Single-step formation of degradable intracellular biomolecule microreactors

ACS Nano

Volumn 5, Issue 9, 2011, Pages 6886-6893

  Dierendonck, Marijke ^a   De Koker, Stefaan ^a   De Rycke, Riet ^b   Bogaert, Pieter ^b   Grooten, Johan ^a   Vervaet, Chris ^a   Remon, Jean Paul ^a   De Geest, Bruno G ^a  

^a GHENT UNIVERSITY   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

dendritic cells; drug delivery; microparticles; polyelectrolytes; vaccines

Indexed keywords

AQUEOUS MEDIUM; DENDRITIC CELLS; HORSE-RADISH PEROXIDASE; MICRO REACTOR; MICRO-PARTICLES; OPPOSITELY CHARGED POLYELECTROLYTES; OVALBUMINS; SINGLE-STEP;

BIOMOLECULES; CHEMICAL REACTORS; DISSOLUTION; DRUG DELIVERY; ENZYMES; POLYELECTROLYTES; VACCINES;

DRUG PRODUCTS;

ELECTROLYTE; MANNITOL;

ARTICLE; BIOREACTOR; CHEMISTRY; CRYSTALLIZATION;

BIOREACTORS; CRYSTALLIZATION; ELECTROLYTES; MANNITOL;

EID: 80053327217     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn200901g     Document Type: Article

References (28)

