Etiology and prevalence of abnormal serum alanine aminotransferase levels in a general population in Northeast China

Chinese Medical Journal

Volumn 124, Issue 17, 2011, Pages 2661-2668

  Zhang, Hong ^a   Jiang, Yan Fang ^a   He, Shu Mei ^a   Sun, Jie ^a   Gu, Qing ^a   Feng, Xiang Wei ^a   Du, Bing ^a   Wang, Wei ^a   Shi, Xiao Dong ^a   Wang, Chun Yan ^a   Zhang, Si Qi ^a   Li, Wan Yu ^a   Niu, Jun Qi ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Alanine aminotransferase; Hepatitis B virus; Hepatitis C virus; Non alcoholic fatty liver disease

Indexed keywords

ALANINE AMINOTRANSFERASE; GLUCOSE; HEPATITIS ANTIBODY; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; BODY MASS; CHINA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ECHOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; HEPATITIS B; HUMAN; HYPERTRANSAMINASEMIA; INCOME; MALE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; POPULATION STRUCTURE; RISK FACTOR; SEX DIFFERENCE; SOCIAL STATUS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ALANINE TRANSAMINASE; FATTY LIVER; FEMALE; HEPATITIS B; HEPATITIS C; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; SEX FACTORS; YOUNG ADULT;

EID: 80052528385     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.17.017     Document Type: Article

References (30)

1. World Health Organization. The world health report: shaping the future. Geneva: World Health Organization; 2003: 17.
2. Pendino GM, Mariano A, Surace P, Caserta CA, Fiorillo MT, Amante A, et al. Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town. Hepatology 2005; 41: 1151-1159.
3. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003; 37: 917-923.
4. Wang Y, Dong J, Liu HY, Wang DQ, Tian YP. Biochemical characteristics and risk factors in non-alcoholic fatty liver. Front Biosci 2010; 2: 105-110.
5. Qu JB, Zhang ZW, Shimbo S, Watanabe T, Nakatsuka H, Matsuda-Inoguchi N, et al. Urban-rural comparison of HBV and HCV infection prevalence in eastern China. Biomed Environ Sci 2000; 13: 243-253.
6. Chen CH, Huang MH, Yang JC, Nien CK, Yang CC, Yeh YH, et al. Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan. J Gastroenterol Hepatol 2007; 22: 1482-1489.
7. Chang CJ, Ko YC, Liu HW. Serum alanine aminotransferase levels in relation to hepatitis B and C virus infections among drug abusers in an area hyperendemic for hepatitis B. Dig Dis Sci 2000; 45: 1949-1952.
8. Jamali KM, Merat S. Persistent alanine aminotransferase elevation among the general Iranian population: prevalence and causes. World J Gastroenterol 2008; 14: 2867-2871.
9. Sanyal AJ. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 2002; 123: 1705-1725.
10. Lee JK, Shim JH, Lee HC, Lee SH, Kim KM, Lim YS, et al. Estimation of the healthy upper limits for serum alanine aminotransferase in Asian populations with normal liver histology. Hepatology 2010; 51: 1577-1583.
11. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1-10.
12. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome: a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabetic Med 2006; 23: 469-480.
13. Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003; 98: 960-967.
14. Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003; 124: 71-79.
15. Oh SY, Kang MS. The association between increased alanine aminotransferase activity and metabolic factors in nonalcoholic fatty liver disease. Metabolism 2006; 55: 1604-1609.
16. Kim J, Jo I. Relationship between body mass index and alanine aminotransferase concentration in non-diabetic Korean adults. Eur J Clin Nutr 2010; 64: 169-175.
17. Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol 2009; 50: 204-210.
18. Sun L, Lü SZ. Association between non-alcoholic fatty liver disease and coronary artery disease severity. Chin Med J 2011; 124: 867-872.
19. Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002; 35: 373-379.
20. Bugianesi E, Manzini P, D'Antico S, Vanni E, Longo F, Leone N, et al. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 2004; 39: 179-187.
21. Tian JL, Zhang Y, Chen BY. Sleep apnea hypopnea syndrome and liver injury. Chin Med J 2010; 123: 89-94.
22. Wang TH, Xiao XH. The association between common genetic variation in the FTO gene and metabolic syndrome in Han Chinese. Chin Med J 2010; 123: 1852-1858.
23. Kurugol Z, Koturoglu G, Aksit S, Ozacar T, Kayimbasoglu S, Ozbalikci S, et al. Seroprevalence of hepatitis B infection in the Turkish population in Northern Cyprus. Turk J Pediatr 2009; 51: 120-126.
24. Zhang ZW, Shimbo S, Qu JB, Liu ZM, Cai XC, Wang LQ, et al. Hepatitis B and C virus infection among adult women in Jilin Province, China: an urban-rural comparison in prevalence of infection markers. Southeast Asian J Trop Med Public Health 2000; 31: 530-536.
25. Maio G, d'Argenio P, Stroffolini T, Bozza A, Sacco L, Tosti ME, et al. Hepatitis C virus infection and alanine transaminase levels in the general population: a survey in a southern Italian town. J Hepatol 2000; 33: 116-120.
26. Soguero C, Joo M, Chianese-Bullock KA, Nguyen DT, Tung K, Hahn YS. Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J Virol 2002; 76: 9345-9354.
27. Hayashi NK, Takehara T. Immunopathogenesis of type C hepatitis: dendritic cell in HCV infection. J Gastroenterol Hepatol 2004; 19: 84-87.
28. Gu XB, Wang D. Relationship between serum HBV DNA level and HBV-specific, nonspecific cytotoxic T lymphocytes and natural killer cells in patients with chronic hepatitis B. Chin Med J 2009; 122: 2129-2132.
29. Liu MY, Gao X, Gao J. Association of abnormality of liver enzymes and metabolic syndrome in patients with nonalcoholic fatty liver disease. Natl Med J China (Chin) 2007; 87: 253-255.
30. Chen WB. Diagnostics. Beijing: People's Medical Publishing House; 2004: 402-403.