Interface dynamics explain assembly dependency of influenza neuraminidase catalytic activity

Journal of Biomolecular Structure and Dynamics

Volumn 33, Issue 1, 2015, Pages 104-120

  Von Grafenstein, Susanne ^a   Wallnoefer, Hannes G ^a   Kirchmair, Johannes ^b   Fuchs, Julian E ^a   Huber, Roland G ^a   Schmidtke, Michaela ^c   Sauerbrei, Andreas ^c   Rollinger, Judith M ^a   Liedl, Klaus R ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

influenza; molecular dynamics simulation; neuraminidase; oligomerization; protein assembly

Indexed keywords

DIMER; MONOMER; TETRAMER; VIRUS SIALIDASE; PROTEIN BINDING; SIALIDASE; VIRAL PROTEIN;

ARTICLE; BINDING SITE; CATALYSIS; CLOSTRIDIUM PERFRINGENS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME STABILITY; GENE INSERTION; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; INFLUENZA A VIRUS; METABOLISM; MOLECULAR GENETICS; PLIABILITY; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; HUMANS; HYDROGEN BONDING; INFLUENZA A VIRUS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NEURAMINIDASE; PLIABILITY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; VIRAL PROTEINS;

EID: 84908562562     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2013.855142     Document Type: Article

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