Synthesis of (R)- or (S)-valinol using ω-transaminases in aqueous and organic media

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 20, 2014, Pages 5558-5562

  Fuchs, Christine S ^a   Simon, Robert C ^b   Riethorst, Waander ^c   Zepeck, Ferdinand ^c   Kroutil, Wolfgang ^b  

^a AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Amino alcohols; Biocatalysis; Reductive amination; Valinol; Transaminases

Indexed keywords

2 PROPYL AMINE; ALANINE; ALIPHATIC AMINE; AMINOALCOHOL; AMINOTRANSFERASE; KETONE; METHYL TERT BUTY ETHER; OMEGA TRANSAMINASE; ORGANIC SOLVENT; PHOSPHATE; UNCLASSIFIED DRUG; VALINOL; ETHER DERIVATIVE; TERT BUTYL METHYL ETHER; VALINE; WATER;

AMINATION; AQUEOUS SOLUTION; ARTICLE; ASYMMETRIC CATALYSIS; BIOCATALYSIS; CHIRALITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENANTIOMER; NONHUMAN; PHYSICAL CHEMISTRY; REACTION ANALYSIS; SYNTHESIS; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; STEREOISOMERISM;

AMINATION; METHYL ETHERS; MOLECULAR STRUCTURE; STEREOISOMERISM; TRANSAMINASES; VALINE; WATER;

EID: 84908399165     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.05.055     Document Type: Article

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