Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice

Neuropharmacology

Volumn 88, Issue , 2015, Pages 171-179

  Ren, Zhen ^a,b   Sahir, Nadia ^a   Murakami, Shoko ^a   Luellen, Beth A ^a   Earnheart, John C ^a   Lal, Rachnanjali ^a   Kim, Ju Young ^c   Song, Hongjun ^c   Luscher, Bernhard ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model of anxious depression; Hippocampal synaptogenesis; Neurogenesis; Postnatal development; Synaptic spines

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; 4 AMINOBUTYRIC ACID; GABRG2 PROTEIN, MOUSE; GLUTAMIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BRAIN CELL; CELL AGING; CELL DAMAGE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC SPINE; DISEASE ASSOCIATION; FEMALE; GRANULE CELL; HIPPOCAMPUS; IN VITRO STUDY; MAJOR DEPRESSION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SYNAPTOGENESIS; 129 MOUSE; ANIMAL; BRAIN CORTEX; CELL CULTURE; DEFICIENCY; DENDRITE; DEPRESSION; DISEASE MODEL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPSE;

ANIMALS; ANXIETY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; DENDRITES; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HIPPOCAMPUS; MICE, 129 STRAIN; NEUROGENESIS; PHENOTYPE; RECEPTORS, GABA-A; SYNAPSES;

EID: 84908395491     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.07.019     Document Type: Article

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