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Volumn 24, Issue 10, 2014, Pages 1057-1066

Resistance and intolerance to statins

Author keywords

Ezetimibe; Intolerance; LDL cholesterol; PCSK9; Resistance; Statins

Indexed keywords

ALIROCUMAB; AMIODARONE; APOLIPOPROTEIN E; BREAST CANCER RESISTANCE PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ESTER TRANSFER PROTEIN; COLESEVELAM; COLESTIPOL; COLESTYRAMINE; CREATINE KINASE; EZETIMIBE; FARNESOID X RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN; LOMITAPIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MIPOMERSEN; MULTIDRUG RESISTANCE PROTEIN; NICOTINIC ACID; PRAVASTATIN; SIMVASTATIN; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; THYROID HORMONE; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN; AZETIDINE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BILE ACID; HYPOCHOLESTEROLEMIC AGENT;

EID: 84908505976     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2014.05.009     Document Type: Review
Times cited : (187)

References (83)
  • 1
    • 84870544551 scopus 로고    scopus 로고
    • Dyslipidemias in the prevention of cardiovascular disease: risks and causality
    • Graham I., Cooney M.T., Bradley D., Dudina A., Reiner Z. Dyslipidemias in the prevention of cardiovascular disease: risks and causality. Curr Cardiol Rep 2012, 14:709-720.
    • (2012) Curr Cardiol Rep , vol.14 , pp. 709-720
    • Graham, I.1    Cooney, M.T.2    Bradley, D.3    Dudina, A.4    Reiner, Z.5
  • 2
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS guidelines for the management of dyslipidaemias: the task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • Reiner Ž., Catapano A.L., De Backer G., Graham I., Taskinen M.R., Wiklund O. ESC/EAS guidelines for the management of dyslipidaemias: the task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011, 32:1769-1818.
    • (2011) Eur Heart J , vol.32 , pp. 1769-1818
    • Reiner, Ž.1    Catapano, A.L.2    De Backer, G.3    Graham, I.4    Taskinen, M.R.5    Wiklund, O.6
  • 3
    • 84902576469 scopus 로고    scopus 로고
    • ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines
    • Stone N.J., Robinson J., Lichtenstein A.H., Bairey Merz C.N., Lloyd-Jones D.M., Blum C.B., et al. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol 2013, 10.1016/j.jacc.2013.11.002.
    • (2013) J Am Coll Cardiol
    • Stone, N.J.1    Robinson, J.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Lloyd-Jones, D.M.5    Blum, C.B.6
  • 4
    • 84881100168 scopus 로고    scopus 로고
    • Statins in the primary prevention of cardiovascular disease
    • Reiner Ž. Statins in the primary prevention of cardiovascular disease. Nat Rev Cardiol 2013, 10:453-464.
    • (2013) Nat Rev Cardiol , vol.10 , pp. 453-464
    • Reiner, Ž.1
  • 5
    • 84884930035 scopus 로고    scopus 로고
    • Prevalence and types of persistent dyslipidemia in patients treated with statins
    • Reiner Ž., Tedeschi-Reiner E. Prevalence and types of persistent dyslipidemia in patients treated with statins. Croat Med J 2013, 54:339-345.
    • (2013) Croat Med J , vol.54 , pp. 339-345
    • Reiner, Ž.1    Tedeschi-Reiner, E.2
  • 6
    • 84888120293 scopus 로고    scopus 로고
    • EUROASPIRE III study group. Treatment potential for dyslipidaemia management in patients with coronary heart disease across Europe: findings from the EUROASPIRE III survey
    • Reiner Ž., De Bacquer D., Kotseva K., Prugger C., De Backer G., Wood D. EUROASPIRE III study group. Treatment potential for dyslipidaemia management in patients with coronary heart disease across Europe: findings from the EUROASPIRE III survey. Atherosclerosis 2013, 231:300-307.
    • (2013) Atherosclerosis , vol.231 , pp. 300-307
    • Reiner, Ž.1    De Bacquer, D.2    Kotseva, K.3    Prugger, C.4    De Backer, G.5    Wood, D.6
  • 7
    • 84862119222 scopus 로고    scopus 로고
    • European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)
    • Perk J., De Backer G., Gohlke H., Graham I., Reiner Z., Verschuren M., et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012, 33:1635-1701.
    • (2012) Eur Heart J , vol.33 , pp. 1635-1701
    • Perk, J.1    De Backer, G.2    Gohlke, H.3    Graham, I.4    Reiner, Z.5    Verschuren, M.6
  • 8
    • 84898950294 scopus 로고    scopus 로고
    • The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011
    • Ray K.K., Kastelein J.J., Matthijs Boekholdt S., Nicholls S.J., Khaw K.T., Ballantyne C.M., et al. The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011. Eur Heart J 2014, 25:960-968.
