P63-Mediated activation of the β-catenin/c-Myc signaling pathway stimulates esophageal squamous carcinoma cell invasion and metastasis

Cancer Letters

Volumn 353, Issue 1, 2014, Pages 124-132

  Lee, Kwang Bok ^a   Ye, Shuai ^a   Park, Man Hee ^b   Park, Byung Hyun ^a   Lee, Ju Seog ^c   Kim, Soo Mi ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Catholic University of Pusan   (South Korea)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

C Myc; Esophageal squamous carcinoma cell; P63; Twist; catenin

Indexed keywords

BETA CATENIN; MESSENGER RNA; MOLECULAR MARKER; MYC PROTEIN; PROTEIN P63; SUSD2 PROTEIN; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; UROKINASE; VIMENTIN; CTNNB1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MYC PROTEIN, HUMAN; NUCLEAR PROTEIN; SUSD2 PROTEIN, HUMAN; TP63 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; TWIST1 PROTEIN, HUMAN;

ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; ESOPHAGEAL CANCER CELL LINE; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE EXPRESSION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; C-MYC; CELL MOTION; ESOPHAGEAL SQUAMOUS CARCINOMA CELL; ESOPHAGUS TUMOR; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; P63; PATHOLOGY; RNA INTERFERENCE; SQUAMOUS CELL CARCINOMA; TIME; TUMOR CELL LINE; TUMOR INVASION; TWIST; Β-CATENIN;

C-MYC; ESOPHAGEAL SQUAMOUS CARCINOMA CELL; P63; TWIST; Β-CATENIN;

BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MEMBRANE GLYCOPROTEINS; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; TWIST TRANSCRIPTION FACTOR; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VIMENTIN;

EID: 84908365063     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.07.016     Document Type: Article

References (32)

