Cytotoxic effect of carotenoid phytonutrient lycopene on P. falciparum infected erythrocytes

Molecular and Biochemical Parasitology

Volumn 197, Issue 1, 2014, Pages 15-20

  Agarwal, Shalini ^a,b   Sharma, Vijeta ^c   Kaul, Tanushri ^a   Abdin, M Z ^b   Singh, Shailja ^c  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

^b HAMDARD UNIVERSITY   (India)

^c SHIV NADAR UNIVERSITY   (India)

Author keywords

Cytotoxicity; Egress; Lycopene; Malaria; Oxidative stress; Prooxidant

Indexed keywords

LYCOPENE; REACTIVE OXYGEN METABOLITE; ANTIMALARIAL AGENT; CAROTENOID;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIOXIDANT ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG EFFECT; ERYTHROCYTE; GROWTH INHIBITION; IN VITRO STUDY; MALARIA CONTROL; MAMMAL CELL; MEMBRANE POTENTIAL; MEROZOITE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PATHOGEN CLEARANCE; PHYTONUTRIENT; PLASMODIUM FALCIPARUM; SCHIZONT; TROPHOZOITE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; LIFE CYCLE STAGE; MALARIA, FALCIPARUM; METABOLISM; PARASITOLOGY; PATHOLOGY; TIME;

ANTIMALARIALS; CAROTENOIDS; ERYTHROCYTES; HUMANS; LIFE CYCLE STAGES; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; TIME FACTORS;

EID: 84908458824     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2014.09.005     Document Type: Article

References (28)

1. Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, et al. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 2012;379(9814):413-31, http://dx.doi.org/10.1016/S0140-6736(12)60034-8.
2. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005;434(7030):214-7, http://dx.doi.org/10.1038/nature03342.
3. Rosenthal PJ. Antimalarial drug discovery: old and new approaches. J Exp Biol 2003;206:3735-44, http://dx.doi.org/10.1242/jeb.00589.
4. Batista R, Junior AJS, Oliviera AB. Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products. Molecules 2009;14(8):3037-72, http://dx.doi.org/10.3390/molecules14083037.
5. Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, et al. Highlevel semi-synthetic production of the potent antimalarial artemisinin. Nature 2013;496:528-32, http://dx.doi.org/10.1038/nature12051.
6. Aust O, Stahl W, Sies H, Tronnier H, Heinrich U. Supplementation with tomatobased product increases lycopene, phytofluene and phytoene levels in human serum and protects against UV-light-induced erythema. Int J Vitam Nutr Res 2005;75(1):54-60.
7. Clinton SK. Lycopene: chemistry, biology, and implication for human health and disease. Nutr Rev 1998;56(2 Pt 1):35-51.
8. Mascio PD, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274(2):532-8.
9. Cristina TS, Jose PC, Mónica TR, Dolores JF, Arturo CS, Norma SG, et al. Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Evidence-based Complement Altern Med 2013;2013:705121, http://dx.doi.org/10.1155/2013/705121.
10. Das BS, Thurnham DI, Das DB. Plasma alpha-tocopherol, retinol and carotenoids in children with falciparum malaria. Am J Clin Nutr 1996;64(1):94-100.
11. Shankar AH, Genton B, Semba RD, Baisor M, Paino J, Tamja S, et al. Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial. Lancet 1999;354(9174):203-9, http://dx.doi.org/10.1016/S0140-6736(98)08293-2.
12. Metzger A, Mukasa G, Shankar AH, Ndeezi G, Melikian G, Semba RD. Antioxidant status and acute malaria in children in Kampala, Uganda. Am J Trop Med Hyg 2001;65(2):115-9.
13. Palozza P, Luberto C, Calviello G, Ricci P, Bartoli GM. Antioxidant and prooxidant role of b-carotene in murine normal and tumor thymocytes: effects of oxygen partial pressure. Free Radic Biol Med 1997;22(6):1065-73.
14. Lowe GM, Booth LA, Young AJ, Bilton RF. Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic Res 1999;30(2):141-51.
15. Young AJ, Lowe GM. Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys 2001;385(1):20-7.
16. Yeh SL, Hu ML. Antioxidant and prooxidant effects of lycopene in comparison with β-carotene on oxidant-induced damage in Hs68 cells. J Nutr Biochem 2000;11(11-12):548-54.
17. Cui L, Miao J, Cui L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob Agents Chemother 2007;51(2):488-94, http://dx.doi.org/10.1128/AAC.01238-06.
18. Agarwal S, Singh MK, Garg S, Chitnis CE, Singh S. Ca(2+)-mediated exocytosis of subtilisin-like protease 1: a key step in egress of Plasmodium falciparum merozoites. Cell Microbiol 2013;15(6):910-21, http://dx.doi.org/10.1111/cmi.12086.
19. Klonis N, Creek DJ, Tilley L. Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins. Curr Opin Microbiol 2013;16(6):722-7, http://dx.doi.org/10.1016/j.mib.2013.07.005.
20. Müller S. Redox and antioxidant systems of the malaria parasite Plasmodium falciparum. Mol Microbiol 2004;53(5):1291-305.
21. Komatsuya K, Hata M, Balogun EO, Hikosaka K, Suzuki S, Takahashi K, et al. Synergy of ferrous ion on 5-aminolevulinic acid-mediated growth inhibition of Plasmodium falciparum. J Biochem 2013;154(6):501-4, http://dx.doi.org/10.1093/jb/mvt096.
22. LeBel CP, Ischiropoulos H, Bondy SC. Evaluation of the probe 29,79-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 1992;5(2):227-31.
23. Fu Y, Tilley L, Kenny S, Klonis N. Dual labeling with a far red probe permits analysis of growth and oxidative stress in P. falciparum-infected erythrocytes. Cytometry A 2010;77(3):253-63, http://dx.doi.org/10.1002/cyto.a.20856.
24. Lew VL, Tiffert T, Ginsburg H. Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum-infected red blood cells. Blood 2003;101(10):4189-94.
25. Yakes FM, Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A 1997;94(2):514-9.
26. Pasini EM, van den Ierssel D, Vial HJ, Kocken CH. A novel live-dead staining methodology to study malaria parasite viability. Malar J 2013;12:190, http://dx.doi.org/10.1186/1475-2875-12-190.
27. Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, et al. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A 2011;108(28):11405-10, http://dx.doi.org/10.1073/pnas.1104063108.
28. Caulfield LE, Richard SA, Black RE. Undernutrition as an underlying cause of malaria morbidity and mortality in children less than five years old. Am J Trop Med Hyg 2004;71(Suppl. 2):55-63.