Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population

Annals of Human Biology

Volumn 38, Issue 6, 2011, Pages 760-763

  Prakash, Jai ^a   Srivastava, Neena ^a   Awasthi, Shally ^a   Agarwal, C G ^a   Natu, S M ^a   Rajpal, Naresh ^b   Mittal, Balraj ^c  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b Vivakanand Polyclinic   (India)

^c SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Adiposity; insulin; polymorphism

Indexed keywords

FTO PROTEIN, HUMAN; PROTEIN;

BODY MASS; DISEASE INCIDENCE; FAT; GENETIC VARIATION; GLUCOSE; HOMEOSTASIS; HORMONE; OBESITY; PHENOTYPE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; POLYMORPHISM;

ARTICLE; BLOOD; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HUMAN; INDIA; OBESITY; PATHOPHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDIA; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS;

INDIA;

EID: 80054963552     PISSN: 03014460     EISSN: 14645033     Source Type: Journal    
DOI: 10.3109/03014460.2011.614278     Document Type: Article

References (15)

1. Cha W, Choi M, Kim S, Park L, Kim R, Kim Y, Shin D. 2008. Replication of genetic effects of FTO polymorphisms on BMI in a Korean population. Obesity (Silver Spring) 16:2187-2189.
2. Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T, Lee A, Moir L, Mecinović J, Quwailid MM, Schofield CJ, Ashcroft FM, Cox RD. 2009. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 5:e1000599.
3. Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougneres P, Kovacs P, Marre M, Balkau B, Cauchi S, Chevre JC, Froguel P. 2007. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39:724-726. (Pubitemid 46848595)
4. Do R, Bailey D, Desbiens K, Belisle A, Montpetit A, Bouchard C, Perusse L, Vohl C, Engert C. 2008. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 57:1147-1150.
5. Frayling M. 2007. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657-662.
6. Gerken T, Girard A, Tung C, Webby J, Saudek V, Hewitson S, Yeo S, McDonough A, Cunliffe S, McNeill A, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll P, Ma M, Jovanovic Z, Farooqi S, Sedgwick B, Barroso I, Lindahl T, Ponting P, Ashcroft M, O'Rahilly S, Schofield J. 2007. The obesity-associated FTO gene encodes a 2-oxoglutaratedependent nucleic acid demethylase. Science 318:1469-1472. (Pubitemid 350208961)
7. Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T. 2007. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 50:2461-2466. (Pubitemid 350060646)
8. Hubacek A, Bohuslavova R, Kuthanova L, Kubinova R, Peasey A, Pikhart H, Marmot G, Bobak M. 2008. The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study. Obesity (Silver Spring) 16:2764-2766.
9. Hunt C, Stone S, Xin Y, Scherer A, Magness L, Iadonato P, Hopkins N, Adams D. 2008. Association of the FTO gene with BMI. Obesity (Silver Spring) 16:902-904. (Pubitemid 351465652)
10. Kahn B, Flier S. 2000. Obesity and insulin resistance. J Clin Invest 106: 473-481. (Pubitemid 30666380)
11. Li H, Wu Y, Loos J, Hu B, Liu Y, Wang J, Yu Z, Lin X. 2008. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 57: 264-268.
12. Matthews R, Hosker P, Rudenski S, Naylor A, Treacher F, Turner C. 1985. Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419.
13. Price A, Li D, Zhao H. 2008. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. BMC Med Genet 9:4.
14. Wing R, Ziegler J, Langefeld D, Ng C, Haffner M, Norris M, Goodarzi O, Bowden W. 2009. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet 125:615-626.
15. Young S, Pestaner C, Gibberman V. 1975. Effects of drugs on clinical laboratory tests. Clin Chem 21:1D-432D.