1. Guo W., Jiang Y.G. Current gene expression studies in esophageal carcinoma. Curr. Genomics 2009, 10:534-539.
2. Enzinger P.C., Mayer R.J. Esophageal cancer. New Engl. J. Med. 2003, 349:2241-2252.
3. Yang A., Kaghad M., Wang Y., Gillett E., Fleming M.D., Dotsch V., Andrews N.C., Caput D., McKeon F. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 1998, 2:305-316.
4. Osada M., Ohba M., Kawahara C., Ishioka C., Kanamaru R., Katoh I., Ikawa Y., Nimura Y., Nakagawara A., Obinata M., Ikawa S. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat. Med. 1998, 4:839-843.
5. Bergholz J., Xiao Z.X. Role of p63 in development, tumorigenesis and cancer progression. Cancer Microenviron.: Official J. Int. Cancer Microenviron. Soc. 2012, 5:311-322.
6. Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R.T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999, 398:714-718.
7. Mills A.A., Zheng B., Wang X.J., Vogel H., Roop D.R., Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999, 398:708-713.
8. Senoo M., Pinto F., Crum C.P., McKeon F. p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell 2007, 129:523-536.
9. Koster M.I., Kim S., Mills A.A., DeMayo F.J., Roop D.R. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 2004, 18:126-131.
10. Wu N., Rollin J., Masse I., Lamartine J., Gidrol X. p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network. J. Biol. Chem. 2012, 287:5627-5638.
11. Daniely Y., Liao G., Dixon D., Linnoila R.I., Lori A., Randell S.H., Oren M., Jetten A.M. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am. J. Physiol. Cell Physiol. 2004, 287:C171-181.
12. Tannapfel A., Schmelzer S., Benicke M., Klimpfinger M., Kohlhaw K., Mossner J., Engeland K., Wittekind C. Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer. J. Pathol. 2001, 195:163-170.
13. Sasaki Y., Morimoto I., Ishida S., Yamashita T., Imai K., Tokino T. Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. Gene Ther. 2001, 8:1401-1408.
14. Ito Y., Takeda T., Wakasa K., Tsujimoto M., Sakon M., Matsuura N. Expression of p73 and p63 proteins in pancreatic adenocarcinoma: p73 overexpression is inversely correlated with biological aggressiveness. Int. J. Mol. Med. 2001, 8:67-71.
15. Cao L.Y., Yin Y., Li H., Jiang Y., Zhang H.F. Expression and clinical significance of S100A2 and p63 in esophageal carcinoma. World J. Gastroenterol.: WJG 2009, 15:4183-4188.
16. Hu H., Xia S.H., Li A.D., Xu X., Cai Y., Han Y.L., Wei F., Chen B.S., Huang X.P., Han Y.S., Zhang J.W., Zhang X., Wu M., Wang M.R. Elevated expression of p63 protein in human esophageal squamous cell carcinomas. Int. J. Cancer. J. Int. du Cancer 2002, 102:580-583.
17. Morita M., Uramoto H., Nakata S., Ono K., Sugaya M., Yoshimatsu T., Oyama T., Hanagiri T., Sugio K., Yasumoto K. Expression of deltaNp63 in squamous cell carcinoma of the esophagus. Anticancer Res. 2005, 25:3533-3539.
18. Jing P., Zou J., Zhang J., Jiang X. DeltaNp63 promotes UMUC3 cell invasiveness and migration through claudin1 in vitro. Mol. Med. Rep. 2013, 7:1026-1030.
19. Danilov A.V., Neupane D., Nagaraja A.S., Feofanova E.V., Humphries L.A., DiRenzo J., Korc M. DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance. PLoS ONE 2011, 6:e26815.
20. Gu X., Coates P.J., Boldrup L., Nylander K. p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck. Cancer Lett. 2008, 263:26-34.
21. Ye S., Lee K.B., Park M.H., Lee J.S., Kim S.M. p63 regulates growth of esophageal squamous carcinoma cells via the Akt signaling pathway. Int. J. Oncol. 2014.
22. Ye S., Lee K.B., Park M.H., Lee J.S., Kim S.M. p63 regulates growth of esophageal squamous carcinoma cells via the Akt signaling pathway. Int. J. Oncol. 2014, 44:2153-2159.
23. Li X.J., Leem S.H., Park M.H., Kim S.M. Regulation of YAP through an Akt-dependent process by 3,3'-diindolylmethane in human colon cancer cells. Int. J. Oncol. 2013, 43:1992-1998.
24. Drewelus I., Gopfert C., Hippel C., Dickmanns A., Damianitsch K., Pieler T., Dobbelstein M. p63 antagonizes Wnt-induced transcription. Cell Cycle 2010, 9:580-587.
25. Piccolo S., Enzo E., Montagner M. p63, Sharp1, and HIFs: master regulators of metastasis in triple-negative breast cancer. Cancer Res. 2013, 73:4978-4981.
26. Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ. 2011, 18:1487-1499.
27. Bretones G., Delgado M.D., Leon J. Myc and cell cycle control. Biochim. et Biophys. Acta 2014.
28. Dang C.V. MYC on the path to cancer. Cell 2012, 149:22-35.
29. Ma L., Young J., Prabhala H., Pan E., Mestdagh P., Muth D., Teruya-Feldstein J., Reinhardt F., Onder T.T., Valastyan S., Westermann F., Speleman F., Vandesompele J., Weinberg R.A. MiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat. Cell Biol. 2010, 12:247-256.
30. Song Y., Wu J., Oyesanya R.A., Lee Z., Mukherjee A., Fang X. Sp-1 and c-Myc mediate lysophosphatidic acid-induced expression of vascular endothelial growth factor in ovarian cancer cells via a hypoxia-inducible factor-1-independent mechanism. Clin. Cancer Res.: Official J. Am. Assoc. Cancer Res. 2009, 15:492-501.
31. Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426.
32. He T.C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T., Morin P.J., Vogelstein B., Kinzler K.W. Identification of c-MYC as a target of the APC pathway. Science 1998, 281:1509-1512.