    • (2014) Eur Heart J , vol.25 , pp. 960-968
    • Ray, K.K.1    Kastelein, J.J.2    Matthijs Boekholdt, S.3    Nicholls, S.J.4    Khaw, K.T.5    Ballantyne, C.M.6
  • 9
    • 41149174566 scopus 로고    scopus 로고
    • Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment
    • Krauss R.M., Mangravite L.M., Smith J.D., Medina M.W., Wang D., Guo X., et al. Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment. Circulation 2008, 117:1537-1544.
    • (2008) Circulation , vol.117 , pp. 1537-1544
    • Krauss, R.M.1    Mangravite, L.M.2    Smith, J.D.3    Medina, M.W.4    Wang, D.5    Guo, X.6
  • 12
    • 69549111453 scopus 로고    scopus 로고
    • Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the treating to new targets (TNT) cohort
    • Thompson J.F., Hyde C.L., Wood L.S., Paciga S.A., Hinds D.A., Cox D.R., et al. Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the treating to new targets (TNT) cohort. Circ Cardiovasc Genet 2009, 2:173-181.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 173-181
    • Thompson, J.F.1    Hyde, C.L.2    Wood, L.S.3    Paciga, S.A.4    Hinds, D.A.5    Cox, D.R.6
  • 13
    • 57149124098 scopus 로고    scopus 로고
    • A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study
    • Donnelly L.A., Doney A.S., Dannfald J., Whitley A.L., Lang C.C., Morris A.D., et al. A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study. Pharmacogenet Genomics 2008, 18:1021-1026.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 1021-1026
    • Donnelly, L.A.1    Doney, A.S.2    Dannfald, J.3    Whitley, A.L.4    Lang, C.C.5    Morris, A.D.6
  • 14
    • 49949088790 scopus 로고    scopus 로고
    • Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER
    • Polisecki E., Muallem H., Maeda N., Peter I., Robertson M., McMahon A.D., et al. Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Atherosclerosis 2008, 200:109-114.
    • (2008) Atherosclerosis , vol.200 , pp. 109-114
    • Polisecki, E.1    Muallem, H.2    Maeda, N.3    Peter, I.4    Robertson, M.5    McMahon, A.D.6
  • 15
    • 56649105136 scopus 로고    scopus 로고
    • ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment
    • Rebecchi I.M., Rodrigues A.C., Arazi S.S., Genvigir F.D., Willrich M.A., Hirata M.H., et al. ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. Biochem Pharmacol 2009, 77:66-75.
    • (2009) Biochem Pharmacol , vol.77 , pp. 66-75
    • Rebecchi, I.M.1    Rodrigues, A.C.2    Arazi, S.S.3    Genvigir, F.D.4    Willrich, M.A.5    Hirata, M.H.6
  • 17
    • 1842637753 scopus 로고    scopus 로고
    • Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner
    • Kajinami K., Brousseau M.E., Ordovas J.M., Schaefer E.J. Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner. Am J Cardiol 2004, 93:1046-1050.
    • (2004) Am J Cardiol , vol.93 , pp. 1046-1050
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 18
    • 33645028973 scopus 로고    scopus 로고
    • Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms
    • Bernsdorf A., Giessmann T., Modess C., Wegner D., Igelbrink S., Hecker U., et al. Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms. Br J Clin Pharmacol 2006, 61:440-450.
    • (2006) Br J Clin Pharmacol , vol.61 , pp. 440-450
    • Bernsdorf, A.1    Giessmann, T.2    Modess, C.3    Wegner, D.4    Igelbrink, S.5    Hecker, U.6
  • 20
    • 67651196989 scopus 로고    scopus 로고
    • Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response
    • Voora D., Shah S.H., Reed C.R., Zhai J., Crosslin D.R., Messer C., et al. Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response. Circ Cardiovasc Genet 2008, 1:100-106.
    • (2008) Circ Cardiovasc Genet , vol.1 , pp. 100-106
    • Voora, D.1    Shah, S.H.2    Reed, C.R.3    Zhai, J.4    Crosslin, D.R.5    Messer, C.6
  • 21
    • 79960148136 scopus 로고    scopus 로고
    • Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins
    • Generaux G.T., Bonomo F.M., Johnson M., Doan K.M. Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins. Xenobiotica 2011, 41:639-651.
