Spray-dried polyelectrolyte microparticles in oral antigen delivery: Stability, biocompatibility, and cellular uptake

Biomacromolecules

Volumn 15, Issue 6, 2014, Pages 2301-2309

  De Smet, Rebecca ^a   Verschuere, Stephanie ^a   Allais, Liesbeth ^a   Leclercq, Georges ^a   Dierendonck, Marijke ^a   De Geest, Bruno G ^a   Van Driessche, Isabel ^a   Demoor, Tine ^a   Cuvelier, Claude A ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; MICROSPHERES; VACCINES;

CLINICAL APPLICATION; COSTIMULATORY MOLECULES; GASTRIC CONDITIONS; INTESTINAL EPITHELIAL CELLS; INTRACELLULAR COMPARTMENTS; PARTICLE UPTAKES; POROUS MICROSPHERES; TOLERANCE INDUCTIONS;

ANTIGENS;

CALCIUM CARBONATE; HLA ANTIGEN CLASS 2; MANNITOL; MICROSPHERE; POLYELECTROLYTE; PROTEINASE; ANTIGEN; BIOMATERIAL; BOVINE SERUM ALBUMIN; OVALBUMIN;

ARTICLE; BIOCOMPATIBILITY; CACO 2 CELL LINE; CELL MATURATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; HT 29 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE FLUID; NANOPORE; PARTICLE SIZE; PHAGOLYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; SURFACE PROPERTY; UPREGULATION; CELL SURVIVAL; DRUG EFFECTS; DRUG STABILITY; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PROCEDURES;

ADMINISTRATION, ORAL; ANTIGENS; BIOCOMPATIBLE MATERIALS; CACO-2 CELLS; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HT29 CELLS; HUMANS; MICROSPHERES; OVALBUMIN; SERUM ALBUMIN, BOVINE;

EID: 84902150804     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm5005367     Document Type: Article

References (45)

