O'Leary ST, Bairey Merz CN, Krantz DS. Changes in heart rate and heart rate variability before ambulatory ischemic events. J Am Coll Cardiol 38: 742-749, 2001.
21. Kupper NH, Willemsen G, van den Berg M, de Boer D, Posthuma D, Boomsma DI, de Geus EJ. Heritability of ambulatory heart rate variability. Circulation 110: 2792-2796, 2004.
22. Laaksonen DE, Laitinen T, Schonberg J, Rissanen A, Niskanen LK. Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome. J Hypertens 21: 371-378, 2003.
23. Lane JD, Manus DC. Persistent cardiovascular effects with repeated caffeine administration. Psychosom Med 51: 373-380, 1989.
24. Lee YC, Wang HP, Lin LY, Lee BC, Chiu HM, Wu MS, Chen MF, Lin JT. Heart rate variability in patients with different manifestations of gastroesophageal reflux disease. Auton Neurosci 116: 39-45, 2004.
25. Levy WC, Cerqueira MD, Harp GD, Johannessen KA, Abrass IB, Schwartz RS, Stratton JR. Effect of endurance exercise training on heart rate variability at rest in healthy young and older men. Am J Cardiol 82: 1236-1241, 1998.
26. Liao D, Sloan RP, Cascio WE, Folsom AR, Liese AD, Evans GW, Cai J, Sharrett AR. Multiple metabolic syndrome is associated with lower heart rate variability. The Atherosclerosis Risk in Communities Study. Diabetes Care 21: 2116-2122, 1998.
27. Loos RJ, Katzmarzyk PT, Rao DC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rankinen T, Bouchard C. Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study. J Clin Endocrinol Metab 88: 5935-5943, 2003.
28. Mac Neale LR. Methodology of Genetic Studies of Twins and Families. Dordrecht: Kluwer Academic, 1992.
29. Neale M. Mx: Statistical Modelling (Computer Program and Manual). Richmond, VA: Medical College of Virginia, Department of Psychiatry, 1999.
30. Perciaccante A, Fiorentini A, Paris A, Serra P, Tubani L. Circadian rhythm of the autonomic nervous system in insulin resistant subjects with normoglycemia, impaired fasting glycemia, impaired glucose tolerance, type 2 diabetes mellitus. BMC Cardiovasc Disord 6: 19, 2006.
31. Perini R, Fisher N, Veicsteinas A, Pendergast DR. Aerobic training and cardiovascular responses at rest and during exercise in older men and women. Med Sci Sports Exerc 34: 700-708, 2002.
32. Piccirillo G, Vetta F, Viola E, Santagada E, Ronzoni S, Cacciafesta M, Marigliano V. Heart rate and blood pressure variability in obese normotensive subjects. Int J Obes Relat Metab Disord 22: 741-750, 1998.
33. Pierratos A, McFarlane P, Chan CT, Kwok S, Nesrallah G. Daily hemodialysis 2006. State of the art. Minerva Urol Nefrol 58: 99-115, 2006.
34. Poirier P, Hernandez TL, Weil KM, Shepard TJ, Eckel RH. Impact of diet-induced weight loss on the cardiac autonomic nervous system in severe obesity. Obes Res 11: 1040-1047, 2003.
35. Pope CA 3rd, Eatough DJ, Gold DR, Pang Y, Nielsen KR, Nath P, Verrier RL, Kanner RE. Acute exposure to environmental tobacco smoke and heart rate variability. Environ Health Perspect 109: 711-716, 2001.
36. Quilliot D, Fluckiger L, Zannad F, Drouin P, Ziegler O. Impaired autonomic control of heart rate and blood pressure in obesity: role of age and of insulin-resistance. Clin Auton Res 11: 79-86, 2001.
37. Ropponen A, Levalahti E, Simonen R, Videman T, Battie MC. Repeatability of lifetime exercise reporting. Scand J Med Sci Sports 11: 185-192, 2001.
38. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 115: 3579-3586, 2005.
39. Sarna S, Kaprio J, Sistonen P, Koskenvuo M. Diagnosis of twin zygosity by mailed questionnaire. Hum Hered 28: 241-254, 1978.
