Functional recovery following peripheral nerve injury in the transgenic Thy1 -GFP rat

Journal of the Peripheral Nervous System

Volumn 18, Issue 3, 2013, Pages 220-231

  Kemp, Stephen W P ^a,b   Phua, Peter D ^a   Stanoulis, Krisanne N ^a   Wood, Matthew D ^b   Liu, Edward H ^a   Gordon, Tessa ^a,b,c   Borschel, Gregory H ^a,b,c,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

functional recovery; nerve injury; nerve regeneration; skilled locomotion; transgenic rat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BEHAVIOR; CONFERENCE PAPER; CONTROLLED STUDY; HEALING; LOCOMOTION; MOTOR NERVE; MOTOR UNIT; MUSCLE MASS; MUSCLE STRENGTH; NERVE REGENERATION; NEUROANATOMY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SCIATIC NERVE INJURY; SENSORY NERVE; SPRAGUE DAWLEY RAT; TRANSGENIC RAT;

FUNCTIONAL RECOVERY; NERVE INJURY; NERVE REGENERATION; SKILLED LOCOMOTION; TRANSGENIC RAT;

ANIMALS; ANTIGENS, THY-1; AXOTOMY; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; GREEN FLUORESCENT PROTEINS; LOCOMOTION; MALE; MOTOR NEURONS; MOTOR SKILLS; MUSCLE STRENGTH; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RECOVERY OF FUNCTION; SCIATIC NEUROPATHY; SENSORY RECEPTOR CELLS; SPINAL CORD; STILBAMIDINES;

EID: 84884370950     PISSN: 10859489     EISSN: 15298027     Source Type: Journal    
DOI: 10.1111/jns5.12035     Document Type: Conference Paper

References (54)