1. World Health Organization. Diarrhoeal Disease; Fact Sheet Number 330; World Health Organization: Geneva, Switzerland, 2013.
2. Holmgren, J.; Svennerholm, A. M. Vaccines against mucosal infections Curr. Opin. Immunol. 2012, 24, 343-353
3. Wilkhu, J.; McNeil, S. E.; Kirby, D. J.; Perrie, Y. Formulation design considerations for oral vaccines Ther. Delivery 2011, 2, 1141-1164
4. Malik, B.; Goyal, A. K.; Mangal, S.; Zakir, F.; Vyas, S. P. Implication of Gut Immunology in the Design of Oral Vaccines Curr. Mol. Med. 2010, 10, 47-70
5. Lycke, N. Recent progress in mucosal vaccine development: potential and limitations Nat. Rev. Immunol. 2012, 12, 592-605
6. Borges, O.; Lebre, F.; Bento, D.; Borchard, G.; Junginger, H. E. Mucosal Vaccines: Recent Progress in Understanding the Natural Barriers Pharm. Res. 2010, 27, 211-223
7. Owen, J. L.; Sahay, B.; Mohamadzadeh, M. New generation of oral mucosal vaccines targeting dendritic cells Curr. Opin. Chem. Biol. 2013, 17, 918-824
8. De Koker, S.; Lambrecht, B. N.; Willart, M. A.; van Kooyk, Y.; Grooten, J.; Vervaet, C.; Remon, J. P.; De Geest, B. G. Designing polymeric particles for antigen delivery Chem. Soc. Rev. 2011, 40, 320-339
9. McNeela, E. A.; Lavelle, E. C. Recent Advances in Microparticle and Nanoparticle Delivery Vehicles for Mucosal Vaccination Curr. Top. Microbiol. 2012, 354, 75-99
10. Vyas, S. P.; Gupta, P. N. Implication of nanoparticles/microparticles in mucosal vaccine delivery Expert Rev. Vaccines 2007, 6, 401-418
11. Bramwell, V. W.; Perrie, Y. Particulate delivery systems for vaccines: what can we expect? J. Pharm. Pharmacol. 2006, 58, 717-728
12. Mishra, N.; Goyal, A. K.; Tiwari, S.; Paliwal, R.; Paliwal, S. R.; Vaidya, B.; Mangal, S.; Gupta, M.; Dube, D.; Mehta, A.; Vyas, S. P. Recent advances in mucosal delivery of vaccines: role of mucoadhesive/biodegradable polymeric carriers Expert Opin. Ther. Pat. 2010, 20, 661-679
13. Esposito, E.; Roncarati, R.; Cortesi, R.; Cervellati, F.; Nastruzzi, C. Production of Eudragit microparticles by spray-drying technique: influence of experimental parameters on morphological and dimensional characteristics Pharm. Dev. Technol. 2000, 5, 267-78
14. McAdams, D.; Chen, D. X.; Kristensen, D. Spray drying and vaccine stabilization Expert Rev. Vaccines 2012, 11, 1211-1219
15. Sollohub, K.; Cal, K. Spray drying technique: II. Current applications in pharmaceutical technology J. Pharm. Sci. 2010, 99, 587-597
16. Vehring, R. Pharmaceutical particle engineering via spray drying Pharm. Res. 2008, 25, 999-1022
17. Volodkin, D. V.; Larionova, N. I.; Sukhorukov, G. B. Protein encapsulation via porous CaCO3 microparticles templating Biomacromolecules 2004, 5, 1962-1972
18. Rivera-Gil, P.; De Koker, S.; De Geest, B. G.; Parak, W. J. Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules Nano Lett. 2009, 9, 4398-4402
19. Kastl, L.; Sasse, D.; Wulf, V.; Hartmann, R.; Mircheski, J.; Ranke, C.; Carregal-Romero, S.; Martinez-Lopez, J. A.; Fernandez-Chacon, R.; Parak, W. J.; Elsasser, H. P.; Rivera Gil, P. Multiple internalization pathways of polyelectrolyte multilayer capsules into mammalian cells ACS Nano 2013, 7, 6605-6618
20. Reibetanz, U.; Halozan, D.; Brumen, M.; Donath, E. Flow cytometry of HEK 293T cells interacting with polyelectrolyte multilayer capsules containing fluorescein-labeled poly(acrylic acid) as a pH sensor Biomacromolecules 2007, 8, 1927-1933
21. Becker, A. L.; Johnston, A. P.; Caruso, F. Layer-by-layer-assembled capsules and films for therapeutic delivery Small 2010, 6, 1836-1852
22. De Koker, S.; De Geest, B. G.; Singh, S. K.; De Rycke, R.; Naessens, T.; Van Kooyk, Y.; Demeester, J.; De Smedt, S. C.; Grooten, J. Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens Angew. Chem., Int. Ed. 2009, 48, 8485-8489
23. De Koker, S.; Naessens, T.; De Geest, B. G.; Bogaert, P.; Demeester, J.; De Smedt, S.; Grooten, J. Biodegradable Polyelectrolyte Microcapsules: Antigen Delivery Tools with Th17 Skewing Activity after Pulmonary Delivery J. Immunol. 2010, 184, 203-211
24. Dierendonck, M.; De Koker, S.; Cuvelier, C.; Grooten, J.; Vervaet, C.; Remon, J. P.; De Geest, B. G. Facile Two-Step Synthesis of Porous Antigen-Loaded Degradable Polyelectrolyte Microspheres Angew. Chem., Int. Ed. 2010, 49, 8620-8624
