Can evidence from genome-wide association studies and positive natural selection surveys be used to evaluate the thrifty gene hypothesis in East Asians?

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Koh, Xuan Han ^a   Liu, Xuanyao ^a   Teo, Yik Ying ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 5; TRANSCRIPTION FACTOR PAX4;

ALLELE; ARF5 GENE; ARTICLE; C2CD4A GENE; C2CD4B GENE; CONTROLLED STUDY; EAST ASIAN; EUROPEAN; GCC1 GENE; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HHEX GENE; HIGH RISK POPULATION; HUMAN; IDE GENE; NATURAL SELECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PAX4 GENE; POPULATION DIFFERENTIATION; SINGLE NUCLEOTIDE POLYMORPHISM; SND1 GENE; THADA GENE; THRIFTY GENE HYPOTHESIS; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MODEL; CHINA; CHROMOSOME 7; GENETIC PREDISPOSITION; GENETIC SELECTION; GENETICS; HAPLOTYPE MAP; MULTIGENE FAMILY;

ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CHROMOSOMES, HUMAN, PAIR 7; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HAPMAP PROJECT; HUMANS; MODELS, GENETIC; MULTIGENE FAMILY; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION, GENETIC;

EID: 84908372862     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110974     Document Type: Article

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