Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor

PLoS Computational Biology

Volumn 10, Issue 7, 2014, Pages

  Arkhipov, Anton ^a   Shan, Yibing ^a   Kim, Eric T ^a   Shaw, David E ^a,b  

^a D E SHAW RESEARCH   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; CELL PROLIFERATION; CELL SIGNALING; DIMERIZATION; ENZYME ACTIVITY; LIGANDS; MOLECULAR DYNAMICS;

BINDING-SITES; BOUND LIGANDS; CELL DIFFERENTIATION; CELL MIGRATION; COOPERATIVITY; EPIDERMAL GROWTH FACTOR RECEPTORS; EXTRACELLULAR LIGANDS; LIGAND BINDING; MEMBRANE INTERACTIONS; RECEPTOR SIGNALING;

DIMERS;

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROPHOBICITY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LIGAND BINDING; MEMBRANE BINDING; MOLECULAR DYNAMICS; PROTEIN GLYCOSYLATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIMULATION; ANIMAL; BIOLOGY; CELL MEMBRANE; CHEMISTRY; CHICKEN; MAMMAL; METABOLISM; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; ZEBRA FISH;

ANIMALS; BINDING SITES; CELL MEMBRANE; CHICKENS; COMPUTATIONAL BIOLOGY; LIGANDS; MAMMALS; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; ZEBRAFISH;

EID: 84905460438     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003742     Document Type: Article

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