Fasudil regulates T cell responses through polarization of BV-2 cells in mice experimental autoimmune encephalomyelitis

Acta Pharmacologica Sinica

Volumn 35, Issue 11, 2014, Pages 1428-1438

  Chen, Chan ^a   Li, Yan Hua ^b   Zhang, Qiong ^a   Yu, Jie Zhong ^b   Zhao, Yong Fei ^a   Ma, Cun Gen ^b,c   Xiao, Bao Guo ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANXI DATONG UNIVERSITY   (China)

^c SHANXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

cell polarization; cytokine; experimental autoimmune encephalomyelitis; fasudil; microglia; multiple sclerosis; neuroinflammation; T cell

Indexed keywords

CD11B ANTIGEN; CD23 ANTIGEN; FASUDIL; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 17; TUMOR NECROSIS FACTOR ALPHA; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ANTIINFLAMMATORY AGENT; AUTACOID; CYTOKINE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT; PROTEIN KINASE INHIBITOR; RHO KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POLARITY; CELL STRUCTURE; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; MACROPHAGE; MICROGLIA; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYMOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; COCULTURE TECHNIQUES; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE, INBRED C57BL; MICROGLIA; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; PHENOTYPE; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; T-LYMPHOCYTES, REGULATORY;

EID: 84908463623     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.68     Document Type: Article

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