Immune cell entry to the CNS - A focus for immunoregulation of EAE

Research in Immunology

Volumn 149, Issue 9, 1998, Pages

  Owens, T ^a   Tran, E ^a   Hassan Zahraee, M ^a   Krakowski, M ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; B LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; CYTOTOXIC T LYMPHOCYTE; DEMYELINATING DISEASE; GRANULOCYTE; HELPER CELL; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; T LYMPHOCYTE SUBPOPULATION;

EID: 0032209150     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2494(99)80005-4     Document Type: Article

References (54)

1. Aloisi, F., Penna, G., Cerase, J., Menendez Iglesias, B. & Adorini, L. (1997), IL-12 production by central nervous system microglia is inhibited by astrocytes. J. Immunol., 159, 1604-1612.
2. Barten, D.M., Clark, R.B. & Ruddle, N.H. (1995), Presence of T cells with activated and memory phenotypes in inflammatory spinal cord lesions. J. Immunol., 155, 5409-5418.
3. Bauer, J., Huitinga., I., Zhao, W., Lassmann, H., Hickey, W.F. & Dijkstra, C.D. (1995), The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental allergic encephalomyelitis. Glia, 15, 437-446.
4. Berger, T., Weerth, S., Kojima, K., Linington, C., Wekerle, H. & Lassmann, L. (1997), Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system. Lab. Invest., 76, 355-364.
5. Bogdan, C. (1998), The multiplex function of nitric oxide in (auto)immunity. J. Exp. Med., 187, 1361-1365.
6. Brosnan, C.F., Bornstein, M.B. & Bloom, B.R. (1981), The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis. J. Immunol., 126, 614-620.
7. Chiang, C.S., Powell, H.C., Gold, L.H., Samimi, A. & Campbell, I.L. (1996), Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice. Clin. Invest., 97, 1512-1524.
8. Corbin, J.G., Kelly, D., Rath, E.M., Baerwald, K.D., Suzuki, K. & Popko, B. (1996), Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. Mol. Cell. Neurosci., 7, 354-370.
9. Engelhardt, B., Vestweber, D., Hallmann, R. & Schulz, M. (1997), E-and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis. Blood, 90, 4459-4472.
10. Fagan, A.M. & Gage, F.H. (1994), Mechanisms of sprouting in the adult central nervous system: cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus. Neuroscience, 58,705-725.
11. + T cells compared. J. Immunol., 154, 4309-4321.
12. Ford, A.L., Foulcher, E., Lemckert, F.A. & Sedgwick, J.D. (1996), Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med., 184, 1737-1745.
13. Glabinski, A.R., Krakowski, M., Owens, T., and Ransohoff, R.M. (1998), Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis. J. Neurovirol. (in press).
14. Gold, R., Hartung, H.P. & Lassmann, H. (1997), T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms. Trends Neurosci., 20, 399-404.
15. Hassan-Zahraee, M., Wu, J. & Gordon, J. (1998), Rapid synthesis of IFNγ by T cells in skin may play a pivotal role in the human skin immune system. Int. Immunol. (in press).
16. Hickey, W.F., Hsu, B.L. & Kimura, H. (1991), T-lymphocyte entry into the central nervous system. J. Neurosci. Res., 28, 254-260.
17. Hickey, W.F., Vass, K. & Lassmann, H. (1992), Bone marrow-derived elements in the central nervous system: An immunohistochemical and ultrastructural survey of rat chimeras. J. Neuropathol. Exp. Neurol., 51, 246-256.
18. Horwitz, M.S., Evans, C.F., Mc Gavern, D.B., Rodriguez, M. & Oldstone, M.B. (1997), Primary demyelination in transgenic mice expressing interferon-gamma. Nat. Med., 3, 1037-1041.
19. Huitinga, I., Ruuls, S.R., Jung, S., van Rooijen, N., Hartung, H.-P. & Dijkstra, C.D. (1995), Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune excephalomyelitis in Lewis rats. Clin. Exp. Immunol., 100, 344-351.
20. Irani, D.V., Lin, K.-I. & Griffin, D.E. (1997), Regulation of brain-derived T cells during acute central nervous system inflammation. J. Immunol., 158, 2318-2326.
21. Korner, H., Riminton, D.S., Strickland, D.H., Lemckert, F.A., Pollard, J.D. & Sedgwick, J.D. (1997), Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J. Exp. Med., 186, 1585-1590.
22. Krakowski, M.L. & Owens, T. (1996), Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol., 26, 1641-1646.
23. + T cell cytokine profile in experimental allergic encephalomyelitis. Eur. J. Immunol., 27, 2840-2847.
24. Lannes-Vieira, J., Gehrmann, J., Kreutzberg, G.W. & Wekerle, H. (1994), The inflammatory lesion of T cell line transferred experimental autoimmune encephalomyelitis of the Lewis rat: distinct nature of parenchymal and perivascular infiltrates. Acta Neuropathol., 87, 435-442.
25. Lin, X., Pease, L.R., Murray, P.D., Rodriguez, M. (1998), Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity. J. Immunol., 160, 5661-5668.
26. Linington, C., Bradl, M., Lassmann, H., Brunner, C. & Vass, K. (1988), Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am. J. Pathol., 130, 443-454.
27. Liu, J., Marino, M.W., Wong, G., Grail, D., Dunn, A., Bettadapura, J., Slavin, A.J., Old, L. & Bernard, C.C. (1998), TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat. Med., 4, 78-83.
