Expression and significance of fat mass and obesity associated gene and forkhead transcription factor O1 in non-alcoholic fatty liver disease

Chinese Medical Journal

Volumn 127, Issue 21, 2014, Pages 3771-3776

  Zhang, Jie Lei ^a   Li, Shan ^a   Li, Jing Yi ^a   Han, Chao ^a   Wang, Zhi Fang ^a   Li, Chong ^a   Wang, Xiao Man ^a   Liu, Zhen Zhen ^a   Wen, Jian Guo ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Adenosine monophosphate activated protein kinase; Fat mass and obesity associated gene; Forkhead box O1; Non alcoholic fatty liver disease

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FAT DROPLET; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LOW DENSITY LIPOPROTEIN; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; CHOLESTEROL; FORKHEAD TRANSCRIPTION FACTOR;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; LIPID DIET; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATIVE STRESS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETICS; LIVER; METABOLISM; PATHOLOGY;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHOLESTEROL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIVER; MICE; MICE, INBRED C57BL; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; TRIGLYCERIDES;

EID: 84908425881     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20141017     Document Type: Article

References (23)

1. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
2. Guo J, Ren W, Li A, Ding Y, Guo W, Su D, et al. Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease. Digest Dis Sci 2013; 58: 1004-1009.
3. Valenti L, Rametta R, Dongiovanni P, Maggioni M, Fracanzani AL, Zappa M, et al. Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis. Diabetes 2008; 57: 1355-1362.
4. Pitman RT, Fong JT, Billman P, Puri N. Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner. PloS One 2012; 7: e38444.
5. Li X, Zheng C, Rosenthal RJ. The new concept of bariatric surgery in China revaluation of surgical indications and criteria of therapeutic effect of laparoscopy for treatment of obesity. Obes Surg 2008; 18: 1180-1182.
6. Sun L, Lü SZ. Association between non-alcoholic fatty liver disease and coronary artery disease severity. Chin Med J 2011; 124: 867-872.
7. Targher G, Zoppini G, Day CP. Risk of all-cause and cardiovascular mortality in patients with chronic liver disease. Gut 2011; 60: 1602-1603. author reply 1603-1604.
8. Thiruvagounder M, Khan S, Sheriff DS. Non-alcoholic fatty liver disease (NAFLD) Is it an emerging risk factor for coronary artery disease? Preliminary study in a local Indian population. Sultan Qaboos Univ Med J 2010; 10: 221-226.
9. Adams LA, Waters OR, Knuiman MW, Elliott RR, Olynyk JK. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am J Gastroenterol 2009; 104: 861-867.
10. Scorletti E, Calder PC, Byrne CD. Non-alcoholic fatty liver disease and cardiovascular risk: metabolic aspects and novel treatments. Endocrine 2011; 40: 332-343.
11. Forbes S, Taylor-Robinson SD, Patel N, Allan P, Walker BR, Johnston DG. Increased prevalence of non-alcoholic fatty liver disease in European women with a history of gestational diabetes. Diabetologia 2011; 54: 641-647.
12. Zhang H, Jiang YF, He SM, Sun J, Gu Q, Feng XW, et al. Etiology and prevalence of abnormal serum alanine aminotransferase levels in a general population in Northeast China. Chin Med J 2011; 124: 2661-2668.
13. Hickner RC, Brunson MA, McCammon M, Mahar MT, Garry JP, Houmard JA. Diabetic groups as defined by ADA and NDDG criteria have a similar aerobic capacity, blood pressure and body composition. Diabetologia 2001; 44: 26-32.
14. Monroy A, Kamath S, Chavez AO, Centonze VE, Veerasamy M, Barrentine A. Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Diabetologia 2009; 52: 2169-2181.
15. Prakash J, Srivastava N, Awasthi S, Agarwal CG, Natu SM, Rajpal N, et al. Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population. Ann Hum Biol 2011; 38: 760-763.
16. Matsumoto M, Han S, Kitamura T, Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 2006; 116: 2464-2472.
17. Kuo YT, Lin TH, Chen WL, Lee HM. Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells. Eur J Pharmacol 2012; 692: 10-18.
18. Zabena C, González-Sánchez JL, Martínez-Larrad MT, Torres- García A, Alvarez-Fernández-Represa J, Corbatón-Anchuelo A, et al. The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. Obes Surg 2009; 19: 87-95.
19. Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, et al. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 2011; 60: 258-268.
20. Hinney A1, Nguyen TT, Scherag A, Friedel S, Brönner G, Müller TD, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PloS One 2007; 2: e1361.
21. Yajnik CS1, Janipalli CS, Bhaskar S, Kulkarni SR, Freathy RM, Prakash S, et al. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia 2009; 52: 247-252.
22. Samaras K, Botelho NK, Chisholm DJ, Lord RV. Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in health. Obes Surg 2010; 20: 108-113.
23. Guan L, Shang XR, Liu FH, Song JY, Ma J, Wang HJ. Association of INSIG2 rs9308762 with ALT level independent of BMI. J Pediatr Gastroenterol Nutr 2014; 58: 155-159.