1. Abercrombie M, (1946). Estimation of nuclear population from microtome sections. Anat Rec 94: 239-247.
2. Alant JD, Kemp SW, Khu KJ, Kumar R, Webb AA, Midha R, (2011). Traumatic neuroma in continuity injury model in rodents. J Neurotrauma 29: 1691-1703.
3. Badr Y, O'Leary S, Kline DG, (2009). Management of one hundred seventy-one operative and nonoperative obstetrical birth palsies at the Louisiana State University Health Sciences Center. Neurosurgery 65: A67-A73.
4. Bain JR, Mackinnon SE, Hunter DA, (1989). Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg 83: 129-138.
5. Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS, (2007). Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J Neurosci Res 85: 2272-2283.
6. Bridge PM, Ball DJ, Mackinnon SE, Nakao Y, Brandt K, Hunter DA, Hertl C, (1994). Nerve crush injuries-a model for axonotmesis. Exp Neurol 127: 284-290.
7. Brushart TM, (2011). Nerve Repair. Oxford University Press, New York.
8. Cazzin C, Ring CJ, (2010). Recent advances in the manipulation of murine gene expression and its utility for the study of human neurological disease. Biochim Biophys Acta 1802: 796-807.
9. Charreau B, Tesson L, Soulillou JP, Pourcel C, Anegon I, (1996). Transgenesis in rats: technical aspects and models. Transgenic Res 5: 223-234.
10. Crabbe JC, Wahlsten D, Dudek BC, (1999). Genetics of mouse behavior: interactions with laboratory environment. Science 284: 1670-1672.
11. de Medinaceli L, Freed WJ, Wyatt RJ, (1982). An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 77: 634-643.
12. Elliot D, Lloyd M, Hazari A, Sauerland S, Anand P, (2010). Relief of the pain of neuromas-in-continuity and scarred median and ulnar nerves in the distal forearm and wrist by neurolysis, wrapping in vascularized forearm fascial flaps and adjunctive procedures. J Hand Surg Eur Vol 35: 575-582.
13. Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR, (2000). Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28: 41-51.
14. Francis JS, Olariu A, Kobayashi E, Leone P, (2007). GFP-transgenic Lewis rats as a cell source for oligodendrocyte replacement. Exp Neurol 205: 177-189.
15. Fujioka H, Suzuki M, Yamanouchi K, Ohta A, Nagashima H, Kato M, Nishihara M, (2003). Generation of transgenic rats expressing enhanced green fluorescent protein in gonadotropin-releasing hormone neurons. J Reprod Dev 49: 523-529.
16. Hayashi A, Koob JW, Liu DZ, Tong AY, Hunter DA, Parsadanian A, Mackinnon SE, Myckatyn TM, (2007). A double-transgenic mouse used to track migrating Schwann cells and regenerating axons following engraftment of injured nerves. Exp Neurol 207: 128-138.
17. Hegedus J, Putman CT, Gordon T, (2007). Time course of preferential motor unit loss in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 28: 154-164.
18. Jenq CB, Coggeshall RE, (1985). Long-term patterns of axon regeneration in the sciatic nerve and its tributaries. Brain Res 345: 34-44.
19. Kanaya F, Firrell JC, Breidenbach WC, (1996). Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration. Plast Reconstr Surg 98: 1264-1271.
20. Kemp SW, Syed S, Walsh W, Zochodne DW, Midha R, (2009). Collagen nerve conduits promote enhanced axonal regeneration, schwann cell association, and neovascularization compared to silicone conduits. Tissue Eng Part A 15: 1975-1988.
21. Kemp SW, Alant J, Walsh SK, Webb AA, Midha R, (2010). Behavioural and anatomical analysis of selective tibial nerve branch transfer to the deep peroneal nerve in the rat. Eur J Neurosci 31: 1074-1090.
22. Kemp SW, Webb AA, Dhaliwal S, Syed S, Walsh SK, Midha R, (2011). Dose and duration of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve injury in the rat. Exp Neurol 229: 460-470.
23. Kline DG, Hudson AR, (1995). Nerve Injuries: Operative Results for Major Nerve Injuries, Entrapments and Tumors. W.B. Saunders, Philadelphia.
24. Lad SP, Nathan JK, Schubert RD, Boakye M, (2010). Trends in median, ulnar, radial, and brachioplexus nerve injuries in the United States. Neurosurgery 66: 953-960.
25. Magill CK, Moore AM, Borschel GH, Mackinnon SE, (2010). A new model for facial nerve research: the novel transgenic Thy1-GFP rat. Arch Facial Plast Surg 12: 315-320.
26. Major LA, Jones KE, (2005). Simulations of motor unit number estimation techniques. J Neural Eng 2: 17-34.
27. Major LA, Hegedus J, Weber DJ, Gordon T, Jones KE, (2007). Method for counting motor units in mice and validation using a mathematical model. J Neurophysiol 97: 1846-1856.
28. Martins RS, Siqueira MG, Da Silva CF, Plese JP, (2006). Correlation between parameters of electrophysiological, histomorphometric and sciatic functional index evaluations after rat sciatic nerve repair. Arq Neuropsiquiatr 64: 750-756.