    • (2011) Xenobiotica , vol.41 , pp. 639-651
    • Generaux, G.T.1    Bonomo, F.M.2    Johnson, M.3    Doan, K.M.4
  • 22
    • 3242808852 scopus 로고    scopus 로고
    • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
    • Niemi M., Schaeffeler E., Lang T., Fromm M.F., Neuvonen M., Kyrklund C., et al. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics 2004, 14:429-440.
    • (2004) Pharmacogenetics , vol.14 , pp. 429-440
    • Niemi, M.1    Schaeffeler, E.2    Lang, T.3    Fromm, M.F.4    Neuvonen, M.5    Kyrklund, C.6
  • 23
    • 80053184849 scopus 로고    scopus 로고
    • Pharmacogenetics of OATP transporters reveals that SLCO1B1 c.388A>G variant is determinant of increased atorvastatin response
    • Rodrigues A.C., Perin P.M., Purim S.G., Silbiger V.N., Genvigir F.D., Willrich M.A., et al. Pharmacogenetics of OATP transporters reveals that SLCO1B1 c.388A>G variant is determinant of increased atorvastatin response. Int J Mol Sci 2011, 12:5815-5827.
    • (2011) Int J Mol Sci , vol.12 , pp. 5815-5827
    • Rodrigues, A.C.1    Perin, P.M.2    Purim, S.G.3    Silbiger, V.N.4    Genvigir, F.D.5    Willrich, M.A.6
  • 24
    • 33748645938 scopus 로고    scopus 로고
    • Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy
    • Takane H., Miyata M., Burioka N., Shigemasa C., Shimizu E., Otsubo K., et al. Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy. J Hum Genet 2006, 51:822-826.
    • (2006) J Hum Genet , vol.51 , pp. 822-826
    • Takane, H.1    Miyata, M.2    Burioka, N.3    Shigemasa, C.4    Shimizu, E.5    Otsubo, K.6
  • 26
    • 45349087988 scopus 로고    scopus 로고
    • Variation in Niemann-Pick C1-like 1 gene as a determinant of apolipoprotein B-100 kinetics and response to statin therapy in centrally obese men
    • Chan D.C., Watts G.F., Wang J., Hegele R.A., van Bockxmeer F.M., Barrett P.H. Variation in Niemann-Pick C1-like 1 gene as a determinant of apolipoprotein B-100 kinetics and response to statin therapy in centrally obese men. Clin Endocrinol (Oxf) 2008, 69:45-51.
    • (2008) Clin Endocrinol (Oxf) , vol.69 , pp. 45-51
    • Chan, D.C.1    Watts, G.F.2    Wang, J.3    Hegele, R.A.4    van Bockxmeer, F.M.5    Barrett, P.H.6
  • 27
    • 77951069483 scopus 로고    scopus 로고
    • Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly
    • Polisecki E., Peter I., Simon J.S., Hegele R.A., Robertson M., Ford I., et al. Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly. J Lipid Res 2010, 51:1201-1207.
    • (2010) J Lipid Res , vol.51 , pp. 1201-1207
    • Polisecki, E.1    Peter, I.2    Simon, J.S.3    Hegele, R.A.4    Robertson, M.5    Ford, I.6
  • 28
    • 84862331165 scopus 로고    scopus 로고
    • The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin
    • Hu M., Lui S.S., Tam L.S., Li E.K., Tomlinson B. The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin. J Lipid Res 2012, 53:1384-1389.
    • (2012) J Lipid Res , vol.53 , pp. 1384-1389
    • Hu, M.1    Lui, S.S.2    Tam, L.S.3    Li, E.K.4    Tomlinson, B.5
  • 29
    • 22744439625 scopus 로고    scopus 로고
    • A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin
    • Kajinami K., Brousseau M.E., Ordovas J.M., Schaefer E.J. A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin. Atherosclerosis 2005, 180:407-415.
    • (2005) Atherosclerosis , vol.180 , pp. 407-415
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 30
    • 0028901424 scopus 로고
    • Effect of apolipoprotein E and A-IV phenotypes on the low density lipoprotein response to HMG CoA reductase inhibitor therapy
    • Ordovas J.M., Lopez-Miranda J., Perez-Jimenez F., Rodriguez C., Park J.S., Cole T., et al. Effect of apolipoprotein E and A-IV phenotypes on the low density lipoprotein response to HMG CoA reductase inhibitor therapy. Atherosclerosis 1995, 113:157-166.
    • (1995) Atherosclerosis , vol.113 , pp. 157-166
    • Ordovas, J.M.1    Lopez-Miranda, J.2    Perez-Jimenez, F.3    Rodriguez, C.4    Park, J.S.5    Cole, T.6
  • 31
    • 79956356914 scopus 로고    scopus 로고
    • Effect of apolipoprotein E polymorphism on statin-induced decreases in plasma lipids and cardiovascular events
    • Hubacek J.A., Vrablik M. Effect of apolipoprotein E polymorphism on statin-induced decreases in plasma lipids and cardiovascular events. Drug Metabol Drug Interact 2011, 26:13-20.
