Weighing the benefits of high-dose simvastatin against the risk of myopathy

New England Journal of Medicine

Volumn 365, Issue 4, 2011, Pages 285-287

  Egan, Amy ^a   Colman, Eric ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; AMLODIPINE; ATORVASTATIN; CREATINE KINASE MM; CYANOCOBALAMIN; DILTIAZEM; EZETIMIBE PLUS SIMVASTATIN; FOLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ROSUVASTATIN; SIMVASTATIN;

CARDIOVASCULAR EFFECT; CHOLESTEROL BLOOD LEVEL; CREATINE KINASE BLOOD LEVEL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FATALITY; DRUG LABELING; DRUG MEGADOSE; DRUG SAFETY; DYSLIPIDEMIA; FOOD AND DRUG ADMINISTRATION; HEART INFARCTION; HUMAN; MUSCLE WEAKNESS; MYALGIA; MYOPATHY; PRESCRIPTION; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; RHABDOMYOLYSIS; RISK BENEFIT ANALYSIS; SHORT SURVEY;

EID: 79960864934     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp1106689     Document Type: Short Survey

References (4)

1. Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005;366:1267-78. [Errata, Lancet 2005;366:1358, 2008;371: 2084.]
2. Smith MEB, Lee NJ, Haney E, Carson S. Drug class review: HMG-CoA reductase inhibitors (statins) and fixed-dose combination products containing a statin. Final report. Update 5. Portland: Oregon Health & Science University, November 2009. (http://www.ncbi.nlm.nih.gov/books/NBK47273/pdf/TOC. pdf.)
3. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group. Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a doubleblind randomised trial. Lancet 2010;376:1658-69.
4. The SEARCH Collaborative Group. SLCO1B1 variants and statin-induced myopathy - a genomewide study. N Engl J Med 2008;359:789-99.