MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone

Biochemical and Biophysical Research Communications

Volumn 453, Issue 1, 2014, Pages 160-165

  Huang, Quan ^a   Jiang, Zhengyu ^a   Meng, Tong ^a   Yin, Huabin ^a   Wang, Jing ^a   Wan, Wei ^a   Cheng, Mo ^a   Yan, Wangjun ^a   Liu, Tielong ^a   Song, Dianwen ^a   Chen, Haiyan ^b   Wu, Zhipeng ^a   Xu, Wei ^a   Li, Zhenxi ^a   Zhou, Wang ^a   Xiao, Jianru ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

Giant cell tumor of bone; miR 30a 5p; Osteoclast differentiation; RunX2

Indexed keywords

MICRORNA; MICRORNA 30A; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MIRN30 MICRORNA, HUMAN; RNA; RUNX2 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOCLASTOMA; OSTEOLYSIS; RNA BINDING; ANIMAL; BONE TUMOR; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OSTEOCLAST; PATHOLOGY; PREVENTION AND CONTROL; TUMOR CELL CULTURE; TUMOR SUPPRESSOR GENE; UPREGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BONE NEOPLASMS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GIANT CELL TUMOR OF BONE; HUMANS; MICE; MICE, INBRED C57BL; MICRORNAS; MOLECULAR SEQUENCE DATA; OSTEOCLASTS; OSTEOLYSIS; RNA, NEOPLASM; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84908350489     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.09.076     Document Type: Article

References (20)

1. R. Gupta, V. Seethalakshmi, and N.A. Jambhekar Clinicopathologic profile of 470 giant cell tumors of bone from a cancer hospital in Western India Ann. Diagn. Pathol. 12 4 2008 239 248
2. Z. Wu, X. Yang, and J. Xiao Aneurysmal bone cyst secondary to giant cell tumor of the mobile spine: a report of 11 cases Spine (Phila Pa 1976) 36 21 2011 E1385 90
3. M. Wuelling, C. Engels, and N. Jesse Histogenesis of giant cell tumors Pathology 23 5 2002 332 339
4. W. Zhou, H. Yin, T. Wang, T. Liu, and Z. Li MiR-126-5p regulates osteolysis formation and GCTSC proliferation in giant cell tumor through inhibition of PTHrP Bone 66 2014 267 276 (Sep. 25)
5. M. Devarapalli, B.J. Lawrence, and S.V. Madihally Modeling nutrient consumptions in large flow-through bioreactors for tissue engineering Biotechnol. Bioeng. 103 5 2009 1003 1015
6. R. Islam, H.S. Bae, W.J. Yoon, K.M. Woo, J.H. Baek, H.H. Kim, T. Uchida, and H.M. Ryoo Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP J. Cell. Physiol. 229 12 2014 2166 2174
7. I.W. Mak, R.W. Cowan, S. Popovic, N. Colterjohn, G. Singh, and M. Ghert Upregulation of MMP-13 via Runx2 in the GCTSC of giant cell tumor of bone Bone 45 2 2009 377 386
8. S. Singh, I.W. Mak, R.W. Cowan, R. Turcotte, G. Singh, and M. Ghert The role of TWIST as a regulator in giant cell tumor of bone J. Cell. Biochem. 112 9 2011 2287 2295
9. M.R. Fabian, and N. Sonenberg The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC Nat. Struct. Mol. Biol. 19 6 2012 586 593
10. J. Fu, X. Xu, L. Kang, L. Zhou, S. Wang, and J. Lu MiR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2 Biochem. Biophys. Res. Commun. 445 2 2014 314 319
11. N. Zhang, X. Wang, Q. Huo, M. Sun, and C. Cai MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin Oncogene 33 24 2014 3119 3128
12. Y. Yu, L. Cao, L. Yang, R. Kang, M. Lotze, and D. Tang MicroRNA 30A promotes autophagy in response to cancer therapy Autophagy 8 5 2012 853 855
13. M. Zhong, Z. Bian, and Z. Wu MiR-30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma Cell. Physiol. Biochem. 31 2-3 2013 209 218
14. G.A. Franzetti, K. Laud-Duval, D. Bellanger, M.H. Stern, X. Sastre-Garau, and O. Delattre MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor Oncogene 32 33 2013 3915 3921
15. Q. Zhou, M. Yang, H. Lan, and X. Yu MiR-30a negatively regulates TGF-β1-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting Snai1 Am. J. Pathol. 183 3 2013 808 819
16. X. Wu, Z. Li, and Z. Yang Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca2+-nuclear factor of activated T-cells cytoplasmic 1 signaling pathways J. Bone Miner. Res. 27 6 2012 1298 1308
17. M.D. Adhami, H. Rashid, H. Chen, and A. Javed Runx2 activity in committed osteoblasts is not essential for embryonic skeletogenesis Connect. Tissue Res. 55 2014 102 106
18. D.C. Wang, H.F. Wang, and Z.N. Yuan Runx2 induces bone osteolysis by transcriptional suppression of TSSC1 Biochem. Biophys. Res. Commun. 438 4 2013 635 639
19. J.H. Jonason, G. Xiao, M. Zhang, L. Xing, and D. Chen Post-translational regulation of Runx2 in bone and cartilage J. Dent. Res. 88 8 2009 693 703
20. J. Pratap, J.B. Lian, A. Javed, G.L. Barnes, A.J. van Wijnen, J.L. Stein, and G.S. Stein Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone Cancer Metastasis Rev. 25 4 2006 589 600