Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Zhang, Yongmei ^a   Mao, Richeng ^a   Yan, Ran ^b,c   Cai, Dawei ^b,c   Zhang, Yijun ^a   Zhu, Haoxiang ^a   Kang, Yaoyue ^a   Liu, Hongyan ^a   Wang, Jinyu ^a   Qin, Yanli ^a   Huang, Yuxian ^a   Guo, Haitao ^b,c   Zhang, Jiming ^a  

^a FUDAN UNIVERSITY   (China)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DNA; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; VIRUS DNA; HEPATITIS B SURFACE ANTIGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA EXTRACTION; DNA METHYLATION; DNA REPLICATION; DNA SEQUENCE; DNA TRANSCRIPTION; EPIGENETICS; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER BIOPSY; MALE; MIDDLE AGED; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PROMOTER REGION; RNA SYNTHESIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; START CODON; YOUNG ADULT; AGE; BLOOD; CHEMISTRY; CHRONIC HEPATITIS B; COMPLICATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HEPG2 CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOLOGY; LIVER CIRRHOSIS; SEVERITY OF ILLNESS INDEX; VIROLOGY; VIRUS GENOME; VIRUS REPLICATION;

HEPATITIS B VIRUS;

ADULT; AGE FACTORS; CPG ISLANDS; DNA METHYLATION; DNA, VIRAL; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; GENOTYPE; HEP G2 CELLS; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HOST-PATHOGEN INTERACTIONS; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 84908544638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110442     Document Type: Article

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