1. Jain, S.; Yap, W. T.; Irvine, D. J. Synthesis of Protein-Loaded Hydrogel Particles in an Aqueous Two-Phase System for Coincident Antigen and CpG Oligonucleotide Delivery to Antigen- Presenting Cells Biomacromolecules 2005, 6, 2590-2600 (Pubitemid 41388270)
2. Gokmen, M. T.; Du Prez, F. E. Porous Polymer Particles-A Comprehensive Guide to Synthesis, Characterization, Functionalization and Applications. Prog. Polym. Sci., in press.
3. Decher, G. Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites Science 1997, 277, 1232-1237 (Pubitemid 27449063)
4. Caruso, F.; Caruso, R. A.; Mohwald, H. Nanoengineering of Inorganic and Hybrid Hollow Spheres by Colloidal Templating Science 1998, 282, 1111-1114 (Pubitemid 28516238)
5. Donath, E.; Sukhorukov, G. B.; Caruso, F.; Davis, S. A.; Mohwald, H. Novel Hollow Polymer Shells by Colloid-Templated Assembly of Polyelectrolytes Angew. Chem., Int. Ed. 1998, 37, 2202-2205 (Pubitemid 28450870)
6. Sukhorukov, G. B.; Brumen, M.; Donath, E.; Mohwald, H. Hollow Polyelectrolyte Shells: Exclusion of Polymers and Donnan Equilibrium J. Phys. Chem. B 1999, 103, 6434-6440 (Pubitemid 129613754)
7. De Geest, B. G.; Vandenbroucke, R. E.; Guenther, A. M.; Sukhorukov, G. B.; Hennink, W. E.; Sanders, N. N.; Demeester, J.; De Smedt, S. C. Intracellularly Degradable Polyelectrolyte Microcapsules Adv. Mater. 2006, 18, 1005
8. De Koker, S.; De Geest, B. G.; Singh, S. K.; De Rycke, R.; Naessens, T.; Van Kooyk, Y.; Demeester, J.; De Smedt, S. C.; Grooten, J. Polyelectrolyte Microcapsules as Antigen Delivery Vehicles to Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens Angew. Chem., Int. Ed. 2009, 48, 8485-8489
9. De Koker, S.; Lambrecht, B. N.; Willart, M. A. M.; Van Kooyk, Y.; Grooten, J.; Vervaet, C.; Remon, J. P.; De Geest, B. G. Designing Polymeric Particles for Antigen Delivery Chem. Soc. Rev. 2011, 40, 320-339
10. De Koker, S.; Naessens, T.; De Geest, B. G.; Bogaert, P.; Demeester, J.; De Smedt, S. C.; Grooten, J. Biodegradable Polyelectrolyte Microcapsules: Antigen Delivery Tools with Th17 Skewing Activity after Pulmonary Delivery J. Immunol. 2010, 184, 203-211
11. De Cock, L. J.; Lenoir, J.; Vermeersch, V.; De Koker, S.; Skirtach, A. G.; Dubruel, P.; Adriaens, E.; Vervaet, C.; Remon, J. P.; De Geest, B. G. Polyelectrolyte Induced In Vivo Mucosal Irritation Is Dramatically Reduced upon Complexation Biomaterials 2011, 32, 1967-1977
12. De Geest, B. G.; De Koker, S.; Gonnissen, Y.; De Cock, L. J.; Grooten, J.; Remon, J. P.; Vervaet, C. A Single Step Process for the Synthesis of Antigen Laden Thermosensitive Microparticles Soft Matter 2010, 6, 305-310
13. De Rose, R.; Zelikin, A. N.; Johnston, A. P. R.; Sexton, A.; Chong, S. F.; Cortez, C.; Mulholland, W.; Caruso, F.; Kent, S. J. Binding, Internalization, and Antigen Presentation of Vaccine-Loaded Nanoengineered Capsules in Blood Adv. Mater. 2008, 20, 4698-4703
14. Sexton, A.; Whitney, P. G.; Chong, S. F.; Zelikin, A. N.; Johnston, A. P. R.; De Rose, R.; Brooks, A. G.; Caruso, F.; Kent, S. J. A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules ACS Nano 2009, 3, 3391-3400
15. Balabushevich, N. G.; Sukhorukov, G. B.; Larionova, N. I. Polyelectrolyte Multilayer Microspheres as Carriers for Bienzyme System: Preparation and Characterization Macromol. Rapid Commun. 2005, 26, 1168-1172 (Pubitemid 41092878)
16. Kreft, O.; Prevot, M.; Mohwald, H.; Sukhorukov, G. B. Shell-in-Shell Microcapsules: A Novel Tool for Integrated, Spatially Confined Enzymatic Reactions Angew. Chem., Int. Ed. 2007, 46, 5605-5608 (Pubitemid 47121640)
17. Wang, Y. J.; Caruso, F. Nanoporous Protein Particles through Templating Mesoporous Silica Spheres Adv. Mater. 2006, 18, 795-800
18. Stein, E. W.; Volodkin, D. V.; McShane, M. J.; Sukhorukov, G. B. Real-Time Assessment of Spatial and Temporal Coupled Catalysis within Polyelectrolyte Microcapsules Containing Coimmobilized Glucose Oxidase and Peroxidase Biomacromolecules 2006, 7, 710-719
19. Dierendonck, M.; De Koker, S.; Cuvelier, C.; Grooten, J.; Vervaet, C.; Remon, J. P.; De Geest, B. G. Facile Two Step Synthesis of Porous Antigen Loaded Degradable Polyelectrolyte Microspheres Angew. Chem., Int. Ed. 2010, 49, 8620-8624
20. Lynn, D. M.; Amiji, M. M.; Langer, R. pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Angew. Chem., Int. Ed. 2001, 40, 1707-1710 (Pubitemid 32441087)
21. Hulse, W. L.; Forbes, R. T.; Bonner, M. C.; Getrost, M. Influence of Protein on Mannitol Polymorphic Form Produced during Co-spray Drying Int. J. Pharm. 2009, 382, 67-72
22. Andya, J. D.; Maa, Y. F.; Costantino, H. R.; Nguyen, P. A.; Dasovich, N.; Sweeney, T. D.; Hsu, C. C.; Shire, S. J. The Effect of Formulation Excipients on Protein Stability and Aerosol Performance of Spray-Dried Powders of a Recombinant Humanized Anti-IgE Monoclonal Antibody Pharm. Res. 1999, 16, 350-358 (Pubitemid 29162091)
23. Vriezema, D. M.; Garcia, P. M. L.; Oltra, N. S.; Hatzakis, N. S.; Kuiper, S. M.; Nolte, R. J. M.; Rowan, A. E.; van Hest, J. C. M. Positional Assembly of Enzymes in Polymersome Nanoreactors for Cascade Reactions Angew. Chem., Int. Ed. 2007, 46, 7378-7382 (Pubitemid 47556160)
24. 3 Particles upon Ultrasound Disruption of Attached Substrate-Filled Liposomes Angew. Chem., Int. Ed. 2010, 49, 8116-8120
25. Javier, A. M.; Kreft, O.; Semmling, M.; Kempter, S.; Skirtach, A. G.; Bruns, O. T.; del Pino, P.; Bedard, M. F.; Raedler, J.; Kaes, J. et al. Uptake of Colloidal Polyelectrolyte-Coated Particles and Polyelectrolyte Multilayer Capsules by Living Cells Adv. Mater. 2008, 20, 4281-4287
26. Moon, J. J.; Suh, H.; Bershteyn, A.; Stephan, M. T.; Liu, H.; Huang, B.; Sohail, M.; Luo, S.; Ho Um, S.; Khant, H. et al. Interbilayer-Crosslinked Multilamellar Vesicles as Synthetic Vaccines for Potent Humoral and Cellular Immune Responses Nat. Mater. 2011, 10, 243-251
27. Broaders, K. E.; Cohen, J. A.; Beaudette, T. T.; Bachelder, E. M.; Frechet, J. M. J. Acetalated Dextran Is a Chemically and Biologically Tunable Material for Particulate Immunotherapy Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 5497-5502
28. Palankar, R.; Skirtach, A. G.; Kreft, O.; Bedard, M.; Garstka, M.; Gould, K.; Mohwald, H.; Sukhorukov, G. B.; Winterhalter, M.; Springer, S. Controlled Intracellular Release of Peptides from Microcapsules Enhances Antigen Presentation on MHC Class I Molecules Small 2009, 5, 2168-2176