    • (2011) Drug Metabol Drug Interact , vol.26 , pp. 13-20
    • Hubacek, J.A.1    Vrablik, M.2
  • 32
    • 84860271201 scopus 로고    scopus 로고
    • Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)
    • Deshmukh H.A. Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). J Lipid Res 2012, 53:1000-1011.
    • (2012) J Lipid Res , vol.53 , pp. 1000-1011
    • Deshmukh, H.A.1
  • 33
    • 33646443979 scopus 로고    scopus 로고
    • Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
    • Berge K.E., Ose L., Leren T.P. Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy. Arterioscler Thromb Vasc Biol 2006, 26:1094-1100.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1094-1100
    • Berge, K.E.1    Ose, L.2    Leren, T.P.3
  • 34
    • 33749025102 scopus 로고    scopus 로고
    • Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk
    • Humphries S.E., Whittall R.A., Hubbart C.S., Maplebeck S., Cooper J.A., Soutar A.K., et al. Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk. J Med Genet 2006, 43:943-949.
    • (2006) J Med Genet , vol.43 , pp. 943-949
    • Humphries, S.E.1    Whittall, R.A.2    Hubbart, C.S.3    Maplebeck, S.4    Cooper, J.A.5    Soutar, A.K.6
  • 35
    • 77952684555 scopus 로고    scopus 로고
    • Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters
    • Dong B., Wu M., Li H., Kraemer F.B., Adeli K., Seidah N.G., et al. Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. J Lipid Res 2010, 51:1486-1495.
    • (2010) J Lipid Res , vol.51 , pp. 1486-1495
    • Dong, B.1    Wu, M.2    Li, H.3    Kraemer, F.B.4    Adeli, K.5    Seidah, N.G.6
  • 36
    • 0034066644 scopus 로고    scopus 로고
    • Lipid-lowering response of the HMG-CoA reductase inhibitor fluvastatin is influenced by polymorphisms in the low-density lipoprotein receptor gene in Brazilian patients with primary hypercholesterolemia
    • Salazar L.A., Hirata M.H., Quintão E.C., Hirata R.D. Lipid-lowering response of the HMG-CoA reductase inhibitor fluvastatin is influenced by polymorphisms in the low-density lipoprotein receptor gene in Brazilian patients with primary hypercholesterolemia. J Clin Lab Anal 2000, 14:125-131.
    • (2000) J Clin Lab Anal , vol.14 , pp. 125-131
    • Salazar, L.A.1    Hirata, M.H.2    Quintão, E.C.3    Hirata, R.D.4
  • 37
    • 84860798384 scopus 로고    scopus 로고
    • Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER) trial
    • Chasman D.I., Giulianini F., MacFadyen J., Barratt B.J., Nyberg F., Ridker P.M. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER) trial. Circ Cardiovasc Genet 2012, 5:257-264.
    • (2012) Circ Cardiovasc Genet , vol.5 , pp. 257-264
    • Chasman, D.I.1    Giulianini, F.2    MacFadyen, J.3    Barratt, B.J.4    Nyberg, F.5    Ridker, P.M.6
  • 38
    • 17644416360 scopus 로고    scopus 로고
    • Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia
    • Miltiadous G., Xenophontos S., Bairaktari E., Ganotakis M., Cariolou M., Elisaf M. Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia. Pharmacogenet Genomics 2005, 15:219-225.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 219-225
    • Miltiadous, G.1    Xenophontos, S.2    Bairaktari, E.3    Ganotakis, M.4    Cariolou, M.5    Elisaf, M.6
  • 39
    • 84885031446 scopus 로고    scopus 로고
    • Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment
    • Donnelly L.A., van Zuydam N.R., Zhou K., Tavendale R., Carr F., Maitland-van der Zee A.H., et al. Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment. Pharmacogenet Genomics 2013, 23:518-525.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 518-525
    • Donnelly, L.A.1    van Zuydam, N.R.2    Zhou, K.3    Tavendale, R.4    Carr, F.5    Maitland-van der Zee, A.H.6
  • 40
    • 0028149212 scopus 로고
    • Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers
    • Hannuksela M.L., Liinamaa M.J., Kesäniemi Y.A., Savolainen M.J. Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers. Atherosclerosis 1994, 110:35-44.