28. Martin, R., McFarland, H.F. & McFarlin, D.E. (1992), Immunological aspects of demyelinating diseases. Annu. Rev. Immunol., 10, 153-187.
29. Martiney, J.A., Rajan, A.J., Charles, P.C., Cerami, A., Ulrich, P.C., Macphail, S., Tracey, K.J. & Brosnan, C.F. (1998), Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent. J. Immunol., 160, 5588-5595.
30. Merrill, J.E. & Benveniste, E.N. (1996), Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci., 19, 331-338.
31. Miller, S.D., McRae, B.L., Vanderlugt, C.L., Nikcevich, K.M., Pope, J.G., Pope, L. & Karpus, W.J. (1995), Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol. Rev., 144, 225-244.
32. Morrissey, S.P., Stodal, H., Zettl, U., Simonis, C., Jung, S., Kiefer, R., Lassmann, H., Hartung, H.P., Haase, A. & Toyka, K.V. (1996), In vivo MRI and its histological correlates in acute adoptive transfer experimental allergic encephalomyelitis. Quantification of inflammation and oedema. Brain, 119, 239-248.
33. Namer, I.J., Steibel, J., Poulet, P., Armspach, J.P., Mohr, M., Mauss, Y. & Chambron, J. (1993), Blood-brain barrier breakdown in MBP-specific T cell induced experimental allergic encephalomyelitis. A quantitative in vivo MRI study. Brain, 116, 147-159.
34. Norga, K., Paemen, L., Masure, S., Dillen, C., Heremans, H., Billiau, A., Carton, H., Cuzner, L., Olsson, T., Van Damme, J. et al. (1995), Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine. Inflamm. Res., 44, 529-534.
35. Olsson, T., Diener, P., Ljungdahl, A., Hojeberg, B., Van Der Meide, P.H. & Kristensson, K. (1992), Facial nerve transection causes expansion of myelin autoreactive T cells in regional lymph nodes and T cell homing to the facial nucleus. Autoimmunity, 13, 117-126.
36. Owens, T., Renno, T., Taupin, V. & Krakowski, M. (1994), Inflammatory cytokines in the brain: Does the CNS shape immune responses? Immunol. Today, 15, 566-571.
37. Owens, T. & Sriram, S. (1995), The immunology of MS and of its animal model, EAE. Neurologic Clinics, 13, 51-73.
38. Probert, L., Akassoglou, K., Kassiotis, G., Pasparakis, M., Alexopoulou, L. & Kollias, G. (1997), TNF-α transgenic and knockout models of CNS inflammation and degenration. J. Neuroimmunol., 72, 137-141.
39. Raine, C.S. (1984), Biology of disease analysis of autoimmune demyelination: its impact upon multiple sclerosis. Lab. Invest., 50, 608-635.
40. Ransohoff, R.M. (1997), Chemokines in neurological disease models: correlation between chemokine expression patterns and inflammatory pathology. J. Leukoc. Biol., 62, 645-652.
41. Romanic, A.M., Graesser, D., Baron, J.L., Visintin, I., Janeway, C.A. JR & Madri, J.A. (1997), T cell adhesion to endothelial cells and extracellular matrix is modulated upon transendothelial cell migration. Lab. Invest., 76, 11-23.
42. Rostworowski, M., Balasingam, V., Chabot, S., Owens, T. & Yong, V.W. (1997), Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma. J. Neurosci., 17, 3664-3674.
43. Sedgwick, J.D., Ford, A.L., Foulcher, E. & Airriess, R. (1998), Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts. J. Immunol., 160, 5320-5330.
44. Segal, B.M., Dwyer, B.K. & Shevach, E.M. (1998), An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med., 187, 537-546.
45. Skundric, D.S., Huston, K., Shaw, M., Tse, H.Y. & Raine, C.S. (1994), Experimental allergic encephalomyelitis. T cell trafficking to the central nervous system in a resistant Thy-1 congenic mouse strain. Lab. Invest., 71, 671-679.
46. Sriram, S. & Rodriguez, M. (1997), Indictment of the microglia as the villain in multiple sclerosis. Neurology, 48, 464-470.
47. Streit, W.J. & Braeber, M.B. (1993), Heterogeneity of microglial and perivascular cell populations: insights gained from the facial nucleus paradigm. Glia, 7, 68-74.
48. Taupin, V., Renno, T., Bourbonniere, L., Peterson, A.C., Rodriguez, M. & Owens, T. (1997), Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor-alpha in the central nervous system. Eur. J. Immunol., 27, 905-913.
49. Tran, E.H., Hoekstra, K., van Rooijen, N., Dijkstra, C.D. & Owens, T. (1998), Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J. Immunol., 161, 3767-3775.
50. Van Der Laan, L.J.W., De Groot, C.J.A, Elices, M.J. & Dijkstra, C.D. (1997), Extracellular matrix proteins expressed by human adult astrocytes in vivo and in vitro: an astrocyte surface protein containing the CS1 domain contributes to binding of lymphoblasts. J. Neurosci. Res., 50, 539-548.
51. Wekerle, H., Linington, C., Lassmann, H. & Meyermann, R. (1986), Cellular immune reactivity within the CNS. TINS, 9, 291-297.
52. Weller, R.O., Engelhardt, B. & Phillips, M.J. (1996), Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways. Brain Pathol., 6, 275-288.
53. Willenborg, D.O., Fordham, S., Bernard, C.C., Cowden, W.B. & Ramshaw, I.A. (1996), IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol., 157, 3223-3227.
54. Yong, V.W., Krekoski, C.A., Forsyth, P.A., Bell, R. & Edwards, D.R. (1998), Matrix metalloproteinases and diseases of the CNS. Trends Neurosci., 21, 75-80.