25. Dierendonck, M.; De Koker, S.; De Rycke, R.; Bogaert, P.; Grooten, J.; Vervaet, C.; Remon, J. P.; De Geest, B. G. Single-Step Formation of Degradable Intracellular Biomolecule Microreactors ACS Nano 2011, 5, 6886-6893
26. Dierendonck, M.; De Koker, S.; Vervaet, C.; Remon, J. P.; De Geest, B. G. Interaction between polymeric multilayer capsules and immune cells J. Controlled Release 2012, 161, 592-599
27. U.S. Pharmacopeia XXIV and National Formulary 19; The United States Pharmacopeial Convention: Rockville, MD, 2000; pp 2235-2236.
28. Song, J. W.; Ren, L. M.; Yin, C. Y.; Ji, Y. Y.; Wu, Z. F.; Li, J. X.; Xiao, F. S. Stable, porous, and bulky particles with high external surface and large pore volume from self-assembly of zeolite nanocrystals with cationic polymer J. Phys. Chem. C 2008, 112, 8609-8613
29. Finnie, K. S.; Waller, D. J.; Perret, F. L.; Krause-Heuer, A. M.; Lin, H. Q.; Hanna, J. V.; Barbe, C. J. Biodegradability of sol-gel silica microparticles for drug delivery J. Sol-Gel Sci. Technol. 2009, 49, 12-18
30. Tao, Z. M.; Toms, B.; Goodisman, J.; Asefa, T. Mesoporous Silica Microparticles Enhance the Cytotoxicity of Anticancer Platinum Drugs ACS Nano 2010, 4, 789-794
31. Cunben, L.; Hein, S.; Wang, K. Chitosan-Carrageenan polyelectrolyte complex for the delivery of protein drugs ISRN Biomater. 2013, 2013, 629807-1-629807-6
32. Landry, F. B.; Bazile, D. V.; Spenlehauer, G.; Veillard, M.; Kreuter, J. Degradation of poly(D,L-lactic acid) nanoparticles coated with albumin in model digestive fluids (USP XXII) Biomaterials 1996, 17, 715-723
33. De Geest, B. G.; Willart, M. A.; Lambrecht, B. N.; Pollard, C.; Vervaet, C.; Remon, J. P.; Grooten, J.; De Koker, S. Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function Angew. Chem. 2012, 51, 3862-3866
34. De Geest, B. G.; Willart, M. A.; Hammad, H.; Lambrecht, B. N.; Pollard, C.; Bogaert, P.; De Filette, M.; Saelens, X.; Vervaet, C.; Remon, J. P.; Grooten, J.; De Koker, S. Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection ACS Nano 2012, 6, 2136-2149
35. Volpe, D. A. Drug-permeability and transporter assays in Caco-2 and MDCK cell lines Future Med. Chem. 2011, 3, 2063-2077
36. Scaldaferri, F.; Pizzoferrato, M.; Gerardi, V.; Lopetuso, L.; Gasbarrini, A. The gut barrier: new acquisitions and therapeutic approaches J. Clin. Gastroenterol. 2012, 46 (Suppl) S12-S17
37. Desai, M. P.; Labhasetwar, V.; Walter, E.; Levy, R. J.; Amidon, G. L. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent Pharm. Res. 1997, 14, 1568-1573
38. He, C.; Yin, L.; Tang, C.; Yin, C. Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs Biomaterials 2012, 33, 8569-8578
39. Cartiera, M. S.; Johnson, K. M.; Rajendran, V.; Caplan, M. J.; Saltzman, W. M. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells Biomaterials 2009, 30, 2790-2798
40. Javier, A. M.; Kreft, O.; Semmling, M.; Kempter, S.; Skirtach, A. G.; Bruns, O. T.; del Pino, P.; Bedard, M. F.; Raedler, J.; Kaes, J.; Plank, C.; Sukhorukov, G. B.; Parak, W. J. Uptake of Colloidal Polyelectrolyte-Coated Particles and Polyelectrolyte Multilayer Capsules by Living Cells Adv. Mater. 2008, 20, 4281-4287
41. Cohen, S.; Coue, G.; Beno, D.; Korenstein, R.; Engbersen, J. F. J. Bioreducible poly(amidoamine)s as carriers for intracellular protein delivery to intestinal cells Biomaterials 2012, 33, 614-623
42. Hershberg, R. M.; Framson, P. E.; Cho, D. H.; Lee, L. Y.; Kovats, S.; Beitz, J.; Blum, J. S.; Nepom, G. T. Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing J. Clin. Invest. 1997, 100, 204-215
43. Byrne, B.; Madrigal-Estebas, L.; McEvoy, A.; Carton, J.; Doherty, D. G.; Whelan, A.; Feighery, C.; O'Donoghue, D. P.; O'Farrelly, C. Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules Hum. Immunol. 2002, 63, 977-986
44. Mayer, L.; Eisenhardt, D.; Salomon, P.; Bauer, W.; Plous, R.; Piccinini, L. Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease Gastroenterology 1991, 100, 3-12
45. De Smet, R.; Demoor, T.; Verschuere, S.; Dullaers, M.; Ostroff, G. R.; Leclercq, G.; Allais, L.; Pilette, C.; Dierendonck, M.; De Geest, B. G.; Cuvelier, C. A. β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination J. Controlled Release 2013, 172, 671-678