    • (1994) Atherosclerosis , vol.110 , pp. 35-44
    • Hannuksela, M.L.1    Liinamaa, M.J.2    Kesäniemi, Y.A.3    Savolainen, M.J.4
  • 41
    • 19944431793 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects
    • Boekholdt S.M., Sacks F.M., Jukema J.W., Shepherd J., Freeman D.J., McMahon A.D., et al. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. Circulation 2005, 111:278-287.
    • (2005) Circulation , vol.111 , pp. 278-287
    • Boekholdt, S.M.1    Sacks, F.M.2    Jukema, J.W.3    Shepherd, J.4    Freeman, D.J.5    McMahon, A.D.6
  • 43
    • 77649250557 scopus 로고    scopus 로고
    • Association of the TNF-{alpha}-C-857T polymorphism with resistance to the cholesterol-lowering effect of HMG-CoA reductase inhibitors in type 2 diabetic subjects
    • Takahashi T., Takahashi K., Yamashina M., Maesawa C., Kajiwara T., Taneichi H., et al. Association of the TNF-{alpha}-C-857T polymorphism with resistance to the cholesterol-lowering effect of HMG-CoA reductase inhibitors in type 2 diabetic subjects. Diabetes Care 2010, 33:463-466.
    • (2010) Diabetes Care , vol.33 , pp. 463-466
    • Takahashi, T.1    Takahashi, K.2    Yamashina, M.3    Maesawa, C.4    Kajiwara, T.5    Taneichi, H.6
  • 45
    • 84875983072 scopus 로고    scopus 로고
    • Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study
    • Hopewell J.C., Parish S., Offer A., Link E., Clarke R., Lathrop M., et al. Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study. Eur Heart J 2013, 34:982-992.
    • (2013) Eur Heart J , vol.34 , pp. 982-992
    • Hopewell, J.C.1    Parish, S.2    Offer, A.3    Link, E.4    Clarke, R.5    Lathrop, M.6
  • 47
    • 33644609683 scopus 로고    scopus 로고
    • Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the cholesterol and pharmacogenetics (CAP) Study
    • Simon J.A., Lin F., Hulley S.B., Blanche P.J., Waters D., Shiboski S., et al. Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the cholesterol and pharmacogenetics (CAP) Study. Am J Cardiol 2006, 97:843-850.
    • (2006) Am J Cardiol , vol.97 , pp. 843-850
    • Simon, J.A.1    Lin, F.2    Hulley, S.B.3    Blanche, P.J.4    Waters, D.5    Shiboski, S.6
  • 48
    • 84895059003 scopus 로고    scopus 로고
    • Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation
    • Y1 Chen, Ku H., Zhao L., Wheeler D.C., Li L.C., Li Q., et al. Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation. Arterioscler Thromb Vasc Biol 2014, 34:365-376.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 365-376
    • Y1, C.1    Ku, H.2    Zhao, L.3    Wheeler, D.C.4    Li, L.C.5    Li, Q.6
  • 49
    • 33751228682 scopus 로고    scopus 로고
    • Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy
    • Boccara F., Simon T., Lacombe K., Cohen A., Laloux B., Bozec E., et al. Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy. AIDS 2006, 20:2395-2398.
    • (2006) AIDS , vol.20 , pp. 2395-2398
    • Boccara, F.1    Simon, T.2    Lacombe, K.3    Cohen, A.4    Laloux, B.5    Bozec, E.6
  • 50
    • 38049005910 scopus 로고    scopus 로고
    • Are HIV positive patients resistant to statin therapy?
    • Johns K.W., Bennett M.T., Bondy G.P. Are HIV positive patients resistant to statin therapy?. Lipids Health Dis 2007, 6:27.
    • (2007) Lipids Health Dis , vol.6 , pp. 27
    • Johns, K.W.1    Bennett, M.T.2    Bondy, G.P.3
  • 51
    • 80054725744 scopus 로고    scopus 로고
    • Statin resistant dyslipidemia in a patient treated with amiodarone
    • Al-Sarraf A., Li M., Frohlich J. Statin resistant dyslipidemia in a patient treated with amiodarone. BMJ Case Rep 2011, 10.1136/bcr.08.2011.4620.
    • (2011) BMJ Case Rep
    • Al-Sarraf, A.1    Li, M.2    Frohlich, J.3
  • 52
    • 77952091681 scopus 로고    scopus 로고
    • Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
    • Kaddurah-Daouk R., Baillie R.A., Zhu H., Zeng Z.B., Wiest M.M., Nguyen U.T., et al. Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study. Metabolomics 2010, 6:191-201.