29. McComas AJ, Fawcett PR, Campbell MJ, Sica RE, (1971). Electrophysiological estimation of the number of motor units within a human muscle. J Neurol Neurosurg Psychiatry 34: 121-131.
30. Monte-Raso VV, Barbieri CH, Mazzer N, Yamasita AC, Barbieri G, (2008). Is the Sciatic Functional Index always reliable and reproducible? J Neurosci Methods 170: 255-261.
31. Moore AM, Borschel GH, Santosa KA, Flagg ER, Tong AY, Kasukurthi R, Newton P, Yan Y, Hunter DA, Johnson PJ, Mackinnon SE, (2011). A transgenic rat expressing green fluorescent protein (GFP) in peripheral nerves provides a new hindlimb model for the study of nerve injury and regeneration. J Neurosci Methods 204: 19-27.
32. Munro CA, Szalai JP, Mackinnon SE, Midha R, (1998). Lack of association between outcome measures of nerve regeneration. Muscle Nerve 21: 1095-1097.
33. Noble J, Munro CA, Prasad VS, Midha R, (1998). Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. J Trauma 45: 116-122.
34. Picciotto MR, Wickman K, (1998). Using knockout and transgenic mice to study neurophysiology and behavior. Physiol Rev 78: 1131-1163.
35. Popova E, Rentzsch B, Bader M, Krivokharchenko A, (2008). Generation and characterization of a GFP transgenic rat line for embryological research. Transgenic Res 17: 955-963.
36. Ray WZ, Mackinnon SE, (2010). Management of nerve gaps: autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol 223: 77-85.
37. Rosberg HE, Carlsson KS, Hojgard S, Lindgren B, Lundborg G, Dahlin LB, (2005). Injury to the human median and ulnar nerves in the forearm-analysis of costs for treatment and rehabilitation of 69 patients in southern Sweden. J Hand Surg Br 30: 35-39.
38. Secer HI, Solmaz I, Anik I, Izci Y, Duz B, Daneyemez MK, Gonul E, (2009). Surgical outcomes of the brachial plexus lesions caused by gunshot wounds in adults. J Brachial Plex Peripher Nerve Inj 4: 11.
39. Shenaq JM, Shenaq SM, Spira M, (1989). Reliability of sciatic function index in assessing nerve regeneration across a 1 cm gap. Microsurgery 10: 214-219.
40. Sun HH, Saheb-Al-Zamani M, Yan Y, Hunter DA, Mackinnon SE, Johnson PJ, (2012). Geldanamycin accelerated peripheral nerve regeneration in comparison to FK-506 in vivo. Neurosci 223: 114-123.
41. Varejao AS, Meek MF, Ferreira AJ, Patricio JA, Cabrita AM, (2001). Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis. J Neurosci Methods 108: 1-9.
42. Varejao AS, Melo-Pinto P, Meek MF, Filipe VM, Bulas-Cruz J, (2004). Methods for the experimental functional assessment of rat sciatic nerve regeneration. Neurol Res 26: 186-194.
43. Vidal M, Morris R, Grosveld F, Spanopoulou E, (1990). Tissue-specific control elements of the Thy-1 gene. EMBO J 9: 833-840.
44. Wahlsten D, (2001). Standardizing tests of mouse behavior: reasons, recommendations, and reality. Physiol Behav 73: 695-704.
45. Wahlsten D, Metten P, Phillips TJ, Boehm SL, Burkhart-Kasch S, Dorow J, Doerksen S, Downing C, Fogarty J, Rodd-Henricks K, Hen R, McKinnon CS, Merrill CM, Nolte C, Schalomon M, Schlumbohm JP, Sibert JR, Wenger CD, Dudek BC, Crabbe JC, (2003a). Different data from different labs: lessons from studies of gene-environment interaction. J Neurobiol 54: 283-311.
46. Wahlsten D, Rustay NR, Metten P, Crabbe JC, (2003b). In search of a better mouse test. Trends Neurosci 26: 132-136.
47. Whishaw IQ, (1995). A comparison of rats and mice in a swimming pool place task and matching to place task: some surprising differences. Physiol Behav 58: 687-693.
48. Whishaw IQ, (1999). The laboratory rat, the Pied Piper of twentieth century neuroscience. Brain Res Bull 50: 411.
49. Whishaw IQ, Sarna JR, Pellis SM, (1998). Evidence for rodent-common and species-typical limb and digit use in eating, derived from a comparative analysis of ten rodent species. Behav Brain Res 96: 79-91.
50. Whishaw IQ, Metz GA, Kolb B, Pellis SM, (2001). Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: a behavioral review and theoretical proposal. Dev Psychobiol 39: 151-170.
51. Wood MD, Kemp SW, Weber C, Borschel GH, Gordon T, (2011). Outcome measures of peripheral nerve regeneration. Ann Anat 193: 321-333.
52. Yan Y, Sun HH, Mackinnon SE, Johnson PJ, (2011). Evaluation of peripheral nerve regeneration via in vivo serial transcutaneous imaging using transgenic Thy1-YFP mice. Exp Neurol 232: 7-14.
53. Zhao CS, Puurunen K, Schallert T, Sivenius J, Jolkkonen J, (2005). Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone. Behav Brain Res 160: 260-266.
54. Zochodne DW, (2008). Neurobiology of Peripheral Nerve Regeneration. Cambridge University Press, New York.