Nanoporous polyelectrolyte vaccine microcarriers. A formulation platform for enhancing humoral and cellular immune responses

Journal of Controlled Release

Volumn 195, Issue , 2014, Pages 99-109

  De Koker, Stefaan ^a   Fierens, Kaat ^a,b   Dierendonck, Marijke ^a   De Rycke, Riet ^a   Lambrecht, Bart N ^a,b   Grooten, Johan ^a   Remon, Jean Paul ^a   De Geest, Bruno G ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Antigens; Microparticles; Polyelectrolytes; Spray drying; Vaccines

Indexed keywords

ANTIGENS; POLYELECTROLYTES; POLYOLS; SPRAY DRYING; VACCINES;

BIOLOGICAL EVALUATION; DILUTE AQUEOUS SOLUTION; ENCAPSULATED PROTEINS; INTRACELLULAR PATHOGENS; MICRO-PARTICLES; MICROPARTICULATE VACCINES; NANOPOROUS POLYELECTROLYTES; OPPOSITELY CHARGED POLYELECTROLYTES;

IMMUNE SYSTEM;

DEXTRAN SULFATE; MANNITOL; NANOCARRIER; NANOPOROUS POLYELECTROLYTE MICROPARTICLE; OVALBUMIN; POLYARGININE; POLYELECTROLYTE; UNCLASSIFIED DRUG; DRUG CARRIER; PEPTIDE; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS PRESENTATION; DENDRITIC CELL; DISPERSION; HUMORAL IMMUNITY; IMMUNOBIOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LEACHING; MOUSE; NONHUMAN; PROCESS OPTIMIZATION; PROTEIN PROCESSING; SPRAY DRYING; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; POROSITY; TRANSGENIC MOUSE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DEXTRAN SULFATE; DRUG CARRIERS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; MANNITOL; MICE, INBRED C57BL; MICE, TRANSGENIC; OVALBUMIN; PEPTIDES; POROSITY; VACCINES;

EID: 84908562984     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.07.043     Document Type: Article

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