    • (2010) Metabolomics , vol.6 , pp. 191-201
    • Kaddurah-Daouk, R.1    Baillie, R.A.2    Zhu, H.3    Zeng, Z.B.4    Wiest, M.M.5    Nguyen, U.T.6
  • 53
    • 84863617024 scopus 로고    scopus 로고
    • Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment
    • Trupp M., Zhu H., Wikoff W.R., Baillie R.A., Zeng Z.B., Karp P.D., et al. Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. PLoS One 2012, 7:e38386.
    • (2012) PLoS One , vol.7 , pp. e38386
    • Trupp, M.1    Zhu, H.2    Wikoff, W.R.3    Baillie, R.A.4    Zeng, Z.B.5    Karp, P.D.6
  • 54
    • 79251568625 scopus 로고    scopus 로고
    • Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data
    • d12
    • Bell K.J., Kirby A., Hayen A., Irwig L., Glasziou P. Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data. Br Med J 2011, 342. d12.
    • (2011) Br Med J , vol.342
    • Bell, K.J.1    Kirby, A.2    Hayen, A.3    Irwig, L.4    Glasziou, P.5
  • 55
    • 0037167013 scopus 로고    scopus 로고
    • Adherence with statin therapy in elderly patients with and without acute coronary syndromes
    • Jackevicius C.A., Mamdani M., Tu J.V. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. J Am Med Assoc 2002, 288:462-467.
    • (2002) J Am Med Assoc , vol.288 , pp. 462-467
    • Jackevicius, C.A.1    Mamdani, M.2    Tu, J.V.3
  • 56
    • 77956238180 scopus 로고    scopus 로고
    • Predictors of nonadherence to statins: a systematic review and meta-analysis
    • Mann D.M., Woodward M., Muntner P., Falzon L., Kronish I. Predictors of nonadherence to statins: a systematic review and meta-analysis. Ann Pharmacother 2010, 44:1410-1421.
    • (2010) Ann Pharmacother , vol.44 , pp. 1410-1421
    • Mann, D.M.1    Woodward, M.2    Muntner, P.3    Falzon, L.4    Kronish, I.5
  • 57
    • 78649678941 scopus 로고    scopus 로고
    • The effects of adherence and persistence on clinical outcomes in patients treated with statins: a systematic review
    • Simpson R.J., Mendys P. The effects of adherence and persistence on clinical outcomes in patients treated with statins: a systematic review. J Clin Lipidol 2010, 4:462-471.
    • (2010) J Clin Lipidol , vol.4 , pp. 462-471
    • Simpson, R.J.1    Mendys, P.2
  • 58
    • 78649692072 scopus 로고    scopus 로고
    • Public perceptions of cardiovascular risk factors in Croatia: the PERCRO survey
    • Reiner Ž Sonicki Z., Tedeschi-Reiner E. Public perceptions of cardiovascular risk factors in Croatia: the PERCRO survey. Prev Med 2010, 51:494-496.
    • (2010) Prev Med , vol.51 , pp. 494-496
    • Reiner Ž, S.Z.1    Tedeschi-Reiner, E.2
  • 60
    • 78649749546 scopus 로고    scopus 로고
    • Physicians' perception, knowledge and awareness of cardiovascular risk factors and adherence to prevention guidelines: the PERCRO-DOC survey
    • Reiner Ž., Sonicki Z., Tedeschi-Reiner E. Physicians' perception, knowledge and awareness of cardiovascular risk factors and adherence to prevention guidelines: the PERCRO-DOC survey. Atherosclerosis 2010, 213:598-603.
    • (2010) Atherosclerosis , vol.213 , pp. 598-603
    • Reiner, Ž.1    Sonicki, Z.2    Tedeschi-Reiner, E.3
  • 61
    • 84866457328 scopus 로고    scopus 로고
    • The perception and knowledge of cardiovascular risk factors among medical students
    • Reiner Ž., Sonicki Z., Tedeschi-Reiner E. The perception and knowledge of cardiovascular risk factors among medical students. Croat Med J 2012, 53:278-284.
    • (2012) Croat Med J , vol.53 , pp. 278-284
    • Reiner, Ž.1    Sonicki, Z.2    Tedeschi-Reiner, E.3
  • 62
    • 84883777708 scopus 로고    scopus 로고
    • Treatment strategies in patients with statin intolerance: the cleveland clinic experience
    • Mampuya W.M., Frid D., Rocco M., Huang J., Brennan D.M., Hazen S.L., et al. Treatment strategies in patients with statin intolerance: the cleveland clinic experience. Am Heart J 2013, 166:597-603.
    • (2013) Am Heart J , vol.166 , pp. 597-603
    • Mampuya, W.M.1    Frid, D.2    Rocco, M.3    Huang, J.4    Brennan, D.M.5    Hazen, S.L.6
  • 63
    • 79955400711 scopus 로고    scopus 로고
    • Statin induced myopathy: a review and update
    • Abd T.T., Jacobson T.A. Statin induced myopathy: a review and update. Expert Opin Drug Saf 2011, 10:373-387.
