Expression and clinical significance of S100A2 and p63 in esophageal carcinoma

World Journal of Gastroenterology

Volumn 15, Issue 33, 2009, Pages 4183-4188

  Cao, Li Yu ^a   Yin, Yu ^a   Li, Hao ^a   Jiang, Yan ^a   Zhang, Hong Fu ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Esophageal carcinoma; Immunohistochemistry; In situ hybridization; p63; S100A2

Indexed keywords

MESSENGER RNA; PROTEIN P63; PROTEIN S 100; PROTEIN S 100A2; UNCLASSIFIED DRUG; CHEMOTACTIC FACTOR; S100A2 PROTEIN, HUMAN; TP63 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELLULAR DISTRIBUTION; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS MUCOSA; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPH NODE METASTASIS; MALE; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TUMOR DIFFERENTIATION; AGED; CHEMISTRY; ESOPHAGUS; ESOPHAGUS TUMOR; GENETICS; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CHEMOTACTIC FACTORS; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; RNA, MESSENGER; S100 PROTEINS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 70449706066     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.4183     Document Type: Article

References (22)

1. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Proc Natl Acad Sci USA 1993; 90: 6547-6551
2. Nakayama S, Kretsinger RH. Evolution of the EF-hand family of proteins. Annu Rev Biophys Biomol Struct 1994; 23: 473-507
3. Wicki R, Franz C, Scholl FA, Heizmann CW, Schafer BW. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. Cell Calcium 1997; 22: 243-254
4. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998; 2: 305-316
5. Tannapfel A, Schmelzer S, Benicke M, Klimpfinger M, Kohlhaw K, Mossner J, Engeland K, Wittekind C. Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer. J Pathol 2001; 195: 163-170
6. Sasaki Y, Morimoto I, Ishida S, Yamashita T, Imai K, Tokino T. Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. Gene Ther 2001; 8: 1401-1408
7. Ito Y, Takeda T, Wakasa K, Tsujimoto M, Sakon M, Matsuura N. Expression of p73 and p63 proteins in pancreatic adenocarcinoma: p73 overexpression is inversely correlated with biological aggressiveness. Int J Mol Med 2001; 8: 67-71
8. Gendler SJ, Cohen EP, Craston A, Duhig T, Johnstone G, Barnes D. The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours. Int J Cancer 1990; 45: 431-435 (Pubitemid 20087187)
9. Schafer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW. Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics 1995; 25: 638-643
10. Weterman MA, Wilbrink M, Dijkhuizen T, van den Berg E, Geurts van Kessel A. Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation. Hum Genet 1996; 98: 16-21 (Pubitemid 26181276)
11. Pietas A, Schluns K, Marenholz I, Schafer BW, Heizmann CW, Petersen I. Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family. Genomics 2002; 79: 513-522 (Pubitemid 34274292)
12. Watson PH, Leygue ER, Murphy LC. Psoriasin (S100A7). Int J Biochem Cell Biol 1998; 30: 567-571
13. Lioumi M, Olavesen MG, Nizetic D, Ragoussis J. High-resolution YAC fragmentation map of 1q21. Genomics 1998; 49: 200-208 (Pubitemid 28240686)
14. Liu D, Rudland PS, Sibson DR, Platt-Higgins A, Barraclough R. Expression of calcium-binding protein S100A2 in breast lesions. Br J Cancer 2000; 83: 1473-1479
15. Maelandsmo GM, Florenes VA, Mellingsaeter T, Hovig E, Kerbel RS, Fodstad O. Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma. Int J Cancer 1997; 74: 464-469 (Pubitemid 27400171)
16. Gupta S, Hussain T, MacLennan GT, Fu P, Patel J, Mukhtar H. Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma. J Clin Oncol 2003; 21: 106-112
17. Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M. Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes. Cancer Sci 2005; 96: 844-857
18. Lauriola L, Michetti F, Maggiano N, Galli J, Cadoni G, Schafer BW, Heizmann CW, Ranelletti FO. Prognostic significance of the Ca(2+) binding protein S100A2 in laryngeal squamous-cell carcinoma. Int J Cancer 2000; 89: 345-349
19. Ji J, Zhao L, Wang X, Zhou C, Ding F, Su L, Zhang C, Mao X, Wu M, Liu Z. Differential expression of S100 gene family in human esophageal squamous cell carcinoma. J Cancer Res Clin Oncol 2004; 130: 480-486 (Pubitemid 39119292)
20. Kyriazanos ID, Tachibana M, Dhar DK, Shibakita M, Ono T, Kohno H, Nagasue N. Expression and prognostic significance of S100A2 protein in squamous cell carcinoma of the esophagus. Oncol Rep 2002; 9: 503-510
21. Glickman JN, Yang A, Shahsafaei A, McKeon F, Odze RD. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol 2001; 32: 1157-1165 (Pubitemid 33104425)
22. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999; 398: 708-713