40. Schuit AJ, van Amelsvoort LG, Verheij TC, Rijneke RD, Maan AC, Swenne CA, Schouten EG. Exercise training and heart rate variability in older people. Med Sci Sports Exerc 31: 816-821, 1999.
41. 3-adrenergic receptor and autonomic nervous system activity. J Clin Endocrinol Metab 84: 1623-1627, 1999.
42. Simonen R, Levalahti E, Kaprio J, Videman T, Battie MC. Multivariate genetic analysis of lifetime exercise and environmental factors. Med Sci Sports Exerc 36: 1559-1566, 2004.
43. Singh JP, Larson MG, O'Donnell CJ, Levy D. Genetic factors contribute to the variance in frequency domain measures of heart rate variability. Auton Neurosci 90: 122-126, 2001.
44. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Corey D, Levy D. Genome scan linkage results for heart rate variability (the Framingham Heart Study). Am J Cardiol 90: 1290-1293, 2002.
45. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Evans JC, Levy D. Heritability of heart rate variability: the Framingham Heart Study. Circulation 99: 2251-2254, 1999.
46. Sinnreich R, Friedlander Y, Luria MH, Sapoznikov D, Kark JD. Inheritance of heart rate variability: the Kibbutzim Family Study. Hum Genet 105: 654-661, 1999.
47. Sinnreich R, Friedlander Y, Sapoznikov D, Kark JD. Familial aggregation of heart rate variability based on short recordings: the Kibbutzim Family Study. Hum Genet 103: 34-40, 1998.
48. 2B-adrenergic receptor gene and autonomic nervous function in central obesity. Obes Res 11: 962-970, 2003.
49. Snieder H, Boomsma DI, Van Doornen LJ, De Geus EJ. Heritability of respiratory sinus arrhythmia: dependency on task and respiration rate. Psychophysiology 34: 317-328, 1997.
50. Sondermeijer HP, van Marle AG, Kamen P, Krum H. Acute effects of caffeine on heart rate variability. Am J Cardiol 90: 906-907, 2002.
51. Stein PK, Ehsani AA, Domitrovich PP, Kleiger RE, Rottman JN. Effect of exercise training on heart rate variability in healthy older adults. Am Heart J 138: 567-576, 1999.
52. Stein PK, Kleiger RE, Rottman JN. Differing effects of age on heart rate variability in men and women. Am J Cardiol 80: 302-305, 1997.
53. 1R influences heart rate variability conditional on sodium excretion. Hypertension 44: 156-162, 2004.
54. Task Force of the European Society of Cardiology, and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 17: 354-381, 1996.
55. Tsuji H, Venditti FJ Jr, Manders ES, Evans JC, Larson MG, Feldman CL, Levy D. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 90: 878-883, 1994.
56. Tulppo MP, Hautala AJ, Makikallio TH, Laukkanen RT, Nissila S, Hughson RL, Huikuri HV. Effects of aerobic training on heart rate dynamics in sedentary subjects. J Appl Physiol 95: 364-372, 2003.
57. Umetani K, Singer DH, McCraty R, Atkinson M. Twenty-four-hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol 31: 593-601, 1998.
58. Uusitalo AL, Laitinen T, Vaisanen SB, Lansimies E, Rauramaa R. Effects of endurance training on heart rate and blood pressure variability. Clin Physiol Funct Imaging 22: 173-179, 2002.
59. Uusitalo AL, Laitinen T, Vaisanen SB, Lansimies E, Rauramaa R. Physical training and heart rate and blood pressure variability: a 5-yr randomized trial. Am J Physiol Heart Circ Physiol 286: H1821-H1826, 2004.
60. Vallejo M, Marquez MF, Borja-Aburto VH, Cardenas M, Hermosillo AG. Age, body mass index, and menstrual cycle influence young women's heart rate variability - a multivariable analysis. Clin Auton Res 15: 292-298, 2005.
61. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care 26: 1553-1579, 2003.
62. Voss A, Busjahn A, Wessel N, Schurath R, Faulhaber HD, Luft FC, Dietz R. Familial and genetic influences on heart rate variability. J Electrocardiol 29 Suppl: 154-160, 1996.