    • (2011) Expert Opin Drug Saf , vol.10 , pp. 373-387
    • Abd, T.T.1    Jacobson, T.A.2
  • 64
    • 84888004991 scopus 로고    scopus 로고
    • SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink
    • Carr D.F., O'Meara H., Jorgensen A.L., Campbell J., Hobbs M., McCann G., et al. SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink. Clin Pharmacol Ther 2013, 94:695-701.
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 695-701
    • Carr, D.F.1    O'Meara, H.2    Jorgensen, A.L.3    Campbell, J.4    Hobbs, M.5    McCann, G.6
  • 65
    • 79960864934 scopus 로고    scopus 로고
    • Weighing the benefits of high-dose simvastatin against the risk of myopathy
    • Egan A., Colman E. Weighing the benefits of high-dose simvastatin against the risk of myopathy. N Engl J Med 2011, 365:285-287.
    • (2011) N Engl J Med , vol.365 , pp. 285-287
    • Egan, A.1    Colman, E.2
  • 66
    • 81255165866 scopus 로고    scopus 로고
    • Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference
    • Mancini G.B., Baker S., Bergeron J., Fitchett D., Frohlich J., Genest J., et al. Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference. Can J Cardiol 2011, 27:635-662.
    • (2011) Can J Cardiol , vol.27 , pp. 635-662
    • Mancini, G.B.1    Baker, S.2    Bergeron, J.3    Fitchett, D.4    Frohlich, J.5    Genest, J.6
  • 67
    • 84863621057 scopus 로고    scopus 로고
    • Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: prevalence, predictors and relation with vitamin D
    • Riphagen I.J., van der Veer E., Muskiet F.A., DeJongste M.J. Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: prevalence, predictors and relation with vitamin D. Curr Med Res Opin 2012, 28:1247-1252.
    • (2012) Curr Med Res Opin , vol.28 , pp. 1247-1252
    • Riphagen, I.J.1    van der Veer, E.2    Muskiet, F.A.3    DeJongste, M.J.4
  • 68
    • 49649106710 scopus 로고    scopus 로고
    • Statins in liver disease: a molehill, an iceberg, or neither?
    • Argo C.K., Loria P., Caldwell S.H., Lonardo A. Statins in liver disease: a molehill, an iceberg, or neither?. Hepatology 2008, 48:662-669.
    • (2008) Hepatology , vol.48 , pp. 662-669
    • Argo, C.K.1    Loria, P.2    Caldwell, S.H.3    Lonardo, A.4
  • 69
    • 84892546104 scopus 로고    scopus 로고
    • Statin use is not associated with presence of and severity of nonalcoholic fatty liver disease
    • Oni E.T., Sinha P., Karim A., Martin S.S., Blaha M.J., Agatston A.S., et al. Statin use is not associated with presence of and severity of nonalcoholic fatty liver disease. Arch Med Res 2014, 45:52-57.
    • (2014) Arch Med Res , vol.45 , pp. 52-57
    • Oni, E.T.1    Sinha, P.2    Karim, A.3    Martin, S.S.4    Blaha, M.J.5    Agatston, A.S.6
  • 71
    • 84886254094 scopus 로고    scopus 로고
    • Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels
    • Tikkanen M.J., Fayyad R., Faergeman O., Olsson A.G., Wun C.C., Laskey R., et al. Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels. Int J Cardiol 2013, 168:3846-3852.
    • (2013) Int J Cardiol , vol.168 , pp. 3846-3852
    • Tikkanen, M.J.1    Fayyad, R.2    Faergeman, O.3    Olsson, A.G.4    Wun, C.C.5    Laskey, R.6
  • 72
    • 84884591325 scopus 로고    scopus 로고
    • Pharmacotherapies for lipid modification: beyond the statins
    • Gotto A.M., Moon J.E. Pharmacotherapies for lipid modification: beyond the statins. Nat Rev Cardiol 2013, 10:560-570.
    • (2013) Nat Rev Cardiol , vol.10 , pp. 560-570
    • Gotto, A.M.1    Moon, J.E.2
  • 73
    • 84884162159 scopus 로고    scopus 로고
    • Managing the residual cardiovascular disease risk associated with HDL-cholesterol and triglycerides in statin-treated patients: a clinical update
    • Reiner Ž. Managing the residual cardiovascular disease risk associated with HDL-cholesterol and triglycerides in statin-treated patients: a clinical update. Nutr Metab Cardiovasc Dis 2013, 23:799-807.
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , pp. 799-807
    • Reiner, Ž.1
  • 74
    • 74049091227 scopus 로고    scopus 로고
    • Combined therapy in the treatment of dyslipidemia
    • Reiner Ž. Combined therapy in the treatment of dyslipidemia. Fundam Clin Pharmacol 2010, 24:19-28.
    • (2010) Fundam Clin Pharmacol , vol.24 , pp. 19-28
    • Reiner, Ž.1
  • 75
    • 16844387200 scopus 로고    scopus 로고
    • Efficacy of ezetimibe in patients with statin-resistant and statin-intolerant familial hyperlipidaemias
    • Wierzbicki A.S., Doherty E., Lumb P.J., Chik G., Crook M.A. Efficacy of ezetimibe in patients with statin-resistant and statin-intolerant familial hyperlipidaemias. Curr Med Res Opin 2005, 21:333-338.
    • (2005) Curr Med Res Opin , vol.21 , pp. 333-338
    • Wierzbicki, A.S.1    Doherty, E.2    Lumb, P.J.3    Chik, G.4    Crook, M.A.5
  • 76
    • 4544350316 scopus 로고    scopus 로고
    • Effectiveness and tolerability of ezetimibe add-on therapy to a bile acid resin-based regimen for hypercholesterolemia
    • Xydakis A.M., Guyton J.R., Chiou P., Stein J.L., Jones P.H., Ballantyne C.M. Effectiveness and tolerability of ezetimibe add-on therapy to a bile acid resin-based regimen for hypercholesterolemia. Am J Cardiol 2004, 94:795-797.
    • (2004) Am J Cardiol , vol.94 , pp. 795-797
    • Xydakis, A.M.1    Guyton, J.R.2    Chiou, P.3    Stein, J.L.4    Jones, P.H.5    Ballantyne, C.M.6
  • 77
    • 76149129688 scopus 로고    scopus 로고
    • Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin
    • Lakoski S.G., Xu F., Vega G.L., Grundy S.M., Chandalia M., Lam C., et al. Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin. J Clin Endocrinol Metab 2010, 95:800-809.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 800-809
    • Lakoski, S.G.1    Xu, F.2    Vega, G.L.3    Grundy, S.M.4    Chandalia, M.5    Lam, C.6
  • 79
    • 84868518061 scopus 로고    scopus 로고
    • Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease
    • Stein E.A., Dufour R., Gagne C., Gaudet D., East C., Donovan J.M., et al. Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease. Circulation 2012, 126:2283-2292.
    • (2012) Circulation , vol.126 , pp. 2283-2292
    • Stein, E.A.1    Dufour, R.2    Gagne, C.3    Gaudet, D.4    East, C.5    Donovan, J.M.6
  • 80
    • 84888090979 scopus 로고    scopus 로고
    • Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial
    • Thomas G.S., Cromwell W.C., Ali S., Chin W., Flaim J.D., Davidson M. Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 2013, 62:2178-2184.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 2178-2184
    • Thomas, G.S.1    Cromwell, W.C.2    Ali, S.3    Chin, W.4    Flaim, J.D.5    Davidson, M.6
  • 81
    • 84871945617 scopus 로고    scopus 로고
    • Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study
    • Cuchel M., Meagher E.A., du Toit Theron H., Blom D.J., Marais A.D., Hegele R.A., et al. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 2013, 381:40-46.
    • (2013) Lancet , vol.381 , pp. 40-46
    • Cuchel, M.1    Meagher, E.A.2    du Toit Theron, H.3    Blom, D.J.4    Marais, A.D.5    Hegele, R.A.6
  • 82
    • 84870478439 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study
    • Giugliano R.P., Desai N.R., Kohli P., Rogers W.J., Somaratne R., Huang F., et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study. Lancet 2012, 380:2007-2017.
    • (2012) Lancet , vol.380 , pp. 2007-2017
    • Giugliano, R.P.1    Desai, N.R.2    Kohli, P.3    Rogers, W.J.4    Somaratne, R.5    Huang, F.6
  • 83
    • 84892679366 scopus 로고    scopus 로고
    • Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the open-label study of long-term evaluation against LDL-C (OSLER) randomized trial
    • Koren M.J., Giugliano R.P., Raal F.J., Sullivan D., Bolognese M., Langslet G., et al. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the open-label study of long-term evaluation against LDL-C (OSLER) randomized trial. Circulation 2014, 129:234-243.
    • (2014) Circulation , vol.129 , pp. 234-243
    • Koren, M.J.1    Giugliano, R.P.2    Raal, F.J.3    Sullivan, D.4    Bolognese, M.5    Langslet, G.6


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